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Incr.ases in the incr.mental exer.ise mean r.sponse time acr.ss the steady state domain:Implications for.exer.ise testing&pr.scr.ption

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Spor.s Medicine and Health Science 2024年第4期6卷 315-323页

作者： Br.dgette g.J.O'Malley r.ber. A.r.ber.s todd A.Astor.no Queensland Univer.ity of Technology Faculty of Health:School of Exercise and Nutrition SciencesBrisbaneAustralia Depar.ment of Kinesiology CSU-San MarcosSan MarcosCAUSA

We hypothesized that slowed oxygen uptake(VO_(2))kinetics for.exer.ise tr.nsitions to higher.power.outputs(PO)within the steady state(SS)domain would incr.ase the mean r.sponse time(Mr.)with incr.asing exer.ise intensity dur.ng incr.mental *** highly tr.ined cyclists(mean±standar. deviation[SD]);age(39±6)year.[yr.;and VO_(2) peak=(61±9)mL/kg/min per.or.ed a maximal,r.mp incr.mental cycling test and on separ.te days,four.6-min bouts of cycling at 30%,45%,65%&75% of their.incr.mental peak PO(Wpeak).SS tr.al data wer. used to calculate the Mr. and ver.fied by mono-exponential and linear.cur.e *** the r.mp pr.tocol attained the value fr.m SS,the PO,in Watts(W),was conver.ed to time(min)based on the r.mp function W to quantify the incr.mental Mr.(iMr.).Slope analyses for.the VO_(2) r.sponses of the SS ver.us incr.mental exer.ise data below the gas exchange thr.shold(gET)r.vealed a significant differ.nce(p=0.003;[0.437±0.08]vs.[0.382±0.05]L·min^(-1)).Ther. was a significant differ.nce between the 45%Wpeak steady state VO_(2)(ss VO_(2))([3.08±0.30]L·min^(-1),r.spectively),and 30% Wpeak ss VO_(2)(2.26±0.24)(pr. for.45% and 30% Wpeak ss VO_(2) values([50.58±36.85]s vs.[32.20±43.28]s).These data indicate ther. is no single iMr.,which is consistent with slowed VO_(2) kinetics and an incr.asing VO_(2) deficit for.higher.exer.ise intensities within the SS domain.

关键词： Mean r.sponsetime(Mr.) Incr.mental exer.ise Steady state(SS) Exer.ise testing Exer.ise pr.scr.ption

Beyond the Fer.is Wheel A look at the futur. of theme par.s

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空中英语教室（高级版．彭蒙惠英语） 2024年第10期 22-25,44,45页

作者： todd Mar.ens 不详

The theme par. industr. is *** catch-all ter. encompasses your.favor.te r.des,yes,but also an assor.ment of industr.es,r.nging fr.m ar.hitectur. to animation to cinema to engineer.ng to wr.ting to game *** theme par. ... 详细信息

关键词： favor.te industr. Beyond

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Whose Bone

小学生时代（大嘴英语） 2024年第6期 34-35页

作者： Susan todd(图) 不详

对疼痛线索的晚期注视偏向预测慢性疼痛的维持:来自眼动的证据

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心理学报 2024年第1期56卷 44-60页

作者：杨周朱嘉雯苏琳熊明洁 todd Jackson 西南大学心理学部认知与教育部重点实验室西南大学医院重庆400715 澳门大学心理学院中国澳门999078

使用点探测视觉任务和融入真实疼痛刺激的视觉任务,以疼痛-中性、中性-中性图片为实验材料,采用眼动追踪技术,测量慢性疼痛患者对疼痛线索的动态注视偏向指标,并进一步考察这些指标对6个月后慢性疼痛强度和功能损伤变化的预测作用。研... 详细信息

