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Critical quality indicators of high-performance polyetherimide(ULTEM)over the MEX 3D printing key generic control parameters:Prospects for personalized equipment in the defense industry

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Defence Technology(防务技术) 2025年第1期43卷 150-167页

作者： Nectarios Vidakis Markos Petousis Constantine David Nektarios k.Nasikas Dimitrios Sagris Nikolaos Mountakis Mariza Spiridaki Amalia Moutsopoulou Emmanuel Stratakis Dept.of Mechanical Engineering Hellenic Mediterranean UniversityHeraklion 71410Greece Dept.of Mechanical Engineering International Hellenic UniversitySerres Campus 62124Greece Division of Mathematics and Engineering Sciences Department of Military SciencesHellenic Army AcademyGR 16673VariAtticaGreece Institute of Electronic Structure and Laser(IESL) Foundation for Research and Technology(FORTH)N.Plastira 100Vassilika Vouton 70013HeraklionCreteGreece Qingdao Innovation and Development Center Harbin Engineering UniversityQingdao 266000China

Additive Manufacturing(AM)can provide customized parts that conventional techniques fail to *** important parameter in AM is the quality of the parts,as a result of the material extrusion 3D printing(3D-P)*** can be very important in defense-related applications,where optimum performance needs to be *** quality of the Polyetherimide 3D-P specimens was examined by considering six control parameters,namely,infill percentage,layer height,deposition angle,travel speed,nozzle,and bed *** quality indicators were the root mean square(Rq)and average(Ra)roughness,porosity,and the actual to nominal dimensional *** examination was performed with optical profilometry,optical microscopy,and micro-computed tomography *** Taguchi design of experiments was applied,with twenty-five runs,five levels for each control parameter,on five *** additional confirmation runs were conducted,to ensure *** equations were constructed to express the quality indicators in terms of the control *** modeling approaches were applied to the experimental data,to compare their efficiency,i.e.,Linear Regression Model(LRM),Reduced Quadratic Regression Model,and Quadratic Regression Model(QRM).QRM was the most accurate one,still the differences were not high even considering the simpler LRM model.

关键词： Polyetherimide(PEI) Material extrusion(MEX) Three-dimensional printing(3D-P) Critical quality indicators(CQIs) Quadratic regression model(QRM) Taguchi

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Targeting the EGF receptor family in non-small cell lung cancerincreased complexity and future perspectives

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Cancer Biology & Medicine 2022年第11期19卷 1543-1564页

作者： tobias Boch Jens kohler Melanie Janning Sonja Loges DkFZ-Hector Cancer Institute at the University Medical Center Mannheim Mannheim 68135Germany Division of Personalized Medical Oncology(A420) German Cancer Research Center(DKFZ)Heidelberg 69120Germany Department of Personalized Oncology University Medical Center MannheimMedical Faculty MannheimHeidelberg UniversityMannheim 68135Germany

Lung cancer remains the leading cause of cancer-associated mortality worldwide,but with the emergence of oncogene targeted therapies,treatment options have tremendously *** to their biological relevance,members of the ERBB receptor family,including the EGF receptor(EGFR),HER2,HER3 and HER4,are among the best studied oncogenic *** EGFR mutations are frequently observed in non-small cell lung cancer(NSCLC),and small molecule tyrosine kinase inhibitors(TkIs)are the established first line treatment option for patients whose tumors bear"typical/classical"EGFR mutations(exon 19 deletions,L858R point mutations).Additionally,new TkIs are rapidly evolving with better efficacy to overcome primary and secondary treatment resistance(e.g.,that due to T790M or C797S resistance mutations).Some atypical EGFR mutations,such as the most frequent exon 20 insertions,exhibit relative resistance to earlier generation TkIs through steric *** this subgroup,newer TkIs,such as mobocertinib and the bi-specific antibody amivantamab have recently been approved,whereas less frequent atypical EGFR mutations remain *** contrast to EGFR,HER2 has long remained a challenging target,but better structural understanding has led to the development of newer generations of *** recent FDA approval of the antibody-drug conjugate trastuzumab-deruxtecan for pretreated patients with HER2 mutant NSCLC has been an important therapeutic ***3 and HER4 also exert oncogenic potential,and targeted treatment approaches are being developed,particularly for ***,strategies to inhibit the oncogenic function of ERBB receptors in NSCLC are currently evolving at an unprecedented pace;therefore,this review summarizes current treatment standards and discusses the outlook for future developments.

