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Overlap of concurrent extrahepatic autoimmune diseases is associated with milder disease severity of newly diagnosed autoimmune hepatitis

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Hepatobiliary & Pancreatic Diseases International 2021年第1期20卷 21-27页

作者： tobias Mühling Helmut Rohrbach Wolfgang Schepp Felix Gundling Department of Gastroenterology Internal Medicine ⅡUniversity of WürzburgWürzburgGermany Department of Pathology Academic Teaching Hospital BogenhausenTechnical University of MunichMunich 81925Germany Department of Gastroenterology Hepatology and Gastrointestinal OncologyAcademic Teaching Hospital BogenhausenTechnical University of MunichMunich 81925Germany Department of Internal Medicine Division of GastroenterologyGastrointestinal Oncology and DiabetologyKemperhof KoblenzKoblenzGermany

Background:Concurrent extrahepatic autoimmune disorders(CEHAID)are frequently observed in autoimmune hepatitis(AIH).It is not clear whether there is any prognostic significance of CEHAID on *** aim of this study was to examine the prognostic impact of CEHAID and the correlation with the disease severity of ***:This study included 65 hospitalized subjects who fulfilled the accepted criteria for AIH during an 8-year period(2009–2016).All records were manually screened for presence of associated autoimmune *** severity of AIH was assessed by liver laboratory tests including the ratio of aspartate aminotransferase to alanine aminotransferase(AST/ALT)and liver ***:Among the enrolled patients,52(80%)were female(median age 61 years,IQR 45–75).Fifty-six(86.2%)were classified as type-1 *** 26(40%)patients at least one additional extrahepatic autoimmune disease was ***-four subjects were referred to our hospital because of acute presentation of AIH(supposed by an acute elevation of hepatic enzymes)for subsequent liver biopsy resulting in initial diagnosis of *** group was stratified into 3 subgroups:(A)AIH alone(n=14);(B)overlap with primary biliary cirrhosis(PBC)/primary sclerosing cholangitis(PSC)(n=11);and(C)with CEHAID(n=9).AST/ALT ratio was the lowest in subgroup C(median 0.64,IQR 0.51–0.94;P=0.023),compared to subgroup A(median 0.91,IQR 0.66–1.10)and subgroup B(median 1.10,IQR 0.89–1.36).Patients with AIH alone showed a trend to the highest grade of fibrosis(mean 2.3;95%CI:1.5–3.0)with no statistical significance compared to subjects with CEHAID(lowest grade of fibrosis;mean 1.5;95%CI:0.2–2.8;P=0.380)whereas the ongoing inflammation was ***:AST/ALT ratio and extent of fibrosis were lower in subjects with AIH and CEHAID,compared to subjects with only ***,the occurrence of CEHAID might be a predictor for lower disease severity of newly diagnosed acute onset AIH,possibly caused by an e

关键词： Autoimmune hepatitis Concurrent extrahepatic autoimmune disease Serum aminotransferase activities

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Thermal scanning probe lithography-a review

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Microsystems & Nanoengineering 2020年第1期6卷 1117-1140页

作者： Samuel tobias Howell Anya Grushina Felix Holzner Juergen Brugger Microsystems Laboratory Ecole Polytechnique Federale de Lausanne(EPFL)1015 LausanneSwitzerland Heidelberg Instruments Nano-SwissLitho AG Technoparkstrasse 18005 ZürichSwitzerland

Fundamental aspects and state-of-the-art results of thermal scanning probe lithography(t-SPL)are reviewed here.t-SPL is an emerging direct-write nanolithography method with many unique properties which enable original or improved nano-patterning in application fields ranging from quantum technologies to material *** particular,ultrafast and highly localized thermal processing of surfaces can be achieved through the sharp heated tip in t-SPL to generate high-resolution *** investigate t-SPL as a means of generating three types of material interaction:removal,conversion,and *** of these categories is illustrated with process parameters and application examples,as well as their respective opportunities and *** intention is to provide a knowledge base of t-SPL capabilities and current limitations and to guide nanoengineers to the best-fitting approach of t-SPL for their challenges in nanofabrication or material *** potential applications of nanoscale modifications with thermal probes still wait to be explored,in particular when one can utilize the inherently ultrahigh heating and cooling rates.

