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Proton pump inhibitors and all-cause mortality risk among cancer patients

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World Journal of Clinical Oncology 2025年第1期16卷 34-42页

作者： Arunkumar Krishnan Carolin Victoria schneider Declan Walsh Department of Supportive Oncology Atrium Health Levine CancerCharlotteNC 28204United States Department of medicine Section of Hematology and OncologyWake Forest University School of MedicineWinston-SalemNC 27101United States Department of medicine Ⅲ GastroenterologyMetabolic Diseasesand Intensive CareUniversity Hospital RWTH AachenAachen 52074Germany

BACKGROUND Proton pump inhibitors(PPIs)are widely used,including among cancer patients,to manage gastroesophageal reflux and other gastric acid-related *** evidence suggests associations between long-term PPI use and higher risks for various adverse health outcomes,including greater *** To investigate the association between PPI use and all-cause mortality among cancer patients by a comprehensive analysis after adjustment for various confounders and a robust methodological approach to minimize *** This retrospective cohort study used data from the TriNetX research network,with electronic health records from multiple healthcare *** study employed a new-user,active comparator design,which compared newly treated PPI users with non-users and newly treated histamine2 receptor antagonists(H2RA)users among adult cancer *** prescribed PPIs(esomeprazole,lansoprazole,omeprazole,pantoprazole,or rabeprazole)users were compared to non-users or newly prescribed H2RAs(cimetidine,famotidine,nizatidine,or ranitidine)*** primary outcome was all-cause *** patient in the main group was matched to a patient in the control group using 1:1 propensity score matching to reduce confounding *** Cox regression models were used to estimate hazard ratios(HRs)and 95% confidence interval(CI).RESULTS During the follow-up period(median 5.4±1.8 years for PPI users and 6.5±1.0 years for non-users),PPI users demonstrated a higher all-cause mortality rate than non-users after 1 year,2 years,and at the end of follow up(HRs:2.34-2.72).Compared with H2RA users,PPI users demonstrated a higher rate of all-cause mortality HR:1.51(95%CI:1.41-1.69).Similar results were observed across sensitivity analyses by excluding deaths from the first 9 months and 1-year post-exposure,confirming the robustness of these *** a sensitivity analysis,we analyzed all-cause mortality outcomes between former PPI users and individual

关键词： All-cause mortality Cancer Histamine-2 receptor antagonists mortality malignancy Proton pump inhibitors Carcinoma Outcome

Human mesenchymal stem cell morphology, migration, and differentiation on micro and nano-textured titanium

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Bioactive materials 2019年第1期4卷 249-255页

作者： Emily G.Long merve Buluk michelle B.Gallagher Jennifer m.schneider Justin L.Brown Department of Biomedical Engineering The Pennsylvania State University122 CBEB BuildingUniversity ParkPA16802USA Titan Spine Inc.Mequon Research Center6140 W.Executive DriveSuite AMequonWI53092USA

Orthopedic implants rely on facilitating a robust interaction between the implant material surface and the surrounding bone ***,the interface will encourage osseointegration with the host bone,resulting in strong fixation and implant ***,implant failure can occur due to the lack of integration with bone tissue or bacterial *** chosen material and surface topography of orthopedic implants are key factors that influence the early events following implantation and may ultimately define the success of a *** attachment,rapid migration and improved differentiation of stem cells to osteoblasts are necessary to populate the surface of biomedical implants,potentially preventing biofilm formation and implant-associated *** article explores these early stem cell specific events by seeding human mesenchymal stem cells(mSCs)on four clinically relevant materials:polyether ether ketone(PEEK),Ti6Al4V(smooth Ti),macro-micro rough Ti6Al4V(Endoskeleton®),and macro-micro-nano rough Ti6Al4V(nanoLOCK®).The results demonstrate the incorporation of a hierarchical macro-micro-nano roughness on titanium produces a stellate morphology typical of mature osteoblasts/osteocytes,rapid and random migration,and improved osteogenic differentiation in seeded *** suggests rapid coverage of a surface by stem cells coupled with stimulation of bone differentiation minimizes the opportunity for biofilm formation while increasing the rate of device integration with the surrounding bone tissue.

