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Telomeric DNA breaks in human induced pluripotent stem cells trigger ATR-mediated arrest and telomerase-independent telomere damage repair

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Journal of Molecular Cell Biology 2024年第3期16卷 46-60页

作者： Katrina N.Estep John W.tobias Rafael J.Fernandez Brinley M.Beveridge F.Brad Johnson Department of Pathology and Laboratory Medicine University of PennsylvaniaPhiladelphiaPA 19104USA Quantiative Biosciences Merck&Co.Inc.West PointPA 19486USA Penn Genomic Analysis Core University of PennsylvaniaPhiladelphiaPA 19104USA

Although mechanisms of telomere protection are well-defined in differentiated cells,how stem cells sense and respond to telomere dysfunction,in particular telomeric double-strand breaks(DSBs),is poorly ***,we report the DNA damage signaling,cell cycle,and transcriptome changes in human induced pluripotent stem cells(iPSCs)in response to telomere-internal *** engineer human iPSCs with an inducible TRF1-FokI fusion protein to acutely induce DSBs at *** this model,we demonstrate that TRF1-FokI DSBs activate an ATR-dependent DNA damage response,which leads to p53-independent cell cycle arrest in *** CRISPR–Cas9 to cripple the catalytic domain of telomerase reverse transcriptase,we show that telomerase is largely dispensable for survival and lengthening of TRF1-FokI-cleaved telomeres,which instead are effectively repaired by robust homologous recombination(HR).In contrast to HR-based telomere maintenance in mouse embryonic stem cells,where HR causes ZSCAN4-dependent extension of telomeres beyond their initial lengths,HR-based repair of telomeric breaks is sufficient to maintain iPSC telomeres at a normal length,which is compatible with sustained survival of the cells over several days of TRF1-FokI *** findings suggest a previously unappreciated role for HR in telomere maintenance in telomerase-positive iPSCs and reveal distinct iPSC-specific responses to targeted telomeric DNA damage.

关键词： telomeres telomerase alternative lengthening of telomeres pluripotent stem cells DNA damage double-strand breaks

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Enhanced thermal stability of organic solar cells comprising ternary D-D-A bulk-heterojunctions

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npj Flexible Electronics 2017年第1期1卷 92-99页

作者： Dominik Landerer Adrian Mertens Dieter Freis Robert Droll tobias Leonhard Alexander Deniz Schulz Daniel Bahro Alexander Colsmann Light Technology Institute Karlsruhe Institute of Technology(KIT)Engesserstrasse 1376131 KarlsruheGermany Material Research Center for Energy Systems(MZE) Karlsruhe Institute of Technology(KIT)Strasse am Forum 776131 KarlsruheGermany

Ternary absorber blends have recently been identified as promising concepts to spectrally broaden the absorption of organic bulkheterojunction solar cells and hence to improve their power conversion *** this work,we demonstrate that D-D-A ternary blends comprising two donor polymers and the acceptor PC61BM can also significantly enhance the thermal stability of the solar *** harsh thermal stress at 120°C for 2 h,the ternary solar cells show only a minor relative deterioration of 10%.Whereas the polymer/fullerene blend PTB7-Th:PC61BM is rather unstable under these conditions,its degradation was efficiently suppressed by incorporating the near infrared-absorbing polymer PDTP–*** ellipsometry investigations and an effective medium analysis of the ternary absorber blend revealed that the domain conformation in presence of PDTP–DFBT remains stable whereas the domain conformation changes in its *** ternary PTB7-Th:PDTP–DFBT:PC61BM solar cells yield thermally stable power conversion efficiencies of up to 6%.

关键词： ternary stability absorber

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Realizing optimal hydrogen evolution reaction properties via tuning phosphorous and transition metal interactions

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Green Energy & Environment 2020年第4期5卷 506-512页

作者： Haishun Jiang Siyu Zhao Wenyao Li tobias P.Neville Isil Akpinar Paul R.Shearing Dan J.L.Brett Guanjie He School of Materials Engineering Shanghai University of Engineering ScienceShanghai201620China Electrochemical Innovation Lab Department of Chemical EngineeringUniversity College LondonLondonWC1E 7JEUnited Kingdom School of Chemistry University of LincolnJoseph Banks LaboratoriesGreen LaneLincolnLN67DLUnited Kingdom Faculty of Engineering Environmental EngineeringAksaray UniversityAksaray68100Turkey

Hydrogen is one of the most attractive renewables for future energy application,therefore it is vital to develop cost-effective and highlyefficient electrocatalysts for the hydrogen evolution reaction(HER)to promote the generation of hydrogen from mild *** this work,Co–Mo phosphide nanosheets with the adjustable ratio of Co and Mo were fabricated on carbon cloth by a facile hydrothermal-annealing *** to the unique nanostructures,abundant active surfaces and small resistance were *** electrocatalytic performances are obtained,such as the small overpotential of^67.3 mV to realize a current density of 10 mA cm^(-2) and a Tafel slope of 69.9 mV dec^(-1).Rapid recovery of the current response under multistep chronoamperometry is realized and excellent stability retained after the CV test for 2000 *** change of electronic states of different elements was carefully studied which suggested the optimal electrochemical performance can be realized by tuning phosphorous and metal interactions.

