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Vitamin E treatment for children with chronic hepatitis B:A randomized placebo controlled trial

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World Journal of gastroenterology 2008年第47期14卷 7208-7213页

作者： Patrick gerner Hans-georg Posselt Andreas Krahl Antje Ballauff Albina Innerhofer Christa Binder tobias g wenzl Matthias Zense Ariadne Hector gerhard Dockter Rüdiger Adam Jenny Neubert Martin Claβen Robert van gemmern Stefan Wirth Children's Hospital Duisburg-Essen University Klinik 2Essen 45122Germany Witten/Herdecke University HELIOS KlinikumWuppertalGermany Children's Hospital Frankfurt University Frankfurt am Main 60590Germany Children's Hospital Darmstadt 64287Germany Children's Hospital Essen University Klinik 2Essen 45122Germany Children's Hospital St.Anna Wien Austria 1090Germany Children's Hospital Aachen University Aachen 52074Germany Children's Hospital St.Clemens Münster 48153Germany Children's Hospital Homburg University Homburg/Saar 66421Germany Children's Hospital Mannheim University Mannheim 68167Germany Children's Hospital Düsseldorf University Düsseldorf 40225Germany Children's Hospital Bremen University Bremen 28195Germany Pharmacy of HELIOS Klinikum Wuppertal 42883Germany Children's Hospital HELIOS Klinikum Wuppertal42283Germany Witten/Herdecke University Witten/HerdeckeGermany

AIM:To evaluate the safety and efficacy of vitamin E in children with chronic hepatitis B.METHODS:We randomly assigned patients with chronic hepatitis B,positive for hepatitis B e antigen(HBeAg),to receive either vitamin E or placebo once daily for 6 mo in a 3:1 ratio and double-blind manner.The primary end point was HBeAg seroconversion,defined as the loss of HBeAg,undetectable levels of serum hepatitis B virus DNA,and the appearance of antibodies against HBeAg 12 mo after therapy.RESULTS:At baseline visit,49 patients had normal and 43 had increased serum aminotransferase levels.Twenty-nine patients did not respond to previous treatment with interferon-α or lamivudine.Seventy-six children completed the study;16 were non-compliant(n = 7),lost to follow-up(n = 7),or started another antiviral treatment(n = 3).Intention-to-treat analysis showed HBeAg seroconversion in 16 children(23.2%) treated with vitamin E and two(8.7%) in the placebo group(P = 0.13).Vitamin E was well tolerated.CONCLUSION:There is only a tendency that vitamin E may promote HBeAg seroconversion.Therefore larger studies are needed to clarify the role of antioxidants in the therapy of chronic hepatitis B.

关键词：垂直传播免疫力重复处理婴幼儿慢性乙肝

Typical Refractory Wear Phenomena in Copper Vessels and Novel Monitoring Technologies

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China's Refractories 2021年第2期30卷 16-21页

作者： Dean gREgUREK Katja REINHARTER Juergen SCHMIDL Christine wenzl Alfred SPANRINg RHI Magnesita Leoben 8700Austria RHI Magnesita Wien 1120Austria

Copper smelting furnaces are typically lined with magnesia-chromite refractories,which are exposed to multiple and complex stresses.The selection of the processing route,furnace type,and slag system is dictated by the specific ore type available;which will determine the individual refractory wear.This paper evaluates the common refractory wear mechanisms as observed in the copper Peirce-Smith converter and in the copper anode furnace.The chemical factors include corrosion caused by fayalite type slag and sulphur supply,as well as by Cu-oxide attack.Changes in the temperature during the furnace operation(thermal shock)create stresses in the brick lining which can only be absorbed to a limited extent.Mechanical factors include erosion,caused primarily by the movement of the metal bath,slag and charging material,as well as stresses in the brickwork due to punching.Finally,improper lining procedures can also affect the service life.All these wear parameters lead to severe degeneration of the brick microstructure and a decreased lining life,and in the worst case overheated furnace structures and possibly dangerous hot spots or even breakouts.Therefore,a detailed investigation and understanding of the wear mechanisms through“post-mortem studies”together with thermochemical calculations by FactSageTM software is an important prerequisite for the refractory producer.Based on these research results,combined with specific process knowledge,appropriate brick lining solutions for copper processing furnaces can be recommended.In addition to the described efforts to investigate refractory wear and optimise lining qualities,it is also essential to monitor the process and the effect on the refractories to further improve both safety and process.For this purpose,technologies using sensors and novel digital solutions can be applied.

