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Evaluating the Efficacy of Cervical Tactile Ultrasound Technique as a predictive Tool for Spontaneous preterm Birth

Open Journal of Obstetrics and Gynecology 2024年第5期14卷 832-846页

作者： Vladimir Egorov todd Rosen Jennifer Hill Meena Khandelwal Victors Kurtenoks Brendan Francy Noune Sarvazyan Advanced Tactile Imaging Inc. Ewing New Jersey USA Department of Obstetrics Gynecology and Reproductive Sciences Rutgers Robert Wood Johnson Medical School New Brunswick New Jersey USA Department of Maternal-Fetal Medicine Cooper Medical School of Rowan University Camden New Jersey USA

Background: premature cervical softening and shortening may be considered an early mechanical failure that predispose to preterm birth. purpose: This study aims to explore the applicability of an innovative cervical tactile ultrasound approach for predicting spontaneous preterm birth (spTB). Materials and Methods: Eligible participants were women with low-risk singleton pregnancies in their second trimester, enrolled in this prospective observational study. A Cervix Monitor (CM) device was designed with a vaginal probe comprising four tactile sensors and a single ultrasound transducer operating at 5 MHz. The probe enabled the application of controllable pressure to the external cervical surface, facilitating the acquisition of stress-strain data from both anterior and posterior cervical sectors. Gestational age at delivery was recorded and compared against cervical elasticity. Results: CM examination data were analyzed for 127 women at 24p>0/7p> - 28p>6/7p> gestational weeks. spTB was observed in 6.3% of the cases. The preterm group exhibited a lower average cervical stress-to-strain ratio (elasticity) of 0.70 ± 0.26 kpa/mm compared to the term group’s 1.63 ± 0.65 kpa/mm with a p-value of 1.1 × 10p>−p>p>4p>. Diagnostic accuracy for predicting spontaneous preterm birth based solely on cervical elasticity data was found to be 95.0% (95% CI, 88.5 - 100.0). Conclusion: These findings suggest that measuring cervical elasticity with the designed tactile ultrasound probe has the potential to predict spontaneous preterm birth in a cost-effective manner.

关键词： Cervical Elasticity Spontaneous preterm Birth Tactile Ultrasound probe

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始新世中期安宁河断裂冲断变形特征及其构造意义:来自断层泥自生伊利石K-Ar定年的证据

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地学前缘 2024年第4期31卷 297-313页

作者：童馗李智武刘树根 I.Tonguç UYSAL 施泽进李金玺 Andrew todd 武文慧王自剑刘升武李轲华天成都理工大学油气藏地质及开发工程全国重点实验室四川成都610059 成都理工大学地质资源与地质工程博士后流动站四川成都610059 CSIRO Energy 26 Dick Perry AvenueKensingtonWA 6151Australia 西华大学四川成都610039 School of the Environment The University of QueenslandBrisbaneQLD 4072Australia 西南油气田分公司勘探开发研究院四川成都610051

青藏高原及其周缘褶皱-冲断带变形方式和时限是验证高原形成众多大陆岩石圈变形动力学端员模型的关键。近年发展起来的断层泥自生伊利石K-Ar定年技术为精确限定褶皱-冲断带变形时限提供了有效手段。鲜水河—安宁河—小江断裂系作为伴随... 详细信息

