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[Y(dbm)_(3)(H_(2)O)]:Synthesis,thermal behavior and spin-coating precursor for Y_(2)O_(3)layer formation

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Journal of Rare Earths 2017年第12期35卷 1248-1254页

作者： Elaheh Pousaneh Andrea Preuβ Khaybar Assim Julian Noll Alexander Jakob tobias Rüffer Heinrich Lang Technische Universitat Chemnitz Faculty of Natural SciencesInstitute of ChemistryInorganic Chemistry

The synthesis,structure and thermal behavior of [Y（dbm）3（H2 O）]（3）（dbm = 1,3-diphenyl-1,3-propandionate） and its use as a spin-coating precursor for Y2 O3 deposition is reported. Complex 3 was prepared by the reaction of [Y（NO3）3·6 H2 O]（1） with 3 equiv of Hdbm（2） in presence of NaOH. The molecular structure of 3 in the solid-state was determined by single X-ray crystal diffraction. Both C1 symmetric crystallographically independent species of 3 possess a YO7 coordination setup with minor deviation from an ideal capped octahedron coordination geometry（∧ enantiomer）. Complex 3 forms a1 D chain, due to intermolecular hydrogen bonds between the coordinated H2 O molecule and the 0 atom of the dbm ligand, respectively. The thermal decomposition behavior of 3 was investigated by thermogravimetric studies in the temperature range of 40-800 ℃ and 40-1300 ℃ under an oxygen and argon atmosphere, respectively. Powder X-ray diffraction（PXRD） measurements of the residues confirmed the formation of Y2 O3. Complex 3 was applied as a spin-coating precursor for yttrium oxide film formation on either Si wafers with a continuous 100 nm thick SiO2 film, or with a native oxide *** as-deposited Y2 O3 layers are smooth, conformal, dense and transparent and are of a thickness of 27 and 30 nm, respectively.

关键词： Yttrium β-Diketonate Yttrium oxide Spin-coating Solid-state structure Vapor pressure

Dynamics of Submersible Mussel Rafts in Waves and Current

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China Ocean Engineering 2015年第3期29卷 431-444页

作者： WANG Xin-xin M.Robinson SWIFT tobias DEWHURST Igor TSUKROV Barbaros CELIKKOL Carter NEWELL Center for Ocean Engineering and Mechanical Engineering Department University of New Hampshire Laboratory of Fisheries Engineering Fisheries College Ocean University of China Pemaquid Mussel Farms

To investigate the dynamics of submersible mussel rafts, the finite element program Aqua-FETM, developed by the University of New Hampshire（UNH）, was applied to rafts moored at the surface and submerged. The submerged configuration is used to reduce wave forcing and to avoid contact with floating ice during winters in northern waters. Each raft consists of three pontoons connected by a grid framework. Rafts are intended to support densely spaced mussel ropes hung from the framework. When submerged, the pontoons are flooded, and the raft is held vertically by floats attached by lines. The computer models were developed in Aqua-FE？ to simulate the effects of waves and current. They were validated by comparison with wave tank results by use of a 1/10 scale raft physical model. Comparisons showed good agreement for the important heave（vertical） and pitch（rotational） motions, though there was a tendency towards conservative results for wave and current drag. Full-scale simulations of surface and submerged single raft and two rafts connected in tandem were performed. Submerged raft wave response was found to be reduced relative to that at the surface for both the single and two-raft configurations. In particular, the vertical motion of mussel rope connection points was significantly reduced by submergence, resulting in reduced potential for mussel drop-off. For example, the maximum vertical velocities of mussel rope attachment points in the submerged two raft case were 7%-20% of the corresponding velocities when at the surface.

关键词： mussel raft submersible mussel ropes finite element model waves and current storm response

Versatile multiplexed super-resolution imaging of nanostructures by Quencher-Exchange-PAINT

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Nano Research 2018年第12期11卷 6141-6154页

作者： tobias Lutz Alexander H.Clowsley Ruisheng Lin Stefano Pagliara Lorenzo Di Michele Christian Soeller Living Systems Institute & Biomedical Physics University of ExeterExeter EX44QDUK Cavendish Laboratory University of CambridgeCambridge CB30HEUK

The optical super-resolution technique DNA-PAINT (Point Accumulation Imaging in Nanoscale Topography) provides a flexible way to achieve imaging of nanoscale structures at ∼10-nanometer resolution. In DNA-PAINT, fluorescently labeled DNA “imager” strands bind transiently and with high specificity to complementary target “docking” strands anchored to the structure of interest. The localization of single binding events enables the assembly of a super-resolution image, and this approach effectively circumvents photobleaching. The solution exchange of imager strands is the basis of Exchange-PAINT, which enables multiplexed imaging that avoids chromatic aberrations. Fluid exchange during imaging typically requires specialized chambers or washes, which can disturb the sample. Additionally, diffusional washout of imager strands is slow in thick samples such as biological tissue slices. Here, we introduce Quencher-Exchange-PAINT—a new approach to Exchange-PAINT in regular open-top imaging chambers—which overcomes the comparatively slow imager strand switching via diffusional imager washout. Quencher-Exchange-PAINT uses “quencher” strands, i.e., oligonucleotides that prevent the imager from binding to the targets, to rapidly reduce unwanted single-stranded imager concentrations to negligible levels, decoupled from the absolute imager concentration. The quencher strands contain an effective dye quencher that reduces the fluorescence of quenched imager strands to negligible levels. We characterized Quencher-Exchange-PAINT when applied to synthetic, cellular, and thick tissue samples. Quencher-Exchange-PAINT opens the way for efficient multiplexed imaging of complex nanostructures, e.g., in thick tissues, without the need for washing steps.

