检索结果-南通市图书馆

Charcoal Nanoparticles as a Delivery System for Doxorubicin and Sorafenib in Treatment of Hepatocellular Carcinoma

Advances in Nanoparticles 2024年第3期13卷 45-60页

作者： Aisha Elgurashi Abdulla toga khalid mohamed gader Marvit Osman Widdatallah Omer Abdullah E. Gouda Samah Mamdouh mohamed A. Shemis Department of Clinical Pharmacy Faculty of Pharmacy University of Medical Sciences and Technology Khartoum Sudan Department of Pharmacology Faculty of Pharmacy University of Medical Sciences and Technology Khartoum Sudan Department of Biochemistry and Molecular Biology Theodor Bilharz Research Institute Giza Egypt

Background: Hepatocellular carcinoma (HCC) is the most common type of liver cancer and one of the leading causes of cancer-related death worldwide. Advanced HCC displays strong resistance to chemotherapy, and traditional chemotherapy drugs do not achieve satisfactory therapeutic efficacy. The delivery of therapeutic compounds to the target site is a major challenge in the treatment of many diseases. Objective: This study aims to evaluate activated charcoal nanoparticles as a drug delivery system for anticancer agents (Sorafenib and Doxorubicin) in Hepatocellular Cancer Stem Cells. Method: The percent efficiency of entrapment (% EE) of the doxorubicin and sorafenib entrapped onto the activated charcoal was obtained by determining the free doxorubicin and sorafenib concentration in the supernatant-prepared solutions. Then the characterizations of nanoparticles were formed by determination of the particle size distribution, zeta potential, and polydispersity index (PDI). The anticancer activity of activated Charcoal, Doxorubicin-ACNP, sorafenib-ACNP, free doxorubicin, and free sorafenib solutions was measured based on cell viability percentage in HepG2 cell lines (ATCC-CCL 75). In vitro RBC’s toxicity of Doxorubicin/sorafenib loaded charcoal was estimated by hemolysis percentage. Results: The synthesized Doxorubicin-ACNP and Sorafenib-ACNP were evaluated and their physiochemical properties were also examined. Essentially, the percent Efficiency of Entrapment (EE %) was found to be 87.5% and 82.66% for Doxorubicin-ACNP and Sorafenib-ACNP, respectively. The loading capacity was 34.78% and 24.31% for Doxorubicin-ACNP and Sorafenib-ACNP. Using the Dynamic Light scattering [DLS] for the determination of the hydrodynamic size and surface zeta potential, a narrow sample size distribution was obtained of (18, 68, and 190 nm for charcoal, 105, 255, and 712 nm for doxorubicin, and 91, 295, and 955 nm for sorafenib), respectively. A surface charge of −13.2, −15.6 and −17 was obta

关键词： Activated Charcoal Nanoparticles (ACNP) Drug Delivery System Sorafenib and Doxorubicin Hepatocellular Cancer Stem Cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Structural, electronic, and optical studies of chalcogenides stannite Cu2CdSnX4（X=S, Se, and Te）: insights from the DFT study

引用

Optoelectronics Letters 2025年第2期21卷 69-76页

作者： Jamal GUERROUM mohamed AL-HATTAB Lhoucine MOUDOU khalid RAHMANI Youssef LACHTIOUI Omar BAJJOU Laboratory of Engineering in Chemistry and Physics of Matter Faculty of Sciences and Technics Sultan Moulay Slimane University Ecole Normale Supérieure Mohammed V University in Rabat College of Graduate Studies University of South Africa

In this paper,we have calculated the structural,electronic,and optical properties of chalcogenide stannite Cu2CdSnX4（X=S,Se,Te） *** calculations are based on the density functional theory （DFT） method and are performed using the Cambridge sequential total energy package （CASTEP） code included in the Biovia Material Studio 20 *** optical properties have been studied in a domain that extends energetically from 10 meV to 40 *** results show that Cu2CdSnX4（X=S,Se,Te） stannite exhibits absorption in the visible region,the refractive index decreases with increasing energy,and the refractive index values are n=3.2,3.73 and 3.75 for Cu2CdSnS4,Cu2CdSnSe4and Cu2CdSnTe4,*** show also high conductivity,which implies that this material is promising for solar *** results argue in favor of the use of these materials in various potential *** density of state,band structures,and structural properties of Cu2CdSnX4（X=S,Se,and Te） stannite are also studied in this work.

