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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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除了卖萌我什么都不会

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

2017年

作者：花栗鼠toby

花栗鼠toby著的《除了卖萌我什么都不会》是一本可爱有趣，富有创意和生活气息的漫画。toby是一直平凡可爱的小鸭子，和你我一样，有点懒惰，有点胆小，但充满想象力和爱心。书中记录了toby的日常小趣事、精彩小脑洞和一些天马行空的想... 详细信息

ISBN: (纸本)9787534059193

花栗鼠toby著的《除了卖萌我什么都不会》是一本可爱有趣，富有创意和生活气息的漫画。toby是一直平凡可爱的小鸭子，和你我一样，有点懒惰，有点胆小，但充满想象力和爱心。书中记录了toby的日常小趣事、精彩小脑洞和一些天马行空的想法。这本小书是我们压力生活中的慰藉，也是治愈日常心伤的良药。一本让你看了会开心的漫画书。

关键词：漫画作品集中国现代

来源：汇雅图书（南通市图书馆... 评论

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn j.W.So Konstantin Feinberg Marina Manoraj jenny Cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

Diagnostics for a troubled backbone:testing topological hypotheses of trapelioid lichenized fungi in a large-scale phylogeny of Ostropomycetidae(Lecanoromycetes)

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Fungal Diversity 2015年第4期73卷 239-258页

作者： Philipp Resl Kevin Schneider Martin Westberg Christian Printzen Zdeněk Palice Göran Thor Alan Fryday Helmut Mayrhofer toby Spribille Institute of Plant Sciences NAWI GrazUniversity of GrazHolteigasse 6A-8010 GrazAustria Department of Botany Swedish Museum of Natural HistoryP.O.Box 50007SE-10405 StockholmSweden Senckenberg Forschungsinstitut und Naturmuseum Senckenberganlage 25D-60325 Frankfurt am MainGermany Institute of Botany Academy of Sciences of the Czech RepublicZámek 125243 PrůhoniceCzech Republic Department of Botany Faculty of SciencesCharles University in PragueBenátská212801 Praha 2Czech Republic Department of Ecology Swedish University of Agricultural SciencesP.O.Box 7044SE-75007 UppsalaSweden Herbarium Department of Plant BiologyMichigan State UniversityEast LansingMI 48824USA Division of Biological Sciences University of Montana32 Campus DriveMissoulaMT 59812USA

Trapelioid fungi constitute a widespread group of mostly crust-forming lichen mycobionts that are key to understanding the early evolutionary splits in the Ostropomycetidae,the second-most species-rich subclass of lichenized *** uncertain phylogenetic resolution of the approximately 170 species referred to this group contributes to a poorly resolved backbone for the entire *** on a data set including 657 newly generated sequences from four ribosomal and four protein-coding gene loci,we tested a series of a priori and new evolutionary hypotheses regarding the relationships of trapelioid clades within *** found strong support for a monophyletic group of nine core trapelioid genera but no statistical support to reject the long-standing hypothesis that trapelioid genera are sister to Baeomycetaceae or ***,we can reject a sister group relationship to Ostropales with high *** data also shed light on several longstanding questions,recovering Anamylopsoraceae nested within Baeomycetaceae,elucidating two major monophyletic groups within trapelioids(recognized here as Trapeliaceae and Xylographaceae),and rejecting the monophyly of the genus *** transfer eleven species of the latter genus to Lambiella and describe the genus Parainoa to accommodate a previously misunderstood species of *** phylogenetic studies in Ostropomycetidae have invoked Bdivergence order^for drawing taxonomic conclusions on higher level *** data show that if backbone support is lacking,contrasting solutions may be recovered with different or added *** accordingly urge caution in concluding evolutionary relationships from unresolved phylogenies.

关键词： Ascomycota Fungi Lambiella Lecanoromycetes Ostropomycetidae Parainoa Paraphyly SOWH test Taxon sampling

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你会喜欢笨蛋吗？

作者：花栗鼠toby绘

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美国早期特殊教育师资培养体系反思及启示

中国特殊教育 2010年第5期 58-64页

作者：苏雪云 toby Long Lorelei Emma Marian jarrett 华东师范大学特殊教育学系上海200062 乔治敦大学儿童与人类研究中心美国华盛顿特区20057 乔治华盛顿大学教育与人类发展研究院美国华盛顿特区20057

早期特殊教育不仅在促进每个障碍儿童的发展和提高其家庭生活质量方面起着至关重要的作用,而且有着巨大的社会效益和经济效益,是和谐社会的重要组成部分。美国法律规定0-21岁的所有障碍儿童有权获得免费和适当的教育,由具有专业化水平... 详细信息

早期特殊教育不仅在促进每个障碍儿童的发展和提高其家庭生活质量方面起着至关重要的作用,而且有着巨大的社会效益和经济效益,是和谐社会的重要组成部分。美国法律规定0-21岁的所有障碍儿童有权获得免费和适当的教育,由具有专业化水平的相关人员为这些儿童提供服务和支持。本文从政策层面到实践层面对美国的早期特殊教育师资培养体系进行了系统、全面地分析,了解其现状和存在的挑战,以及未来发展的趋势,以期为促进我国早期特殊教育师资培养体系的发展提供一些理论和实践上的参考。

关键词：早期特殊教育师资培养

A UNIVERSAL FILE FORMAT FOR POWDER DIFFRACTION DATA ARCHIVE AND INTERCHANGE:THE IUCR CRYSTALLOGRAPHIC INFORMATION FILE FORMAT

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A UNIVERSAL FILE FORMAT FOR POWDER DIFFRACTION DATA ARCHIVE ...

