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Evaluating the Efficacy of Cervical Tactile Ultrasound Technique as a Predictive Tool for spontaneous Preterm Birth

Open Journal of Obstetrics and Gynecology 2024年第5期14卷 832-846页

作者： Vladimir Egorov todd Rosen Jennifer Hill Meena Khandelwal Victors Kurtenoks Brendan Francy Noune sarvazyan Advanced Tactile Imaging Inc. Ewing New Jersey USA Department of Obstetrics Gynecology and Reproductive Sciences Rutgers Robert Wood Johnson Medical School New Brunswick New Jersey USA Department of Maternal-Fetal Medicine Cooper Medical School of Rowan University Camden New Jersey USA

Background: Premature cervical softening and shortening may be considered an early mechanical failure that predispose to preterm birth. Purpose: This study aims to explore the applicability of an innovative cervical tactile ultrasound approach for predicting spontaneous preterm birth (sPTB). Materials and Methods: Eligible participants were women with low-risk singleton pregnancies in their second trimester, enrolled in this prospective observational study. A Cervix Monitor (CM) device was designed with a vaginal probe comprising four tactile sensors and a single ultrasound transducer operating at 5 MHz. The probe enabled the application of controllable pressure to the external cervical surface, facilitating the acquisition of stress-strain data from both anterior and posterior cervical sectors. Gestational age at delivery was recorded and compared against cervical elasticity. Results: CM examination data were analyzed for 127 women at 24sup>0/7sup> - 28sup>6/7sup> gestational weeks. sPTB was observed in 6.3% of the cases. The preterm group exhibited a lower average cervical stress-to-strain ratio (elasticity) of 0.70 ± 0.26 kPa/mm compared to the term group’s 1.63 ± 0.65 kPa/mm with a p-value of 1.1 × 10sup>−sup>sup>4sup>. Diagnostic accuracy for predicting spontaneous preterm birth based solely on cervical elasticity data was found to be 95.0% (95% CI, 88.5 - 100.0). Conclusion: These findings suggest that measuring cervical elasticity with the designed tactile ultrasound probe has the potential to predict spontaneous preterm birth in a cost-effective manner.

关键词： Cervical Elasticity spontaneous Preterm Birth Tactile Ultrasound Probe

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A unique subseafloor microbiosphere in the Mariana Trench driven by episodic sedimentation

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Marine Life science & Technology 2024年第1期6卷 168-181页

作者： Jiwen Liu Da-Wei Li Xinxin He Ronghua Liu Haojin Cheng Chenglong su Mengna Chen Yonghong Wang Zhongsheng Zhao Hanyue Xu Zhangyu Cheng Zicheng Wang Nikolai Pedentchouk David J.Lea-smith Jonathan D.todd Xiaoshou Liu Meixun Zhao Xiao-Hua Zhang Frontiers science Center for Deep Ocean Multispheres and Earth system and College of Marine Life SciencesOcean University of ChinaQingdao 266003China Laboratory for Marine Ecology and Environmental science Laoshan LaboratoryQingdao 266237China Institute of Evolution and Marine Biodiversity Ocean University of ChinaQingdao 266003China Key Laboratory of Marine Chemistry Theory and Technology Ministry of EducationOcean University of ChinaQingdao 266100China Key Lab of submarine Geosciences and Prospecting Techniques Ministry of Education/College of Marine GeosciencesOcean University of ChinaQingdao 266100China Key Laboratory of Physical Oceanography Ministry of Education/Research Vessel CentreOcean University of ChinaQingdao 266100China school of Environmental sciences University of East AngliaNorwich NR47TJUK school of Biological sciences University of East AngliaNorwich NR47TJUK

Hadal trenches are characterized by enhanced and infrequent high-rate episodic sedimentation events that likely introduce not only labile organic carbon and key nutrients but also new microbes that significantly alter the subseafloor ***,the role of high-rate episodic sedimentation in controlling the composition of the hadal subseafloor microbiosphere is ***,analyses of carbon isotope composition in a~750 cm long sediment core from the Challenger Deep revealed noncontinuous deposition,with anomalous ^(14)C ages likely caused by seismically driven mass transport and the funneling effect of trench *** community composition and diverse enzyme activities in the upper~27 cm differed from those at lower depths,probably due to sudden sediment deposition and differences in redox condition and organic matter *** lower depths,microbial population numbers,and composition remained relatively constant,except at some discrete depths with altered enzyme activity and microbial phyla abundance,possibly due to additional sudden sedimentation events of different *** is provided of a unique role for high-rate episodic sedimentation events in controlling the subsurface microbiosphere in Earth’s deepest ocean floor and highlight the need to perform thorough analysis over a large depth range to characterize hadal benthic *** depositional processes are likely crucial in shaping deep-water geochemical environments and thereby the deep subseafloor biosphere.

