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Factors affecting visual outcome of myopic choroidal neovascularization treated with verteporfin photodynamic therapy

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International Journal of Ophthalmology(English edition) 2013年第3期6卷 327-330页

作者： Colin S. Tan Milton C. Chew Kai-Hung lim tock-han lim National Healthcare Group Eye Institute Tan Tock Seng Hospital Fundus Image Reading Center National Healthcare Group Eye Institute

AIM: To evaluate the visual outcomes of choroidal neovascularization (CNV) secondary to pathological myopia and the impact of novel risk factors affecting the final visual outcome. ·METHODS: Interventional case series of 18 consecutive patients with pathological myopia treated with photodynamic therapy (PDT). Inclusion criteria were spherical equivalent -6D or worse or features of pathological myopia on retinal examination. The main outcome measure was final best -corrected visual acuity (BCVA). ·RESULTS: Of 18 eyes, 13 (72.2%) avoided moderate visual loss (≥3 lines of LogMAR BCVA) and 5 eyes (27.8%) improved by at least 1 line after 1 year. Patients with LogMAR BCVA ≤0.3 (Snellen equivalent 20/40) at one year were younger than those with BCVA >0.3 (mean age 39.0 vs 61.6 years, P =0.001). A higher proportion of eyes with greatest linear dimension (GLD) of ≤1 000μm avoided moderate visual loss (100% vs 50%, P =0.026). Among patients who were treated within 2 weeks of visual symptoms, 88.9% avoided the loss of 3 or more lines compared to 55.6% for those who presented later. The mean improvement in LogMAR BCVA of those with GLD ≤1 000μm was +0.12 compared to a loss of 0.55 LogMAR units for those with GLD >1 000μm (P =0.02). Visual outcomes were not associated with gender or refractive error.·CONCLUSION: Good visual outcome in myopic CNV is associated with younger age, smaller lesion size and earlier initiation of treatment. These factors are relevant for ophthalmologists considering treatment options for myopic CNV.

关键词： myopic choroidal neovascularization pathologic myopia photodynamic therapy

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Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong Lee Su Bin lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

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Advanced metal–organic frameworks for aqueous sodium-ion rechargeable batteries

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Journal of Energy Chemistry 2021年第2期30卷 396-406,I0014页

作者： Dongkyu Choi Seonguk lim Dongwook han School of Nano Convergence Technology Hallym UniversityChuncheon 24252Gangwon-doRepublic of Korea Nano Convergence Technology Center Hallym UniversityChuncheon 24252Gangwon-doRepublic of Korea

Inexpensive and abundant sodium resources make energy storage systems using sodium chemistry promising replacements for typical lithium-ion rechargeable batteries(LIBs).Fortuitously,aqueous sodium-ion rechargeable batteries(ASIBs),which operate in aqueous electrolytes,are cheaper,safer,and more ionically conductive than batteries that operate in conventional organic electrolytes;furthermore,they are suitable for grid-scale energy storage *** electrode materials for storing Na~+ ions in ASIBs,a variety of multifunctional metal-organic frameworks(MOFs) have demonstrated great potential in terms of having porous 3 D crystal structures,compatibility with aqueous solutions,long cycle lives(≥1000 cycles),and ease of *** present review describes MOF-derived technologies for the successful application of MOFs to ASIBs and suggests future challenges in this area of research based on the current understanding.

关键词： Metal–Organic Framework(MOF) Prussian blue Metal hexacyanoferrate Aqueous electrolyte Sodium-ion Rechargeable battery

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Complete Solution of Sun Tracking for Heliostat

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Communications in Theoretical Physics 2006年第1期45卷 165-166页

作者： CHEN Ying-Tian lim Boon-han lim Chern-Sing Department of Astronomy and Applied Physics University of Science and Technology of China Hefei 230026 China

A general solution of sun tracking for an arbitrarily oriented heliostat towards an arbitrarily located target on the earth is published. With the most general form of solar tracking formulae, it is seen that the used azimuthelevation, spinning-elevation tracking formulae etc. are the special cases of it. The possibilities of utilizing the general solution and its significance in solar energy engineering are discussed.