关键词： wear phenomena copper vessel monitoring technologies

锂离子聚合物电池电量的非线性贝叶斯估计(英文)

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中国科学技术大学学报 2012年第8期42卷 628-639页

作者：赵奇 wenzl Heinz Bohn Christian 电子信息技术研究所克劳斯塔尔工业大学38678 电力能源技术研究所克劳斯塔尔工业大学38678

精确的电量估计对于电池控制系统有着非常重要的意义.为此提出一种新颖的锂离子聚合物电池模型,其电量估计将由非线性贝叶斯推断方法来实现.

关键词：锂离子聚合物电池等效电路模型电池电量估计贝叶斯推断 Sigma point卡尔曼滤波器序贯蒙特卡洛方法

Impact of extinction coefficient of phosphor on thermal load of color conversion elements of phosphor converted LEDs

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Journal of Rare Earths 2014年第3期32卷 201-206页

作者： F.P.wenzl P.Fulmek C.Sommer S.Schweitzer W.Nemitz P.Hartmann P.Pachler H.Hoschopf F.Schrank g.Langer J.Nicolics Institute for Surface Technologies and Photonics Joanneum Research Forschungsgesm.b.H. Franz-Pichler Stra?e 30 A-8160 Weiz Austria Institute of Sensor & Actuator Systems Vienna University of Technology Tridonic Jennersdorf gmbH Technologiepark 10 A-8380 Jennersdorf Austria Austria Technologie & Systemtechnik Ag Fabriksgasse 13 A-8700 Leoben Austria

Besides their direct impact on the respective correlated color temperature, the extinction coefficient and the quantum effi- ciency of the phosphor also have tremendous impact on the thermal load of the color conversion elements of phosphor converted LEDs under operation. Because of the low thermal conductivity of the silicone matrix in which the phosphor particles are typically embedded, the by far highest temperatures within the LED assembly are reached within the color conversion element. Based on a combined optical and thermal simulation procedure we show that in particular a larger value for the extinction coefficient might have a beneficial impact on the resulting thermal load.

关键词： light-emitting diode color conversion phosphor rare earths

应用大股骨头假体治疗多次失败的人工髋关节翻修术的罕见指征

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德国医学 2001年第2期18卷 91-92页

作者： A.Siegel U.Rüchert M.wenzl 吴宗键 ENDO-Klinik Holstenstrae 2D-22767 HamburgGermany 北京解放军总医院

近30年来,除个别病例以外(如人工髋关节经过多次翻修,使骨盆与股骨之间负重功能受到限制),人工髋关节置换取得了卓越的临床疗效。目前不太清楚是因为人工关节磨损,还是因为人工关节置换手术过程失败导致一部分病人必须行人工关节翻修术... 详细信息

近30年来,除个别病例以外(如人工髋关节经过多次翻修,使骨盆与股骨之间负重功能受到限制),人工髋关节置换取得了卓越的临床疗效。目前不太清楚是因为人工关节磨损,还是因为人工关节置换手术过程失败导致一部分病人必须行人工关节翻修术。多次翻修手术后,虽植骨内固定,更换假体。

关键词：人工关节翻修术大股骨头胶体罕见指征

Mobilizing Crop Biodiversity

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Molecular Plant 2020年第10期13卷 1341-1344页

