检索结果-南通市图书馆

Disseminated Intravascular Coagulation in a Patient with Metastatic Pancreatic Neuroendocrine Tumour: A Case Report and Review of the Literature

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Case Reports in Clinical Medicine 2014年第10期3卷 549-553页

作者： Rhian Sian Davies toby wells Sarah Gwynne Department of Clinical Oncology Singleton Hospital Swansea UK Department of Radiology Singleton Hospital Swansea UK

A 67-year-old female patient presented with weight loss, diarrhoea and thrombocytopaenia of unknown aetiology. A computerised tomography (CT) scan demonstrated a mass in the head of the pancreas with liver metastases. A liver biopsy demonstrated a well-differentiated neuroendocrine carcinoma. She was commenced on a somatostatin analogue. Three months later she presented with spontaneous bleeding. Blood test demonstrated results consistent with disseminated intravascular coagulation (DIC). A restaging CT scan showed evidence of disease progression. The DIC was felt to be due to the underlying progressive malignancy. Having considered the potential risks associated with cytotoxic therapy in the context of a consumptive coagulopathy, the patient was commenced on weekly Carboplatin. The patient’s blood counts improved rapidly, and her bruising and bleeding resolved. Following a few weeks of stable blood results and clinical stability, her cytotoxic treatment was changed to a combination of Carboplatin and Etoposide, and to date she remains well on treatment.

关键词： Pancreatic Neuroendocrine Tumour Disseminated Intravascular Coagulation Consumptive Coagulopathy

Primary and Secondary Microplastic and Nanoplastic Regulations: Perspectives on Water Industry Impacts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Protection 2024年第6期15卷 697-715页

作者： Shirin Estahbanati Giridhar Upadhyaya Martha J. M. wells Katherine Y. Bell Brown and Caldwell New York NY USA Brown and Caldwell Irvine CA USA EnviroChem Services Cookeville TN USA Brown and Caldwell Nashville TN USA

Plastic pollution, both primary and secondary, is an environmental challenge, prompting regulatory actions at global and regional levels. With increasing research about the impacts of micro- and nanoplastics on ecosystems and human health, governments worldwide have undertaken efforts to address this issue. The global community has advanced regulatory efforts that have led to the implementation of national laws or regulations in numerous countries. These measures ban or restrict the use of primary and secondary microplastics and nanoplastics. An overview of global and European regulatory frameworks is presented to provide context for the United States (US). In the endeavor to document plastics regulation development in the US, a description of regulatory agencies and their roles in advancing policy and rules as well as future direction and areas for improvement in regulating plastics are introduced. A discussion of what emerging regulations mean to utilities and industries is also provided along with a comparison of regulatory frameworks.

关键词： Microplastic Regulation Environmental Governance Plastic Pollution Mitigation Regulatory Framework

Considerations for the use of porcine organ donation models in preclinical organ donor intervention research

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Animal Models and Experimental Medicine 2024年第3期7卷 283-296页

作者： Frazer I.Heinis Shaheed Merani Nicholas W.Markin Kim F.Duncan Michael J.Moulton Lance Fristoe William E.Thorell Raechel A.Sherrick Tami R.wells Matthew T.Andrews Marian Urban School of Natural Resources Institute of Agriculture and Natural ResourcesUniversity of Nebraska-LincolnLincolnNebraskaUSA Division of Transplantation and Vascular Surgery Department of SurgeryUniversity of Nebraska Medical CenterOmahaNebraskaUSA Department of Anesthesiology University of Nebraska Medical CenterOmahaNebraskaUSA Division of Cardiothoracic Surgery Department of SurgeryUniversity of Nebraska Medical CenterOmahaNebraskaUSA Clinical Perfusion Nebraska Medicine-Nebraska Medical CenterOmahaNebraskaUSA Department of Neurosurgery University of Nebraska Medical CenterOmahaNebraskaUSA Nutrition and Health Sciences College of Education and Human SciencesUniversity of Nebraska-LincolnLincolnNebraskaUSA Department of Comparative Medicine University of Nebraska Medical CenterOmahaNebraskaUSA

Use of animal models in preclinical transplant research is essential to the optimization of human allografts for clinical *** models of organ donation and preservation help to advance and improve technical elements of solid organ recovery and facilitate research of ischemia-reperfusion injury,organ preservation strategies,and future donor-based *** considerations include cost,public opinion regarding the conduct of animal research,translational value,and relevance of the animal model for clinical *** present an overview of two porcine models of organ donation:donation following brain death(DBD)and donation following circulatory death(DCD).The cardiovascular anatomy and physiology of pigs closely resembles those of humans,making this species the most appropriate for pre-clinical *** are also considered a potential source of organs for human heart and kidney *** is imperative to minimize animal loss during procedures that are surgically *** present our experience with these models and describe in detail the use cases,procedural approach,challenges,alternatives,and limitations of each model.