青藏高原及其周缘褶皱-冲断带变形方式和时限是验证高原形成众多大陆岩石圈变形动力学端员模型的关键。近年发展起来的断层泥自生伊利石K-Ar定年技术为精确限定褶皱-冲断带变形时限提供了有效手段。鲜水河—安宁河—小江断裂系作为伴随印度-欧亚板块碰撞造山和高原物质侧向挤出过程形成的大型左旋走滑断裂系,其变形过程可为解译印度-欧亚板块碰撞远程应力向东传递方式提供关键证据。本文选取安宁河断裂冕宁—西昌段作为研究对象,在详细构造解析以明确其构造运动学特征的基础上,开展了断层泥自生伊利石K-Ar定年研究,以期精确限定安宁河断裂脆性变形的时间。构造解析表明安宁河断裂在近EW向挤压作用下经历了冲断变形,断层带发育碎斑岩和断层泥,指示为脆性变形。安宁河断裂不同粒级断层泥样品的黏土矿物学和伊利石K-Ar定年分析揭示,随着样品粒级减小,高温2M1型伊利石含量相对低温1M/1Md型伊利石含量逐渐减少,其K-Ar年龄总体呈变年轻趋势,表明不同粒级伊利石K-Ar年龄是由碎屑2M1型和自生1M/1Md型两个多型端员组成的混合年龄。伊利石年龄分析获得自生1M/1Md型伊利石的年龄为(42.6±9.4)Ma,表明安宁河断裂经历了始新世中期的冲断变形。结合前人构造变形、沉积学、低温热年代学和古地磁等研究,我们认为始新世中期青藏高原腹地及其周缘褶皱-冲断带发生准同期的构造挤压变形,其动力学机制可能与印度-欧亚板块硬碰撞以及青藏高原地块的陆内俯冲所导致的先存构造带活化有关。始新世中期安宁河断裂发生冲断变形直接证明印度-欧亚板块碰撞初期的远程应力已传递至青藏高原东南缘地区。

关键词：安宁河断裂断层泥自生伊利石 K-Ar定年始新世中期

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A unique subseafloor microbiosphere in the Mariana Trench driven by episodic sedimentation

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Marine Life Science & Technology 2024年第1期6卷 168-181页

作者： Jiwen Liu Da-Wei Li Xinxin He Ronghua Liu Haojin Cheng Chenglong Su Mengna Chen Yonghong Wang Zhongsheng Zhao Hanyue Xu Zhangyu Cheng Zicheng Wang Nikolai pedentchouk David J.Lea-Smith Jonathan D.todd Xiaoshou Liu Meixun Zhao Xiao-Hua Zhang Frontiers Science Center for Deep Ocean Multispheres and Earth System and College of Marine Life SciencesOcean University of ChinaQingdao 266003China Laboratory for Marine Ecology and Environmental Science Laoshan LaboratoryQingdao 266237China Institute of Evolution and Marine Biodiversity Ocean University of ChinaQingdao 266003China Key Laboratory of Marine Chemistry Theory and Technology Ministry of EducationOcean University of ChinaQingdao 266100China Key Lab of Submarine Geosciences and prospecting Techniques Ministry of Education/College of Marine GeosciencesOcean University of ChinaQingdao 266100China Key Laboratory of physical Oceanography Ministry of Education/Research Vessel CentreOcean University of ChinaQingdao 266100China School of Environmental Sciences University of East AngliaNorwich NR47TJUK School of Biological Sciences University of East AngliaNorwich NR47TJUK

Hadal trenches are characterized by enhanced and infrequent high-rate episodic sedimentation events that likely introduce not only labile organic carbon and key nutrients but also new microbes that significantly alter the subseafloor ***,the role of high-rate episodic sedimentation in controlling the composition of the hadal subseafloor microbiosphere is ***,analyses of carbon isotope composition in a~750 cm long sediment core from the Challenger Deep revealed noncontinuous deposition,with anomalous ^(14)C ages likely caused by seismically driven mass transport and the funneling effect of trench *** community composition and diverse enzyme activities in the upper~27 cm differed from those at lower depths,probably due to sudden sediment deposition and differences in redox condition and organic matter *** lower depths,microbial population numbers,and composition remained relatively constant,except at some discrete depths with altered enzyme activity and microbial phyla abundance,possibly due to additional sudden sedimentation events of different *** is provided of a unique role for high-rate episodic sedimentation events in controlling the subsurface microbiosphere in Earth’s deepest ocean floor and highlight the need to perform thorough analysis over a large depth range to characterize hadal benthic *** depositional processes are likely crucial in shaping deep-water geochemical environments and thereby the deep subseafloor biosphere.