关键词： utilize heated limitations

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Morphological stability of three-dimensional cementite rods in polycrystalline system:A phase-field analysis

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Journal of Materials Science & Technology 2021年第18期77卷 252-268页

作者： tobias Mittnacht P.G.Kubendran Amos Daniel Schneider Britta Nestler Institute of Applied Materials(IAM-CMS) Karlsruhe Institute of Technology(KIT)Strasse am Forum 776131 KarlsruheGermany Institute of Digital Materials Science(IDM) Karlsruhe University of Applied SciencesMoltkestr.3076133 KarlsruheGermany Department of Metallurgical and Materials Engineering National Institute of TechnologyTiruchirappalli-620015Tamil NaduIndia

Transformations accompanying shape-instability govern the morphological configuration and distribution of the phases in a *** to the influence of the microstructure on the properties of a material,in the present work,the stability of three-dimensional rods in a‘representative'polycrystalline system is extensively analysed.A multiphase-field model,which recovers the physical laws and sharpinterface relations,and includes grain boundary diffusion,is adopted to investigate the morphological evolution of the ***,the efficiency of the numerical approach is ensured by establishing the volume-preserving chemical equilibrium through the incorporation TCFe8(CALPHAD)data and solving phase-field evolution in the Allen-Cahn *** morphological evolution of the rod in the representative multiphase system exhibits a unique transformation mechanism which is significantly different from the evolution of an isolated *** is realised that,in a polycrystalline arrangement,irrespective of the initial size of the rod,the shape-change begins with the energy-minimising events at the triple *** early transformation renders a characteristic morphology at the longitudinal ends of the structure,which introduces sufficient driving-force through the curvature-difference for the subsequent morphological *** continued mass transfer to the terminations,ultimately,breaks-off the rod into separate entities that are entangled in the grain *** increase in the aspect ratio of the rod,it is identified that the source of mass transfer,which turns into the ovulation site,shifts from the *** increases the number of fragmentation events and introduces satellite *** size of the satellite particle is dictated by a definite ovulation criterion,which is ascertained by examining the transformation of different-sized rods.A comprehensive understanding of the transformation kinetics and mechanism governing the mo

关键词： Shape instability Pearlite spheroidization Sub-critical annealing Phase-field simulations

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Management of decompensated liver cirrhosis in the surgical intensive care unit

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Hepatobiliary Surgery and Nutrition 2023年第1期12卷 95-98页

作者： Philipp Kasper tobias Goeser Department of Gastroenterology and Hepatology Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany

Liver cirrhosis is the end-stage of chronic progressive liver diseases(1).The most common causes of cirrhosis worldwide include alcohol-related liver disease,non-alcoholic fatty liver disease,hepatitis B,hepatitis C,autoimmune liver diseases(e.g.,autoimmune hepatitis),cholestatic liver diseases(e.g.,primary biliary cholangitis,primary sclerosing cholangitis),hemochromatosis or Wilsons’disease(1).

关键词： Liver cirrhosis complications decompensation surgery critical care medicine

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Cytotoxic innate lymphoid cells sense tumor-derived IL-15: a novel mechanism of cancer immunosurveillance

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Signal Transduction and Targeted Therapy 2022年第10期7卷 3628-3629页

作者： tobias Franz Jonas Negele Sascha Kahlfuss Institute of Molecular and Clinical Immunology Medical FacultyOtto-von-Guericke University MagdeburgMagdeburgGermany Institute of Medical Microbiology and Hospital Hygiene Medical FacultyOtto-von-Guericke University MagdeburgMagdeburgGermany Health Campus Immunology Infectiology and Inflammation(GCI3)Medical FacultyOtto-Von-Guericke University MagdeburgMagdeburgGermany Center for Health and Medical Prevention(CHaMP) Otto-von-Guericke-UniversityMagdeburgGermany