作者： Susan McCouch Zahra Katy Navabi Michael Abberton Noelle L.Anglin Rosa Lia Barbieri Michael Baum Kirstin Bett Helen Booker gerald L.Brown glenn J.Bryan Luigi Cattivelli David Charest Kellye Eversole Marcelo Freitas Kioumars ghamkhar Dario grattipaglia Robert Henry Maria Cleria Valadares Inglis Tofazzal Islam Zakaria Kehel Paul J.Kersey graham J.King Stephen Kresovich Emily Marden Sean Mayes Marie Noelle Ndjiondjiop Henry T.Nguyen Samuel Rezende Paiva Roberto Papa Peter W.B.Phillips Awais Rasheed Christopher Richards Mathieu Flouard Maria Jose Amstalden Sampaio Uwe Scholz Paul D.Shaw Brad Sherman S.Evan Staton Nils Stein Jan Svensson Mark Tester Jose Francisco Montenegro Valls Rajeev Varshney Stephen Visscher Eric von Wettberg Robbie Waugh Peter wenzl Loren H.Rieseberg Plant Breeding and genetics School of Integrated Plant SciencesCornell UniversityIthacaNY14853USA DivSeek Global Institute for Food Security110 Gymnasium PlaceUniversity of SaskatchewanSaskatoonSKS7N 0W9Canada lnternational Institute of Tropical Agriculture(IITA) PMB 5320Oyo RdIbadanNigeria International Potato Center(CIP)1895 Avenida La Molina Lima Peru 12Lima 15023Peru Embrapa genetic Resources and Biotechnology Parque Estacjao BiologicaFinal Av W5 NorteCaixa Postal 0237270770-917-Brasilia DFBrazil International Center for Agricultural Research in the Dry Areas(I CAR DA) Station Exp.INRA-Quich.Rue Hafiane Cherkaoui.Agdal.Rabat-Instituts10111RabatMorocco Department of Plant Sciences University of Saskatchewan51 Campus Dr.SaskatoonSK S7N 5A8Canada Department of Plant Agriculture University of GuelphRm 316Crop Science Bldg50 Stone Rd EGuelphON N1G 2W1Canada genome Prairie 111 Research DriveSuite 101SaskatoonSKS7N 3R2Canada The James Hutt on Institute Errol RoadInvergowrieDundeeDD25DAUK CREA Research Centre for Genomics and Bioinformaticsvia San Protaso 302Fiorenzuola d'Arda29017Italy genome British Columbia 400-575 West 8th AvenueVancouverBCV5Z 0C4Canada International Wheat genome Sequencing Consortium 2841 NE Marywood CtLee's SummitMO.64086USA Forage Science Grasslands Research CentreAgResearchPalmerston North4410New Zealand Queensla nd Alliance for Agriculture and Food Inn ovation University of QueenslandBrisbaneQLD 4072Australia Institute of Biotechnology and genetic Engineering(IBgE) Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh Southern Cross University PO Box 157LismoreNSW 2480Australia Royal Botanic gardens KewRichmondSurreyTW93AEUK Feed the Future Innovation Lab for Crop Improvement 431 Weill HallCornell UniversityIthacaNY14853USA Department of Botany and Biodiversity Research Centre University of British ColumbiaVancouverBC V6R 2A5Canada Crops For the Future(UK)CIC 76-80 Baddow Road ChelmsfordEs

Over the past 70 years,the world has witnessed extraordinary growth in crop productivity,enabled by a suite of technological advances,including higher yielding crop varieties,improved farm management,synthetic agrochemicals,and agricultural mechanization.While this"green Revolution"intensified crop production,and is credited with reducing famine and malnutrition,its benefits were accompanied by several undesirable collateral effects(Pingali,2012).These include a narrowing of agricultural biodiversity,stemming from increased monoculture and greater reliance on a smaller number of crops and crop varieties for the majority of our calories.This reduction in diversity has created vulnerabilities to pest and disease epidemics,climate variation,and ultimately to human health(Harlan,1972).

关键词： intensified crops agricultural