关键词： Co-Mo Phosphide Nanosheets Hydrogen evolution reaction Metal-phosphorous interactions

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Intraductal ultrasound substantiates diagnostics of bile duct strictures of uncertain etiology

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World Journal of Gastroenterology 2013年第6期19卷 874-881页

作者： tobias Meister Hauke S Heinzow Carina Woestmeyer Philipp Lenz Josef Menzel Torsten Kucharzik Wolfram Domschke Dirk Domagk Department of Medicine B University of Münster Department of Medicine Ⅱ HELIOS AlbertSchweitzer University Teaching Hospital Department of MedicineⅡ Klinikum IngolstadtD-85049 IngolstadtGermany Department of Medicine University Teaching Hospital Lüneburg

AIM:To report the largest patient cohort study investigating the diagnostic yield of intraductal ultrasound (IDUS) in indeterminate strictures of the common bile ***:A patient cohort with bile duct strictures of unknown etiology was examined by ***,specificity and accuracy rates of IDUS were calculated relating to the definite diagnoses proved by histopathology or long-term follow-up in those patients who did not undergo *** of the endosonographic report allowed drawing conclusions with respect to the T and N staging in 147 *** staging was compared to the postoperative histopathological staging data allowing calculation of sensitivity,specificity and accuracy rates for T and N *** endoscopic retrograde cholangio-pancreatography and IDUS procedures were performed under fluoroscopic guidance using a side-viewing duodenoscope (Olympus TJF 160,Olympus,Ltd.,Tokyo,Japan).All procedures were performed under conscious sedation (propofol combined with pethidine) according to the German *** IDUS,a 6 F or 8 F ultrasound miniprobe was employed with a radial scanner of 15-20 MHz at the tip of the probe (Aloka Co.,Tokyo,Japan).RESULTS:A total of 397 patients (210 males,187 females,mean age 61.43 ± 13 years) with indeterminate bile duct strictures were *** hundred and sixty-four patients were referred to the department of surgery for operative exploration,thus surgical histopathological correlation was available for those *** of 264 patients,174 had malignant disease proven by surgery,in 90 patients benign disease was *** these patients decision for surgical exploration was made due to suspicion for malignant disease in multimodal diagnostics (computed tomography scan,endoscopic ultrasound or magnetic resonance imaging).Twenty benign bile duct strictures were misclassified by IDUS as malignant while 14 patients with malignant strictures were initially misdiagnosed by IDUS as benign resulting in s

关键词： Intraductal ultrasound Bile duct strictures Accuracy

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LabVIEW GUI

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2002年

作者： David J. ritter.

来源：畅想之星图书光盘版（南... 评论

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Tetranuclear yttrium and gadolinium 2-acetylcyclopentanoate clusters：Synthesis and their use as spin-coating precursors for metal oxide film formation for field-effect transistor fabrication

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Journal of Rare Earths 2018年第10期36卷 1098-1105页

作者： Elaheh Pousaneh Andrea Preuβ Khaybar Assim tobias Rüffer Marcus Korb Jana Tittmann-Otto Sascha Hermann Stefan E.Schulz Heinrich Lang Technische Universitat Chemnitz Faculty of Natural Sciences Institute of Chemistry Inorganic Chemistry D-09107 Chemnitz Germany Technische Universitiat Chemnitz Center for Mierotechnologies D-09107 Chemnitz Germany Fraunhofer Institute for Electronic Nano Systems ENAS Technologie-Campus 3 D-09126 Chemnitz Germany

Lanthanide clusters [Ln4（μ3-OH）2（η2-accp）4（（μ-O）-η2-accp）6]（Ln = Y（4）,Gd（5）; accp = 2-acetylcyclopentanoate） are accessible by treatment of [M（NO33·6 H2 O]（M = Y（1）,Gd（2）） with 3 equiv. of Haccp（3） in presence of NaOH. The molecular structures of 4 and 5） in the solid-state are discussed. The thermal behavior of 4 and 5 was studied by TG under Ar and O2, showing multistep decomposition processes. Additionally, DSC studies were carried out under an atmosphere of O2. PXRD measurements of the TG residues confirm the formation of Ln2 ***-coating experiments were carried out with 4 and 5 for Ln2 O3 film deposition on silicon substrates. The layers are smooth, close and are of thicknesses of 18.87±1.13 nm and 25.59 ± 4.55 nm for Ln = Y and Gd, which was evidenced by SEM and EDX studies. Field-effect transistors were successfully fabricated by deposition of carbon nanotubes on top of the Y2 O3 films and formation of palladium contacts by a lift-off procedure. An on/off ratio of more than 4 orders of magnitude is achieved without considerable leakage currents. These results demonstrate the potential use of spin-coated Y2 O3 as a gate dielectric in electronic devices.

