检索结果-南通市图书馆

Modularization of adhesion G protein-coupled receptor(aGPCR)structure:how alternative splicing regulates synaptogenesis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第5期9卷 1793-1795页

作者： tobias Langenhan Rudolf Schönheimer Institute of Biochemistry Division of General BiochemistryMedical FacultyLeipzig UniversityLeipzigGermany Comprehensive Cancer Center Central Germany(CCCG) Leipzig UniversityLeipzigGermany Institute of Biology Faculty of Life SciencesLeipzig UniversityLeipzigGermany

A recent report has uncovered a fascinating aspect of how neurons utilize alternative splicing of transcripts of an adhesion G protein-coupled receptor(aGPCR)gene to serve specific functions in the life of a synapse.1 The work provides significant insight into the ability of cells to support distinct biochemical and physiological operations through post-transcriptional processing of genetic information that is encoded in a single aGPCR locus.

关键词： GPCR utilize operations

重症医疗病房中的谵妄无论是否致命，在世界范围内谵妄对患者都是一个严重威胁

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

英国医学杂志中文版 2015年第3期18卷 125-126页

作者： Valene J Page tobias kurth 姜南彭斌 Intensive Care Unit Wafford GeneralHospital WaffordWD18 0HB UK Inserm ResearchCenter forEpidemiology andBiostatistics TeamNeuroepidemiologyBordeaux France 北京协和医院神经科

最近几年，人们对重症医疗病房（ICU）中患者谵妄的关注度快速上升。考虑到谵妄很常见，尤其是机械通气的患者中十分常见，于是一个问题被反复提及：“谵妄会直接增加患者的死亡率吗？抑或仅仅是一个伴发现象？”在一篇文章中（见本期第... 详细信息

最近几年，人们对重症医疗病房（ICU）中患者谵妄的关注度快速上升。考虑到谵妄很常见，尤其是机械通气的患者中十分常见，于是一个问题被反复提及：“谵妄会直接增加患者的死亡率吗？抑或仅仅是一个伴发现象？”在一篇文章中（见本期第126页；doi：10．1136／bmj．g6652）Klein Klouwenberg和他的同事们尝试回答了这个问题。在他们的前瞻性队列研究中，作者使用了复杂的统计模型以证明谵妄可能不直接增加病死率，这推翻了以往的大规模观察性研究的结论。

关键词：重症监护世界性患者威胁

痴呆能预防吗？存在可控的危险因素，但采取针对性的公众卫生措施尚无依据

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

英国医学杂志中文版 2011年第1期14卷 8-9页

作者：杨莹雪(译) 王玉平(校) tobias kurth 首都医科大学宣武医院神经内科

认知功能下降和痴呆不仅对人类健康构成重大威胁，也是家庭及社会的负担，据估计，其发病率在全球范围内将有所增加^1。由于缺乏有效的治疗措施，采取能够防止或延缓痴呆发生的预防措施十分必要。但是在此之前，我们应确定需要干预的因... 详细信息

认知功能下降和痴呆不仅对人类健康构成重大威胁，也是家庭及社会的负担，据估计，其发病率在全球范围内将有所增加^1。由于缺乏有效的治疗措施，采取能够防止或延缓痴呆发生的预防措施十分必要。但是在此之前，我们应确定需要干预的因素及干预人群。

关键词：痴呆危险因素预防可控卫生公众取针认知功能下降

Extension of Flow Behaviour and Damage Models for Cast Iron Alloys with Strain Rate Effect

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2024年第3期37卷 297-310页

作者： Chuang Liu Dongzhi Sun Xianfeng Zhang Florence Andrieux tobias Gersterc School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China Fraunhofer Institute for Mechanics of Materials(IWM) 79108 FreiburgGermany Fraunhofer Institute for High Speed Dynamics Ernst-Mach-Institute(EMI)79104 FreiburgGermany

Cast iron alloys with low production cost and quite good mechanical properties are widely used in the automotive *** study the mechanical behavior of a typical ductile cast iron(GJS-450)with nodular graphite,uni-axial quasi-static and dynamic tensile tests at strain rates of 10^(-4),1,10,100,and 250 s^(-1)were carried *** order to investigate the influence of stress state on the deformation and fracture parameters,specimens with various geometries were used in the *** strain curves and fracture strains of the GJS-450 alloy in the strain rate range of 10^(-4)to 250 s^(-1)were obtained.A strain rate-dependent plastic flow model was proposed to describe the mechanical behavior in the corresponding strain-rate *** available damage model was extended to take the strain rate into account and calibrated based on the analysis of local fracture *** with the proposed plastic flow model and the damage model were conducted to observe the deformation and fracture *** results show that the strain rate has obviously nonlinear effects on the yield stress and fracture strain of GJS-450 *** predictions with the proposed plastic flow and damage models at various strain rates agree well with the experimental results,which illustrates that the rate-dependent plastic flow and damage models can be used to describe the mechanical behavior of cast iron alloys at elevated strain *** proposed plastic flow and damage models can be used to describe the deformation and fracture analysis of materials with similar properties.