关键词： titanium implantation roughness

morphological stability of three-dimensional cementite rods in polycrystalline system:A phase-field analysis

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Journal of materials Science & Technology 2021年第18期77卷 252-268页

作者： tobias mittnacht P.G.Kubendran Amos Daniel schneider Britta Nestler Institute of Applied materials(IAm-CmS) Karlsruhe Institute of Technology(KIT)Strasse am Forum 776131 KarlsruheGermany Institute of Digital materials Science(IDm) Karlsruhe University of Applied SciencesMoltkestr.3076133 KarlsruheGermany Department of metallurgical and materials Engineering National Institute of TechnologyTiruchirappalli-620015Tamil NaduIndia

Transformations accompanying shape-instability govern the morphological configuration and distribution of the phases in a *** to the influence of the microstructure on the properties of a material,in the present work,the stability of three-dimensional rods in a‘representative'polycrystalline system is extensively analysed.A multiphase-field model,which recovers the physical laws and sharpinterface relations,and includes grain boundary diffusion,is adopted to investigate the morphological evolution of the ***,the efficiency of the numerical approach is ensured by establishing the volume-preserving chemical equilibrium through the incorporation TCFe8(CALPHAD)data and solving phase-field evolution in the Allen-Cahn *** morphological evolution of the rod in the representative multiphase system exhibits a unique transformation mechanism which is significantly different from the evolution of an isolated *** is realised that,in a polycrystalline arrangement,irrespective of the initial size of the rod,the shape-change begins with the energy-minimising events at the triple *** early transformation renders a characteristic morphology at the longitudinal ends of the structure,which introduces sufficient driving-force through the curvature-difference for the subsequent morphological *** continued mass transfer to the terminations,ultimately,breaks-off the rod into separate entities that are entangled in the grain *** increase in the aspect ratio of the rod,it is identified that the source of mass transfer,which turns into the ovulation site,shifts from the *** increases the number of fragmentation events and introduces satellite *** size of the satellite particle is dictated by a definite ovulation criterion,which is ascertained by examining the transformation of different-sized rods.A comprehensive understanding of the transformation kinetics and mechanism governing the mo

关键词： Shape instability Pearlite spheroidization Sub-critical annealing Phase-field simulations

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Cheap and secure metatransactions on the blockchain using hash-based authorisation and preferred batchers

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Blockchain(Research and Applications) 2023年第2期4卷 41-66页

作者： William Hughes tobias magnusson Alejandro Russo Gerardo schneider Dept.of Computer Science and Engineering University of Gothenburg41296GothenburgSweden Dept.of Computer Science and Engineering Chalmers University41296GothenburgSweden

Smart contracts are self-executing programs running in the blockchain allowing for decentralised storage and execution without a ***-chain execution is expensive,with miners charging fees for distributed execution according to a cost model defined in the *** particular,transactions have a high fixed *** present multiCall,a transaction-batching interpreter for Ethereum that reduces the cost of smart contract executions by gathering multiple users’transactions into a *** current implementation of multiCall includes the following features:the ability to emulate Ethereum calls and create transactions,both from multiCall itself and using an identity unique to the user;the ability to cheaply pay Ether to other multiCall users;and the ability to authorise emulated transactions on behalf of multiple users in a single transaction using hash-based authorisation rather than more expensive *** improves upon a previous version of *** experiments show that multiCall provides a saving between 57%and 99%of the fixed transaction cost compared with the standard approach of sending Ethereum transactions directly.

