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Surgically Induced Corneal Astigmatism Following Cataract Surgery

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Open Journal of Ophthalmology 2015年第2期5卷 47-53页

作者： Derya Buran Kacnici tolga Kocatürk Harun Cakmak Sema Oruc Dündar Department of Ophthalmology Aydin State HospitalAydinTurkey Department of Ophthalmology Adnan Menderes University Medical FacultyAydinTurkey

Aim: To study the surgically induced astigmatism (SIA) caused by two different type main incisions in phacoemulsification. Methods: Sixty-eight eyes of 65 patients who underwent phacoemul-sification were randomly divided into two groups according to main incision type: 2.8 mm superior limbal incision (in Group 1) and 2.8 mm upper clear corneal incision (in Group 2). Surgical techniques did not differ between the groups except for the main incisions. All patients received detailed ophthalmological examination in addition to keratometry at the pre- and post-operatively. The preoperative and postoperative astigmatisms were calculated by the vector analysis method and the SIA was compared between the groups. Results: The mean SIA values were 1.3 ± 0.67 D, 0.89 ± 0.47 D, 0.77 ± 37 D in Group 1 and 1.42 ± 0.62 D, 1.15 ± 0.54 D, 0.94 ± 0.47 D in Group 2 on the first day, first week and first month postoperatively, respectively. According to the vector analysis, SIA was less in Group 1 than Group 2;although the difference was not statistically significant (p > 0.05). Conclusion: Although less astigmatism was detected in the superior limbal incision group, this difference was not statistically significant.

关键词： Cataract Phacoemulsification Surgically Induced Astigmatism

Effect of Different Bleaching Applications on the Surface Properties and Staining Susceptibility of Dental Composites

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Journal of Wuhan University of Technology(Materials Science) 2016年第3期31卷 677-683页

作者： Pinlar Gul Osman tolga Harorli Nilgün Ak Mustafa Gündogdu Department of Restorative Dentistry Faculty of DentistryAtaturk University25240-ErzurumTurkey Department of Restorative Dentistry Faculty of DentistryAkdeniz University07058-AntalyaTurkey Department of Prosthetic Dentistry Faculty of Dentistry Ataturk University25240-ErzurumTurkey

The aim of this study was to investigate the effects of two bleaching systems on micro hardness, surface roughness and color stability of two novel dental composites. Ormocer based restorative Admira and nano-filled composite Clearfil Majesty Esthetic were bleached with 10% carbamide peroxide （Opalescence PF） or 35% hydrogen peroxide （Beyond Max 5） and subsequently immersed in four different staining solutions （coffee, tea, red wine, and cola）. Distilled water was used as a control. Color measurements were performed with a spectrophotometer. Vickers micro hardness and roughness data were analyzed with two- way analysis of variance for repeated measures. The analysis of variance was used to compare the color change values. Duncan＇s multiple comparison test was applied to compare the results （a = 5%）. AE~＂ values over 3.3 were considered clinically unacceptable. Micro hardness and surface roughness values of the tested composites were decreased significantly after bleaching applications. Red wine and tea storage caused perceptible discolorations in the composite resin materials after 30 days of 3-hour immersion. Home or office bleaching applications can affect the surface properties of resin composites and accelerate the staining process.

关键词： composite resin bleaching surface roughness micro hardness discoloration

Self-medication with nutritional supplements and herbal over-the-counter products

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Natural Products and Bioprospecting 2011年第2期1卷 62-70页

作者： tolga EICHHORN Henry Johannes GRETEN Thomas EFFERTH Department of Pharmaceutical Biology Institute of Pharmacy and BiochemistryJohannes Gutenberg UniversityStaudinger Weg 555128 MainzGermany Heidelberg School of Chinese Medicine Karlsruher Straße 1269126 HeidelbergGermanyand Biomedical Sciences Institute Abel SalazarUniversity of PortoPortugal

In recent years,the popularity increased for nutritional supplements and herbal *** drugs,but not herbal therapies are paid by health *** are sold over-the-counter(OTC)on the patients’own ***,there are potential risks of self-medication,*** self-diagnosis,severe adverse reactions,dangerous drug interactions,risk of addiction *** are often used by patients at their own discretion without knowledge of and control by their *** users are at risk of *** medications taken by older patients increase the risk for adverse drug reactions,drug-drug interactions,and compliance problems for this age group(polypharmacy).Herbals should be discontinued prior to operations to avoid interactions with anesthetics or *** preparations may also be carcinogenic or interfere with cancer *** women use various OTC ***,in many cases,it is unclear whether their use is safe for mother or ***-medication with herbals is also largely distributed among anxious and depressive patients,and patients with other conditions and *** popularity of herbal products has also brought concerns on quality,efficacy and *** of botanical misidentification,contaminations with heavy metals,pesticides,radioactivity,organic solvents,microbials as well as adulteration with chemical drugs necessitate the establishment of international quality control *** effects have been reported for more than 300 plant species,and some commonly used herbs have been demonstrated to interact with Western *** care professionals have a critical responsibility assessing the self-care ability of their *** are available for pharmacists with information on action,side effects and toxicities as well as herbdrug *** is a need for established guidelines regarding the correct use of nutritional supplements and herbal OTC pre

