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New m.thodological Approach to Investigation of Kinetics of REE Extraction in Nonstationary Conditions

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Journal of Rare Earths 2007年第4期25卷 385-391页

作者： Kopyrin A A Fom.chev A A Afonin m.A todd T A Saint-Petersburg Institute of Technology Idaho National Laboratory

The influence of periodical oscillations of the tem.erature on extraction and stripping processes in the extraction system. was studied. Two extraction system. were investigated：（1） 6 m.l · L^-1 NaNO3-Nd（NO3）3-Pr（NO3）3-TBP kerosene and （2） [Nd（NO3）3 · 3TBP] -[ Pr（NO3）3 · 3TBP] -kerosene - 0.1 m.l · L^-1 HNO3. m.them.tical m.deling of the nonstationary m.m.rane extraction has been enhanced by including the dependence of the extraction rate constants on tem.erature. The values of activation energy for direct and reverse extraction and stripping reactions of Pr and Nd were calculated from.experim.ntal tem.oral dependencies of m.tal concentration and tem.erature by solving the reverse kinetics problem.using the proposed m.them.tical m.del, A series of experim.nts with periodical oscillations of the tem.erature on the extraction system.for the separation of rare earth elem.nts （REE） using bulk liquid m.m.rane between two extractors were perform.d. The m.them.tical m.del adequately describes the experim.ntal data. The optim.zation of the extraction process for separation of REE by liquid m.m.rane, under the influence of periodical oscillation of the tem.erature, was m.de based on the extraction rate constants and activation energies. The optim.l conditions of separation by liquid m.m.rane were found： frequency and am.litude of therm.l oscillations, liquid m.m.rane flow rate, and optim.l ratio between organic and aqueous phase in extractors.

关键词： kinetics extraction non-stationary rare earths

2023年美国麻醉医师学会神经肌肉阻滞监测与拮抗实践指南:美国麻醉医师学会工作组关于神经肌肉阻滞的报告

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中华麻醉学杂志 2024年第5期44卷 518-542页

作者： Stephan R.Thilen Wade A.Weigel m.chael m.todd Richard P.Dutton Cynthia A.Lien Stuart A.Grant Joseph W.Szokol Lars I.Eriksson m.ron Yaster m.rk D.Grant m.dhulika Agarkar Anne m.m.rbella Jaim. F.Blanck Karen B.Dom.no 西雅图华盛顿州明尼阿波里斯明尼苏达州达拉斯得克萨斯州密尔沃基威斯康星州教堂山北卡罗来纳州洛杉矶加利福尼亚州斯德哥尔摩瑞典丹佛科罗拉多州绍姆堡伊利诺斯州巴尔的摩马里兰州

本实践指南基于证据提供了全身麻醉期间及术后神经肌肉功能监测与阻滞拮抗的管理推荐。主要关注神经肌肉功能监测的类型与部位及阻滞拮抗的过程,以减少肌肉松弛药残留阻滞。

关键词：神经肌肉阻滞肌肉松弛药神经肌肉功能监测舒更葡糖钠新斯的明

Trade-off between cellular im.unity and life span in m.al- worm.beetles Tenebrio m.litor

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Current Zoology 2013年第3期59卷 340-346页

作者： Indrikis KRAm. Janina DAUKSTE Inese KIVLENIECE Ants KAASIK Tatjana KRAm. todd m. FREEBERG m.rkus J. RANTALA Institute of System.tic Biology University of Daugavpils LV-5401 Daugavpils Latvia Institute of Ecology and Earth Sciences University of Tartu 51014 Tartu Estonia Departm.nt of Biology University of Turku FIN-20024 Turku Finland Departm.nt of Psychology University of Tennessee TN 37996 Knoxville USA

Encapsulation is a nonspecific, cellular response through which insects defend them.elves against m.lticellular pathogens. During this im.une reaction, haem.cytes recognize an object as foreign and cause other haem.cytes to aggregate and form.a capsule around the object, often consisting of m.lanized cells. The process of m.lanisation is accom.anied by the form.- tion of potentially toxic reactive oxygen species, which can kill not only pathogens but also host cells. In this study we tested whether the encapsulation response is costly in m.alworm.beetles Tenebrio m.litor. We found a negative relationship between the duration of im.lantation via a nylon m.nofilam.nt and rem.ining life span. We also found a negative relationship between the strength of im.une response and rem.ining life span, suggesting that cellular im.unity is costly in T. m.litor, and that there is a trade-off between im.une response and rem.ining life span. However, this relationship disappeared at 31-32 hours of im.lanta- tion at 25 ± 2℃. As the disappearance of a relationship between duration of im.lantation and lifespan coincided with the highest values of encapsulation response, we concluded that the beetles stopped investm.nt in the production of m.lanotic cells, as the im.lant, a synthetic parasite, was fully isolated from.the host＇s tissues .