关键词： Hadal subseafloor Deep water sediment Mariana Trench Radiocarbon Microbial community Redox potential

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Molecular Docking Studies on Streptomycin Antileishmanial Activity

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Open Journal of physical Chemistry 2024年第2期14卷 36-48页

作者： todd A. Young Matthew George Jr. Ayele Gugssa William M. Southerland Yayin Fang Clarence M. Lee Department of Biology Howard University Washington DC United States Department of Biochemistry and Molecular Biology Howard University Washington DC United States

Resistance to pentavalent antimonial drugs and the lack of vaccines make it urgent to find novel therapeutic options to treat Leishmaniasis, a tropical disease caused by the Leishmania protozoan parasite. The study reported here is to investigate if Streptomycin, an aminoglycoside, and Amphotericin B, the second-line treatment drug, exhibit antileishmanial activity through a similar mechanism. By using MOE (Molecular Operating Environment), we performed molecular docking studies on these drugs binding to a range of targets including ribosome targets in Leishmania and H. sapiens. Our study shows that the two drugs do not bind to the same pockets in Leishmania targets but to the same pockets in the human ribosome, with some differences in interactions. Moreover, our 2D maps indicated that Amphotericin B binds to the A-site in the human cytoplasmic ribosome, whereas streptomycin does not.

关键词： Leishmaniasis Streptomycin Amphotericin B Molecular Docking Aminoglycosides Antileishmanial

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Identification and characterization of new plant microRNAs using EST analysis

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Cell Research 2005年第5期15卷 336-360页

作者： George p.COBB1,todd A.ANDERSON The Institute of Environmental and Human Health (TIEHH) and Department of Environmental Toxicology Texas Tech University Lubbock TX 79409-1163 USA The Institute of Environmental and Human Health (TIEHH) and Department of Environmental Toxicology Texas Tech University Lubbock TX 79409-1163 USA

Seventy-five previously known plant microRNAs (miRNAs) were classified into 14 families according to their gene sequence identity. A total of 18,694 plant expressed sequence tags (EST) were found in the GenBank EST databases by comparing all previously known Arabidopsis miRNAs to GenBank’s plant EST databases with BLAST algorithms. After removing the EST sequences with high numbers (more than 2) of mismatched nucleotides, a total of 812 EST contigs were identified. After predicting and scoring the RNA secondary structure of the 812 EST sequences using mFold software, 338 new potential miRNAs were identified in 60 plant species. miRNAs are widespread. Some microRNAs may highly conserve in the plant kingdom, and they may have the same ancestor in very early evolution. There is no nucleotide substitution in most miRNAs among many plant species. Some of the new identified potential miRNAs may be induced and regulated by environmental biotic and abiotic stresses. Some may be preferentially expressed in specific tissues, and are regulated by developmental switching. These findings suggest that EST analysis is a good alternative strategy for identifying new miRNA candidates, their targets, and other genes. A large number of miRNAs exist in different plant species and play important roles in plant developmental switching and plant responses to environmental abiotic and biotic stresses as well as signal transduction. Environmental stresses and developmental switching may be the signals for synthesis and regulation of miRNAs in plants. A model for miRNA induction and expression, and gene regulation by miRNA is hypothesized.

关键词： microRNA plant environmental stress gene regulation expressed sequence tags.

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FunnelCloud:a cloud-based system for exploring tornado events

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International Journal of Digital Earth 2017年第10期10卷 1030-1054页

作者： Jie Lian Michael p.McGuire todd W.Moore Department of Computer and Information Sciences Towson UniversityTowsonMDUSA Department of Geography and Environmental planning Towson UniversityTowsonMDUSA

Recent research has shown an increase in the number of extreme tornado outbreaks per *** characterization of the spatio-temporal pattern of tornado events is therefore a critical task in the analysis of meteorological ***,there are a large number of available meteorological datasets that can be used for such ***,much of these data are distributed across multiple websites and are not accessible in a central *** poses a significant challenge for a scientist who is interested in exploring meteorological patterns associated with tornado *** paper presents a novel system which uses cloud-based technology for integrating,storing,exploring,analyzing,and visualizing meteorological data associated with tornado *** system employs a novel NoSQL database schema and web services architecture for data integration and provides a user friendly interface that allows scientists to explore the spatio-temporal pattern of tornado ***,scientists can use this interface to analyze the relationship between different meteorological variables and properties of tornado outbreaks using a number of spatio-temporal statistical and data mining *** efficacy of the system is demonstrated on a use case centered on the analysis of climatic indicators of large spatio-temporally clustered tornado outbreaks.