关键词： Oncology NSCLC EGFR HER2 HER3 HER4

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Detectability of Discrete Event Systems Under Sensor Attacks

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Journal of Systems Science & Complexity 2025年第01期 150-177页

作者： RITSUkA k. LIN Feng LAFORTUNE Stéphane WANG Caisheng Department of Electrical Engineering and Computer Science University of Michigan Department of Electrical and Computer Engineering Wayne State University

The authors consider the property of detectability of discrete event systems in the presence of sensor attacks in the context of cyber-security. The authors model the system using an automaton and study the general notion of detectability where a given set of state pairs needs to be(eventually or periodically) distinguished in any estimate of the state of the system. The authors adopt the ALTER sensor attack model from previous work and formulate four notions of CA-detectability in the context of this attack model based on the following attributes: strong or weak; eventual or periodic. The authors present verification methods for strong CA-detectability and weak CA-detectability. The authors present definitions of strong and weak periodic CA-detectability that are based on the construction of a verifier automaton called the augmented CA-observer. The development also resulted in relaxing assumptions in prior results on D-detectability, which is a special case of CA-detectability.

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Unveiling the impact:COVID-19's influence on bacterial resistance in the kingdom of Bahrain

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World Journal of Virology 2025年第1期14卷 83-98页

作者： Nermin k Saeed Safiya k Almusawi Noor A Albalooshi Mohammed Al-Beltagi Medical Microbiology Section Department of PathologySalmaniya Medical ComplexGovernmental HospitalsManama 12Bahrain Medical Microbiology Section Department of PathologyRoyal College of Surgeons in Ireland-Medical University of BahrainBusaiteen 15503MuharraqBahrain Department of Paediatrics Faculty of MedicineTanta UniversityTanta 31511AlghrabiaEgypt Department of Pediatric University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671AlgharbiaBahrain

BACkGROUND Antibiotic resistance is a growing global health threat,and understanding local trends in bacterial isolates and their susceptibility patterns is crucial for effective infection control and antimicrobial *** coronavirus disease 2019(COVID-19)pandemic has introduced additional complexities,potentially influencing these *** To analyze trends in bacterial isolates and their antibiotic susceptibility patterns at Salmaniya Medical Complex from 2018 to 2023,with a specific focus on the impact of the COVID-19 pandemic on these *** A retrospective analysis of microbiological data was conducted,covering the period from 2018 to *** study included key bacterial pathogens such as Escherichia coli(***),klebsiella pneumoniae,Acinetobacter baumannii,Pseudomonas aeruginosa,and Staphylococcus aureus,among *** antibiotic susceptibility profiles of these isolates were assessed using standard laboratory *** contextualize the findings,the findings were compared with similar studies from other regions,including China,India,Romania,Saudi Arabia,the United Arab Emirates,Malaysia,and United *** The study revealed fluctuating trends in the prevalence of bacterial isolates,with notable changes during the COVID-19 *** example,a significant increase in the prevalence of Staphylococcus aureus was observed during the pandemic years,while the prevalence of *** showed a more variable *** resistance rates varied among the different pathogens,with a concerning rise in resistance to commonly used antibiotics,particularly among klebsiella pneumoniae and ***,the study identified an alarming increase in the prevalence of multidrug-resistant(MDR)strains,especially within klebsiella pneumoniae and *** *** impact of the COVID-19 pandemic on these trends was evident,with shifts in the frequency,resistance patterns,and the emergence of MDR bacteria among several key ***