关键词： Refractive index

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

A new systematic firefly algorithm for forecasting the durability of reinforced recycled aggregate concrete

引用

Frontiers of Structural and Civil Engineering 2022年第3期16卷 329-346页

作者： Wafaa mohamed SHABAN khalid ELBAZ mohamed AMIN Ayat gamal ASHOUR Department of Civil and Environmental Engineering College of EngineeringShantou UniversityShantou 515063China Department of Civil Engineering Misr Higher Institute of Engineering and TechnologyMansouraEgypt Department of Civil Engineering Higher Future Institute of Engineering and TechnologyMansouraEgypt Guangdong Engineering Center for Structure Safety and Health Monitoring Shantou UniversityShantou 515063China Civil and Architectural Construction Department Faculty of Technology and EducationSuez UniversityIsmailiaEgypt Department of Civil and Environmental Engineering Collage of EngineeringUniversity of SharjahSharjah 27272UAE

This study presents a new systematic algorithm to optimize the durability of reinforced recycled aggregate *** proposed algorithm integrates machine learning with a new version of the firefly algorithm called chaotic based firefly algorithm(CFA)to evolve a rational and efficient predictive *** CFA optimizer is augmented with chaotic maps and Levy flight to improve the firefly performance in forecasting the chloride penetrability of strengthened recycled aggregate concrete(RAC).A comprehensive and credible database of distinctive chloride migration coefficient results is used to establish the developed algorithm.A dataset composite of nine effective parameters,including concrete components and fundamental characteristics of recycled aggregate(RA),is used as input to predict the migration coefficient of strengthened RAC as output,k-fold cross validation algorithm is utilized to validate the hybrid *** numerical benchmark analyses are applied to prove the superiority and applicability of the CFA algorithm in predicting chloride *** show that the developed CFA approach significantly outperforms the firefly algorithm on almost tested functions and demonstrates powerful *** addition,the proposed strategy can be an active tool to recognize the contradictions in the experimental results and can be especially beneficial for assessing the chloride resistance of RAC.

关键词： chloride penetrability recycled aggregate concrete machine learning concrete components durability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gaining-Sharing Knowledge Based Algorithm for Solving Stochastic Programming Problems

引用

Computers, Materials & Continua 2022年第5期71卷 2847-2868页

作者： Prachi Agrawal khalid Alnowibet Ali Wagdy mohamed Yogananda School of Artificial Intelligence Computers&Data ScienceShoolini UniversitySolan173229India Statistics and Operations Research Department College of ScienceKing Saud UniversityRiyadh11451Kingdom of Saudi Arabia Operations Research Department Faculty of Graduate Studies for Statistical ResearchCairo UniversityGiza12613Egypt Department of Mathematics and Actuarial Science School of Science and EngineeringThe American University in CairoEgypt

This paper presents a novel application of metaheuristic algorithmsfor solving stochastic programming problems using a recently developed gaining sharing knowledge based optimization (GSK) algorithm. The algorithmis based on human behavior in which people gain and share their knowledgewith others. Different types of stochastic fractional programming problemsare considered in this study. The augmented Lagrangian method (ALM)is used to handle these constrained optimization problems by convertingthem into unconstrained optimization problems. Three examples from theliterature are considered and transformed into their deterministic form usingthe chance-constrained technique. The transformed problems are solved usingGSK algorithm and the results are compared with eight other state-of-the-artmetaheuristic algorithms. The obtained results are also compared with theoptimal global solution and the results quoted in the literature. To investigatethe performance of the GSK algorithm on a real-world problem, a solidstochastic fixed charge transportation problem is examined, in which theparameters of the problem are considered as random variables. The obtainedresults show that the GSK algorithm outperforms other algorithms in termsof convergence, robustness, computational time, and quality of obtainedsolutions.

关键词： Gaining-sharing knowledge based algorithm metaheuristic algorithms stochastic programming stochastic transportation problem

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Digital Watermarking Scheme for Securing Textual Database Using Histogram Shifting Model

引用

Computers, Materials & Continua 2022年第6期71卷 5253-5270页

作者： khalid A.El Drandaly Walid Khedr Islam S.mohamed Ayman mohamed Mostafa Faculty of Computers and Informatics Zagazig UniversityZagazig44519Egypt College of Computer and Information Sciences Jouf UniversitySakaka72314Saudi Arabia

Information security is one of the most important methods of protecting the confidentiality and privacy of internet *** greater the volume of data,the more the need to increase the security methods for protecting data from *** task can be challenging for researchers in terms of managing enormous data and maintaining their safety and *** of digital content is a major issue in maintaining the privacy and secrecy of *** this end,digital watermarking is based on the concept of information security through the insertion and detection of an embedded watermark in an efficient *** methodologies in the research on digital watermarking result in data distortion after embedding the *** scenario can reduce the efficiency of detecting watermarks as well as violate data *** study adapts a robust reversible histogram shifting(HS)technique for textual data in relational ***,the study presents a digital watermarking scheme intended for document copyright protection and proof of *** major advantage of the proposed watermarking scheme is that it can protect digital data and preserve data *** the best of our knowledge,this research methodology is promising for use in the HS expansion model for watermarking data on nonnumeric *** addition,the results showed that despite exposing the database to an insertion attacks at 50%and 75%of the watermark,the proposed algorithm can recovermore than half of the embedded watermark in all addition and alteration attacks *** a result,the watermark information can be retained and restored completely.

