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Ten Reasons Why... It's Good to Write

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基础教育外语教学研究 2007年第7期 36-37页

作者： Sian morgan currently studying for an m.A. in TESOL

Writing is a real life activity. Whether it is in social,work or study situations,we write to get things done:to form and maintain social relationships (email,chat groups,text messaging)and for business

关键词：外语英语教学写作日常生活商务人际关系

Cost of treatment support for multidrug-resistant tuberculosis using patient-centred approaches in Ethiopia: a model-based method

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Infectious Diseases of Poverty 2023年第4期12卷 54-62页

作者： Laura Rosu Lucy morgan Ewan m.Tomeny Claire Worthington mengdi Jin Jasper Nidoi David Worthington Liverpool School of Tropical medicine Pembroke PlaceLiverpoolL35QAUK management Science Lancaster UniversityLancasterUK makerere University Lung Institute KampalaUganda

Background Patient and health system costs for treating multidrug-resistant tuberculosis (mDR-TB) remain high even after treatment duration was shortened. many patients do not finish treatment, contributing to increased transmission and antimicrobial resistance. A restructure of health services, that is more patient-centred has the potential to reduce costs and increase trust and patient satisfaction. The aim of the study is to investigate how costs would change in the delivery of mDR-TB care in Ethiopia under patient-centred and hybrid approaches compared to the current *** We used published data, collected from 2017 to 2020 as part of the Standard Treatment Regimen of Anti-Tuberculosis Drugs for Patients with mDR-TB (STREAm) trial, to populate a discrete event simulation (DES) model. The model was developed to represent the key characteristics of patients’ clinical pathways following each of the three treatment delivery strategies. To the pathways of 1000 patients generated by the DES model we applied relevant patient cost data derived from the STREAm trial. Costs are calculated for treating patients using a 9-month mDR-TB treatment and are presented in 2021 United States dollars (USD).Results The patient-centred and hybrid strategies are less costly than the standard-of-care, from both a health system (by USD 219 for patient-centred and USD 276 for the hybrid strategy) and patient perspective when patients do not have a guardian (by USD 389 for patient-centred and USD 152 for the hybrid strategy). Changes in indirect costs, staff costs, transport costs, inpatient stay costs or changes in directly-observed-treatment frequency or hospitalisation duration for standard-of-care did not change our *** Our findings show that patient-centred and hybrid strategies for delivering mDR-TB treatment cost less than standard-of-care and provide critical evidence that there is scope for such strategies to be implemented in routine care. These

关键词： Affordability multidrug-resistant tuberculosis Directly-observed treatment Patient-centred approach Tuberculosis treatment delivery

Use of mRI, metabolomic, and genomic biomarkers to identify mechanisms of chemoresistance in glioma

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Cancer Drug Resistance 2019年第3期2卷 862-876页

作者： Cathy W.Levenson Thomas J.morgan Jr.Pamela D.Twigg Timothy m.Logan Victor D.Schepkin Department of Biomedical Sciences Florida State University College of MedicineTallahasseeFL 32306USA Program in Neuroscience Florida State UniversityTallahasseeFL 32306USA Department of Chemistry and Biochemistry and Institute for molecular Biophysics Florida State UniversityTallahasseeFL 32306USA Current Address:Department of Chemistry University of Alabama in HuntsvilleHuntsvilleAL 35899USA National High magnetic Field Laboratory Florida State UniversityTallahasseeFL 32306USA.

Gliomas are the most common form of central nervous system tumor. The most prevalent form, glioblastoma multiforme, is also the most deadly with mean survival times that are less than 15 months. Therapies are severely limited by the ability of these tumors to develop resistance to both radiation and chemotherapy. Thus, new tools are needed to identify and monitor chemoresistance before and after the initiation of therapy and to maximize the initial treatment plan by identifying patterns of chemoresistance prior to the start of therapy. Here we show how magnetic resonance imaging, particularly sodium imaging, metabolomics, and genomics have all emerged as potential approaches toward the identification of biomarkers of chemoresistance. This work also illustrates how use of these tools together represents a particularly promising approach to understanding mechanisms of chemoresistance and the development individualized treatment strategies for patients.