关键词： botanicals contamination complementary and alternative medicine drug interactions geriatric gynecology insomnia hepatotoxicity menopause nephrotoxicity over-the-counter pain phase I/II enzymes pharmacognosy pharmacovigilance phyto-chemicals phytotherapy phytovigilance quality control

Neurovascular bundle dissection for Nesbit procedure in congenital penile curvature patients： medial or lateral？

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Asian Journal of Andrology 2014年第3期16卷 442-445页

作者： Fatih Akbulut tolga Akman Emre Salabas Murat Dinqer Mazhar Ortac Ates Kadioglu Department of Urology Haseki Training and Research Hospital Istanbul Turkey Department of Urology Istanbul Faculty of Medicine Istanbul Turkey.

The objective of this study was to compare the outcomes of the modified Nesbit procedure using different techniques for dissecting the neurovascular bundle （NVB） to correct ventral congenital penile curvatures （CPCs）. The bundle was mobilized using the medial and lateral dissection technique in 21 （Group 1） and 13 （Group 2） patients, respectively. In the medial technique, Buck＇s fascia is opened at the dorsal side of the penis, the deep dorsal vein is removed at the most prominent site of the curvature and a diamond-shaped tunica albuginea （TA） is excised from the midline of the penis. In the lateral technique, the bundle is mobilized using a longitudinal lateral incision of the Buck＇s fascia above the urethra at the 5 and 7 o＇clock positions via a bilateral approach. The localization and degree of curvature was evaluated using the combined intracavernous injection stimulation test or from the patients＇ photographs. The mean patient age and degree of curvature were similar between groups. The mean operation time was longer for Group 2 （P= 0.01）. In Group 1, nine patients （42.8%） required one diamond excision, 10 （47.6%） required two diamond excisions and two （9.5%） required more than two excisions; in Group 2, six patients （46.2%） required two diamond excisions and seven patients （53.8%） required more than two diamond excisions （P = 0.019）. The differences in penile shortening, penile straightening and numbness of the glans penis were not statistically significant. Medial dissection of the bundle for the modified Nesbit procedure reduces the number of diamond-shaped removals of TA and thus shortens operation time in comparison with its lateral counterpart.

关键词： congenital penile curvature lateral dissection medial dissection nesbit neurovascular bundle ventral curvature

Pectoral muscular twitching： a rare manifestation of spontaneous twiddler syndrome

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Journal of Geriatric Cardiology 2017年第8期14卷 532-533页

作者： Serdar Bozyel tolga Aksu Tumer Erdem Guler Kaznn Serhan Ozcan Mujdat aktas Derince Training and Research Hospital Department of Cardiology Kocaeli Turkey Eregli State Hospital Department of Cardiology Zonguldak Turkey

The twiddler syndrome is maker malfunction, in which vice in its pocket results in an uncommon cause of pace-twisting or rotating of the delead retraction or coiling and subsequent malfunction of an implanted devices such as a pacemaker, an implantable cardioverter-defibrillator （ICD）, cardiac resynchronization therapy （CRT）.

关键词： Pacemaker Twiddler

Adipose-derived stem cells in the treatment of hepatobiliary diseases and sepsis

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World Journal of Clinical Cases 2022年第14期10卷 4348-4356页

作者： Basri Satilmis Gizem Selen Cicek Egemen Cicek Sami Akbulut Tevfik tolga Sahin Sezai Yilmaz Hepatology Research Laboratory Liver Transplant InstituteInonu UniversityMalatya 44000BattalgaziTurkey Department of Biochemistry Faculty of PharmacyInonu UniversityMalatya 44000BattalgaziTurkey Department of Anesthesiology and Reanimation Malatya Training and Research HospitalMalatya 44000YesilyurtTurkey Liver Transplant Institute InonuUniversityMalatya 44000BattalgaziTurkey

Determination of the mesenchymal stem cells is one of the greatest and most exciting achievements that tissue engineering and regenerative medicine have ***-derived mesenchymal stem cells(AD-MSC)are easily isolated and cultured for a long time before losing their stem cell characteristics,which are self-renewal and ***-MSC are mesenchymal stem cells that have pluripotent lineage *** are easily accessible,and the fraction of stem cells in the adipose tissue lysates is highest among all other sources of mesenchymal stem *** is also HLA-DR negative and can be transplanted allogenically without the need for *** advantages have popularized its use in many fields including plastic reconstructive ***,in the field of hepatology and liver transplantation,the progress is ***-MSC have the potential to modulate inflammation,ameliorate ischemia-reperfusion injury,and support liver and biliary tract *** are very important for the treatment of various hepatobiliary ***,the anti-inflammatory potential of these cells has paramount importance in the treatment of *** need alternative therapeutic approaches to treat end-stage liver ***-MSC can provide a means of therapy to bridge to definitive therapeutic alternatives such as liver *** we propose to review theoretic applications of AD-MSC in the treatment of hepatobiliary diseases and sepsis.