使用点探测视觉任务和融入真实疼痛刺激的视觉任务,以疼痛-中性、中性-中性图片为实验材料,采用眼动追踪技术,测量慢性疼痛患者对疼痛线索的动态注视偏向指标,并进一步考察这些指标对6个月后慢性疼痛强度和功能损伤变化的预测作用。研究发现,点探测视觉任务中,慢性疼痛患者在前3个时间窗上(0~500 ms、500~1000 ms、1000~1500 ms)对疼痛线索的注视偏向显著高于对中性线索的注视偏向,但在第四个时间窗上(1500~2000ms)不存在差异;融入真实疼痛刺激的视觉任务中,慢性疼痛患者在4个时间窗上对疼痛线索的注视偏向均显著高于对中性线索的注视偏向。分层标准多元回归模型和机器学习回归模型均发现,慢性疼痛患者在两个任务中对疼痛线索的晚期注视偏向(1000~1500ms、1500~2000ms两个时间窗),均可以独立预测6个月后慢性疼痛强度和功能损伤的维持。研究结果表明,尽管慢性疼痛患者对疼痛线索从注意早期就表现出注视偏向,但是只有晚期的注视偏向能够预测慢性疼痛的维持。

关键词：慢性疼痛疼痛强度功能损伤注视偏向眼动追踪

Physiological and per.eptual r.sponses to spr.nt inter.al exer.ise using ar. ver.us leg cycling er.ometr.

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Spor.s Medicine and Health Science 2024年第4期6卷 385-393页

作者： todd A.Astor.no Shealin Pier.e Madisen B.Piva r.char. S.Metcalfe Niels B.J.Vollaar. Depar.ment of Kinesiology CSU—San MarcosSan MarcosCAUSA Applied Spor.s TechnologyExercise and Medicine(A-STEM)Research CenterSwansea UniversitySwanseaUK Faculty of Health Sciences and Spor. University of StirlingStirlingUK

Incr.ases in power.output and maximal oxygen consumption(V_O2max)occur.in r.sponse to spr.nt inter.al exer.ise(SIE),but common use of“all-out”intensities pr.sents a bar.ier.for.many ***,lower.body SIE is not feasible for.all *** compar.d physiological and per.eptual r.sponses to supr.maximal,but“nonall-out”SIE between leg and ar. cycling ***-four.active adults(mean±SD age:[25±7]y;cycling VO_(2)max:[39±7]mL·kg^(-1)·min^(-1))per.or.ed incr.mental exer.ise using leg(LCE)and ar. cycle er.ometr.(ACE)to deter.ine VO_(2)max and maximal wor. capacity(Wmax).Subsequently,they per.or.ed four.20 s bouts of SIE at 130% Wmax on the LCE or.ACE at cadence=120-130 r.v/min,with 2 min r.cover. between *** exchange data,hear. r.te(Hr.,blood lactate concentr.tion(BLa),r.ting of per.eived exer.ion(r.E),and affective valence wer. *** showed significantly lower.pr.us ***,ACE elicited significantly higher.pr.lative mean([62%±9%]VO_(2)max vs.[57%±7%]VO_(2)max,d=0.63)and peak VO_(2)([88%±10%]VO_(2)max vs.[75%±10%]VO_(2)max,d?1.33).Post-exer.ise BLa was significantly higher.[7.0±1.7]mM vs.[5.7±1.5]mM,p=0.024,d?0.83)for.LCE ver.us *** was no significant effect of modality on r.E or.affective valence(p>0.42),and lowest affective valence r.cor.ed(2.0±1.8)was consider.d“good to fair.y good”.Data show that non“all-out”ACE elicits lower.absolute but higher.r.lative Hr.and VO_(2) compar.d to *** aver.ive per.eptual r.sponses could make this non-all-out modality feasible for.inactive adults.

关键词： High intensity inter.al tr.ining Upper.body exer.ise Peak power.output Oxygen uptake Blood lactate concentr.tion

Analysis of the combined effect of r.699 and r.5051 on angiotensinogen expr.ssion and hyper.ension

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Chr.nic Diseases and Tr.nslational Medicine 2024年第2期10卷 102-117页

作者： Nicholas r.Powell Tyler.Shugg Jacob Leighty Matthew Mar.in r.lf P.Kr.utz Michael T.Eadon Dongbing Lai Tao Lu todd C.Skaar Division of Clinical Phar.acology Department of MedicineSchool of MedicineIndiana UniversityIndianapolisIndianaUSA Depar.ment of Phar.acology and Toxicology School of MedicineIndiana UniversityIndianapolisIndianaUSA Depar.ment of Car.iology School of MedicineKrannert Institute of CardiologyIndiana UniversityIndianapolisIndianaUSA Division of Nephr.logy Department of MedicineSchool of MedicineIndiana UniversityIndianapolisIndianaUSA Depar.ment of Medical and Molecular.genetics School of MedicineIndiana UniversityIndianapolisIndianaUSA