Recently,Li and colleagues provided in Nature immunology1 a novel mechanism of immunosurveillance in epithelial tumors,in which cytotoxic innate lymphoid cells(ILCs)sense IL-15 secreted by the tumor *** the adaptive immune system,including CD8+cytotoxic lymphocytes(CTLs),and innate immune cells such as Natural Killer(NK)cells are capable of providing antitumor immunity through the release of perforins and *** addition,also cytotoxic group 1 innate lymphoid cells(ILC1s)were reported to exert NK cell-like antitumor cell cytotoxicity.

关键词： lymphoid immunity mechanism

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Activated microglia nibbling glycosaminoglycans from spinal cord perineural nets: a new mechanism for neuropathic pain

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Signal Transduction and Targeted Therapy 2022年第10期7卷 3632-3634页

作者： Christa E.Muller tobias Claff PharmaCenter Bonn and Pharmaceutical Institute Pharmaceutical&Medicinal ChemistryUniversity of BonnAn der Immenburg 453121 BonnGermany

n a recent study published in Science,1 Tansley,Khoutorsky et *** a novel mechanism by which activated microglia can induce pain and pain *** involves the degradation of perineural nets(PNNs)around neurons in the spin... 详细信息

关键词： pain al. neural

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Polymeric photonic molecule super-mode lasers on silicon

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Light(Science & Applications) 2013年第1期2卷 150-153页

作者： tobias Grossmann tobias Wienhold Uwe Bog Torsten Beck Christian Friedmann Heinz Kalt Timo Mappes Institute of Applied Physics and DFG Center for Functional Nanostructures CFN Karlsruhe Institute of Technology76128 KarlsruheGermany Institute of Microstructure Technology Karlsruhe Institute of Technology76128 KarlsruheGermany Institute of Functional Interfaces Karlsruhe Institute of Technology76128 KarlsruheGermany Carl Zeiss AG Corporate Research and Technology07745 JenaGermany

Optically coupled microcavities have emerged as photonic structures with promising properties for investigation of fundamental science as well as for *** report on the fabrication and spatially resolved spectroscopy of on-chip photonic molecule(PM)lasers consisting of two coupled,dye-doped polymeric microdisks on a silicon *** investigate the fundamental lasing properties with focus on the spatial distribution of modes,the coupling dependent suppression of lasing modes,and in particular the application-oriented operation of these devices in aqueous *** depositing an additional polymer layer onto the lithographically structured cavities made of dye-doped poly(methyl methacrylate),coupling-gap widths below 150 nm with aspect ratios of the micro-/nanostructure exceeding 9:1 are *** enables strong optical coupling at visible wavelengths despite relatively small resonator radii of 25 μ*** lasing properties of dye-doped PMs are investigated using spatially resolved micro-photoluminescence(μ-PL)*** technique allows for the direct imaging of whispering-gallery modes(WGMs)in the photonics *** subwavelength coupling gaps,we observe lasing from delocalized eigenstates of the PMs(termed in the following as super-modes).Using size-mismatched cavities,the lasing mode suppression for different coupling-gap widths is *** further demonstrate single-mode lasing operation in aqueous environments with PMs,which are realized on a low-cost,polymer-on-silicon platform.

关键词： microcavity lasers photonic molecules visible lasers whispering-gallery modes

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Blood-brain barrier modeling: challenges and perspectives

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Neural Regeneration Research 2015年第6期10卷 889-891页

作者： tobias Ruck Stefan Bittner Sven G.Meuth Department of Neurology University of Münster

The blood-brain barrier （BBB） forms a highly selective inter- face between blood and brain. Extensive research efforts have completely changed our view of the BBB in the last years, from a static, impermeable barrier to a dynamic, highly regulated and specific cellular system. The BBB ultrastructurally consists of specialized brain microvascular endothelial cells （BMEC） characterized by low pinocytic activity,