关键词： Dynamic behavior of materials Strain rate dependency Damage model Voce model Cast iron

Ab initio density response and local field factor of warm dense hydrogen

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Matter and Radiation at Extremes 2024年第5期9卷 48-67页

作者： tobias Dornheim Sebastian Schwalbe Panagiotis Tolias Maximilian P.Böhme Zhandos A.Moldabekov Jan Vorberger Center for Advanced Systems Understanding(CASUS) D-02826 GörlitzGermany Helmholtz-Zentrum Dresden-Rossendorf(HZDR) D-01328 DresdenGermany Space and Plasma Physics Royal Institute of Technology(KTH)Stockholm SE-10044Sweden Technische Universität Dresden D-01062 DresdenGermany

We present quasi-exact ab initio path integral Monte Carlo(PIMC)results for the partial static density responses and local field factors of hydrogen in the warm dense matter regime,from solid density conditions to the strongly compressed *** full dynamic treatment of electrons and protons on the same footing allows us to rigorously quantify both electronic and ionic exchange–correlation effects in the system,and to compare the results with those of earlier incomplete models such as the archetypal uniform electron gas or electrons in a fixed ion snapshot potential that do not take into account the interplay between the two *** full electronic density response is highly sensitive to electronic localization around the ions,and our results constitute unambiguous predictions for upcoming X-ray Thomson scattering experiments with hydrogen jets and fusion *** PIMC results are made freely available and can be used directly for a gamut of applications,including inertial confinement fusion calculations and the modeling of dense astrophysical ***,they constitute invaluable benchmark data for approximate but computationally less demanding approaches such as density functional theory or PIMC within the fixed-node approximation.

关键词： local incomplete rigorous

Hyper spectral resolution stimulated Raman spectroscopy with amplified fs pulse bursts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2024年第3期13卷 566-576页

作者： Hongtao Hu tobias Flöry Vinzenz Stummer Audrius Pugzlys Markus Zeiler Xinhua Xie Aleksei Zheltikov Andrius Baltuška Photonics Institute Technische Universität WienGußhausstraße 27-29Vienna A-1040Austria SwissFEL Paul Scherrer InstituteVilligen PSI 5232Switzerland Institute for Quantum Science and Engineering Department of Physics and AstronomyTexas A&M UniversityCollege StationTX 77843USA

We present a novel approach for Stimulated Raman Scattering(SRS)spectroscopy in which a hyper spectral resolution and high-speed spectral acquisition are achieved by employing amplified offset-phase controlled fs-pulse *** investigate the method by solving the coupled non-linear Schrödinger equations and validate it by numerically characterizing SRS in molecular nitrogen as a model *** spectral resolution of the method is found to be determined by the inverse product of the number of pulses in the burst and the intraburst pulse *** SRS spectrum is obtained through a motion-free scanning of the offset phase that results in a sweep of the Raman-shift *** to high spectral resolution and fast motion-free scanning the technique is beneficial for a number SRS-based applications such as gas sensing and chemical analysis.

关键词： compound spectral resolution

The Structure of Gravity Funnels and Stability Considerations of Matter in SI Units

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of High Energy Physics, Gravitation and Cosmology 2024年第1期10卷 71-81页

作者： tobias Bartusch Bartusch Plasma and Vacuum Kissing Germany

This article describes an extension of the theory of vortices to electromagnetic types with a start point from known fluid systems. From this, properties of gravity-generating objects (particles and black holes) can be derived, which can also describe their possible interior. This also leads to questions about stability, which are then addressed and ultimately lead to considerations of black holes and their possible internal structure. The results fit into the observable areas and can also be directly verified because they were analytically calculated in SI units.

关键词： Black Hole Dark Matter Electromagnetic Gravity Singularity Vortex

Calcium channels caught in peripheral glia’s tug-of-war on axon regeneration in Drosophila

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 475-476页

作者： Jackson Powell tobias Steinschaden Rose Horowitz Yuanquan Song Raymond G.Perelman Center for Cellular and Molecular Therapeutics The Children’s Hospital of PhiladelphiaPhiladelphiaPAUSA The Neuroscience Graduate Group University of PennsylvaniaPhiladelphiaPAUSA Department of Pathology and Laboratory Medicine University of PennsylvaniaPhiladelphiaPAUSA Medical University of Vienna Center for Brain ResearchDepartment of NeuroimmunologyViennaAustria

Neural damage or degeneration is at the crux of many diseases,and treatment of these diseases will require the development of therapeutics to enhance and guide neural *** intrinsic and extrinsic factors dictate a neuron’s ability to regenerate,and the combination of these factors results in the great regenerative capacity of the peripheral nervous system(PNS)and the poor regenerative capacity of the central nervous system(CNS)following *** the core of a neuron’s function is its ability to relay electrochemical signals,and a neuron’s excitability is a key factor in its ability to *** works have focused on the changes in neuronal electrophysiological properties,firing patterns,and ion flux after injury,which differentially activate signaling pathways at the core of *** role of glia in neuron regeneration has long been studied.

关键词： degeneration firing system

Development of a Framework for Equipment Health Management in the Mining Industries in Zambia

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Engineering and Technology 2024年第3期12卷 665-694页

作者： tobias Njobvu Terence Malama Department of Agricultural Engineering The University of Zambia Lusaka Zambia Technology Development and Advisory Unit (TDAU) The University of Zambia Lusaka Zambia

The Zambian mining industry is crucial to the national economy but struggles with inconsistent equipment maintenance practices. This study developed an Equipment Maintenance Management Framework (EMMF) tailored to the industry’s needs. Using surveys, interviews, and on-site visits at eight major mining companies, we identified significant variations in maintenance strategies, CMMS usage, and reliability engineering. The EMMF prioritizes predictive maintenance, efficient CMMS implementation, ongoing training, and robust reliability engineering to shift from reactive to proactive maintenance. We recommend adopting continuous improvement practices and data-driven decision-making based on performance metrics, with a phased EMMF implementation aligning maintenance with strategic business objectives. This framework is poised to enhance operational efficiency, equipment reliability, and safety, fostering sustainable growth in the Zambian mining sector.

关键词： Equipment Maintenance Management Framework (EMMF) Computerized Maintenance Management System (CMMS) Preventive Maintenance Predictive Maintenance Data Analytics