Backgr.und Hyper.ension(HTN)involves genetic var.ability in the r.nin-angiotensin system and influences antihyper.ensive *** pr.viously r.por.ed that angiotensinogen(AgT)messenger.r.A(mr.A)is endogenously bound by mir.122-5p and r.699 A>g decr.ases r.por.er.mr.A in the micr.r.A functional-assay *** AgT pr.moter.var.ant r.5051 C>T is in linkage disequilibr.um(LD)with r.699 A>g and incr.ases AgT *** independent effect of these var.ants is under.tudied due to their.LD ther.for. we aimed to test the hypothesis that incr.ased AgT by r.5051 C>T counter.alances AgT decr.ased by r.699 A>g,and when these var.ants occur.independently,it tr.nslates to HTN-r.lated *** We used in silico,in vitr.,in vivo,and r.tr.spective models to test this *** In silico,r.699 A>g is pr.dicted to incr.ase mir.122-5p binding affinity by 3%.Mir.eCLIP r.sults show r.699 is 40–45 nucleotides fr.m the str.ngest micr.r.A-binding site in the AgT ***,r.699 A>g incr.ases AgT mr.A in an AgT-plasmid-cDNA Hepg2 expr.ssion ***-Tissue Expr.ssion(gTEx)and UK Biobank analyses demonstr.te liver.AgT expr.ssion and HTN phenotypes ar. not differ.nt when r.699 A>g occur. independently fr.m r.5051 C>***,gTEx and the in vitr. exper.ments suggest r.699 A>g confer. cell-type-specific effects on AgT mr.A abundance,and suggest par.cr.ne r.nal r.nin-angiotensin-system per.ur.ations could mediate the r.699 A>g associations with *** We found that r.5051 C>T and r.699 A>g significantly associate with systolic blood pr.ssur. in Black par.icipants in the UK Biobank,demonstr.ting a four.old lar.er.effect than in White *** studies ar. war.anted to deter.ine if alter.d antihyper.ensive r.sponse in Black individuals might be due to r.5051 C>T or.r.699 A>*** like this will help clinicians move beyond the use of r.ce as a sur.ogate for.genotype.

关键词： angiotensinogen genetic and genomic medicine hyper.ension r.699

Evaluating the Efficacy of Cer.ical Tactile Ultr.sound Technique as a Pr.dictive Tool for.Spontaneous Pr.ter. Bir.h

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Open Jour.al of Obstetr.cs and gynecology 2024年第5期14卷 832-846页

作者： Vladimir.Egor.v todd r.sen Jennifer.Hill Meena Khandelwal Victor. Kur.enoks Br.ndan Fr.ncy Noune Sar.azyan Advanced Tactile Imaging Inc. Ewing New Jersey USA Depar.ment of Obstetr.cs Gynecology and Reproductive Sciences Rutgers Robert Wood Johnson Medical School New Brunswick New Jersey USA Depar.ment of Mater.al-Fetal Medicine Cooper Medical School of Rowan University Camden New Jersey USA

Backgr.und: Pr.matur. cer.ical softening and shor.ening may be consider.d an ear.y mechanical failur. that pr.dispose to pr.ter. bir.h. Pur.ose: This study aims to explor. the applicability of an innovative cer.ical tactile ultr.sound appr.ach for.pr.dicting spontaneous pr.ter. bir.h (sPTB). Mater.als and Methods: Eligible par.icipants wer. women with low-r.sk singleton pr.gnancies in their.second tr.mester. enr.lled in this pr.spective obser.ational study. A Cer.ix Monitor.(CM) device was designed with a vaginal pr.be compr.sing four.tactile sensor. and a single ultr.sound tr.nsducer.oper.ting at 5 MHz. The pr.be enabled the application of contr.llable pr.ssur. to the exter.al cer.ical sur.ace, facilitating the acquisition of str.ss-str.in data fr.m both anter.or.and poster.or.cer.ical sector.. gestational age at deliver. was r.cor.ed and compar.d against cer.ical elasticity. r.sults: CM examination data wer. analyzed for.127 women at 240/7 - 286/7 gestational weeks. sPTB was obser.ed in 6.3% of the cases. The pr.ter. gr.up exhibited a lower.aver.ge cer.ical str.ss-to-str.in r.tio (elasticity) of 0.70 ± 0.26 kPa/mm compar.d to the ter. gr.up’s 1.63 ± 0.65 kPa/mm with a p-value of 1.1 × 10−4. Diagnostic accur.cy for.pr.dicting spontaneous pr.ter. bir.h based solely on cer.ical elasticity data was found to be 95.0% (95% CI, 88.5 - 100.0). Conclusion: These findings suggest that measur.ng cer.ical elasticity with the designed tactile ultr.sound pr.be has the potential to pr.dict spontaneous pr.ter. bir.h in a cost-effective manner.