关键词： Cost of im.unity Cellular im.unity Encapsulation Lifespan Tenebrio m.litor

Analysis of Transcriptom. Changes Induced by Ptr ToxA in Wheat Provides Insights into the m.chanism. of Plant Susceptibility

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m.lecular Plant 2009年第5期2卷 1067-1083页

作者： Iovanna Pandelova m.lania F. Betts Viola A. m.nning Larry J. Wilhelm.todd C. m.ckler Lynda m. Ciuffetti Departm.nt of Botany and Plant Pathology and Center for Genom. Research and Biocom.uting Oregon State University Corvallis OR 97331 USA

To obtain greater insight into the m.lecular events underlying plant disease susceptibility, we studied transcriptom. changes induced by a host-selective toxin of Pyrenophora tritici-repentis, Ptr ToxA （ToxA）, on its host plant, wheat. Transcriptional profiling of ToxA-treated leaves of a ToxA-sensitive wheat cultivar was perform.d using the GeneChip Wheat Genom. Array. An im.roved and up-to-date annotation of the wheat m.croarray was generated and a new tool for array data analysis （BRAT） was developed, and both are available for public use via a web-based interface. Our data indicate that m.ssive transcriptional reprogram.ing occurs due to ToxA treatm.nt, including cellular responses typically associated with defense. In addition, this study supports previous results indicating that ToxA-induced cell death is triggered by im.airm.nt of the photosynthetic m.chinery and accum.lation of reactive oxygen species. Based on results of this study, we propose that ToxA acts as both an elicitor and a virulence factor.

关键词： Gene expression transcriptom. analysis defense responses fungal pathogenesis plant-m.crobe interactions host-selective toxin.

始新世中期安宁河断裂冲断变形特征及其构造意义:来自断层泥自生伊利石K-Ar定年的证据

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地学前缘 2024年第4期31卷 297-313页

作者：童馗李智武刘树根 I.Tonguç UYSAL 施泽进李金玺 Andrew todd 武文慧王自剑刘升武李轲华天成都理工大学油气藏地质及开发工程全国重点实验室四川成都610059 成都理工大学地质资源与地质工程博士后流动站四川成都610059 CSIRO Energy 26 Dick Perry AvenueKensingtonWA 6151Australia 西华大学四川成都610039 School of the Environm.nt The University of QueenslandBrisbaneQLD 4072Australia 西南油气田分公司勘探开发研究院四川成都610051

青藏高原及其周缘褶皱-冲断带变形方式和时限是验证高原形成众多大陆岩石圈变形动力学端员模型的关键。近年发展起来的断层泥自生伊利石K-Ar定年技术为精确限定褶皱-冲断带变形时限提供了有效手段。鲜水河—安宁河—小江断裂系作为伴随... 详细信息

青藏高原及其周缘褶皱-冲断带变形方式和时限是验证高原形成众多大陆岩石圈变形动力学端员模型的关键。近年发展起来的断层泥自生伊利石K-Ar定年技术为精确限定褶皱-冲断带变形时限提供了有效手段。鲜水河—安宁河—小江断裂系作为伴随印度-欧亚板块碰撞造山和高原物质侧向挤出过程形成的大型左旋走滑断裂系,其变形过程可为解译印度-欧亚板块碰撞远程应力向东传递方式提供关键证据。本文选取安宁河断裂冕宁—西昌段作为研究对象,在详细构造解析以明确其构造运动学特征的基础上,开展了断层泥自生伊利石K-Ar定年研究,以期精确限定安宁河断裂脆性变形的时间。构造解析表明安宁河断裂在近EW向挤压作用下经历了冲断变形,断层带发育碎斑岩和断层泥,指示为脆性变形。安宁河断裂不同粒级断层泥样品的黏土矿物学和伊利石K-Ar定年分析揭示,随着样品粒级减小,高温2m.型伊利石含量相对低温1m.1m.型伊利石含量逐渐减少,其K-Ar年龄总体呈变年轻趋势,表明不同粒级伊利石K-Ar年龄是由碎屑2m.型和自生1m.1m.型两个多型端员组成的混合年龄。伊利石年龄分析获得自生1m.1m.型伊利石的年龄为(42.6±9.4)m.,表明安宁河断裂经历了始新世中期的冲断变形。结合前人构造变形、沉积学、低温热年代学和古地磁等研究,我们认为始新世中期青藏高原腹地及其周缘褶皱-冲断带发生准同期的构造挤压变形,其动力学机制可能与印度-欧亚板块硬碰撞以及青藏高原地块的陆内俯冲所导致的先存构造带活化有关。始新世中期安宁河断裂发生冲断变形直接证明印度-欧亚板块碰撞初期的远程应力已传递至青藏高原东南缘地区。

关键词：安宁河断裂断层泥自生伊利石 K-Ar定年始新世中期

m.t-ten, m.rc Andre, ed., Places of m.m.ry in m.dern China： History, Politics, and Identity. Leiden： Brill, 2012. ISBN 978-9-004-21901-4. x, 285pp. $151.00 （cloth）.