关键词： Sodium mRI diffusion genes resistance glycolysis warburg effect

Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 713C and SARS-CoV-2 main protease

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Acta Pharmaceutica Sinica B 2022年第10期12卷 3924-3933页

作者： Bo Qin Gregory B.Craven Pengjiao Hou Julian Chesti Xinran Lu Emma S.Child Rhodri m.L.morgan Wenchao Niu Lina Zhao Alan Armstrong David J.mann Sheng Cui NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100076China Department of Life Sciences Imperial College LondonSouth Kensington CampusLondon SW72AZUK Department of Chemistry Imperial College LondonMolecular Sciences Research HubWhite City CampusWood LaneLondon W120BZUK CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy PhysicsUniversity of Chinese Academy of SciencesBeijing 100049China

RNA viruses are critically dependent upon virally encoded proteases to cleave the viral polyproteins into functional *** of these proteases exhibit a similar fold and contain an essential catalytic cysteine,offering the opportunity to inhibit these enzymes with electrophilic small *** we describe the successful application of quantitative irreversible tethering(qIT)to identify acrylamide fragments that target the active site cysteine of the 3C protease(3Cpro)of Enterovirus 71,the causative agent of hand,foot and mouth disease in humans,altering the substrate binding ***,we re-purpose these hits towards the main protease(mpro)of SARS-CoV-2 which shares the 3C-like fold and a similar active *** hit fragments covalently link to the catalytic cysteine of mpro to inhibit its *** demonstrate that targeting the active site cysteine of mpro can have profound allosteric effects,distorting secondary structures to disrupt the active dimeric unit.

关键词： SARS-CoV-2 Protease inhibitors Covalent fragments Allosteric inhibition EV71

Stool DNA-based versus colonoscopy-based colorectal cancer screening: Patient perceptions and preferences

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Family medicine and Community Health 2015年第3期3卷 2-8页

作者： matthew V.Abola todd F.Fennimore marcia m.Chen Zhengyi Chen Ashutosh K.Sheth Gregory Cooper Li Li Department of Family medicine and Community Health Case Western Reserve University School of Medicine11001 Cedar AvenueSuite 200ClevelandOH 44106USA Division of Gastroenterology University Hospitals Case Medical Center11100 Euclid AvenueClevelandOH 44106USA Case Comprehensive Cancer Center Case Western Reserve University School of Medicine10900 Euclid AvenueClevelandOH 44106USA Swetland Center for Environmental Health Case Western Reserve University11000 Cedar AvenueSuite 402ClevelandOH 44106USA

Objective:Stool DNA(sDNA)tests offer a noninvasive form of colon cancer screening for pa-tients,and although the test is expected to increase uptake of colon cancer screening,it is unknown if patients’perceptions of the sDNA test differ according to race and other patient ***:We conducted a self-administered survey of patients undergoing both a colonoscopy and an sDNA test to evaluate perceptions of sDNA ***:Of the 613 participants who were sent surveys,423 responded(69%response rate).Respondents self-identified as African American(n=127,30%),Caucasian(n=284,67%),and other ethnicity(n=12,3%).In general,participants found the sDNA test more suitable than a colonos-copy(n=309,75%).In univariate analyses,a higher percentage of Caucasians as compared with African Americans found the sDNA test more suitable than a colonoscopy(89%vs.76%,pmore Caucasians than African Americans preferred the sDNA test(43%vs.32%,pment for covariates reduced these racial differences to no significance.A family history of colo-rectal cancer remains a significant factor for patient’s preferences for screening regardless of ***:Our study shows no racial differences in the perception of and preference for sDNA testing for colon *** to increase the uptake of sDNA testing may help reduce racial disparities in colorectal cancer.