关键词： Multidrug-resistant organisms Antibiotic susceptibility COVID-19 pandemic Antimicrobial stewardship Bacterial isolates Salmaniya Medical Complex Bahrain

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Distributed Mallows Model Averaging for Ridge Regressions

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Acta Mathematica Sinica,English Series 2025年第2期41卷 780-826页

作者： Haili Zhang Alan T.k.Wan kang You Guohua Zou School of Undergraduate Education Shenzhen Polytechnic UniversityShenzhen 518055P.R.China Department of Management Sciences and School of Data Science City University of Hong KongKowloonHong Kong 999077P.R.China School of Mathematical Sciences Capital Normal UniversityBeijing 100048P.R.China

Ridge regression is an effective tool to handle multicollinearity in *** is also an essential type of shrinkage and regularization methods and is widely used in big data and distributed data *** divide and conquer trick,which combines the estimator in each subset with equal weight,is commonly applied in distributed *** overcome multicollinearity and improve estimation accuracy in the presence of distributed data,we propose a Mallows-type model averaging method for ridge regressions,which combines estimators from all *** method is proved to be asymptotically optimal allowing the number of subsets and the dimension of variables to be *** consistency of the resultant weight estimators tending to the theoretically optimal weights is also ***,the asymptotic normality of the model averaging estimator is *** simulation study and real data analysis show that the proposed model averaging method often performs better than commonly used model selection and model averaging methods in distributed data cases.

关键词： Asymptotic normality asymptotic optimality consistency distributed data Mallows model averaging ridge regression

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Second-generation trabecular micro-bypass stent implantation: Retrospective analysis after 12- and 24-month follow-up

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Eye and Vision 2020年第1期7卷 1-10页

作者： Raphael Neuhann tobias Neuhann Neuhann Augentagesklinik MarienplatzMarienplatz 18-1980331 MunichGermany

Background:The study aimed to investigate the 24-month safety and efficacy of implantation of two secondgeneration iStent inject trabecular micro-bypass stents with concomitant cataract ***:This consecutive case series included 164 eyes of 109 patients implanted with the iStent inject®device with concomitant cataract *** series was comprised of eyes with primary open-angle glaucoma(n=84),pseudoexfoliation glaucoma(n=42),normal-tension glaucoma(n=18),and ocular hypertension(n=20).All 164 eyes reached 9–14 months of follow-up(“12-month consistent cohort”),with a subset of 88 eyes reaching 21–26 months of follow-up(“24-month consistent cohort”).Performance outcome measures included intraocular pressure(IOP)and number of glaucoma *** outcomes included intra-or postoperative complications,the need for secondary procedures and corrected distance visual *** of change in continuous(e.g.,IOP)and categorical(e.g.,proportions of eyes on zero medications)measures between baseline and postoperative times were made with the paired t-test and McNemar’s chi-squared test,***:At 12 months postoperatively,IOP was reduced by 25.5%(from 20.0±5.5 mmHg to 14.9±2.0 mmHg;p<0.001);at 24 months postoperatively,IOP was reduced by 26.6%(from 20.3±6.1 mmHg to 14.9±1.9 mmHg;p<0.001).At 12 months postoperatively,mean number of glaucoma medications was reduced by 85.0%(from 2.0±1.0 to 0.3±0.8 medications;p<0.001);at 24 months postoperatively,mean number of medications was reduced by 81.0%(from 2.1±1.1 to 0.4±0.8 medications;p<0.001).After 12 months,96.3%of eyes had an IOP≤18 mmHg and 58.5%of eyes had an IOP≤15 mmHg,with 81.1%of eyes free of any medication,compared to 1.8%of eyes medication-free in the 12-month cohort at *** 24 months,98.9%of eyes had an IOP≤18 mmHg and 53.4%of eyes had an IOP≤15 mmHg,with 72.7%free of medication compared to 1.1%of eyes medication-free in the 24-month cohort at ***,a high safe