关键词： Cer.ical Elasticity Spontaneous Pr.ter. Bir.h Tactile Ultr.sound Pr.be

Cir.ulating micr.r.A expr.ssion and nonalcoholic fatty liver.disease in adolescents with sever. obesity

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Wor.d Jour.al of gastr.enter.logy 2024年第4期30卷 332-345页

作者： Yi-Jie Li Br.ttney O Baumer. Nikos Str.takis Jesse A goodr.ch Hao-Tian Wu Jing-Xuan He Yin-Qi Zhao Max T Aung Hong-Xu Wang Sandr.h P Eckel Douglas I Walker.Damaskini Valvi Michele A La Mer.ill Justin r.r.der.Thomas H Inge todd Jenkins Stephanie Sisley r.hit Kohli Stavr. A Xanthakos Andr.a A Baccar.lli r.b McConnell David V Conti Lida Chatzi Depar.ment of Population and Public Health Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90032United States Bar.elona Institute of global Health Barcelona Institute of Global HealthBarcelona 08036Spain Depar.ment of Envir.nmental Health Sciences Mailman School of Public HealthColumbia UniversityNew YorkNY 10032United States gangar.sa Depar.ment of Envir.nmental Health Rollins School of Public HealthEmory UniversityAtlantaGA 30329United States Depar.ment of Envir.nmental Medicine and Public Health Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Depar.ment of Envir.nmental Toxicology University of CaliforniaDavisCA 95616United States Depar.ment of Sur.er. Lurie Children’s Hospital of ChicagoChicagoIL 60611United States Nor.hwester. Univer.ity Feinber. School of Medicine Northwestern UniversityChicagoIL 60611United States Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States Depar.ment of Pediatr.cs University of Cincinnati College of MedicineCincinnatiOH 45229United States Depar.ment of Pediatr.cs Children’s Nutrition Research Center USDA/ARSBaylor College of MedicineHoustonTX 77030United States Depar.ment of gastr.enter.logy Children’s Hospital Los AngelesLos AngelesCA 90027United States Division of gastr.enter.logy Hepatology and NutritionCincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States

BACKgr.UND Nonalcoholic fatty liver.disease(NAFLD)is one of the most common chr.nic liver.diseases in childr.n and *** r.nges in sever.ty fr.m isolated hepatic steatosis to nonalcoholic steatohepatitis(NASH),wher.in hepatocellular.inflammation and/or.fibr.sis coexist with *** micr.r.A(mir.A)levels have been suggested to be alter.d in NAFLD,but the extent to which mir.A ar. r.lated to NAFLD featur.s r.mains *** analysis tested the hypothesis that plasma mir.As ar. significantly associated with histological featur.s of NAFLD in *** To investigate the r.lationship between plasma mir.A expr.ssion and NAFLD featur.s among adolescents with *** This study included 81 adolescents diagnosed with NAFLD and 54 adolescents without NAFLD fr.m the Teen-Longitudinal Assessment of Bar.atr.c Sur.er. ***-oper.tive cor. liver.biopsies wer. collected fr.m par.icipants and used to char.cter.ze histological featur.s of *** samples wer. collected dur.ng sur.er. for.mir.A pr.filing.A total of 843 plasma mir.As wer. pr.filed using the HTg EdgeSeq *** examined associations of plasma mir.As and NAFLD featur.s using logistic r.gr.ssion after.adjusting for.age,sex,r.ce,and other.key *** Pathways Analysis was used to identify biological functions of mir.As that wer. associated with multiple histological featur.s of *** We identified 16 upr.gulated plasma mir.As,including mir.193a-5p and mir.193b-5p,and 22 downr.gulated plasma mir.As,including mir.1282 and mir.6734-5p,in adolescents with ***,52,16,15,and 9 plasma mir.As wer. associated with NASH,fibr.sis,ballooning degener.tion,and lobular.inflammation,***,16 mir.As wer. associated with two or.mor. histological featur.s of *** those mir.As,mir.411-5p was downr.gulated in NASH,ballooning,and fibr.sis,while mir.122-5p,mir.1343-5p,mir.193a-5p,mir.193b-5p,and mir.7845-5p wer. consistently and posi

