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南半球的全新世海平面波动

国外第四纪地质 1990年第4期 37-46页

作者： isla.FI 张志良

Alleviated mucosal and neuronal damage in a rat model of Crohn's disease

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World Journal of Gastroenterology 2014年第44期20卷 16690-16697页

作者： Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi Department of Physiology Anatomy and Neuroscience Faculty of Sciences and Informatics University of Szeged Avidin Ltd.

AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s ***:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of *** samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal *** means of the ulcerated area were measured to evaluate the macroscopic mu-cosal *** density of myenteric neurons was determined on whole mounts by Hu C/Hu D *** oxygenase-1(HO-1)expression was evaluated by molecular biological ***:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental *** widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS *** repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed ***-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints ***,the HO-1protein up-regulation after the second TNBS treatment proved to be *** the third treatment HO-1 protein expression could not be ***:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal *** persistent up-regulation of HO-1 m RNA expression may correlate with this.

关键词： Crohn's disease Experimental rat model Heme oxygenase-1 Myenteric neurons Repetitive re-lapsing inflammation

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陆懋德的“信古”与“考古”

四川大学学报（哲学社会科学版） 2022年第6期 166-176页

作者：查晓英四川大学历史文化学院成都610064

在1920年代早期中国史学界的变革中,清华学校国文教授陆懋德利用其收藏经营古董的经验,对中国上古历史进行梳理,提出了与北京大学疑古健将胡适、顾颉刚截然不同的观点,并为东南大学学衡派的学者引为同道。尽管在清华学校改制为大学的过... 详细信息

在1920年代早期中国史学界的变革中,清华学校国文教授陆懋德利用其收藏经营古董的经验,对中国上古历史进行梳理,提出了与北京大学疑古健将胡适、顾颉刚截然不同的观点,并为东南大学学衡派的学者引为同道。尽管在清华学校改制为大学的过程中,陆懋德被迫离职,其在学界的影响力也逐渐减弱,但他的经历显示出,“信古”“疑古”与“考古”三者之间的关系决非层层更迭。

关键词：陆懋德信古疑古考古

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上海绿之丘:废旧仓库怎样变身“丘陵城市”

城市地理 2022年第1期1卷 66-73页

作者：风生(文/图) isla.图) Adam(图) 不详

打开电子地图,不难发现,在黄浦江岸边有一个形似船舰,方方正正的建筑体,面积大得“不像话”,格格不入地矗立岸边。它不同于其他建筑物一样面向江岸,而是故意要“搞特殊”似的横在江边与城市建筑之间。这就是上世纪九十年代修建的上海烟... 详细信息

打开电子地图,不难发现,在黄浦江岸边有一个形似船舰,方方正正的建筑体,面积大得“不像话”,格格不入地矗立岸边。它不同于其他建筑物一样面向江岸,而是故意要“搞特殊”似的横在江边与城市建筑之间。这就是上世纪九十年代修建的上海烟草仓库,如今的上海新地标——绿之丘。

关键词：烟草仓库九十年代电子地图变身新地标黄浦江上海

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Non-Invasive Second Harmonic Generation (SHG) in Macroscopy (MacroSHG) as Bio-Diagnosis to Image Collagen Network Organization in Extracellular Matrix

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Engineering（科研） 2014年第8期6卷 485-490页

作者： Dominique Dumas Elisabeth Werkmeister Sebastien Hupont Céline Huselstein Natalia De isla.Marthe Rousseau Patrick Menu Didier Mainard Ingénierie Moléculaire et Thérapeutique (CNRS FR 3209) Plate Forme d’Imagerie Cellulaire et Tissulaire PTIBC-IBISA NANCY Nancy France Plate-Forme Microscopie-Imagerie-Cytométrie du campus Pasteur Lille (MICPaL) IFR 142 Institut Pasteur de Lille Institut de Biologie de Lille Lille France Universite de Lorraine Physiopathologie Pharmacologie et Ingénierie Articulaires (IMOPA CNRS 7365) Nancy France Universite de Lorraine Physiopathologie Pharmacologie et Ingénierie Articulaires (IMOPA CNRS 7365) Nancy France Ingénierie Moléculaire et Thérapeutique (CNRS FR 3209) Plate Forme d’Imagerie Cellulaire et Tissulaire PTIBC-IBISA NANCY Nancy France