关键词： Information security digital watermarking information hiding histogram shifting technique

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hydrometallurgy two stage process for preparation of (Nd,La,Ce)_(2)O_(3) from end-of-life NiMH batteries

引用

Journal of Rare Earths 2024年第2期42卷 415-423,I0007页

作者： Karim Tanji khalid Ouzaouit mohamed Belghiti Isam Lamsayety Hakim Faqir Intissar Benzakour Centre de recherche REMINEX-Groupe MANAGEM MarrakechMorocco

The present work aims to investigate the recovery of light rare earth elements(LREEs) oxides from end-oflife NiMH batteries using a hydro metallurgical process followed by effective *** operational leaching parameters such as phosphoric acid concentration,temperature,and the solid-liquid ratio were first optimized by Box-Behnken *** results reveal that under optimum conditions([H_(3)PO_(4)]=2 mol/L,T=80℃,and S/L=1:10 g/mL) the leaching efficiencies of Ni,Co reach 98.1% and99.3%.While La,Ce,and Nd elements remain in the leaching residue as(La,Ce,Nd)PO_(4) with yields of 98.2%,98.6%,and 99.6% for La,Ce,and Nd,***,the(La,Ce,Nd)PO_(4) is leached with HCl acid,then the rare earth oxalate was precipitated using oxalic acid at a pH of 1.8 and then the product was calcined at 800℃ for 2 h in order to synthesize the(Nd,La,Ce)_(2)O_(3).The analysis using scanning electron microscopy(SEM) coupled with energy dispersive X-ray spectroscopy(EDX) confirms the homogeneity of(Nd,La,Ce)_(2)O_(3) particles that have two morphologies,i.e.,flower and sticks with a particle size between 3and 6 μ*** unit cell parameters of(Nd,La,Ce)_(2)O_(3) were calculated after Rietveld refinement of the XRD patterns,in the space group of Fm-3m are a=b=c=0.57921 nm and the volume equal to 0.194322 nm^(3).

关键词： NiMH batteries Hydrometallurgical process Leaching Phosphoric acid Box-Behnken Light rare earth oxides

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Managing Delivery of Safeguarding Substances as a Mitigation Against Outbreaks of Pandemics

引用

Computers, Materials & Continua 2021年第7期68卷 1161-1181页

作者： Said Ali Hassan khalid Alnowibet Prachi Agrawal Ali Wagdy mohamed Department of Operations Research and Decision Support Faculty of Computers and Articial IntelligenceCairo UniversityGiza12613Egypt Department of Statistics and Operations Research College of ScienceKing Saud UniversityRiyadhSaudi Arabia Trafc Safety Technologies Chair Vice Deanship of Scientic ResearchKing Saud UniversityRiyadhSaudi Arabia Department of Mathematics and Scientic Computing National Institute of TechnologyHamirpur177005India Operations Research Department Faculty of Graduate Studies for Statistical ResearchCairo UniversityGiza12613Egypt School of Engineering and Applied Sciences Wireless Intelligent Networks Center(WINC)Nile UniversityGizaEgypt

The optimum delivery of safeguarding substances is a major part of supply chain management and a crucial issue in the mitigation against the outbreak of pandemics.A problem arises for a decision maker who wants to optimally choose a subset of candidate consumers to maximize the distributed quantities of the needed safeguarding substances within a specic time period.A nonlinear binary mathematical programming model for the problem is *** decision variables are binary ones that represent whether to choose a specic consumer,and design constraints are formulated to keep track of the chosen *** better illustrate the problem,objective,and problem constraints,a real application case study is *** case study involves the optimum delivery of safeguarding substances to several hospitals in the Al-Gharbia Governorate in *** hospitals are selected to represent the consumers of safeguarding substances,as they are the rst crucial frontline for mitigation against a pandemic outbreak.A distribution truck is used to distribute the substances from the main store to the hospitals in specied required quantities during a given working *** objective function is formulated in order to maximize the total amount of delivered quantities during the specied time *** case study is solved using a novel Discrete Binary Gaining Sharing Knowledge-based Optimization algorithm(DBGSK),which involves two main stages:discrete binary junior and senior gaining and sharing *** has the ability of nding the solutions of the introduced problem,and the obtained results demonstrate robustness and convergence toward the optimal solutions.