关键词： super-resolution microscopy fluorescence imaging DNA nanotechnology DNA-PAINT fluorescence quencher

Assessment of stricturing Crohn's disease:Current clinicalpractice and future avenues

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World Journal of Gastroenterology 2016年第3期22卷 1008-1016页

作者： Dominik Bettenworth tobias M Nowacki Friederike Cordes Boris Buerke Frank Lenze Department of Medicine B University Hospital of Muenster48149 MuensterGermany Department of Clinical Radiology University Hospital of Muenster48149 MuensterGermany

Crohn's disease(CD) is a chronic remittent idiopathic disease. Although the early phase of the disease is commonly characterized by inflammation-driven symptoms, such as diarrhea, the frequency of fibrostenotic complications in patients with CD increases over the long-term course of the disease. This review presents the current diagnostic options for assessing CD-associated strictures. In addition to the endoscopic evaluation of CD strictures, this review summarizes the currently available imaging modalities, including ultrasound and cross-sectional imaging techniques. In addition to stricture detection, differentiating between the primarily inflammatory strictures and the predominantly fibrotic ones is essential for selecting the appropriate treatment strategy(anti-inflammatory medical treatment vs endoscopical or surgical approaches). Therefore, recent imaging advances, such as contrast-enhanced ultrasound and ultrasound elastography, contribute to the development of noninvasive non-radiating imaging of CD-associated strictures. Finally, novel magnetic resonance imaging techniques, such as diffusion-weighted, motility and magnetization transfer imaging, as well as 18F-FDG PET/CT, molecular imaging approaches and biomarkers, are critically reviewed with regard to their potential role in assessing stricturing CD.

关键词： Crohn's disease Inflammatory bowel disease Intestinal stricture Endoscopy Magnetic resonanceimaging Ultrasound Computed tomography 18F-FDGPET/CT CEUS Elastography

Ab initio density response and local field factor of warm dense hydrogen

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Matter and Radiation at Extremes 2024年第5期9卷 48-67页

作者： tobias Dornheim Sebastian Schwalbe Panagiotis Tolias Maximilian P.Böhme Zhandos A.Moldabekov Jan Vorberger Center for Advanced Systems Understanding(CASUS) D-02826 GörlitzGermany Helmholtz-Zentrum Dresden-Rossendorf(HZDR) D-01328 DresdenGermany Space and Plasma Physics Royal Institute of Technology(KTH)Stockholm SE-10044Sweden Technische Universität Dresden D-01062 DresdenGermany

We present quasi-exact ab initio path integral Monte Carlo(PIMC)results for the partial static density responses and local field factors of hydrogen in the warm dense matter regime,from solid density conditions to the strongly compressed *** full dynamic treatment of electrons and protons on the same footing allows us to rigorously quantify both electronic and ionic exchange–correlation effects in the system,and to compare the results with those of earlier incomplete models such as the archetypal uniform electron gas or electrons in a fixed ion snapshot potential that do not take into account the interplay between the two *** full electronic density response is highly sensitive to electronic localization around the ions,and our results constitute unambiguous predictions for upcoming X-ray Thomson scattering experiments with hydrogen jets and fusion *** PIMC results are made freely available and can be used directly for a gamut of applications,including inertial confinement fusion calculations and the modeling of dense astrophysical ***,they constitute invaluable benchmark data for approximate but computationally less demanding approaches such as density functional theory or PIMC within the fixed-node approximation.

关键词： local incomplete rigorous

Signal pathways and precision therapy of small-cell lung cancer

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Signal Transduction and Targeted Therapy 2022年第7期7卷 2293-2310页

作者： Min Yuan Yu Zhao Hendrik-tobias Arkenau Tongnei Lao Li Chu Qing Xu Department of Oncology Shanghai Tenth People’s HospitalTongji University200072 ShanghaiChina Drug Development Unit Sarah Cannon Research InstituteLondonUK Department of Oncology Centro Medico BO CHIMacaoSARChina Department of Radiation Oncology Fudan University Shanghai Cancer Center200032 ShanghaiChina Present address:Department of Oncology Shanghai Medical CollegeFudan University200032 ShanghaiChina