关键词： BBB cell Blood-brain barrier modeling challenges and perspectives ECM

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Fast repetition rate fs pulsed lasers for advanced PLIM microscopy

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Journal of Innovative Optical Health Sciences 2019年第5期12卷 86-94页

作者： Sviatlana Kalinina Alexander Jelzow tobias Plotzing Angelika Rück University of Ulm Core Facility Confocal and Multiphoton MicroscopyN24 Albert-Einstein-Allee 1189081 UlmGermany Becker&Hickl GmbH Nahmitzer Damm 3012277 BerlinGermany Laser Quantum GmbH Max-Stromeyer-Str.11678467 KonstanzGermany

Simultaneous metabolic and oxygen imaging is promising to follow up therapy response,dis-ease development and to determine prognostic *** of metabolic coenzymes is now widely accepted to be the most reliable method to determine cellular ***,oxygen consumption has to be taken into account to understand treatment *** phosphorescence lifetimne of oxygen sensors is able to indicate local oxygen *** phosphorescence lifetime imaging(PLIM)dyes based on ruthenium(I)coordination com-plexes are useful,in detaill TLD1433 which possesses a variety of different triplet states,enables complex photochemistry and redox *** is usally reached by two photon exci-tation of the drug with a femtosecond(fs)pulsed Ti:Sapphire laser working at 80 MHz repe-tition rate and(time-correlated single photon counting)(TCSPC)detection *** interesting question was whether it is possible to follow up PLIM 1using faster repetition *** repetition rates could be advantageous for the induction of specific photochemical reactions because of similar light doses used normally in standard CW light *** this,a default 2p-FLIM-PLIM system was expanded by adding a second fs pulsed laser("helixx")which provides 50 fs pulses at a repetition rate of 250 MHz,more than 2.3 w average power and tunable from 720 nm to 920 *** laser beam was coupled into the AOM instead of the default 80 MHz *** demonstrated siuccessful applications of the 250 MHz laser for PLIM which correlates well with measurements done by excitation with the conventional 80MHx laser source.

关键词： Multiphoton microscopy axygen consumption phosphorescence lifetime microscopy fast repetition rate excitation short laser pulses Ru(I)complexes

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Health care in light of different theories of health——A proposed framework for integrating a social humanistic perspective into health care

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Journal of Integrative Medicine 2019年第5期17卷 321-327页

作者： Lena Gronblom Lundstrom Ulrika Aasa Yan Zhang tobias Sundberg Physiotherapy Unit Department of Community Medicine and RehabilitationUmea University90187 UmeaSweden Harris College o f Nursing and Health Sciences Texas Christian UniversityFort WorthTX 76109USA Australian Research Centre in Complementary and Integrative Medicine (ARCCIM) Faculty of HealthUniversity of Technology SydneyUltimoNSW 2007Australia Musculoskeletal and Sports Injury Epidemiology Center (MUSIC) Institute of Environmental MedicineKarolinska Institutet111 77 StockholmSweden

The objective of this paper is to provide an overview of the biomedical,the biopsychosocial, and the social humanistic theories of health and to propose a framework for integrating the latter into health care. In summary, the definitions of health, illness and disease are essential to the practice of health care and play fundamental roles in how patients’ experiences of being ill are valued and assessed within health care systems. Principally, the biomedical perspective proceeds from pathoanatomical deficiencies defining disease and malfunction;the addition of psychosocial components forms a biopsychosocial *** addition, the social humanistic perspective extends from a person’s will, their ability to act, and the possibility to fulfill wanted actions. Thus, health care that does not address the social humanistic perspective may lack the power to describe how these entities are related to the patient on a personal level;thus,the will of the patient is not always fully addressed. Importantly, by targeting the will of the patient and the patient’s ability to act, the proposed framework of integrating a social humanistic perspective into health care may further emphasize and strengthen the interrelatedness of medical perspectives. A framework for integrating a social humanistic perspective into health care is proposed and its potential impact on health care is discussed.

关键词： Theoretical models Biomedical Biopsychosocial Social humanistic Review

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