关键词： Hadal subseafloor Deep water sediment Mariana Trench Radiocarbon Microbial community Redox potential

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Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity

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World Journal of Gastroenterology 2024年第4期30卷 332-345页

作者： Yi-Jie Li Brittney O Baumert Nikos stratakis Jesse A Goodrich Hao-Tian Wu Jing-Xuan He Yin-Qi Zhao Max T Aung Hong-Xu Wang sandrah P Eckel Douglas I Walker Damaskini Valvi Michele A La Merrill Justin R Ryder Thomas H Inge todd Jenkins stephanie sisley Rohit Kohli stavra A Xanthakos Andrea A Baccarelli Rob McConnell David V Conti Lida Chatzi Department of Population and Public Health sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90032United States Barcelona Institute of Global Health Barcelona Institute of Global HealthBarcelona 08036Spain Department of Environmental Health sciences Mailman School of Public HealthColumbia UniversityNew YorkNY 10032United States Gangarosa Department of Environmental Health Rollins School of Public HealthEmory UniversityAtlantaGA 30329United States Department of Environmental Medicine and Public Health Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Environmental Toxicology University of CaliforniaDavisCA 95616United States Department of surgery Lurie Children’s Hospital of ChicagoChicagoIL 60611United States Northwestern University Feinberg school of Medicine Northwestern UniversityChicagoIL 60611United States Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States Department of Pediatrics University of Cincinnati College of MedicineCincinnatiOH 45229United States Department of Pediatrics Children’s Nutrition Research Center USDA/ARSBaylor College of MedicineHoustonTX 77030United States Department of Gastroenterology Children’s Hospital Los AngelesLos AngelesCA 90027United States Division of Gastroenterology Hepatology and NutritionCincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases in children and *** ranges in severity from isolated hepatic steatosis to nonalcoholic steatohepatitis(NAsH),wherein hepatocellular inflammation and/or fibrosis coexist with *** microRNA(miRNA)levels have been suggested to be altered in NAFLD,but the extent to which miRNA are related to NAFLD features remains *** analysis tested the hypothesis that plasma miRNAs are significantly associated with histological features of NAFLD in *** To investigate the relationship between plasma miRNA expression and NAFLD features among adolescents with *** This study included 81 adolescents diagnosed with NAFLD and 54 adolescents without NAFLD from the Teen-Longitudinal Assessment of Bariatric surgery ***-operative core liver biopsies were collected from participants and used to characterize histological features of *** samples were collected during surgery for miRNA profiling.A total of 843 plasma miRNAs were profiled using the HTG Edgeseq *** examined associations of plasma miRNAs and NAFLD features using logistic regression after adjusting for age,sex,race,and other key *** Pathways Analysis was used to identify biological functions of miRNAs that were associated with multiple histological features of *** We identified 16 upregulated plasma miRNAs,including miR-193a-5p and miR-193b-5p,and 22 downregulated plasma miRNAs,including miR-1282 and miR-6734-5p,in adolescents with ***,52,16,15,and 9 plasma miRNAs were associated with NAsH,fibrosis,ballooning degeneration,and lobular inflammation,***,16 miRNAs were associated with two or more histological features of *** those miRNAs,miR-411-5p was downregulated in NAsH,ballooning,and fibrosis,while miR-122-5p,miR-1343-5p,miR-193a-5p,miR-193b-5p,and miR-7845-5p were consistently and posi

关键词： MicroRNA Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Liver fibrosis Lobular inflammation Ballooning degeneration

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New Methodological Approach to Investigation of Kinetics of REE Extraction in Nonstationary Conditions

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Journal of Rare Earths 2007年第4期25卷 385-391页

作者： Kopyrin A A Fomichev A A Afonin M A todd T A saint-Petersburg Institute of Technology Idaho National Laboratory

