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Female spontaneously diabetic Torii fatty rats develop nonalcoholic steatohepatitis-like hepatic lesions

World Journal of Gastroenterology 2015年第30期21卷 9067-9078页

作者： Yukihito Ishii Yu Motohashi Makoto Muramatsu Yoshiaki Katsuda Katsuhiro Miyajima Tomohiko Sasase Takahisa Yamada tohru matsui Shinichi Kume Takeshi Ohta Japan Tobacco Inc. Central Pharmaceutical Research Institute Japan Tobacco Inc. Central Pharmaceutical Research InstituteToxicology Research Laboratories Niigata University Graduate School of Science and Technology Kyoto University Graduate School of Agriculture

AIM:To investigate the histological features of the liver in spontaneously diabetic Torii(SDT) fatty rats compared with age-matched Sprague-Dawley(SD) ***:Female SDT Leprfa(SDT fatty) rats and age-matched SD rats were fed ad libitum. Body weight and biochemical parameters,such as serum glucose,triglyceride(TG),total cholesterol(TC),alanine aminotransferase(ALT) and aspartate aminotransferase(AST) levels as well as fatty acid and TG accumulation in the liver were evaluated at 8 wk of age in the nonfasting state and at 8-wk intervals from 8 to 40 wk of age. Histopathological examinations of the liver were performed using hematoxylin and eosin and Sirius Red staining as well as double staining for ED-1 and toluidine blue. The expression of genes involved in TG synthesis,inflammation,and fibrosis was examined in the ***:SDT fatty rats showed significantly increased body weight compared with SD rats. Serum glucose,TG,and TC levels were significantly higher in SDT fatty rats compared with SD rats. The serum AST and ALT levels in SDT fatty rats were significantly elevated at 8 wk of age compared with the levels in SD rats. Hepatic TG content was marked in SDT fatty rats from 8 to 32 wk of age. Histopathologically,severe hepatosteatosis accompanied by inflammation was observed at 8 wk of age,and fibrosis started to occur at 32 wk of age. Furthermore,Sirius Red and ED-1 staining were increased in the liver at 32 wk of age. Hepatic gene expression related to TG synthesis,inflammation and fibrosis tended to increase in SDT fatty rats compared with SD rats,and the gene expression related to TG secretion was decreased in SDT fatty rats compared with SD rats. CONCLUSION:Female SDT fatty rats have the potential to become an important animal model of nonalcoholic steatohepatitis with type 2 diabetes and obesity.

关键词： Nonalcoholic steatohepatitis Spontaneouslydiabetic Torii fatty rat Fibrosis Fatty liver Metabolicsyndrome

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Promoting Sustainability with Ecological,Economic and Social Dimensions in Developing Countries

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Chinese Journal of Population,Resources and Environment 2009年第4期7卷 15-18页

作者： Anupam Khajuria Takanori matsui Takashi Machimura tohru Morioka Division of Sustainable Energy and Environmental Engineering Graduate School of EngineeringOsaka UniversityOsaka Yamada-oka 2-1SuitaOsaka 565-0871Japan Graduate School of Engineering Osaka UniversityYamada-oka 2-1SuitaOsaka 565-0871Japan

Sustainable development is one of the most important ideas,and goals of our *** is defined as"development which meets the needs and aspirations of the current generation and develops safe and sound society for future generation".Achieving sustainable development thus involves a vigorous and urgent debate on different *** different dimensions of sustainability as a framework involve all issues such as science,technology,economic growth and development,health,education,finance investment and trade,politics,natural disasters,population growth and terrorism,*** single dimension is responsible to develop sustainable *** article mainly described the integrated relationship among the three dimensions of sustainability.

关键词： sustainability economic growth dimensions ecological and social.

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Involvement of gonadal soma-derived factor in the reproduction of teleosts

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Aquaculture and Fisheries 2024年第3期9卷 417-421页

作者： tohru Kobayashi Laboratory of Molecular Reproductive Biology Institute for Environmental SciencesUniversity of ShizuokaShizuoka422-8526Japan Graduate School of Pharmaceutical and Nutritional Sciences University of ShizuokaShizuoka422-8526Japan

Gonadal soma-derived factor(Gsdf)is a member of the transforming growth factor beta(TGF-β)superfamily and a teleost-specific *** studies suggested that Gsdf promotes spermatogonial proliferation;however recent reports have shed light on its role in sex differentiation based on expression profiles and gain-and loss-of-function *** paper discusses the involvement of Gsdf in gonadal sex differentiation and sex changes in teleosts.