Increased proportion of alcohol-related trauma in a South London major trauma centre during lockdown:A cohort study

Sixteenth Congress of the International Union of Crystallography

作者： B.H.toby j.I.Langford S.R.Hall Air Products & Chemicals Inc. 7201 Hamilton BlvdAllentownPA 18195USA School of Physics & Space Research University of BirminghamBirmingham B15 2TTUK Crystallography Centre University of WANedlands 6009Australia

＜正＞Powder diffraction data definitions have been devised for use with the Crystallographic Information File（CIF） facility for data storage and *** will permit the ready exchange of raw and processed powder data generated by diffractometers of every type commercial sealed-tube X-ray instruments,singlewavelength synchrotron and neutron systems and energy-dispersive or time-of-flight experiments.

关键词：

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Chinese journal of Traumatology 2022年第5期25卷 277-282页

作者： Oliver S.Brown toby O.Smith Andrew j.Gaukroger Prodromos Tsinaslanidis Caroline B.Hing St George's University Hospitals NHS Foundation Trust LondonUnited Kingdom Faculty of Medicine and Health Sciences University of East AngliaNonwvichUnited Kingdom

Purpose:Alcohol has been associated with 10%—35%trauma admissions and 40%trauma-related deaths *** response to the COVID-19 pandemic,the United Kingdom entered a state of"lockdown"on March 23,*** were most significantly eased on june 1,2020,when shops and schools *** purpose of this study was to quantify the effect of lockdown on alcohol-related trauma ***:All adult patients admitted as"trauma calls"to a London major trauma centre during April 2018 and April 2019(pre-lockdown,n=316),and 1st April—31st May 2020(lockdown,n=191)had electronic patient records analysed ***’blood alcohol level and records of intoxication were used to identify alcohol-related *** admissions from pre-lockdown and lockdown cohorts were compared using multiple regression ***:Alcohol-related trauma was present in a significantly higher proportion of adult trauma calls during lockdown(lockdown 60/191(31.4%),***-lockdown 62/316(19.6%);(odds ratio(OR):0.83,95%CI:0.38—1.28,p0.05).Conclusions:The United Kingdom lockdown was independently associated with an increased proportion of alcohol-related *** admissions were increased during the weekend when staffing levels are *** the possibility of further global"waves"of COVID-19,the long-term repercussions of dangerous alcohol-related behaviour to public health must be addressed.

关键词： Trauma Alcohol Lockdown COVID-19 Major trauma centre

Hyperoncotic human albumin solutions for intravenous fluid therapy: Effectiveness of pathogen safety and purification methods, and clinical safety

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Biosafety and Health 2023年第1期5卷 21-29页

作者： toby Simon Philipp Schumann Michael Bieri Kathrin Schirner Eleonora Widmer CSL Plasma 900 Broken Sound ParkwaySuite 400Boca RatonFL 33487the United States CSL Behring AG Wankdorfstrasse 10CH-3014 BernSwitzerland CSL Behring Innovation GmbH Emil-von-Behring-Str.7635041 MarburgGermany

Albumin solutions derived from human plasma have demonstrated clinical benefits as intravenous fluid therapy in clinical settings such as liver disease,sepsis,intensive care,and *** all plasma-derived medicinal products,there is a potential risk from pathogens,including relevant blood-borne viruses,emerging viruses,and prion *** minimize the risk of transmissible infections,the production of human albumin solutions includes rigorous donor selection and plasma testing,and effective pathogen removal and inactivation methods such as fractionation and *** with international pharmacopeial standards for purity and prekallikrein activator and aluminum content is crucial,as is post-marketing pharmacovigilance for the continuous monitoring of adverse *** review focuses on the effectiveness of manufacturing methods in the production of plasma-derived albumin,to ensure the safety of hyperoncotic solutions for volume *** evaluated evidence identified through online database(PubMed)searches and from unpublished sources,on the manufacturing and pathogen safety of plasma-derived albumin *** results confirmed the already established and evolving pathogen reduction capacity of the reviewed manufacturing ***-to-date post-marketing pharmacovigilance data and log 10 reduction factors for known and emerging pathogens during albumin production are *** the goal of ever-increasing clinical safety,potential areas of improvement,such as compliance rates for the completion of donor health questionnaires,are also *** together,the current manufacturing and pathogen reduction steps result in albumin products of greater purity than previous-generation products,with a high margin of pathogen safety against known and emerging pathogens,such as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).

关键词： Hyperoncotic albumin Human albumin solutions Viral reduction Pathogen safety Pasteurization Plasma-derived medicinal product