In this work, we have considered a new multimodality imaging for macroscopy based on Second Harmonic Generation (SHG) method to monitor invasivelessly the matrix collagen. As the triple helicoidally structure of collagen molecules appearing as not centrosymetric, very organized and spatially oriented, collagen fibrils give rise to a very strong SHG signal and can be imaged without any exogenous dye. To integrate a multidimensional scale with a large field of view (non-sliced samples), we have adapted and validated an instrumental coupling between a two photon excitation laser and a macroscope to collect cartography of SHG signal. We introduced an index (F-SHG) based on decay time response measured by TCSPC for respectively Fluorescence (F) and Second Harmonic Generation (SHG) values. For various sample where protein collagen is the major component of extracellular matrix (vessel, skin, carotide vessel, rat femoral head cartilage, mouse tumor, human wharton’s jelly and rat tendon) or not (nacre), we compared the index distribution obtained with MacroSHG. In this work, we showed for the first time that multiscale large field imaging (Macroscopy) combined to Multimodality approaches (SHG-TCSPC) could be an innovative and non-invasive technique to detect and identify some biological interest molecules (collagen) in biomedical topics.

关键词： Multiphoton Macroscopy Second Harmonic Generation Collagen Extracellular Matrix

Tissue Engineering:From Bench to Bed Side Exemples of Applications

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Engineering（科研） 2012年第10期4卷 43-45页

作者： J-F.Stoltz C.Huselstein D.Bensoussan N.de isla.V.Decot CNRS UMR 7561 BiopoleFaculte de Médecine–Universite LorraineVANDOEUVRE LES NANCYFrance CHU de Nancy UTCTBraboisVANDOEUVRE LES NANCYFrance

Tissue engineering is an emerging multidisciplinary field involving surgery medicine, biology, chemistry, mechanics and engineering to improve the health and quality of life by restoring, maintaining or enhancing tissue and organ function?[6;11]. The principle is simple: cells are collected and introduced -with or without modification of their biological properties- into an environment in which physico-chemical and mechanical parameters are kept stable. When they reach maturity, the biotissue or cells can be grafted. The main parameters are: cells, scaffold, biological molecules and mechanical forces. A combination of these parameters can promote cellular differentiation and proliferation. But it should be emphasized that at this time, signalling pathways and the rationale behind the physiological design remain to be elucidated. Among the main medium-term clinical applications are cardiac insufficiency, atherosclerosis, osteoarthritis, diabetes, liver diseases, bladder, and skin. In this paper the examples of cartilage and vascular engineering will be examined.

关键词： Tissue Engineering Stem Cells Scaffolds

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萝卜收获机振动松土铲参数的优化

农业工程学报 2011年第11期27卷 46-50页

作者：付威陈海涛坎杂石河子大学机械电气工程学院石河子832000 东北农业大学工程学院哈尔滨150030

为了确定萝卜收获机振动松土铲的关键参数,利用偏心连杆式振动装置进行松土试验,以机器行走速度、松土铲激振频率和振幅、铲入土角、铲刃倾角作为试验影响因素,土壤孔隙度为响应指标,并采用二次正交旋转回归试验设计,建立了响应指标与... 详细信息

为了确定萝卜收获机振动松土铲的关键参数,利用偏心连杆式振动装置进行松土试验,以机器行走速度、松土铲激振频率和振幅、铲入土角、铲刃倾角作为试验影响因素,土壤孔隙度为响应指标,并采用二次正交旋转回归试验设计,建立了响应指标与各影响因素之间回归数学模型。通过Design-Expert6.0软件对试验参数进行优化,确定机器行走速度0.64m/s、激振器频率2Hz、振幅14.38mm、铲入土角25.72°、铲刃倾角39.68°为最优参数组合,此时土壤孔隙度为50%～60%,该研究为研究和设计萝卜收获机提供依据。