关键词： β-Diketonates Yttrium Gadolinium Thermal analysis Spin coating CNT transistor

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Comparison of the Overall CO_(2) Emissions of Different Powertrain Systems Depending on the Energy Sector Emissions

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同济大学学报（自然科学版） 2024年第S1期52卷 46-50页

作者： tobias STOLL Hans-Jürgen BERNER AndréCASAL KULZER Research Institute for Automotive Engineering and Powertrain Systems Stuttgart(FKFS) 70569 StuttgartGermany Institute of Automotive Engineering(IFS) University of Stuttgart70569 StuttgartGermany

A circular and sustainable economy for the private transport sector requires a holistic view of the emitted CO_(2) *** at the energy supplied to the vehicle in terms of a circular economy leads to *** remaining energy sources or forms are renewable electric energy,green hydrogen and renewable fuels.A holistic view of the CO_(2) emissions of these energy sources and forms and the resulting powertrain technologies must take into account all cradle-to-grave emissions for both the vehicle and the energy *** order to compare the different forms of energy,the three most relevant forms of powertrain technology are considered and a configuration is chosen that allows for an appropriate *** this purpose,data from the FVV project“Powertrain 2040”are used[1]and combined with research data on the energy supply chain for passenger *** three comparable powertrain configurations are a battery electric vehicle,a fuel cell electric vehicle and an internal combustion engine hybrid vehicle fueled with electric ***,the three selected powertrain configurations are presented in terms of their performance,weight,technology and other characteristics.A comparative analysis is carried out for different CO_(2) emissions of the electricity *** electricity mix is used for both the production of the vehicle and the *** results are presented in the form of cradle-to-wheel emissions,which consider the total CO_(2) emissions of the vehicle over its life ***,the results are analyzed and discussed to determine which powertrain technology fits best into which energy sector CO_(2) emissions window.

关键词： vehicles energy supply power system carbon emission

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Synthesis of carbon frameworks with N,O and S-lined pores from gallic acid and thiourea for superior CO2 adsorption and supercapacitors

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Science China Materials 2020年第5期63卷 748-757页

作者： Zhihong Tian Feili Lai tobias Heil Shaokui Cao Markus Antonietti School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China Department of Colloid Chemistry Max Planck Institute of Colloids and InterfacesPotsdam 14476Germany

"C2N"-species have emerged as a promising material with carbon-like applications in sorption,gas separation and energy storage,while with much higher polarity and *** synthesis of"C2N"structure is still based on complex and less-sustainable monomers,which prohibits its broader industrial *** we report a class of well-defined C2(NxOySz)1 carbons with both high content of N/O/S heteroatoms and large specific surface area of up to 1704 m^2 g^-1,which can be efficiently synthesized through a simple additive condensation process using simple gallic acid and thiourea as the building blocks,without subtractive *** 1,4-para tri-doped C2(NxOySz)1 structure leads to sufficient CO2 adsorption capacity(3.0 mmol g^-1 at 273 K,1 bar)and a high CO2/N2 selectivity(47.5 for a 0.15/0.85 CO2/N2 mixture at 273 K).Related to the polarity,the polar frameworks can be used as supercapacitor electrodes,with record specific capacitances as high as 255 F g^-1 at 3.5 V for a symmetric supercapacitor in ionic liquid *** work discloses a general way for preparing a novel family of multifunctional,high heteroatomdoped porous materials for various applications.

关键词： carbon materials structural pores N/O/S doping,CO2 adsorption supercapacitor ionic liquid

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Regional Variation in the SME-Audit Firm Relationship

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Journal of Modern Accounting and Auditing 2012年第3期8卷 340-356页

作者： tobias Svanstrom Hakan Boter BI Norwegian Business School Norway Umea School of Business and Economics Sweden

The purpose of the paper is to examine how the relationship between small and medium sized enterprises （SMEs） and their auditor varies between regions. Auditing literature, regional, and network studies are used to set up hypotheses on differences between rural regions and the metropolitan urban region. Survey data from 421 SMEs are analyzed and findings support that in rural regions, especially those with a strong entrepreneurial culture and tight inter-organizational links, the SME-auditor relationship is to a larger extent trust-based compared to the urban region. In the rural region, the auditor assumes the role as a business support agent providing valuable strategic advice. The SME-auditor relationship is weakest in the urban region where the auditor＇s role is limited.

关键词： SME auditing audit firm business support trust network service quality regional variation

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Optimization Framework for Conceptual Powertrain Design

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Journal of Mechanics Engineering and Automation 2015年第6期5卷 327-337页

作者： tobias Hellberg Martin Meywerk Institute of A utomotive and Powertrain Engineering Helmut-Schmidt-University Hamburg 22043 Germany

With an increasing number of vehicles with alternative powertrains, the choice of the most appropriate powertrain system for a vehicle class or a load cycle is challenging. This paper introduces a method to design an optimal alternative powertrain based on a longitudinal dynamic simulation. The objective function of the minimization problem describes the characteristic map of the traction system. The goal of the optimization is to minimize fuel consumption respectively energy demand. Different types of propulsion systems are investigated. The results show that the proposed method delivers useful alternative powertrains by applying an optimization with reasonable restrictions.

关键词： Simulation in automotive engineering hybrid powertrain optimization longitudinal dynamic vehicle simulation.

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