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世界核心医学期刊文摘(眼科学分册) 2006年第1期 53-54页

作者： Krφyer K. Jensen O.m. Larsen m. 韩静 Department of Ophthalmology Herlev Hospital University of Copenhagen Herlev Ringvej 75 DK-2750 Herlev Denmark

PURPOSE. To describe a method for quantitative mapping of metamorphopsia and abnormalities of oculocentric direction in subjects with epiretinal membranes. mETHODS. Binocular correspondence perimetry was performed using red and green dichoptic stimuli applied in a rectangular grid pattern. The study included 9 healthy subjects and 10 subjects with a unilateral premacular epiretinal membrane and a healthy fellow eye. Interocular visuospatial correspondence was expressed in a visuospatial deviation score and the binocular correspondence perimetry plots were displayed in proportion to fundus photographs. A reference interval was defined as the 95% CI for the average visuospatial deviation score in healthy subjects. RESULTS. In 6 out of 10 subjects with epiretinal membranes, visuospatial alignment deviated beyond the reference interval found in healthy subjects, whereas 4 subjects were within the normal range. The deviation score increased with decreasing visual acuity, although indications of heterogeneity of the subject population were identified, suggesting that visual acuity reduction and metamorphopsia may be dissociated in some types of epiretinal membranes. CONCLU-SIONS. Binocular correspondence perimetry enables quantitative mapping of metamorphopsia and stratification of subjects with epiretinal membranes with respect to normative references. Data from healthy subjects appear to describe a physiological level of tolerance for changes in oculocentric direction, which may apply also to the changes induced by retinal traction.

关键词：视网膜前膜视野检查双眼视物变形

THE INFLUENCE OF ISLAND-INDUCED STRAIN ON THE Si SURFACE mORPHOLOGY IN Ge-Si mULTILAyerS: A TRANSmISSION ELECTRON mICROSCOPY STUDY

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Acta metallurgica Sinica(English Letters) 2005年第3期18卷 228-236页

作者： H.m.Lu E.Spiecker W.Jaeiger L.Vescan Centerformicroanalysis FacultyofEngineeringChristian-Albrechts-UniversityKielKaiserstraβe2Kiel24143Germany／／StateKeyLaboratoryofSiliconMaterialsZhejiangUniversityHangzhou310027China Centerformicroanalysis FacultyofEngineeringChristian-Albrechts-UniversityKielKaiserstraβe2Kiel24143Germany InstitutfürSchichtenundGrenzflaechen ForschungszentrumJülichGmbHJülich52425Germany

Growth and ordering of coherently strained Ge-rich islands in Ge/Si single layer and multilayer systems and the influence of island arrangements on the evolutio n of the surface morphology of Si cap layers during deposition by low-pressure c hemical vapour deposition(LPCVD) on Si(001) substrates at 700℃ have been invest igated by TEm of cross-section and plan-view specimens. At distances between the Ge layers of 35-50nm, vertical order of GeSi islands is observed for Ge-Si bila yer systems and for Ge-Si multilayer systems consisting of 5 layer pairs whereas lateral ordering parallel to substrate directions is observed for the lat ter case only. In agreement with earlier results the vertical ordering in the mu ltilayer system can be understood as result of the elastic interaction between i sland nuclei forming in the layers with close islands in a buried layer below. T he lateral ordering along may be attributed to the anisotropy of the elast ic interaction. Characteristic for all Si surfaces are the spatial correlation b etween the presence of island-induced lattice strain and the appearance of array s of larger square-shaped pyramids with distinct faceting and facet edges along . The results reflect the importance of the control of growth parameters an d of the island-induced strain state for the evolution of the Si top layer surfa ce morphology during LPCVD growth.