Small-cell lung cancer(SCLC)encounters up 15%of all lung cancers,and is characterized by a high rate of proliferation,a tendency for early metastasis and generally poor *** of the patients present with distant metastatic disease at the time of clinical diagnosis,and only one-third are eligible for potentially curative ***,investigations into the genomic make-up of SCLC show extensive chromosomal rearrangements,high mutational burden and loss-of-function mutations of several tumor suppressor *** the clinical development of new treatments for SCLC has been limited in recent years,a better understanding of oncogenic driver alterations has found potential novel targets that might be suitable for therapeutic ***,there are six types of potential treatable signaling pathways in SCLC,including signaling pathways targeting the cell cycle and DNA repair,tumor development,cell metabolism,epigenetic regulation,tumor immunity and *** this point,however,there is still a lack of understanding of their role in SCLC tumor biology and the promotion of cancer *** optimizing drug targets,improving drug pharmacology,and identifying potential biomarkers are the main focus and further efforts are required to recognize patients who benefit most from novel therapies in *** review will focus on the current learning on the signaling pathways,the status of immunotherapy,and targeted therapy in SCLC.

关键词： metabolism immunity alterations

From chip-in-a-lab to lab-on-a-chip:a portable Coulter counter using a modular platform

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Microsystems & Nanoengineering 2018年第1期4卷 57-64页

作者： Stefan Dekker Pelin Kubra Isgor tobias Feijten Loes I.Segerink Mathieu Odijk BIOS Lab on Chip Group MESA+Institute for NanotechnologyUniversity of Twente7500 AE EnschedeNetherlands

The field of microfluidics has been struggling to obtain widespread market *** order to overcome this struggle,a standardized and modular platform is introduced and *** providing easy-to-fabricate modular building blocks which are compatible with mass manufacturing,we decrease the gap from *** standardized blocks are used in combination with an application-specific fluidic circuit *** this board,electrical and fluidic connections are demonstrated by implementing an alternating current Coulter *** multipurpose building block is reusable in many *** this study,it identifies and counts 6 and 11μm *** system is kept in a credit card-sized footprint,as a result of in-house-developed electronics and standardized building *** believe that this easy-to-fabricate,credit card-sized,modular,and standardized prototype brings us closer to clinical and veterinary applications,because it provides an essential stepping stone to fully integrated point-of-care devices.

关键词： sized portable closer

Get it white: color-tunable AC/DC OLEDs

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Light(Science & Applications) 2015年第1期4卷 492-497页

作者： Markus Frobel tobias Schwab Mona Kliem Simone Hofmann Karl Leo Malte C Gather Institute for Applied Photophysics(IAPP) Dresden University of TechnologyD-01069 DresdenGermany School of Physics and Astronomy University of St AndrewsSt Andrews KY169SSUK

Organic light-emitting diodes(OLEDs)have gained considerable attention because of their use of inherently flexible materials and their compatibility with facile roll-to-roll and printing *** addition to high efficiency,flexibility and transparency,reliable color tunability of solid state light sources is a desirable feature in the lighting and display ***,we demonstrate a device concept for highly efficient organic light-emitting devices whose emission color can be easily adjusted from deep-blue through cold-white and warm-white to saturated *** approach exploits the different polarities of the positive and negative half-cycles of an alternating current(AC)driving signal to independently address a fluorescent blue emission unit and a phosphorescent yellow emission unit which are vertically stacked on top of each *** electrode design is optimized for simple fabrication and driving and allows for two-terminal operation by a single *** presented concept for color-tunable OLEDs is compatible with application requirements and versatile in terms of emitter combinations.

关键词： alternating current color mixing color tuning vertical stacking white organic light-emitting devices

Pro?ling and Validation of the Circular RNA Repertoire in Adult Murine Hearts

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Genomics, Proteomics & Bioinformatics 2016年第4期14卷 216-223页

作者： tobias Jakobi Lisa F. Czaja-Hasse Richard Reinhardt Christoph Dieterich Section of Bioinformatics and Systems Cardiology Department of Internal Medicine IIIUniversity Hospital Heidelberg 69120 HeidelbergGermany German Centre for Cardiovascular Research(DZHK) Heidelberg/Mannheim.Germany Max Planck-Genome-Centre Cologne 50829 CologneGermany

For several decades, cardiovascular disease has been the leading cause of death throughout all countries. There is a strong genetic component to many disease subtypes （e.g., cardiomyopa- thy） and we are just beginning to understand the relevant genetic factors. Several studies have related RNA splicing to cardiovascular disease and circular RNAs （circRNAs） are an emerging player, circRNAs, which originate through back-splicing events from primary transcripts, are resis- tant to exonucleases and typically not polyadenylated. Initial functional studies show clear phenotypic outcomes for selected circRNAs. We provide, for the first time, a comprehensive catalogue of RNase R-resistant circRNA species for the adult murine heart. This work combines state-of-the-art circle sequencing with our novel DCC software to explore the circRNA landscape of heart tissue. Overall, we identified 575 circRNA species that pass a beta-binomial test for enrichment （false discovery rate of 1%） in the exonuclease-treated sequencing sample. Several circRNAs can be directly attributed to host genes that have been previously described as associated with cardiovascular disease. Further studies of these candidate circRNAs may reveal disease-relevant properties or functions of specific circRNAs.

关键词： Circular RNA circSeq Cardiovascular disease Cardiomyopathy Computational cardiology