The influence of periodical oscillations of the temperature on extraction and stripping processes in the extraction systems was studied. Two extraction systems were investigated：（1） 6 mol · L^-1 NaNO3-Nd（NO3）3-Pr（NO3）3-TBP kerosene and （2） [Nd（NO3）3 · 3TBP] -[ Pr（NO3）3 · 3TBP] -kerosene - 0.1 mol · L^-1 HNO3. Mathematical modeling of the nonstationary membrane extraction has been enhanced by including the dependence of the extraction rate constants on temperature. The values of activation energy for direct and reverse extraction and stripping reactions of Pr and Nd were calculated from experimental temporal dependencies of metal concentration and temperature by solving the reverse kinetics problem using the proposed mathematical model, A series of experiments with periodical oscillations of the temperature on the extraction system for the separation of rare earth elements （REE） using bulk liquid membrane between two extractors were performed. The mathematical model adequately describes the experimental data. The optimization of the extraction process for separation of REE by liquid membrane, under the influence of periodical oscillation of the temperature, was made based on the extraction rate constants and activation energies. The optimal conditions of separation by liquid membrane were found： frequency and amplitude of thermal oscillations, liquid membrane flow rate, and optimal ratio between organic and aqueous phase in extractors.

关键词： kinetics extraction non-stationary rare earths

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Upper bounds on a two-term exponential sum

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science China Mathematics 2001年第8期44卷 1003-1015页

作者： todd COCHRANE 郑志勇 Department of Mathematics Kansas State University Manhattan KS 66506 USA Department of Mathematics Tsinghua University Beijing 100084 China

We obtain upper bounds for mixed exponential sums of the type $s(\chi ,f,p^m ) = \sum\nolimits_{x = 1}^{p^n } {\chi (x)e} _{p^m } (ax^n + bx)$ where pm is a prime power with m? 2 and X is a multiplicative character (mod pm). If X is primitive or p?(a, b) then we obtain |s(χ,f,p m)| ?2np 2/3 m . If X is of conductor p and p?( a, b) then we get the stronger bound |s(χ,f,p m)|?np m/2.

关键词： exponential sums primitive character weil’sbound

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Between Human and Animal： A study of New Year＇s sacrifice, Kong YijL and Diary of a Madman

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Frontiers of Literary studies in China-selected Publications from Chinese Universities 2012年第3期6卷 374-392页

作者： todd Foley Department of East Asian studies New York University New York NY 10003 USA

A subtle aspect of Lu Xun＇s writing, running through several of his works of fiction, is his animalistic portrayal of some of his most well-known characters. scraping away their humanity as he writes, Lu Xun depicts Kong Yiji, Xianglin sao, and the infamous Madman crawling on their hands and knees, working like draught animals, and abandoning all rational thought. In short, all three end up occupying an ambiguous space between the realms of human and animal. This paper attempts to examine how Lu Xun＇s description and situation of these characters suggests, aside from the standard agendas of May Fourth writing in general, a certain, shared metaphysical conundrum. Drawing on the work of Giorgio Agamben to take the hiatus between human and animal as an occasion for ontological possibility, I will investigate how the dehumanized portrayal of these characters situates them at the threshold of a new becoming： one which has not yet been realized, but which is also rendered impossible either through the character＇s death or return to health. Examining Lu Xun＇s works in this way not only recognizes his major emphasis on social critique, but suggests both that his thought on Chinese society pierces through to the level of metaphysical inquiry, and that the relationship between human and animal marks a productive entry point for this sort of questioning.

关键词： Lu Xun animality Agamben metaphysics Kong Yiji Xianglin sao Madman

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A Breakthrough Performance： Being Human on Can Xue＇s Five spice street

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Frontiers of Literary studies in China-selected Publications from Chinese Universities 2016年第4期10卷 598-622页

作者： todd Foley Department of East Asian studies New York University New York NY 10003 USA

Of the many forms of literary experimentation that arose in China during the 198os, Can Xue＇s writing stands out as some of the strangest and most enigmatic. This article intends to examine her most significant work from that period, Five spice street （Wuxiang jie; first published under the title Breakthrough Performance [Tuwei biaoyan]）, in light of one of the major intellectual concerns in literature at the time： the question of the human. Through a close reading of the novel, I investigate the ways in which Can Xue interrogates and destabilizes the notion of the human with regard to the relationship between subject and object, corporeality, animality, sexuality, language, and time. Overall, I suggest that while Can Xue succeeds in offering a unique and provocative conceptualization of the human in Five spice street, she also refrains from ＂breaking through＂ the general realm of humanist discourse current at the time.

