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Targeting the EGF receptor family in non-small cell lung cancerincreased complexity and future perspectives

Cancer Biology & Medicine 2022年第11期19卷 1543-1564页

作者： tobias boch Jens Kohler Melanie Janning Sonja Loges DKFZ-Hector Cancer Institute at the University Medical Center Mannheim Mannheim 68135Germany Division of Personalized Medical Oncology(A420) German Cancer Research Center(DKFZ)Heidelberg 69120Germany Department of Personalized Oncology University Medical Center MannheimMedical Faculty MannheimHeidelberg UniversityMannheim 68135Germany

Lung cancer remains the leading cause of cancer-associated mortality worldwide,but with the emergence of oncogene targeted therapies,treatment options have tremendously *** to their biological relevance,members of the ERBB receptor family,including the EGF receptor(EGFR),HER2,HER3 and HER4,are among the best studied oncogenic *** EGFR mutations are frequently observed in non-small cell lung cancer(NSCLC),and small molecule tyrosine kinase inhibitors(TKIs)are the established first line treatment option for patients whose tumors bear"typical/classical"EGFR mutations(exon 19 deletions,L858R point mutations).Additionally,new TKIs are rapidly evolving with better efficacy to overcome primary and secondary treatment resistance(e.g.,that due to T790M or C797S resistance mutations).Some atypical EGFR mutations,such as the most frequent exon 20 insertions,exhibit relative resistance to earlier generation TKIs through steric *** this subgroup,newer TKIs,such as mobocertinib and the bi-specific antibody amivantamab have recently been approved,whereas less frequent atypical EGFR mutations remain *** contrast to EGFR,HER2 has long remained a challenging target,but better structural understanding has led to the development of newer generations of *** recent FDA approval of the antibody-drug conjugate trastuzumab-deruxtecan for pretreated patients with HER2 mutant NSCLC has been an important therapeutic ***3 and HER4 also exert oncogenic potential,and targeted treatment approaches are being developed,particularly for ***,strategies to inhibit the oncogenic function of ERBB receptors in NSCLC are currently evolving at an unprecedented pace;therefore,this review summarizes current treatment standards and discusses the outlook for future developments.

关键词： Oncology NSCLC EGFR HER2 HER3 HER4

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To eat or not to eat-relationship of lichen herbivory by snails with secondary compounds and field frequency of lichens

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Journal of Plant Ecology 2015年第6期8卷 642-650页

作者： Steffen boch Markus Fischer Daniel Prati Institute of Plant Sciences and Botanical Garden University of BernAltenbergrain 213013 BernSwitzerland

Aims The biochemical defense of lichens against herbivores and its rela-tionship to lichen frequency are poorly ***,we tested whether chemical compounds in lichens act as feeding defense or rather as stimulus for snail herbivory among lichens and whether experimental feeding by snails is related to lichen fre-quency in the *** In a no-choice feeding experiment,we fed 24 lichen species to snails of two taxa from the Clausilidae and Enidae families and compared untreated lichens and lichens with compounds removed by acetone ***,we related experimental lichen consump-tion with the frequency of lichen species among 158 forest plots in the field(schwäbische alb,germany),where we had also sampled snail and lichen *** findings In five lichen species,snails preferred treated samples over untreated controls,indicating chemical feeding defense,and vice versa in two species,indicating chemical feeding ***,com-pared with less frequent lichen species,snails consumed more of untreated and less of treated samples of more frequent lichen *** one outlier species resulted in the loss of a significant positive relationship when untreated samples were analyzed ***,the interaction between treatment and lichen frequency remained significant when excluding single species or including snail genus instead of taxa,indicating that our results were robust and that lumping the species to two taxa was *** results imply lichen-feeding snails to prefer frequent lichens and avoid less frequent ones because of secondary compound *** supports the idea that consumers adapt to the most abundant food source.