关键词： Si-Ge heteroepitaxy surfaces strain nanostructures transmission electron microscopy

The East Anatolia-Lesser Caucasus ophiolite:An exceptional case of large-scale obduction,synthesis of data and numerical modelling

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Geoscience Frontiers 2020年第1期11卷 83-108页

作者： Y.Rolland m.Hässig D.Bosch O.Bruguier R.melis G.Galoyan G.Topuz L.Sahakyan A.Avagyan m.Sosson Universitéde Nice Sophia Antipolis UMR GéoazurCNRSIRDObservatoire de la Côte d’Azur250 Rue Albert Einstein06560Sophia AntipolisFrance EDYTEm Universitéde Savoie e CNRSUMR 5204Le Bourget du LacFrance Department of Earth Sciences University of GenevaRue des Maraîchers 131205 GenevaSwitzerland University montpellier Géosciences MontpellierUMR-CNRS-UM25243Place Eugene Bataillon34095 MontpellierFrance Institute of Geological Sciences National Academy of Sciences24a Baghramyan AvenueYerevan 0019Armenia Istanbul Teknik Universitesi Avrasya Yer Bilimleri Enstitüsü34469 IstanbulTurkey

We present new,geological,metamorphic,geochemical and geochronological data on the East Anatolian-Lesser Caucasus *** data are used in combination with a synthesis of previous data and numerical modelling to unravel the tectonic emplacement of ophiolites in this *** these data allow the reconstruction of a large obducted ophiolite nappe,thrusted for>100 km and up to 250 km on the Anatolian-Armenian *** ophiolite petrology shows three distinct magmatic series,highlighted by new isotopic and trace element data:(1)The main Early Jurassic Tholeiites(ophiolite s.s.)bear LILEenriched,subduction-modified,mORB chemical *** and petrology of the Tholeiite series substantiates a slow-spreading oceanic environment in a time spanning from the Late Triassic to the middle-Late ***,gabbros and plagiogranites were exhumed by normal faults,and covered by radiolarites,while minor volumes of pillow-lava flows infilled the rift *** towards a subduction-modified geochemical signature suggests emplacement in a marginal basin above a subduction zone.(2)Late Early Cretaceous alkaline lavas conformably emplaced on top of the *** have an OIB *** lavas are featured by large pillow lavas interbedded a carbonate *** show evidence for a large-scale OIB plume activity,which occurred prior to ophiolite obduction.(3)Early-Late Cretaceous calc-alkaline lavas and *** magmatic rocks are found on top of the obducted nappe,above the post-obduction erosion *** series shows similar Sr-Nd isotopic features as the Alkaline series,though having a clear supra-subduction *** are thus interpreted to be the remelting product of a mantle previously contaminated by the OIB *** of data from the Lesser Caucasus to western Anatolia shows a progression from back-arc to arc and fore-arc,which highlight a dissymmetry in the obducted oceanic lithosphere from East to *** metamo

关键词： Ophiolite Obduction Subduction Neotethys

16S rDNA-Based Phylogeny of Non-Symbiotic Bacteria of Entomopathogenic Nematodes from Infected Insect Cadavers

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Genomics, Proteomics & Bioinformatics 2011年第3期9卷 104-112页

作者： m. Razia R. Karthik Raja K. Padmanaban P. Chellapandi S. Sivaramakrishnan Department of Biotechnology School of Life Sciences Bharathidasan University Tiruchirappalli 620024 Tamil Nadu India Department of Bioinformatics School of Life Sciences Bharathidasan University Tiruchirappalli 620024 Tamil Nadu India

Using 16S rDNA gene sequencing technique, three different species of non-symbiotic bacteria of entomopathogenie nematodes （EPNs）（Steinernema sp. and Heterorhabditis sp.） were isolated and identified from infected insect cadavers （Galleria mellonella larvae） after 48-hour post infections. Sequence similarity analysis revealed that the strains SRK3, SRK4 and SRK5 belong to Ochrobactrum cytisi, Schineria larvae and Ochrobactrum anthropi, respectively. The isolates O. anthropi and S. larvae were found to be associated with Heterorhabditis indica strains BDU-17 and yer-136, respectively, whereas O. cytisi was associated with Steinernema siamkayai strain BDU-87. Phenotypically, temporal EPN bacteria were fairly related to symbiotic EPN bacteria （Photorhabdus and Xenorhabdus genera）. The strains SRK3 and SRK5 were phylogeographically similar to several non-symbionts and contaminated EPN bacteria isolated in Germany （LmG3311T） and China （X-14）, while the strain SRK4 was identical to the isolates of S. larvae （L1/57, L1/58, L1/68 and L2/11） from Wohlfahrtia magnifica in Hungary. The result was further confirmed by RNA secondary structure and minimum energy calculations of aligned sequences. This study suggested that the non-symbionts of these nematodes are phylogeographicaily diverged in some extent due to phase variation. Therefore, these strains are not host-dependent, but environment-specific isolates.