关键词： Adipose-derived stem cells Hepatobiliary diseases Sepsis Mesenchymal stem cells Theoretic application

Living donor liver hilar variations: surgical approaches and implications

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Hepatobiliary & Pancreatic Diseases International 2011年第5期10卷 474-479页

作者： Onur Yaprak tolga Demirbas Cihan Duran Murat Dayangac Murat Akyildiz Yaman Tokat Yildiray Yuzer Hepatobiliary and Organ Transplant Center Florence Nightingale Hospital Istanbul Turkey

BACKGROUND: Varied vascular and biliary anatomies are common in the liver. Living donor hepatectomy requires precise recognition of the hilar anatomy. This study was undertaken to study donor vascular and biliary tract variations, surgical approaches and implications in living liver transplant patients. METHODS: Two hundred living donor liver transplantations were performed at our institution between 2004 and 2009. All donors were evaluated by volumetric computerized tomography (CT), CT angiography and magnetic resonance cholangiography in the preoperative period. Intraoperative ultrasonography and cholangiography were carried out. Arterial, portal and biliary anatomies were classified according to the Michels, Cheng and Huang criteria. RESULTS: Classical hepatic arterial anatomy was observed in 129 (64.5%) of the 200 donors. Fifteen percent of the donors had variation in the portal vein. Normal biliary anatomy was found in 126 (63%) donors, and biliary tract variation in 70% of donors with portal vein variations. In recipients with single duct biliary anastomosis, 16 (14.4%) developed biliary leak, and 9 (8.1%) developed biliary stricture; however more than one biliary anastomosis increased recipient biliary complications. Donor vascular variations did not increase recipient vascular complications. Variant anatomy was not associated with an increase in donor morbidity. CONCLUSIONS: Living donor liver transplantation provides information about variant hilar anatomy. The success of the procedure depends on a careful approach to anatomical variations. When the deceased donor supply is inadequate, living donor transplantation is a life-saving alternative and is safe for the donor and recipient, even if the donor has variant hilar anatomy.

关键词： living donor liver transplantation anatomical variation

A new Late Miocene Hystrix(Hystricidae,Rodentia)from Turkey

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Integrative Zoology 2024年第3期19卷 548-563页

作者： Kazım HALAÇLAR Ayla SEVIM EROL tolga KÖROG˘LU Paul RUMMY Tao DENG Serdar MAYDA Natural History Application and Research Centre Ege UniversityTurkey Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijingPeople’s Republic of China Department of Anthropology Faculty of Languages and HistoryGeographyAnkara UniversityTurkey Department of Biology Faculty of SciencesEge UniversityTurkey

TheÇorakyerler fossil locality in Anatolia reveals unique faunal *** study introduces Hystrix kayae ***.,a new Late Miocene porcupine initially classified as Hystrix *** et al.,*** finding expands our knowledge of Late Miocene Anatolian porcupines,bringing the total number of known species to *** *** larger than Hystrix aryanensis and exhibits greater upper cheek tooth crown *** cheek tooth morphology differs from Hystrix depereti,and it possesses distinctive U-shaped choanae unlike Hystrix ***Çorakyerler locality may predate sites with *** and *** but aligns temporally with Hystrix parvae *** study enhances our understanding of Late Miocene porcupine diversity in Anatolia,emphasizing the importance ofÇorakyerler in unraveling the evolutionary history of these fascinating mammals.

关键词： Çorakyerler Hystrix Late Miocene paleobiogeography Turkey

Associating liver partition and portal vein ligation for staged hepatectomy for extensive alveolar echinococcosis:First case report in the literature

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World Journal of Gastrointestinal Surgery 2018年第1期10卷 1-5页

作者： Sami Akbulut Egemen Cicek Mehmet Kolu Tevfik tolga Sahin Sezai Yilmaz Department of Surgery and Liver Transplant Institute Inonu University Faculty of Medicine Department of Radiology Inonu University Faculty of Medicine

Alveolar echinococcosis(AE) is a zoonotic disease that is caused by Echinococcus multilocularis that affects liver and a variety of organs and tissues. It differs from other echinococcal disease because it shows tumor like behavior in the affected organ and tissues. The treatment of choice is concomitant medical therapy and resection with negative margins. Nevertheless, resection with the intent of negative margins(R0) may lead to serious complications such as liver failure. In the present case report, we used Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy(ALPPS) procedure, which was defined in 2012 by Schnitzbauer et al, in a 28-year-old male patient to avoid complications of major liver resection in order to treat alveolar echinococcosis. Until now, we have not encountered any study using ALPPS procedure for the treatment of alveolar echinococcosis. In the present case report we aimed to show that ALPPS procedure can be safely performed for marginnegative resection of primary or recurrent AE that shows a tumor like behavior. It is our opinion that this procedure should be performed in centers that have expertise and sufficient technical capacity to perform liver transplantation and advanced liver surgery.

关键词： Alveolar echinococcosis Extensive disease Associating liver partition portal vein ligation Curative management