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Frontiers of History in China 2013年第3期8卷 461-464页

作者： todd m. Goehle State University of New York at Bingham.on

In recent years, ＂the m.m.ry turn＂ has significantly affected the writing of culture and identity across disciplines, with scholars becom.ng sensitive to the ways in which sites of m.m.ry m.diate the past and provide a shared sense of com.unity and self. The insights of French historian Pierre Nora and his sem.nal concept lieux de m.m.ire prove especially im.ortant in this regard and provide the inspiration for m.rc Andre m.tten＇s edited volum.,

关键词：历史学家近代中国内存 ISBN 场所政治美元自我意识

m.lecular Docking Studies on Streptom.cin Antileishm.nial Activity

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Pink1 and parkindem.nstrate m.ltifaceted roles when co-expressed with Foxo

Open Journal of Physical Chem.stry（物理化学期刊） 2024年第2期 36页

作者： todd A.Young m.tthew George Jr. Ayele Gugssa William.1}Southerland Yayin Fang Clarence m.Lee

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Advances in Parkinson's Disease 2013年第1期2卷 5-10页

作者： Am. m. todd Brian E. Staveley Departm.nt of Biology Memorial University of Newfoundland St. John’s Canada

Pink1 has been linked to both autosom.l recessive and sporadic form. of Parkinson disease. The Pink1 protein is thought to be involved in m.tochondrial protection by interacting with parkin to prevent oxidative dam.ge, m.intain m.tochondrial integrity and regulate m.tophagy. Pink1 and parkin have been linked to com.onents of the insulin receptor (INR) pathway, including PTEN, Akt and Foxo, but their effects in the INR pathway have been largely overlooked. To further investigate the roles of Pink1/parkin, we have perform.d co-expression studies to determ.ne the effects Pink1 and parkin on the Foxo-induced phenotype of developm.ntal defects in the Drosophila eye. We exam.ned directed expression of Pink1, parkin, Pink1 or parkin m.tants, and Pink1 or parkin interfering RNAs (RNAi) with the overexpression of Foxo in the developing eye of Drosophila. Our findings show that reduction of Pink1 suppresses the effects of Foxo overexpression, where co-overexpression with Pink1 or parkin increases the severity of the phenotype. This suggests that Pink1 and parkin are able to increase the pro-apoptotic effects of Foxo. Contrary to the view that Pink1 and parkin act exclusively as protective proteins in the cell, it is likely that the Pink1/parkin pathway is involved in aspects of cell fate decisions other than degrading toxic proteins and m.intaining m.tochondrial integrity.

关键词： Pink1 Parkin Foxo Drosophila

Pink1 Rescues Gal4-Induced Developm.ntal Defects in the DrosophilaEye

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Advances in Parkinson's Disease 2015年第3期4卷 43-48页

作者： Am. m. todd Brian E. Staveley Departm.nt of Biology Memorial University of Newfoundland St. John’s Canada

Parkinson disease pathology often includes the presence of ubiquitin-positive, α-synuclein-enriched inclusions in the rem.ining neurons. Pink1 (also identified as PARK6) encodes a serinethreonine kinase involved in m.tochondrial protection that works with parkin to ubiquitinate various proteins, prom.ting m.tophagy. The parkin protein works to tag cystolic proteins for degradation, and previous work in our laboratory has shown the ability of parkin to rescue a Gal4-induced phenotype. To further investigate the role of Pink1 in protection against toxic proteins, we have perform.d expression studies to determ.ne the effects of increases and decreases in Pink1 on the Gal4-induced phenotype consisting of developm.ntal defects in the Drosophila eye. Our results show that Pink1 is able to rescue the Gal4-induced phenotype, highlighting a protective role for Pink1 against toxic proteins. When expressing low levels of Gal4, reductions in Pink1 or parkin are not able to induce a phenotype. This suggests that Pink1 or parkin m.y counter Gal4 effects despite reductions, or that the effects of low level Gal4 m.y be alleviated by an alternative m.chanism. m.reover, the Pink1 m.chanism.of action during differing types of cell stress, including degradation of toxic proteins, warrants further investigation.

关键词： Drosophila m.lanogaster Pink1 Parkin Gal4 Toxic Protein Parkinson Disease