关键词： solar tracking azimuth-elevation spinning-elevation optical aberration heliostat

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Deep Learning-based Wireless Signal Classification in the IoT Environment

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Computers, Materials & Continua 2022年第6期71卷 5717-5732页

作者： Hyeji Roh Sheungmin Oh Hajun Song Jinseo han Sangsoon lim Department of Computer Engineering Sungkyul UniversityAnyang430742Korea

With the development of the Internet of Things(IoT),diverse wireless devices are increasing *** devices have different wireless interfaces that generate incompatible wireless *** signal has its own physical characteristics with signal modulation and demodulation *** there exist different wireless devices,they can suffer from severe Cross-Technology Interferences(CTI).To reduce the communication overhead due to the CTI in the real IoT environment,a central coordinator can be able to detect and identify wireless signals existing in the same communication *** paper investigates how to classify various radio signals using Convolutional Neural Networks(CNN),Long Short-TermMemory(LSTM)and attention *** can reduce the amount of computation by reducing weights by using convolution,and LSTM belonging to RNNmodels can alleviate the long-term dependence ***,attention mechanism can reduce the short-term memory problem of RNNs by reexamining the data output from the decoder and the entire data entered into the encoder at every point in *** accurately classify radio signals according to their weights,we design a model based on CNN,LSTM,and attention *** a result,we propose a model CLARINet that can classify original data by minimizing the loss and detects changes in *** a case of the real IoT environment with Wi-Fi,Bluetooth and ZigBee devices,we can normally obtain wireless signals from 10 to 20 *** accuracy of CLARINet’s radio signal classification with CNN-LSTM and attention mechanism can be seen that signal-to-noise ratio(SNR)exhibits high accuracy at 16 dB to about 92.03%.

关键词： Attention mechanism wireless signal CNN-LSTM classification deep-learning

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An Ellipsoidal Set-Membership Approach to Distributed Joint State and Sensor Fault Estimation of Autonomous Ground Vehicles

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IEEE/CAA Journal of Automatica Sinica 2021年第6期8卷 1107-1118页

作者： Eman Mousavinejad Xiaohua Ge Senior Member Qing-Long han Teng Joon lim Ljubo Vlacic School of Electrical and Information Engineering The University of SydneySydneyNSW 2006Australia School of Engineering and Built Environment Griffith UniversityGold CoastQLD 4222Australia chool of Software and Electrical Engineering Swinburne University of TechnologyMelbourneVIC 3122Australia

This paper is concerned with the problem of distributed joint state and sensor fault estimation for autonomous ground vehicles subject to unknown-but-bounded(UBB)external disturbance and measurement *** order to improve the estimation reliability and performance in cases of poor data collection and potential communication interruption,a multisensor network configuration is presented to cooperatively measure the vehicular yaw rate,and further compute local state and fault *** this aim,an augmented descriptor vehicle model is first established,where the unknown sensor fault is modeled as an auxiliary state of the system ***,a new distributed ellipsoidal set-membership estimation approach is developed so as to construct an optimized bounding ellipsoidal set which guarantees to contain the vehicle’s true state and the sensor fault at each time step despite the existence of UBB disturbance and measurement ***,a convex optimization algorithm is put forward such that the gain matrix of each distributed estimator can be recursively ***,simulation results are provided to validate the effectiveness of the proposed approach.

关键词： Autonomous ground vehicle(AGV) distributed setmembership estimation fault estimation sensor networks vehicle lateral dynamics

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Evaluation of the safety of hair essence containing 0.05% purified bee venom on the skin and eyes of rabbits

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Journal of Traditional Chinese Medicine 2020年第1期40卷 67-72页

作者： Mi Kyung lim Eun Hye han Sang Ho Lee Jee Hee Kim R&D Center KoreaeundanGyeonggi-do 13207Republic of Korea

OBJECTIVE:To investigate the safety of hair essence containing 0.05%purified bee venom(HE-PBV)on the skin and eyes of New Zealand White ***:HE-PBV which contained 0.05%PBV,purified water,and glycerin,was used as the test *** skin-irritation test(SIT)and eye-irritation test(EIT)were conducted according to the Draize *** the SIT,HE-PBV(0.5 m L)dropped gauze was attached both intact and abraded skin for 24 *** other side of the skin was used as *** 24 and 72 h,the treatment site was observed and scored according to evaluation criteria for skin *** the EIT,the rabbits were divided into two groups:eye-washed(three rabbits)and non-eye-washed(six rabbits).HE-PBV(0.1 m L)was squirted into the right eye of *** left eye was untreated and used as a ***,20-30-s later,the eyes of rabbits in the eye-washed group were washed with^50 m L of physiologic(0.9%)salt ***,1,2,3,4 and 7 d after the start of the EIT,the eyes and behavior of the rabbits were *** degree of eye irritation elicited by HE-PBV was determined in three steps and then the criteria of the classification of eye-irritation ***:The SIT revealed erythema and edema at the site of HE-PBV *** 72 h,the body weight of rabbits was reduced slightly,but other symptoms(except erythema and edema)were not *** Primary Irritation Index score was0.6,and HE-PBV was deemed to be a slight *** EIT did not show mortality or body-weight fluctuation,but hyperemic conjunctiva and eyelid closure were noted after HE-PBV *** for these results,the score for the ophthalmic response on days 1,2,3,4 and 7 was 0,and HE-PBV was deemed to be a ***:These data suggest that HE-PBV did not elicit eye irritation,but was a slight irritant to the skin of rabbits;the latter slight would have been due to the excipients used in manufacture of the hair essence because PBV has been shown to be safe.