关键词： Teleosts Medaka Gsdf Sex determination Sex differentiation Sex change Pituitary

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Catalytic Conversion of Methanol by Oxidative Dehydrogenation

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Journal of Natural Gas Chemistry 2007年第1期16卷 1-5页

作者： Toshihito Ohtake tohru Mori Yutaka Morikawa Department of Electronic Chemistry Interdisciplinary Graduate School of Science and EngineeringTokyo Institute of Technology4259 NagatsutaMidori-kuYokohama 226-8502 Japan

This study investigates the effects of addition of oxygen on the oxidative dehydrogenation （ODH） of methanol when a fluorotetrasilicic mica ion-exchanged with palladium （Pd2^＋-TSM） was used as the catalyst. The reaction proceeded at a very low temperature in the presence of oxygen, and HCOOCH3 was obtained at high selectivity. By calculating the equilibrium conversion, it has been shown that substantial ODH took place for HCOOCH3 production. Consequently, this reaction would make dehydrogenation the dominant reaction at equilibrium. Not all the H dissociated from CH3OH was converted to H20 by oxidation. It has been shown that the H2O was not produced from oxidative dehydrogenation by the direct reaction of CH3OH and O2 when an attempt was made to carry out oxidative dehydrogenation using an isotope oxygen trace method in the gas phase. Therefore, when CHaOH was converted to CO2 and dehydrogenated to HCOOCH3, the C-O bonds were not dissociated.

关键词： C1 chemistry conversion methanol oxidative dehydrogenation catalysis

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Clinical significance of molecular diagnosis for gastric cancer lymph node micrometastasis

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World Journal of Gastroenterology 2014年第38期20卷 13728-13733页

作者： Hiromichi Sonoda tohru Tani Department of Surgery Shiga University of Medical Science

Advances in molecular diagnostic tools have allowed the identification of lymph node micrometastasis(LNM),including isolated tumor cells,in cancer patients. While immunohistochemistry and reverse transcription-polymerase chain reaction have been used to identify LNM in patients with gastric cancer,the clinical significance of this finding remains unclear. Recently,minimally invasive treatments,such as endoscopic submucosal dissection and laparoscopic surgery,are widely performed to help improve postsurgical quality of life(QOL). However,it is important to maintain the balance between QOL and curability when making treatments decision for patients with gastric cancer. If minimally invasive surgery based on accurate intraoperative LNM diagnosis was established,it could be performed safely. Therefore,we reviewed the clinical significance of LNM detected by molecular techniques as an important target for treatment decision making with gastric cancer patients.

关键词： Gastric cancer Lymph node micrometastasis Molecular technique Sentinel lymph node Minimally invasive surgery

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Dysfunction of axonal transport in normal-tension glaucoma:a biomarker of disease progression and a potential therapeutic target

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Neural Regeneration Research 2021年第3期16卷 506-507页

作者： Kazuyuki Hirooka tohru Yamamoto Yoshiaki Kiuchi Department of Ophthalmology and Visual Science Graduate School of Biomedical SciencesHiroshima UniversityHiroshimaJapan Department of Molecular Neurobiology Kagawa University Faculty of MedicineKagawaJapan

Glaucoma and dysfunction of axonal transport:One of the leading causes of irreversible blindness worldwide is glaucoma,with increased intraocula r pressu re(IOP)being the most common risk ***,in some glaucoma patients it has been shown that the IOP does not differ from that of the normal *** Japan,normal-tension glaucoma(NTG),which accounts for 92%of primary open-angle glaucoma,has been shown to be more frequent in the population.

关键词： glaucoma axonal transport

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Cellular response against cytosolic leakage of mitochondrial DNA: insights into the pathology of Parkinson’s disease

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Neural Regeneration Research 2022年第12期17卷 2682-2684页

作者： Akiko Sakai Hideaki matsui Department of Neuroscience of Disease Brain Research InstituteNiigata UniversityNiigataJapan

Mitochondria are important organelles for cellular metabolism and homeostasis,and their abnormalities are implicated in various *** mitochondria originate from protobacterium,their components are easily recognized by pathogen sensors called pattern-recognition receptors as foreign substances in the *** is prominent for mitochondrial DNA(mtDNA)which has different properties from nuclear DNA,such as low,if any,methylation status,vulnerability to oxidation due to the proximity to the oxidative phosphorylation machinery,and its circular *** studies indicate that perturbations in mitochondrial function and homeostasis cause mtDNA to leak into the cytoplasm,where it triggers the innate immune response(West and Shadel,2017).Although inflammatory response is a cellular strategy to resist viral infections,it can also lead to undesirable outcomes by damaging own cells and tissues.