关键词： animal model brain death circulatory death organ transplantation

在线全文

学校读者我要写书评

暂无评论

现在是投资比特币的好时机吗?

商业周刊（中文版） 2024年第4期 27-28页

作者： Charlie wells 孟洁冰(译) 不详

●最近的加密货币反弹行情让理财顾问对比特币有了新的看法无论你是喜欢、讨厌还是长期持有它,不可否认的是,比特币又回来了。在经历了一系列丑闻、破产和价格下跌近77%的“加密货币寒冬”之后,3月11日,比特币首次突破72000美元大关,这... 详细信息

●最近的加密货币反弹行情让理财顾问对比特币有了新的看法无论你是喜欢、讨厌还是长期持有它,不可否认的是,比特币又回来了。在经历了一系列丑闻、破产和价格下跌近77%的“加密货币寒冬”之后,3月11日,比特币首次突破72000美元大关,这一升提振了其他加密货币的行情,以太币甚至狗狗币的价值也随之上涨。

关键词：比特币价格下跌理财顾问加密货币狗狗币行情

Constructing a coplanar heterojunction through enhancedπ-πconjugation in g-C_(3)N_(4)for efficient solar-driven water splitting

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2022年第5期33卷 2579-2584页

作者： Zihao Chen Ben Chong Nathan wells Guidong Yang Lianzhou Wang XJTU-Oxford International Joint Laboratory for Catalysis School of Chemical Engineering and TechnologyXi’an Jiaotong UniversityXi’an 710049China School of Chemical Engineering and Australian Institute for Bioengineering and Nanotechnology the University of QueenslandQLD 4072Australia

Adjusting the electronic structure of graphitic carbon nitride(g-C_(3)N_(4))photocatalyst throughπ-πconju-gation is an effective method to achieve efficient photogenerated carrier *** key challenge ofπ-πconjugation control is to tune the degree of such conjugation without destroying the g-C_(3)N_(4)*** we report a conceptual design that achieves a coplanar heterojunction by enhancing theπ-πconjugation via the doping of crystalline g-C_(3)N_(4)using a conjugated double bond ring molecule,1,3,5-benzenetriol,during calcination *** selection of the dopant enables the facile creation of a unique coplanar heterojunction which not only retains the pristine network structure of g-C_(3)N_(4),but remarkably promotes separation and transfer of photogenerated carriers through the enhancedπ-conjugated endogenous electric *** a result,the new g-C_(3)N_(4)photocatalyst efficiently photocatalyti-cally produces hydrogen from water under visible light irradiation with a high H 2 production rate up to 94.94μmol/h,and a notable external quantum efficiency of 16.4%at 420 nm.

关键词： g-C_(3)N_(4) Charge separation Coplanar heterojunction Enhancedπ-πconjugation Photocatalysis

Assembling a Photoactive 2D Puzzle: From Bulk Powder to LargeArea Films of Semiconducting Transition-Metal Dichalcogenide Nanosheets

在线全文

学校读者我要写书评

暂无评论

Accounts of Materials Research 2023年第4期4卷 348-358页

作者： Rebekah A.wells Kevin Sivula Laboratory for Molecular Engineering of Optoelectronic Nanomaterials Institute of Chemical Sciences and EngineeringÉcole Polytechnique FÉdÉrale de Lausanne1015 LausanneSwitzerland

Two-dimensional(2D)semiconducting materials are poised to revolutionize ultrathin,high-performance optoelectronic *** particular,transition-metal dichalcogenides(TMDs)are well-suited for applications requiring robust and stable materials such as electrocatalytic,photocatalytic,and photo-electrochemical *** of the most compelling assets of these materials is the ability to produce and process 2D TMDs in the nanosheet form using solution-based(SB)exfoliation *** to other methods,SB techniques are typically inexpensive,efficient,and more suitable for scale-up and industrial *** acknowledgment of the importance of this area,much work has been done to develop various SB methods starting from the exfoliation of bulk crystalline TMD materials to the chemical modification of final devices consisting of thin films of semiconducting 2D TMD ***,not all SB methods are equally compatible or interchangeable,and they result in very diverse material and device ***,the aim of this Account is to provide an overview of the developed SB techniques that can serve as a guide for assembling high-performance thin films of 2D *** start by introducing the most popular methods for producing 2D TMDs using liquid-phase exfoliation(LPE),discussing their working mechanisms as well as their advantages and *** we highlight a recently developed LPE technique using electro-intercalation that draws on the advantages of previously presented ***,we discuss processing the as-produced 2D TMD nanosheets via SB separating techniques designed for size and morphology selection while also presenting the ongoing challenges in this *** then examine SB methods for processing the selected 2D nanomaterial dispersions into semiconducting thin *** methods are compared and contrasted,and special attention is paid to a recently developed method that carefully deposits 2D TMD nanoflakes with preferentia