关键词： Alopecia Bee Venoms Hair essence Skin irritancy tests Eye irritancy tests Complementary therapies

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Subacute oral toxicity study of ethanolic leaves extracts of Strobilanthes crispus in rats

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Asian Pacific Journal of Tropical Biomedicine 2012年第12期2卷 948-952页

作者： Kean Tatt lim Vuanghao lim Jin han Chin Faculty of Pharmaceutical Sciences UCSI University Cluster of Integrative Medicine Advanced Medical and Dental InstituteUniversiti Sains Malaysia

Objective:To examine the oral toxicity of repeated dosing of Strobilanthes crispus(***)ethanol leaves extract on the liver and kidney functions in Sprague Dawley ***:Young female rats aged between 8 and 12 week-old were randomly assigned into four groups with five animals each group(n=5).The first group served as control,while the second,third and fourth groups were orally treated with a single dose daily with 150 mg/kg,300 mg/kg,and600 mg/kg of *** ethanol leaves extract for 14 d ***-side observation was conducted for first 4h after each *** body weight changes,food consumptions and water intake were also *** biochemical parameters,i.e.,aspartate aminotransferase,alanine aminotransferase,alkaline phosphatase,creatinine and urea were determined at *** results were expressed as mean±SD and analysed using Dunnett's ***:It was obtained that 14-day oral administration of *** ethanol leaves extract did not cause any adverse effects or lethality to the female Sprague Dawley rats,No significant changes in serum biochemical parameters,relative organs weights,body weights,food intake and water consumptions were observed between the treatment groups and ***:In conclusion,14-day oral administration of *** ethanol leaves extract was safe to be consumed in female rats without affecting the liver and kidney Functions.

关键词： Kidney Liver Oral toxicity Serum enzymes Strobilanthes crispus

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Intramedullary spinal cord metastasis from pancreatic neuroendocrine tumor

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World Journal of Gastroenterology 2014年第38期20卷 14063-14067页

作者： Jung Ho Kim Chang lim Hyun Sang Hoon han Department of Internal Medicine Gachon University Gil Medical Center Department of Pathology Jeju National University School of Medicine Department of Internal Medicine Jeju National University School of Medicine

Intramedullary spinal cord metastasis(ISCM) is very rare and its optimal treatment remains controversial. Pancreatic neuroendocrine tumor(pNET) is a rare tumor that usually presents with hepatic metastasis. Hepatic failure due to tumor progression is the major cause of death in cases of pNET. To date,no report has described a case of ISCM from pNET. Although spinal cord metastasis of a solid tumor is uncommon,it is a critical condition that can cause a potentially irreversible loss of neurologic function. Here,we report the case of a 45-year-old man who presented with leg weakness and voiding difficulty,and was found to have ISCM from pNET. Surgical treatment prevented further neurological deterioration. This is the first case report of ISCM from pNET.

关键词： Intramedullary Spinal cord neoplasm Metastasis Neuroendocrine tumor Pancreas

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Bilateral snapping triceps syndrome:A case report

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World Journal of Clinical Cases 2023年第34期11卷 8228-8234页

作者： Chul-Hyun Cho Kyung-Hwan lim Du-han Kim Department of Orthopedic Surgery Keimyung University Dongsan HospitalKeimyung University School of MedicineDaegu 42601South Korea Orthopedic Surgery Allright HospitalDaegu 42038South Korea

BACKGROUND Snapping triceps syndrome(STS)is a rare disease,while occurrence of bilateral STS is extremely *** is usually accompanied by dislocation of the ulnar nerve and double snapping is a clinically important ***,to the best of our knowledge,there has been no report of bilateral STS in young active *** SUMMARY A 23-year-old male presented with a complaint of discomfort and snapping on the medial side of both elbows while performing *** physical examination,two distinct snaps that were both palpable and audible were detected on additional clinical *** ultrasonography showed that the ulnar nerve and the medial head of the triceps were dislocated anteriorly over the medial epicondyle of the elbow during flexion ***,he was diagnosed as dislocation of the ulnar nerve and *** anterior subcutaneous transposition of the ulnar nerve combined with partial resection of the snapping portion of the triceps was *** patient’s pain and snapping symptoms were resolved immediately after *** months later,the patient was completely asymptomatic and returned to normal *** STS should be included in the differential diagnosis for active young patients who present with painful snapping on the medial side of the elbow joint,particularly when dislocation of the ulnar nerve is *** sonography is used to assist in accurate diagnosis and differentiation between isolated dislocation of the ulnar nerve and STS.

关键词： Triceps Triceps snapping syndrome Ulnar nerve Elbow Dynamic sonography Case report

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