关键词： tornado data warehouse cloud-based system NoSQL data integration spatio-temporal clustering web-mapping

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2023年美国麻醉医师学会神经肌肉阻滞监测与拮抗实践指南:美国麻醉医师学会工作组关于神经肌肉阻滞的报告

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中华麻醉学杂志 2024年第5期44卷 518-542页

作者： Stephan R.Thilen Wade A.Weigel Michael M.todd Richard p.Dutton Cynthia A.Lien Stuart A.Grant Joseph W.Szokol Lars I.Eriksson Myron Yaster Mark D.Grant Madhulika Agarkar Anne M.Marbella Jaime F.Blanck Karen B.Domino 西雅图华盛顿州明尼阿波里斯明尼苏达州达拉斯得克萨斯州密尔沃基威斯康星州教堂山北卡罗来纳州洛杉矶加利福尼亚州斯德哥尔摩瑞典丹佛科罗拉多州绍姆堡伊利诺斯州巴尔的摩马里兰州

本实践指南基于证据提供了全身麻醉期间及术后神经肌肉功能监测与阻滞拮抗的管理推荐。主要关注神经肌肉功能监测的类型与部位及阻滞拮抗的过程,以减少肌肉松弛药残留阻滞。

关键词：神经肌肉阻滞肌肉松弛药神经肌肉功能监测舒更葡糖钠新斯的明

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南京天印山医院

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建筑实践 2024年第4期 152-153页

作者：曹伟孙承磊吉英雷 todd pilgreen Roman Wittmer 舒帆东南大学建筑设计研究院有限公司晋思建筑设计事务所

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Lyapunov exponent,Liao perturbation and persistence

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Science China Mathematics 2020年第9期63卷 1913-1928页

作者： Wenxiang Sun todd Young School of Mathematical Sciences Peking UniversityBeijing 100871China Department of Mathematics Ohio UniversityAthensOH 45701USA

Consider a C1 vector eld together with an ergodic invariant probability that hasℓnonzero Lya-punov *** orthonormal moving frames along a generic orbit we construct a linear system ofℓdi erential equations which is a linearized Liao standard *** show that Lyapunov exponents of this linear system coincide with all the nonzero exponents of the given vector eld with respect to the given ergodic ***,we prove that these Lyapunov exponents have a persistence property meaning that a small perturbation to the linear system(Liao perturbation)preserves both the sign and the value of the nonzero Lyapunov exponents.

关键词： Lyapunov exponent Liao perturbation ergodic probability non-uniformly hyperbolicity

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Kinetics of Molecular Recognition Mediated Nanoparticle Self-Assembly

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Nano Research 2009年第1期2卷 78-84页

作者： Chinmay Soman todd Giorgio Interdisciplinary program in Materials Science Vanderbilt University201 West End AvenueNashvilleTN 37240USA Department of Biomedical Engineering Vanderbilt University201 West End AvenueNashvilleTN 37240USA

Nanoscale quantum dot-antibody conjugates have been shown to self-assemble to form micron-scale aggregates in the presence of specific proteomic *** self-assembly process exhibits sigmoidal kinetics,suggesting that nucleation limits ***-assembly kinetics in this study is characterized by flow cytometric analysis of the aggregation reaction over time.A range of physiologically relevant concentrations of the protein angiopoietin-2,a candidate cancer biomarker,are incubated with quantum dots conjugated with a polyclonal mixture of anti-angiopoietin-2 *** concentration modulates the slopes and inflection times of the sigmoidal kinetics *** understanding of self-assembly kinetics in this system may lead to improvements in sensitivity and specificity of this novel proteomic biomarker detection technique and improve the screening,diagnostics,and therapy response monitoring for cancers and other *** approach to studying the kinetics of nanoparticle self-assembly may also provide a valuable tool for understanding the fundamental characteristics of nanoscale particle aggregation.

关键词： Quantum dot self-assembly kinetics proteomics diagnostics has

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