关键词： Transition critical sheets

Akt isoforms differentially provide for chemoresistance in prostate cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2022年第5期19卷 635-650页

作者： Bo Ma Hanshuang Shao Xia Jiang Zhou Wang Chuanyue(Cary)Wu Diana Whaley Alan wells Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy Cancer InstituteXuzhou Medical UniversityXuzhou 221002China Department of Pathology University of PittsburghPittsburghPA 15261USA Pittsburgh VA Healthcare System PittsburghPA 15213USA Department of Biomedical Informatics University of PittsburghPittsburghPA 15261USA Department of Urology University of PittsburghPittsburghPA 15261USA Department of Pharmacology and Chemical Biology University of PittsburghPittsburghPA 15261USA UPMC Hillman Cancer Center PittsburghPA 15232USA

Objective:Early prostate cancer micrometastatic foci undergo a mesenchymal to epithelial reverting transition,not only aiding seeding and colonization,but also rendering the tumor cells generally *** previously found that upregulated E-cadherin in the epithelial micrometastases activated canonical survival pathways,including PI3K-Akt,that protected the tumor cells from death;however,the extent of protection from blocking the pathway in its entirety was modest,because different isoforms may have alternately affected cell ***,we characterized Akt isoform expressions in primary and metastatic prostate cancers,as well as their individual contributions to ***:Akt isoforms and E-cadherin were manipulated with drugs,knocked down,and over *** cell killing was determined in vitro and in *** survival was calculated from patient records and ***:Pan-Akt inhibition sensitized tumor cells to chemotherapy,and specific blockade of Akt1 or/and Akt2 caused cells to be more *** of Akt3 induced apoptosis.A low dose of Akt1 or Akt2 inhibitor enabled standard chemotherapies to significantly eradicate metastatic prostate tumors in a mouse model,acting as *** human specimens,we found Akt1 and Akt2 positively correlated,whereas Akt3 inversely correlated,with the overall survival of prostate cancer ***1high/Akt2high/Akt3low tumors had the worst ***:E-cadherin-induced activation of Akt1/2 isoforms was the essential mechanism of chemoresistance,whereas Akt3 made cells more *** findings emphasized the need to target Akt1/2,rather than pan-Akt,as a rational therapeutic approach.

关键词： Chemoresistance adjuvant therapy metastasis dormancy Akt isoforms

The limitations of DNA-based approaches to species delimitation cannot be overcome by expanded sampling

在线全文

学校读者我要写书评

暂无评论

Zoological Systematics 2022年第2期47卷 165-167页

作者： Tom wells Tom Carruthers Robert W.Scotland Department of Plant Sciences University of OxfordOxfordUK Royal Botanic Gardens KewRichmondUK

Luo and Zhu(2022)write that“DNA-based integrative taxonomy”requires researchers to ensure they have sufficient sampling to justify the delimitation of a *** we agree that sample size is an undeniably important aspect of species delimitation,this is neither unique to DNA-based approaches,nor sufficient on its own to address their *** the authors also note,increasing sample size is not always *** would add that nor is it always necessary–many species are rare or narrow endemics(Willis&Undy Yule,1922)and the majority of new species are adequately described from only a few specimens(Goodwin et al.,2020).

关键词： limitations expanded overcome

Abscess drain migration into the colon following laparoscopic cholecystectomy

在线全文

学校读者我要写书评

暂无评论

Journal of Interventional Medicine 2023年第3期6卷 137-139页

作者： Daniel K.Derrick Noah Fanous Anne wells Jorge Lopera Department of Radiology UT Health San AntonioSan AntonioTXUSA

Percutaneous abscess drainage is a procedure commonly performed by interventional radiologists to provide source control on infections using CT or ultrasound *** interventionalist has many different sizes and shapes of catheters to treat abscesses of varying sizes and locations,but the general approach to each abscess is similar:provide a percutaneous route for purulence,bacteria,necrotic tissue,and other debris to escape the *** generally considered a low-risk procedure,adverse events can occur due to operator error or other *** present a unique case of an abscess drain placed into a right upper quadrant abscess that formed following laparoscopic cholecystectomy that perforated and entered the *** physicians,both in the emergency department and the radiology reading room,were able to rapidly rule out more common post-operative complications and make the correct diagnosis,likely preventing dangerous sequelae from developing in this patient.

关键词： colon diagnosis drain