关键词： Glaucoma MIGS IStent inject Trabecular Safety Stent Bypass

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Perioperative neurocognitive dysfunction and role of dexmedetomidine in radical colon cancer surgery in elderly patients

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World Journal of Gastrointestinal Surgery 2025年第3期17卷 6-13页

作者： Chandra k Pandey Abhishek kumar Department of Anaesthesiology Medanta Hospital LucknowLucknow 226030Uttar PradeshIndia Department of Anaesthesia King George Medical UniversityLucknow 226003Uttar PradeshIndia

This article explored the application of dexmedetomidine(Dex),a highly selective alpha-2 agonist,in managing postoperative cognitive dysfunction(POCD)in elderly patients undergoing radical colon cancer *** is associated with a progressive decline in physiological functions and an increased risk of adverse surgical outcomes,including POCD,which encompasses many neurocognitive disorders that manifest during the perioperative *** aging population is at a higher risk for POCD,which can lead to prolonged hospital stays,delayed recovery,and increased healthcare *** has neuroprotective,opioid-sparing,and sympatholytic properties,which reduces the incidence and severity of *** was introduced for sedation in patients receiving mechanical ventilation but has since been adopted in anesthesia due to its multifaceted *** appli-cation extends to sedation,analgesia,maintenance of anesthesia,and controlling *** neuroprotective and anti-inflammatory effects have been explored in managing *** article discussed the broad range of patient and procedure-related risk factors for *** identification and intervention are crucial to prevent the progression of POCD,which can have severe physical,psychological,and economic *** article underscored the importance of a mul-tidisciplinary approach in managing POCD,involving the optimization of comor-bidities,depth of anesthesia monitoring,hemodynamic stability,and cerebral oxygenation monitoring.

关键词： Colon cancer Dexmedetomidine General anesthesia Elderly Radical colon cancer surgery Cognitive function

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Enhanced engineering and biocidal polypropylene filaments enabling melt reduction of AgNO_(3) through PVP agent:A scalable process for the defense industry with MEX additive manufacturing

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Defence Technology(防务技术) 2025年第2期44卷 52-66页

作者： Markos Petousis Nikolaos Michailidis Vassilis Papadakis Apostolos Argyros Mariza Spiridaki Nikolaos Mountakis John Valsamos Nektarios k.Nasikas Amalia Moutsopoulou Nectarios Vidakis Department of Mechanical Engineering Hellenic Mediterranean UniversityHeraklion 71410Greece Physical Metallurgy Laboratory Mechanical Engineering DepartmentSchool of EngineeringAristotle University of ThessalonikiThessaloniki 54124Greece Centre for Research&Development of Advanced Materials(CERDAM) Centre for Interdisciplinary Research and InnovationBalkan CentreBuilding B’10th Km Thessaloniki-Thermi RoadThessaloniki 57001Greece Institute of Electronic Structure and Laser of the Foundation for Research and Technology-Hellas(IESL-FORTH)e Hellas N.Plastira 100mHeraklion 70013Greece Department of Industrial Design and Production Engineering University of West AtticaAthens 12243Greece Division of Mathematics and Engineering Sciences Department of Military SciencesHellenic Army AcademyGR 16673VariAtticaGreece

This study focused on the production of polypropylene(PP)/silver(Ag)composites via additive *** study aimed to enhance the quality of medical-grade PP in material extrusion(MEX)three-dimensional printing(3DP)by improving its mechanical properties while simultaneously adding antibacterial *** latter can find extremely important and versatile properties that are applicable in defense and security ***/Ag nanocomposites were prepared using a novel method based on a reaction occurring while mixing appropriate quantities of the starting polymers and additives,namely polyvinylpyrrolidone(PVP)as the matrix material and silver nitrate(AgNO_(3))as the *** process produced three-dimensional(3D)printed filaments,which were then used to create specimens for a series of standardized *** was found that the mechanical properties of the nanocomposites were enhanced in relation to pristine PP,especially for the PP matrix with various loadings of AgNO_(3)and PVP,such as 5.0 wt%and 2.5 wt%,*** voids,inclusions,and actual-to-nominal dimensions also showed improved *** 3DP specimens exhibited a more effective biocidal performance against Staphylococcus aureus than Escherichia coli,which developed an inhibition zone only in the case of PP with filler loading percentages of AgNO_(3)and PVP at 10.0 wt%and 5.0 wt%,respectively Compounds possessing such properties can be beneficial for various applications requiring increased mechanical properties and biocidal capabilities,such as in the Defence or medical industries.