关键词： Can Xue Five spice street (Wuxiang jie) human physicality subjective reality

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Identification and characterization of new plant microRNAs using EsT analysis

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Cell Research 2005年第5期15卷 336-360页

作者： George P.COBB1,todd A.ANDERsON The Institute of Environmental and Human Health (TIEHH) and Department of Environmental Toxicology Texas Tech University Lubbock TX 79409-1163 UsA The Institute of Environmental and Human Health (TIEHH) and Department of Environmental Toxicology Texas Tech University Lubbock TX 79409-1163 UsA

seventy-five previously known plant microRNAs (miRNAs) were classified into 14 families according to their gene sequence identity. A total of 18,694 plant expressed sequence tags (EsT) were found in the GenBank EsT databases by comparing all previously known Arabidopsis miRNAs to GenBank’s plant EsT databases with BLAsT algorithms. After removing the EsT sequences with high numbers (more than 2) of mismatched nucleotides, a total of 812 EsT contigs were identified. After predicting and scoring the RNA secondary structure of the 812 EsT sequences using mFold software, 338 new potential miRNAs were identified in 60 plant species. miRNAs are widespread. some microRNAs may highly conserve in the plant kingdom, and they may have the same ancestor in very early evolution. There is no nucleotide substitution in most miRNAs among many plant species. some of the new identified potential miRNAs may be induced and regulated by environmental biotic and abiotic stresses. some may be preferentially expressed in specific tissues, and are regulated by developmental switching. These findings suggest that EsT analysis is a good alternative strategy for identifying new miRNA candidates, their targets, and other genes. A large number of miRNAs exist in different plant species and play important roles in plant developmental switching and plant responses to environmental abiotic and biotic stresses as well as signal transduction. Environmental stresses and developmental switching may be the signals for synthesis and regulation of miRNAs in plants. A model for miRNA induction and expression, and gene regulation by miRNA is hypothesized.

关键词： microRNA plant environmental stress gene regulation expressed sequence tags.

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Ultra-fast densification of CNTs reinforced alumina based on combustion reaction and quick pressing

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science China(Technological sciences) 2012年第2期55卷 484-489页

作者： FU ZhengYi HUANG LiWei ZHANG JinYong todd Richard state Key Laboratory of Advanced Technology for Materials synthesis and Processing Wuhan University of TechnologyWuhan 430070China Department of Materials University of OxfordOxford OX13PHUK

An ultra-fast densification method based on high heating rate from the combustion reaction for producing carbon nanotubes （CNTs） reinforced alumina ceramics is reported. The heat generated by combustion reaction is adopted to act as a high temperature source to the sample, which results in a heating rate of 1660℃/min of the sample. Then a great mechanical pressure is applied to the sample when the sample gets the expected temperature. The densification process is finished in several minutes. The results indicate that the densification method is beneficial to protect the CNTs from destruction and creates good interracial combination between the nanotubes and the matrix. With the addition of 1 wt% CNTs, the fracture toughness of the ceramics prepared increases about 50%.

关键词： carbon nanotubes alumina combustion reaction quick pressing

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Microchip imaging cytometer:making healthcare available,accessible,and affordable

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Opto-Electronic Advances 2022年第11期5卷 1-15页

作者： Xilong Yuan todd Darcie Ziyin Wei J stewart Aitchison Department of Electrical and Computer Engineering University of TorontoTorontoONM5S 3G4Canada

The Microchip Imaging Cytometer(MIC)is a class of integrated point-of-care detection systems based on the combination of optical microscopy and flow *** devices have the attributes of portability,cost-effectiveness,and adaptability while providing quantitative measurements to meet the needs of laboratory testing in a variety of healthcare *** on the use of microfluidic chips,MIC requires less sample and can complete sample preparation ***,they can provide quantitative testing results simply using a finger prick *** decreased reagent consumption and reduced form factor also help improve the accessibility and affordability of healthcare services in remote and resource-limited *** this article,we review recent developments of the Microchip Imaging Cytometer from the following aspects:clinical applications,microfluidic chip integration,imaging optics,and image ***,we provide an outlook of the field and remark on promising technologies that may enable significant progress in the near future.

关键词： microchip microfluidics flow cytometer imaging cytometer biosensors point-of-care testing biomedical engineering

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