关键词： Colon cancer screening race stool DNA test patient perceptions

四川盆地金秋区块非常规天然气工厂化井作业设想

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天然气工业 2013年第6期33卷 54-59页

作者：李鹴 Hii King-Kai todd Franks 谢明华中国石油西南油气田公司金秋项目管理部壳牌中国勘探与生产有限公司

四川盆地上三叠统须家河组气藏经历了50多年的勘探开发,存在着"储量大、采出低"的难题。工厂化井作业是降低钻完井、井场建设成本,提高作业效率的重要手段。为此,基于北美地区工厂化钻完井作业成功实施的案例,综合分析了四川盆地金秋区... 详细信息

四川盆地上三叠统须家河组气藏经历了50多年的勘探开发,存在着"储量大、采出低"的难题。工厂化井作业是降低钻完井、井场建设成本,提高作业效率的重要手段。为此,基于北美地区工厂化钻完井作业成功实施的案例,综合分析了四川盆地金秋区块须家河组非常规天然气资源的特点,提出了以下工厂化井作业模式:①采用小井眼结构及单井场最多布36口井,井间地下间距650m的井眼数量优选方案;②采用单排、多井丛且有备用井眼(井丛)的丛式井布局模式;③采用3项交叉作业(钻井+完井+生产)模式,缩短井交付周期;④柔性井场布局设计可以有效地避开地形的限制;⑤选用定制钻机和修井机来完成特定作业目的;⑥作业过程中合理设计离线作业以提高钻完井效率;⑦采用批量完井压裂工厂化模式。这种工厂化井作业可为非常规天然气资源高效、低成本开发提供技术思路和实现手段。

关键词：四川盆地金秋区块工厂化钻井丛式井批量钻井交叉作业离线作业欠平衡钻井低成本开发

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冷冻喷丸修边的功能及其不足

橡胶参考资料 1999年第9期29卷 38-38页

作者： Stacy m.morgan 杨钧

冷冻高速喷丸修边是橡胶工业中采用的一种将飞边从橡胶模压制品上去掉的工艺。该工艺采用各种组合的液氮,高速旋转和介质(喷丸)将飞边去掉,是一种高精度,经济和有效的方法(见图1)。

关键词：冷冻喷丸修边橡胶制品修边模压制品

Coherent-interface-induced strain in large lattice-mismatched materials:A new approach for modeling Raman shift

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Nano Research 2022年第3期15卷 2405-2412页

作者： Andrian V.Kuchuk Fernando mde Oliveira Pijush K.Ghosh Yuriy I.mazur Hryhorii V.Stanchu marcio D.Teodoro morgan E.Ware Gregory J.Salamo Institute for Nanoscience and Engineering University of ArkansasFayettevilleAR 72701USA Departamento de Física Universidade Federal de São CarlosSão CarlosSP 13565-905Brazil Department of Electrical Engineering University of ArkansasFayettevilleAR 72701USA

Strain engineering as one of the most powerful techniques for tuning optical and electronic properties of III-nitrides requires reliable methods for strain *** this work,we reveal,that the linear model based on the experimental data limited to within a small range of biaxial strains(man study of strain with nanometer-scale spatial resolution is not valid for the binary wurtzite-structure group-III nitrides GaN and ***,we found that the discrepancy between the experimental values of strain and those calculated via Raman spectroscopy increases as the strain in both GaN and AlN ***,a new model has been developed to describe the strain-induced Raman frequency shift in GaN and AlN for a wide range of biaxial strains(up to 2.5%).Finally,we proposed a new approach to correlate the Raman frequency shift and strain,which is based on the lattice coherency in the epitaxial layers of superlattice structures and can be used for a wide range of materials.

关键词： Raman spectroscopy strain lattice coherency III-nitrides high-resolution X-ray diffraction(HRXRD)

A Network Coding Based Cloud Storage Scheme

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International Journal of Internet and Distributed Systems 2018年第1期3卷 1-8页

作者： Yantao Liu Yasser morgan College of Engineering Bohai University Jinzhou China Faculty of Engineering and Applied Science University of Regina Regina Canada

With this paper, we propose a network coding based cloud storage scheme. The storage system is in the form of an m * n data array. The n columns stand for n storage nodes, which are comprised of a part of systematic nodes storing source symbols and a part of nonsystematic nodes storing parity symbols. Every row of the data array is a (n, k) systematic maximum Distance Separable (mDS) code. A source symbol is only involved in the encoding with the unique row;it locates at and is not used by other rows. Such a design significantly decreases the complexity of encoding and decoding. moreover, in case of single node failures, we use interference alignment to further reduce repair bandwidth. Compared to some existing cloud storage schemes, our scheme significantly reduces resource consumption on storage, update bandwidth and repair bandwidth.

关键词： Network Coding Cloud Storage mDS Code Interference Alignment