关键词： Ethereum Domain-specific language Interpreter Gas optimisation

Co-expression of CDX2 and mUC2 in gastric carcinomas: Correlations with clinico-pathological parameters and prognosis

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World Journal of Gastroenterology 2005年第21期11卷 3182-3188页

作者： Kristina Roessler Stefan P.m(o|¨)nig Paul m.schneider Franz-Georg Hanisch Stephanie Landsberg Juergen Thiele Arnulf H.H(o|¨)lscher Hans P.Dienes Stephan E.Baldus Institute of Pathology University of Cologne 50931 Cologne Germany Department of Visceral and Vascular Surgery University of Cologne 50931 Cologne Germany Center of Biochemistry University of Cologne Cologne Germany Institute of Pathology University of Cologne 50931 CologneGermany Department of Visceral and Vascular Surgery University of Cologne 50931 Cologne Germany

AIm: To evaluate the role of CDX2 homeobox protein as a predictor for cancer progression and prognosis as well as its correlation with mUC2 expression. CDX2 represents a transcription factor for various intestinal genes (including mUC2) and thus an important regulator of intestinal differentiation, which could previously be identified in gastric carcinomas and intestinal metaplasia. mETHODS: Formalin-fixed and paraffin-embedded tissues from 190 gastric carcinoma patients were stained with monodonal antibodies recognizing CDX2 and mUC2, respectively. Immunoreactivity was evaluated semiquantitatively and statistical analyses including x2 tests, uni- and multi-variate survival analyses were performed. RESULTS: CDX2 was mostly expressed in a nuclear or supranuclear pattern,whereas mUC2 showed an almost exclusive supranuclear *** antigens were present in >80% of areas exhibiting intestinal metaplasia. An immunoreactivity in >5% of the tumor area was observed in 57% (CDX2) or in 21% (mUC2) of the *** presence of both molecules did not correlate with WHO, Lauren and Goseki classification (with the exception of a significantly stronger mUC2 expression in mucinous tumors). CDX2 correlated with a lower pT and pN stage in the subgroups of intestinal and stage I cancers and was associated with mUC2 positivity.A prognostic impact of CDX2 or mUC2 was not observed. CONCLUSION: CDX2 and mUC2 play an important role in the differentiation of normal, inflamed, and neoplastic gastric tissues. According to our results, loss of CDX2 may represent a marker of tumor progression in early gastric cancer and carcinomas with an intestinal phenotype.

关键词： CDX2 mUC2 monoclonal antibody Gastric carcinoma Prognosis

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Ⅲ类mHC基因及补体多态现象的复杂性

中国免疫学杂志 1990年第3期 187-189页

作者： Christian Rittner ,Peter m.schneider ,赵修竹

1989年7月27日到29日在mainz六届补体遗传会议及在柏林免疫学会议上,来自23个国家的一个遗传学小组成员对Ⅲ类mHC基因及补体多态现象的复杂性进行了讨论.Ⅲ类基因不仅包括补体,还有其它座位,如肿瘤坏死因子(TNF)α及β、21羟化(?)(21—O... 详细信息

1989年7月27日到29日在mainz六届补体遗传会议及在柏林免疫学会议上,来自23个国家的一个遗传学小组成员对Ⅲ类mHC基因及补体多态现象的复杂性进行了讨论.Ⅲ类基因不仅包括补体,还有其它座位,如肿瘤坏死因子(TNF)α及β、21羟化(?)(21—OH)A及B、热休克蛋白70(HSP70)的重复基因,它们并无功能的相关性。除此之外,补体基因座位也见于染色体1(H,C4BP,CR1,C8A和B)染色体9(C8G)及染色体19(C3)。可能由于发生学、缺乏症及疾病等方面的原因,与mHC连锁的补体基因仍然吸引着众多人的重视.这些研究已成为中性论者(***,Tubingen)与选择论者(T.m(?)o,巴黎)思考的主题.

关键词： mHC 多态现象单倍型单元型同种型基因

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

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SBL-JP-0004:A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology Research 2025年第1期33卷 235-243页

作者： HASSAN m.OTIFI Department of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(GC)remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in GC progression,making them attractive targets for therapeutic ***:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 GC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by molecular docking scores and molecular dynamics *** interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target ***-JP-0004 displayed an half-maximal inhibitory concentration(IC_(50))value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-maximal growth inhibitory concentration(GI50)values of 250.8 and 516.3 nm,respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatment compared to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(GC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 molecular docking molecular dynamics simulation

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

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