关键词： homeostasis metabolism insight

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Flow Induced Acoustic Resonance in In-line Tube Banks

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Journal of Thermal Science 2006年第3期15卷 226-232页

作者： Hiromitsu Hamakawa tohru Fukano Eiichi Nishida YoshikazuS atou Department of Mechanical Engineering Oita University 700 Dannoharu Oita 870-1192 Japan Department of Environmental Symbiosis Engineering Kurume Institute of TechnologyKamitsu-machi 2228 Kurume 830-0052 Japan Department of Mechanical Engineering Shonan Institute of Technology Tujido Nishi Kaigan1-1-25 Fujisawa 251-8511 Japan Honda Motor Co. Ltd. Japan

In the present paper the attention is focused on the relation between vortex shedding phenomena and acoustic resonance which occurred in the two-dimensional model of boiler. There were tube banks with in-line arrangement for small tube pitch ratio. We measured the sound pressure level, the phase delay of acoustic pressures, the spectrum of velocity fluctuation and the gap velocity. As a result, we found two peak frequencies of sound pressure level with different Strouhal numbers St, mainly about 0.26 and 0,52, The noise of St=0.26 was the resonance of transverse mode and St=0.52 was longitudinal mode. The vortex shedding of St=0.15 was generated inside the tube banks without acoustic resonance. As gap velocity increased, we observed that the peak level of spectrum was weak and broad-banded, The onset velocity of the acoustic resonance of longitudinal mode was lower than that of transverse mode.

关键词： acoustic resonance flow induced vibration vortex in-line tube banks

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Structure Analysis and Ion Abundance in CID- MS- MS Spectra of Isomeric Oligosaccharides Using Quadrupole Time - of- flight Mass Spectrometry: Distinguishing between Isomeric Oligosaccharides

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分析测试学报 2001年第Z1期20卷 59-60页

作者： tohru YAMAGAKI Department of Chemistry School of Science The University of Tokyo and CREST Japan Science and Technology Corporation (JST) Hongo Bunkyo- ku Tokyo 113-0033 Japan

N - Linked oligosaccharide were analyzed by using electrospray ionization (ESI) quadrupole time - of- fight mass spectrometry(Q - Tof MS).The isomers showed the same MS and collisioninduced desociation(CID) MS - MS spectra in the m/z values because the sequence of the sugar residues was the *** the relative ion abundance of the specific fragment ion was greatly different between the ***, the isomeric oligosacchariedes were distinguished by using the ion abundance in their CID -MS - MS *** the ion abundance in accurate level, quantitative analysis of the mixtures of isomers were also performed.……

关键词： flight Mass Spectrometry electrospray ionization MS spectra mass spectrometry sequence of

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Different characteristics of 40 kinds of free amino acids and 5-amino levulinic acid between wines and sakes(Japanese rice wines)

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Journal of Future Foods 2024年第4期4卷 361-368页

作者： tohru Kimura Laboratory of Animal Science Joint Faculty of Veterinary MedicineYamaguchi UniversityYamaguchi 753-8515Japan

Based on a systemic analysis for the globa1 burden of disease study from 1990 to 2016,the Global Burden of Diseases(GBD)2016 Alcohol Collaborators reported that alcohol use was a 1eading nisk factor for globa1 disease burden and caused substantial health ***,alcoholic dnink(wines and sakes)contains abundant nutrients,particularly fermentable amino acids denived from grapes and *** acid nutrition and metabolism is strongly associated with health and preventiom against various *** purpose of this study was to elucidate 40 kinds of free amino acid(FAA)profles in wines and *** addition,the present study also provided the contents of 5-aminolevulinic acid(5-AI A)involved in the vital functionality of *** were detected and analyzed by use of an automatic amino acid *** amino acid,branched chain amino acid and Fischer ratio were calculated for each ***1 FAAs showed significant differences between wines and *** abundantly contained almost all FAAs whereas wines had just a lttle content in some *** were rich in arginine,glycine,alanine,valine,glutamic acid and leucine,while wines were remarkably nich in proline(Pro).Wines showed increased FAA levels in 6 kinds of variables(4-hydroxyproline,3-methy1 histidine,B-alanine,a-aminobutyric acid,Pro and a.-aminoadipic acid).In functionally characteristic FAAs,both wines and sakes were considerably abundant in y aminobutynic acid and 5-AI A The total amount of aromatic amino acid and branched chain amino acid were markedly higher in sakes than in *** results revealed that there were the apparent different characteristics in FAA profiles between wines and *** difference resulted from fermentation process in wines(single fermentation)and sakes(paralle1 double fermentation).Forty kinds of FAA profiles are more usefu1 in investigating characteristics of the taste of wines and *** future,detailed FAA analysis has the potential to fi

关键词： Fermentation 5-Amino levulinic acid Free anino acids γ-Aminobutyric acid Sake Wine

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