关键词： acetone rinsing biodiversity exploratories defense strategies gastropoda herbivore resistance lichenivory mollusk grazing plant-animal interaction

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Influence of experimental soil disturbances on the diversity of plants in agricultural grasslands

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Journal of Plant Ecology 2014年第6期7卷 509-517页

作者： Jörg Müller Johannes Heinze Jasmin Joshi Steffen boch Valentin H.Klaus Markus Fischer Daniel Prati Institute of Biochemistry and BiologyUniversity of PotsdamMaulbeerallee 114469 PotsdamGermany Freie Universität Berlin Institut für BiologieBerlin-Brandenburg Institute of Advanced Biodiversity ResearchAltensteinstrasse 614195 BerlinGermany Institute of Plant Sciences University of BernAltenbergrain 213013 BernSwitzerland Institute of Landscape Ecology University of MünsterHeisenbergstr.248149 MünsterGermany Biodiversity and Climate Research Centre BIK-F Senckenberg Gesellschaft für Naturforschung603257 FrankfurtGermany

Aims and Methods Disturbance is supposed to play an important role for biodiversity and ecosystem stability as described by the intermediate disturbance hypoth-esis(IDH),which predicts highest species richness at intermediate levels of *** this study,we tested the effects of artificial soil distur-bances on diversity of annual and perennial vascular plants and bryo-phytes in a field experiment in 86 agricultural grasslands differing in land use in two regions of *** each grassland,we implemented four treatments:three treatments differing in application time of soil dis-turbances and one *** year after experimental disturbance,we recorded vegetation and measured biomass productivity and bare *** analysed the disturbance response taking effects of region and land-use-accompanied disturbance regimes into *** Findings Region and land-use type strongly determined plant species *** disturbances had small positive effects on the species richness of annuals,but none on perennials or *** ground was positively related to species richness of ***,exceeding the creation of 12%bare ground further distur-bance had a detrimental effect on bryophyte species richness,which corresponds to the *** biomass productivity was unaffected by disturbance our results indicate that the disturbance effect on spe-cies richness of annuals was not due to decreased overall produc-tivity,but rather due to short-term lowered inter-and intraspecific competition at the newly created ***,our results highlight the importance of soil disturbances for species richness of annual plants and bryophytes in agricultural ***,most grasslands were disturbed naturally or by land-use practices and our additional experimental soil dis-turbances only had a small short-term ***,total plant diversity in grasslands seemed to be more limited by the availabil-ity of propagules rather tha

关键词： annuals bryophytes colonization intermediate disturbance hypothesis microsites

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Reduction of Native Diversity by Invasive Plants Depends on Habitat Conditions

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American Journal of Plant Sciences 2015年第17期6卷 2718-2733页

作者： Yvonne Künzi Daniel Prati Markus Fischer Steffen boch Institute of Plant Sciences and Botanical Garden University of Bern Bern Switzerland

Invasions by exotic plant species and their impacts on invaded communities are a highly topical field of research because it provides a basis for the management of neophyte populations. However, for many invasive neophyte species in Central Europe little is known about their impacts on invaded plant communities. Moreover, it has hardly been considered whether effects vary among habitat conditions. Here, we selected each ten sites with different habitat conditions invaded by Erigeron annuus, Fallopia japonica, Impatiens glandulifera and Solidago canadensis which were listed as invasive in Switzerland. At each site, we established four 4 m × 1 m subplots covering a gradient from very low to very high cover of the particular neophyte species to investigate the effect of increasing neophyte cover on the species richness, Shannon diversity and evenness of the invaded plant communities. Moreover, we measured soil pH and characterized habitat conditions using Ellenberg indicator values to light and soil fertility. Whereas increasing cover of I. glandulifera had no effect on the diversity of invaded plant communities, an increasing cover of E. annuus negatively affected Shannon diversity. An increasing cover of F. japonica combined with a decreasing soil pH negatively affected the Shannon diversity of invaded plant communities. Similarly, an increasing cover of S. canadensis in combination with decreasing soil fertility negatively affected the Shannon diversity and evenness of invaded communities. Our results indicate that significant effects of increasing neophyte cover are mostly coupled to particular habitat conditions and then rather suppress than eliminate native plant species in invaded communities. We therefore suggest including abiotic variables in further impact studies on biotic invasions. Furthermore, adapting measures to the respective environmental context can be a useful tool in priority setting for the management of invasive neophyte populations and the resto

关键词： Diversity Impact of Neophytes Indicator Values Plant Species Richness

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经典卢森堡系列餐瓷

中国陶瓷设计

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中国陶瓷设计 2014年第6期 104-107页

作者： Villeroy & boch 德国唯宝

传统引领时尚卓越的设计因为永恒的经典而熠熠生辉,正如包含传统气息的餐具系列经典卢森堡(Old Luxemburg)那样,其上装饰有来自法国的"蓝色小花枝"。近250年来,这根蓝色的小花枝就一直点缀着这套生机勃勃的餐具。总的来说,这种细腻的洛...