关键词： Safeguarding substances mitigation against pandemic outbreaks supply chain management metaheuristic optimization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optimum Location of Field Hospitals for COVID-19: A Nonlinear Binary Metaheuristic Algorithm

引用

Computers, Materials & Continua 2021年第7期68卷 1183-1202页

作者： Said Ali Hassan khalid Alnowibet Prachi Agrawal Ali Wagdy mohamed Department of Operations Research and Decision Support Faculty of Computers and Artificial IntelligenceCairo UniversityGiza12613Egypt College of Science Department of Statistics and Operations ResearchKing Saud UniversityRiyadhSaudi Arabia Department of Mathematics and Scientific Computing National Institute of Technology HamirpurHimachal Pradesh177005India Department of Operations Research Faculty of Graduate Studies for Statistical ResearchCairo UniversityGiza12613Egypt Wireless Intelligent Networks Center(WINC) School of Engineering and Applied SciencesNile UniversityGizaEgypt

Determining the optimum location of facilities is critical in many fields,particularly in *** study proposes the application of a suitable location model for field hospitals during the novel coronavirus 2019(COVID-19)*** used model is the most appropriate among the three most common location models utilized to solve healthcare problems(the set covering model,the maximal covering model,and the P-median model).The proposed nonlinear binary constrained model is a slight modification of the maximal covering model with a set of nonlinear *** model is used to determine the optimum location of field hospitals for COVID-19 risk *** designed mathematical model and the solution method are used to deploy field hospitals in eight governorates in Upper *** this case study,a discrete binary gaining–sharing knowledge-based optimization(DBGSK)algorithm is *** DBGSK algorithm is based on how humans acquire and share knowledge throughout their *** DBGSK algorithm mainly depends on two junior and senior binary *** two stages enable DBGSK to explore and exploit the search space efficiently and effectively,and thus it can solve problems in binary space.

关键词： Facility location nonlinear binary model field hospitals for COVID-19 gaining-sharing knowledge-based metaheuristic algorithm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Analysing Various Control Techniques for Manipulator Robotic System (Robogymnast)

引用

Computers, Materials & Continua 2023年第6期75卷 4681-4696页

作者： Mahmoud mohamed Bdereddin Abdul Samad Fatih Anayi Michael Packianather khalid Yahya School of Engineering Cardiff UniversityCardiffCF243AAUK Faculty of Engineering University of ZawiaZawia16418Libya Electrical and Electronic Department Azahra Higher Institution of Sciences and TechnologyAzahraLibya Department of Electrical and Electronics Engineering Nisantasi UniversityIstanbul34398Turkey

The Robogymnast is a highly complex,three-link system based on the triple-inverted pendulum and is modelled on the human example of a gymnast suspended by their hands from the high bar and executing larger and larger upswings to eventually rotate *** links of the Robogymnast correspond respectively to the arms,trunk,and lower limbs of the gymnast,and from its three joints,one is under passive operation,while the remaining two are *** passive top joint poses severe challenges in attaining the smooth movement control needed to operate the Robogymnast *** study assesses four types of controllers used for systems operation and identifies how far response stabilisation is achieved with *** system is simulated using MATLAB Simulink,with findings generated regarding rising and settling time,as well as *** research primarily seeks to exam-ine the application of a linear quadratic regulator controller,proportional-integral-derivative controller,fuzzy linear quadratic regulator controller and linear quadratic regulator-proportional-integral-derivative controller for this type of system and comparisons between the different controllers to demon-strate successful performance,which highlights the claimed advantages of the proposed system.

关键词： Robot gymnast(Robogymnast) proportional-integral-derivative(PID) linear quadratic regulator(LQR) fuzzy linear quadratic regulator(FLQR) Acrobat Robot(Acrobat)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A method for real power transfer allocation using multivariable regression analysis

引用

Journal of Central South University 2012年第1期19卷 179-186页

作者： Hussain Shareef Azah mohamed Saifunizam Abd.khalid Mohd Wazir Mustafa Faculty of Electrical Engineering and Built Environment Universiti Kebangsaan Malaysia43600 BangiMalaysia Faculty of Electrical Engineering Universiti Teknologi Malaysia81310 JohorMalaysia

A multivariable regression(MVR) approach is proposed to identify the real power transfer between generators and *** on solved load flow results,it first uses modified nodal equation method(MNE) to determine real power contribution from each generator to ***,the results of MNE method and load flow information are utilized to determine suitable regression coefficients using MVR model to estimate the power *** 25-bus equivalent system of south Malaysia is utilized as a test system to illustrate the effectiveness of the MVR output compared to that of the MNE *** error of the estimate of MVR method ranges from 0.001 4 to 0.007 ***,when compared to MNE method,MVR method computes generator contribution to loads within 26.40 ms whereas the MNE method takes 360 ms for the calculation of same real power transfer ***,MVR method is more suitable for real time power transfer allocation.

关键词： power tracing multivariable regression power systems deregulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：