关键词： entomopathogen Schineria Ochrobactrum non-symbionts phylogenetics phase variation

molecular cloning and characterization of an ECTO-NOX3 (ENOX3) of <i>Saccharomyces cerevisiae</i>

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Advances in Biological Chemistry 2013年第5期3卷 505-511页

作者： Sara Dick Connie Phung Dorothy m. morré D. James morré Department of Biology Valparaiso University Valparaiso USA morNuCo Inc. Purdue Research Park West Lafayette USA

Exfoliated ECTO-NOX3 (ENOX3) proteins, are members of the human Tm9 superfamily of transmembrane proteins that generate superoxide, are present in blood and other body fluids, and increase activity with age beginning about age 30, hence age-related NOX (arNOX or ENOX3). A yeast deletion library was screened based on NADH fluorescence using a 384 well plate assay to identify a yeast isolate lacking a previously identified cell surface oxidase exhibiting an oscillatory pattern with a period length of 26 min and capable of generating superoxide. The cDNA was cloned from a yeast over expression library using NADH as an impermeant substrate with analysis by Fast Fourier Transform and decomposition fits. The objective was to identify and sequence an ENOX homologue in Saccharomyces cerevisiae with a 26 min rather than a 24 or 25 min period length. The finding identified yer113C as the yeast ENOX3 protein with a 26 min period and capable of generating superoxide. The encoded protein was expressed in bacteria and characterized. Gel slices of expressed proteins revealed a protein of ca. 81,545 kDa with properties paralleling those of human ar-NOX (periodic NADH oxidation, protein disulfide thiol interchange, inhibited by mammalian arNOX inhibitors and superoxide production inhibited by superoxide dismutase). The yer113C sequence exhibited a 44% similarity and a 26% identity with the mammalian ENOX3 SF4 (arNOX SF4) of the Tm9 superfamily of transmembrane proteins1. The yer113C deletion mutant lacked arNOX activity.

关键词： Age-Related NADH Oxidase (arNOX) ECTO-NOX3 Tm9 Superfamily of Transmembrane Proteins molecular Cloning Saccharomyces cerevisiae

一项关于“视锥细胞营养不良疾病中视杆细胞ERG超常反应”的表型研究

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世界核心医学期刊文摘（眼科学分册） 2005年第8期1卷 44-45页

作者： michaelides m. Holder G.E. Webster A.R. A.T. moore 王海燕 Institute of Ophthalmology University College London 11-43 Bath Street London EC1V 9EL United Kingdom Prof.

Aims: To characterise the detailed phenotype of “cone dystrophy with supernor mal rod ERG”in a case series of 10 patients. methods: 10 affected patients were examined clinically and underwent colour fundus photography, with nine undergoi ng detailed electrophysiological testing. Five patients were assessed further wi th fundus autofluorescence (AF)imaging, automated photopic and dark adapted peri metry, and dark adaptometry. Detailed colour vision assessment was performed in six subjects. Blood samples were taken from four patients for DNA extraction and mutation screening of NR2E3was undertaken. Results: The onset of symptoms was i n the first and second decades of life. Subjects presented with reduced central vision and marked photophobia. All individuals were myopic and colour vision tes ting revealed severely reduced colour discrimination predominantly along the red -green axes; tritan colour vision was relatively well preserved. Nyctalopia is a later feature of the disorder. Funduscopy and AF imaging revealed a range of m acular appearances. There was electrophysiological evidence of marked macular dy sfunction, reduced and delayed cone responses, and supernormal and delayed rod r esponses. Photopic and dark adapted perimetry revealed central scotomata with wi despread peripheral sensitivity loss. No disease causing sequence variants in NR 2E3 were identified. Conclusions: The largest case series to date has been descr ibed of the clinical, psychophysical and electrophysiological characteristics of this unusual cone dystrophy with supernormal rod responses. Electrophysiologica l data were consistent with a post-phototransduction, but pre-inner nuclear la yer, site of dysfunction. While the definitive diagnosis can only be made with e lectrophysiological testing, several characteristics that may increase suspicion of this diagnosis are presented.

关键词：视杆细胞 ERG 中心视力自发荧光色觉检查暗适应计黄斑部内核层眼底照相视野计