传统引领时尚卓越的设计因为永恒的经典而熠熠生辉,正如包含传统气息的餐具系列经典卢森堡(Old Luxemburg)那样,其上装饰有来自法国的"蓝色小花枝"。近250年来,这根蓝色的小花枝就一直点缀着这套生机勃勃的餐具。总的来说,这种细腻的洛可可式主题绝对是最著名,同时也是最受青睐的餐具装饰。精致的餐桌文化完美的桌饰取决于很多因素,但人们最先着眼的还是成套餐饮具的外形和装饰。外形与装饰的圆满统一是一套餐具最精炼的特质。无论柔软的波纹或是边缘上精妙的蓝色线条,最微小的细节都能让外形尽显精致典

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童话般的旋律

中国陶瓷设计

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中国陶瓷设计 2014年第5期 100-103页

作者： Villeroy & boch AG 唯宝股份公司

对您来说,什么才是完美装饰的餐桌?是淡雅脱俗?还是华丽奔放?无论何种气氛和场合,您都能在Samarkand(奢华中东)系列找到合适的选择。精致的边框装饰与喧闹的东方奢华,打造了一曲完美的餐桌乐章。顶级瓷器和黄金色调同样代表着此系列产...

对您来说,什么才是完美装饰的餐桌?是淡雅脱俗?还是华丽奔放?无论何种气氛和场合,您都能在Samarkand(奢华中东)系列找到合适的选择。精致的边框装饰与喧闹的东方奢华,打造了一曲完美的餐桌乐章。顶级瓷器和黄金色调同样代表着此系列产品的高贵特质,您甚至可以搭配出"一千零一种"布置方式。庄重与惊艳这种餐具的装饰以其内敛的优雅尽显庄重,又能够以

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萨尔河上的静谧小镇

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缤纷 2008年第9期 144-147页

作者：李甜协力 Villeroy & boch

隶属于德国最小州萨尔州(Saarland)的梅特拉赫(Mettlach)小镇,位于德国、法国和卢森堡的三国交界处,距离德国繁华的商业都市法兰克福不过一个半小时的车程。如果乘坐ICE等列车,一般则要经过萨尔州的首府萨尔布吕肯(Saarbrücken)。从萨... 详细信息

隶属于德国最小州萨尔州(Saarland)的梅特拉赫(Mettlach)小镇,位于德国、法国和卢森堡的三国交界处,距离德国繁华的商业都市法兰克福不过一个半小时的车程。如果乘坐ICE等列车,一般则要经过萨尔州的首府萨尔布吕肯(Saarbrücken)。从萨尔布吕肯取道前往梅特拉赫,会逐渐进入由大片森林包围的山谷,密布的森林和柔缓的山峦阻隔了一切喧嚣,仿佛进入了真正的童话世界。

关键词：森林德国童话世界巴洛克风格当地居民修道院法国历史博物馆古堡

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C2F6气体（Perfluoroethane）视网膜固定术治疗孔源性视 …

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美国医学会眼科杂志（中文版） 1993年第2期5卷 5-7页

作者： boch.,TW 王蔚荃

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浴室角色ABC

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城市住宅 2005年第8期12卷 100-107页

作者：陈丽红 Rondo Emco Circle Villeroy boch

在这个崇尚个性设计的年代里，浴室这个面积不大的空间也成为设计师展现才华的舞台。

关键词：浴室 ABC 个性设计设计师舞台空间

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用于电子战的高性能毫米波本振组件

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航天电子对抗 1992年第1期 48-50页

作者： Erik boch Tony Stajcer 王伟光

一种微型的高稳定度本振组件已被开发用于电子战领域。它由介质稳频FET振荡器(即DRO)、缓冲放大器和平面变容管倍频器组成,集成为一个微型平面电路。此组件具有良好的相位噪声、较高的效率、较高的频稳度和较好的功率稳定度(在工作温度... 详细信息

一种微型的高稳定度本振组件已被开发用于电子战领域。它由介质稳频FET振荡器(即DRO)、缓冲放大器和平面变容管倍频器组成,集成为一个微型平面电路。此组件具有良好的相位噪声、较高的效率、较高的频稳度和较好的功率稳定度(在工作温度范围内)。该组件还成功地通过了在军事实战环境中所遇到的各种复杂的温度和冲击振动等例行试验,试验中本振源性能没有降低。

关键词：毫米波技术电子元件集成电路本机振荡器

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