关键词：收获机优化农业机械振动松土铲萝卜

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矮化密植枣园收获作业视觉导航路径提取

农业工程学报 2017年第9期33卷 45-52页

作者：彭顺正坎杂李景彬石河子大学信息科学与技术学院石河子832000 石河子大学机械电气工程学院石河子832000

针对矮化密植枣园环境的复杂性,提出一种基于图像处理的枣园导航基准线生成算法。选用B分量图进行处理,提出"行阈值分割"方法分割树干与背景;根据拍摄场景及视角提出"行间区域"方法剔除行间噪声;通过统计树干与地面交点位置分布区域选... 详细信息

针对矮化密植枣园环境的复杂性,提出一种基于图像处理的枣园导航基准线生成算法。选用B分量图进行处理,提出"行阈值分割"方法分割树干与背景;根据拍摄场景及视角提出"行间区域"方法剔除行间噪声;通过统计树干与地面交点位置分布区域选取图像五分之二向下区域进行处理;依据树干纵向灰度分布规律,采用浮动窗口灰度垂直投影方法结合形态学开闭运算提取树干区域;基于枣园行间线性分布特征引入"趋势线",而后利用点到直线的距离与设定阈值作比较选取树干与地面的交点;利用交点的位置分布将其归类,并采用最小二乘法原理拟合左右两侧边缘,提取边缘线上各行的几何中心点生成枣园导航基准线。通过对阴天、晴天、顺光、逆光、噪声多元叠加5种条件进行试验,结果表明,该算法具有一定的抗噪性能,单一工况条件导航基准线生成准确率可达83.4%以上,多工况条件准确率为45%。针对5种工况条件的视频检测,结果表明,单一工况条件算法动态检测准确率可达81.3%以上,每帧图像处理平均耗时低于1.7 s,多工况条件检测准确率为42.3%,每帧图像平均耗时1.0 s。该研究可为矮化密植果园实现机器人自主导航作业提供参考。

关键词：机械化农作物图像识别枣园行阈值分割行间去噪趋势线

Does Making Method of Alginate Hydrogel Influence the Chondrogenic Differentiation of Human Mesenchymal Stem Cells?

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Engineering（科研） 2012年第10期4卷 110-113页

作者： Jessica Schiavi Naceur Charif Natalia de isla.Daniele Bensoussan Jean-Francois Stoltz Nadia Benkirane-Jessel Celine Huselstein INSERM-UMR Faculty of medicineStrasbourg UniversityStrasbourgFrance Universitede Lorraine CNRS-UMR–Campus Sante–BiopoleFaculty of medicineLorraine UniversityVandouvre-les-NancyFrance

To overcome cartilage injury, strategies have been developed in the last few years based on tissue engineering to rebuild the defects. Cartilage engineering is principally based on three main biological factors: cells (native cells (chondrocytes) or a more primitive ones as mesenchymal stem cells), scaffolds and functionalization factors (growth factors, mechanical stimulation and/or hypoxia). Cartilage tissue engineering strategies generally result in homogeneous tissue structures with little resemblance to native zonal organization of articular cartilage. The main objective of our work concerns the buildup of complex biomaterials aimed at reconstructing biological tissue with three dimensional cells construction for mimicking cartilage architecture. Our strategy is based on structures formation by simple and progressive spraying of mixed alginate hydrogel and human mesenchymal stem cells (hMSC). In this work, the comportment of cells and more precisely their chondrogenic differentiation potential is compared to a traditional making process: the mold. We report here that spraying method allowed to product a scaffold with hMSC that confer a favorable environment for neocartilage construction.

关键词： Component: Cartilage Tissue Engineering Sodium Alginate Sprayed method Molded Method