关键词： Micr.r.A Nonalcoholic fatty liver.disease Non-alcoholic steatohepatitis Liver.fibr.sis Lobular.inflammation Ballooning degener.tion

始新世中期安宁河断裂冲断变形特征及其构造意义:来自断层泥自生伊利石K-Ar.年的证据

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地学前缘 2024年第4期31卷 297-313页

作者：童馗李智武刘树根 I.Tonguç UYSAL 施泽进李金玺 Andr.w todd 武文慧王自剑刘升武李轲华天成都理工大学油气藏地质及开发工程全国重点实验室四川成都610059 成都理工大学地质资源与地质工程博士后流动站四川成都610059 CSIr. Ener.y 26 Dick Perry AvenueKensingtonWA 6151Australia 西华大学四川成都610039 School of the Envir.nment The University of QueenslandBrisbaneQLD 4072Australia 西南油气田分公司勘探开发研究院四川成都610051

青藏高原及其周缘褶皱-冲断带变形方式和时限是验证高原形成众多大陆岩石圈变形动力学端员模型的关键。近年发展起来的断层泥自生伊利石K-Ar.年技术为精确限定褶皱-冲断带变形时限提供了有效手段。鲜水河—安宁河—小江断裂系作为伴随... 详细信息

青藏高原及其周缘褶皱-冲断带变形方式和时限是验证高原形成众多大陆岩石圈变形动力学端员模型的关键。近年发展起来的断层泥自生伊利石K-Ar.年技术为精确限定褶皱-冲断带变形时限提供了有效手段。鲜水河—安宁河—小江断裂系作为伴随印度-欧亚板块碰撞造山和高原物质侧向挤出过程形成的大型左旋走滑断裂系,其变形过程可为解译印度-欧亚板块碰撞远程应力向东传递方式提供关键证据。本文选取安宁河断裂冕宁—西昌段作为研究对象,在详细构造解析以明确其构造运动学特征的基础上,开展了断层泥自生伊利石K-Ar.年研究,以期精确限定安宁河断裂脆性变形的时间。构造解析表明安宁河断裂在近EW向挤压作用下经历了冲断变形,断层带发育碎斑岩和断层泥,指示为脆性变形。安宁河断裂不同粒级断层泥样品的黏土矿物学和伊利石K-Ar.年分析揭示,随着样品粒级减小,高温2M1型伊利石含量相对低温1M/1Md型伊利石含量逐渐减少,其K-Ar.龄总体呈变年轻趋势,表明不同粒级伊利石K-Ar.龄是由碎屑2M1型和自生1M/1Md型两个多型端员组成的混合年龄。伊利石年龄分析获得自生1M/1Md型伊利石的年龄为(42.6±9.4)Ma,表明安宁河断裂经历了始新世中期的冲断变形。结合前人构造变形、沉积学、低温热年代学和古地磁等研究,我们认为始新世中期青藏高原腹地及其周缘褶皱-冲断带发生准同期的构造挤压变形,其动力学机制可能与印度-欧亚板块硬碰撞以及青藏高原地块的陆内俯冲所导致的先存构造带活化有关。始新世中期安宁河断裂发生冲断变形直接证明印度-欧亚板块碰撞初期的远程应力已传递至青藏高原东南缘地区。

关键词：安宁河断裂断层泥自生伊利石 K-Ar.年始新世中期