关键词： Polypropylene(PP) Polyvinyl pyrrolidone(PVP) Silver nitride(AgNO_(3)) In-situ reactive melt mixing process Material extrusion(MEX)3D printing Biocidal performance

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Strength through unity: Alkaline phosphatase-responsive AIEgen nanoprobe for aggregation-enhanced multi-mode imaging and photothermal therapy of metastatic prostate cancer

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Chinese Chemical Letters 2025年第2期36卷 289-296页

作者： Ze Wang Hao Liang Annan Liu Xingchen Li Lin Guan Lei Li Liang He Andrew k.Whittaker Bai Yang Quan Lin State key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Department of Endocrinology Lequn Branch the First Hospital of Jilin University Department of Urology the First Hospital of Jilin University Australian Institute for Bioengineering and Nanotechnology the University of Queensland

Prostate cancer(PCa) is characterized by high incidence and propensity for easy metastasis, presenting significant challenges in clinical diagnosis and treatment. Tumor microenvironment(TME)-responsive nanomaterials provide a promising prospect for imaging-guided precision therapy. Considering that tumor-derived alkaline phosphatase(ALP) is over-expressed in metastatic PCa, it makes a great chance to develop a theranostics system with ALP responsive in the TME. Herein, an ALP-responsive aggregationinduced emission luminogens(AIEgens) nanoprobe AMNF self-assembly was designed for enhancing the diagnosis and treatment of metastatic PCa. The nanoprobe exhibited self-aggregation in the presence of ALP resulted in aggregation-induced fluorescence, and enhanced accumulation and prolonged retention period at the tumor site. In terms of detection, the fluorescence(FL)/computed tomography(CT)/magnetic resonance(MR) multi-mode imaging effect of nanoprobe was significantly improved post-aggregation, enabling precise diagnosis through the amalgamation of multiple imaging modes. Enhanced CT/MR imaging can achieve assist preoperative tumor diagnosis, and enhanced FL imaging technology can achieve “intraoperative visual navigation”, showing its potential application value in clinical tumor detection and surgical guidance. In terms of treatment, AMNF showed strong absorption in the near infrared region after aggregation, which improved the photothermal treatment effect. Overall, our work developed an effective aggregation-enhanced theranostic strategy for ALP-related cancers.

关键词： AIE ALP responsive Enhanced multi-mode imaging Enhanced photothermal therapy Prostate cancer

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Intelligent ETL for Enterprise Software Applications Using Unstructured Data

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Journal of Software Engineering and Applications 2025年第1期18卷 44-65页

作者： Manthan Joshi Vijay k. Madisetti School of Cybersecurity and Privacy Georgia Institute of Technology Atlanta GA USA

Enterprise applications utilize relational databases and structured business processes, requiring slow and expensive conversion of inputs and outputs, from business documents such as invoices, purchase orders, and receipts, into known templates and schemas before processing. We propose a new LLM Agent-based intelligent data extraction, transformation, and load (IntelligentETL) pipeline that not only ingests PDFs and detects inputs within it but also addresses the extraction of structured and unstructured data by developing tools that most efficiently and securely deal with respective data types. We study the efficiency of our proposed pipeline and compare it with enterprise solutions that also utilize LLMs. We establish the supremacy in timely and accurate data extraction and transformation capabilities of our approach for analyzing the data from varied sources based on nested and/or interlinked input constraints.

关键词： Structured Data Relational Model LLM-Powered Agents Field-Level Extraction knowledge Graph

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