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General Regulatory Patterns of Plant Mineral Nutrient Depletion as Revealed by serat Quadruple Mutants Disturbed in Cysteine Synthesis

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Molecular Plant 2010年第2期3卷 438-466页

作者： Mutsumi Watanabe Hans-Michael Hubberten Kazuki saito Rainer Hoefgen Graduate School of Pharmaceutical Sciences Chiba University 1-33 Yayoi-cho Inage-ku Chiba 263-8522 Japan Max-Planck-lnstitut fuer Molekulare Pflanzenphysiologie Wissenschaftspark Golm Am Muehlenberg 1 14476 Potsdam-Golm RIKEN Plant Science Center Tsurumi-ku Yokohama 230-0045 Japan

Sulfate is an essential macronutrient for plants. Plants have developed strategies to cope with sulfate deficiency, and other nutrient ion limitations. However, the regulation of these adaptive responses and the coordinating signals that underlie them are still poorly characterized. O-acetylserine （OAS） is a marker metabolite of sulfate starvation and has been speculated to have a signaling function. OAS is synthesized by the enzyme serine acetyltransferase （SERAT）, which is encoded by five distinct genes in Arabidopsis. We investigated quadruple knockout mutants of SERAT that retained only one functional isoform. These mutants displayed symptoms of sulfate starvation. Furthermore, some of them displayed phenotypes typical of prolonged sulfate starvation, in particular, developmental programs associated with senescence or stress responses. Thus, we compared metabolite and transcriptome data from these mutants with N-, P-, K-, and S-depleted plants. This revealed many similarities with general nutrient-depletion-induced senescence （NuDIS）, in- dicating the recruitment of existing regulatory programs for nutrient-starvation responses. Several candidate genes that could be involved in these processes were identified, including transcription factors and other regulatory proteins, as well as the functional categories of their target genes. These results outline components of the regulatory network controlling plant development under sulfate stress, forming a basis for further investigations to elucidate the complete network. In turn, this will advance our broader understanding of plant responses to a range of other nutrient stresses.

关键词： Abiotic/environmental stress ion/metabolite sensing senescence functional genomics Arabidopsis sulfur.

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Coaxial boron nitride nanotubes as interfacial dielectric layers to lower interface trap density in carbon nanotube transistors

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Nano Research 2023年第11期16卷 12840-12848页

作者： Keigo Otsuka Taiki Sugihara Taiki Inoue Weijie Jia Satoru Matsushita Takanobu saito Minhyeok Lee Takashi Taniguchi Kenji Watanabe Gregory Pitner Ming-Yang Li Tzu-Ang Chao Rong Xiang Shohei Chiashi Shigeo Maruyama Department of Mechanical Engineering The University of TokyoTokyo 113-8656Japan Department of Applied Physics Osaka UniversityOsaka 565-0871Japan Research Center for Materials Nanoarchitectonics National Institute for Materials ScienceTsukuba 305-0044Japan Research Center for Electronic and Optical Materials National Institute for Materials ScienceTsukuba 305-0044Japan Corporate Research Taiwan Semiconductor Manufacturing CompanySan JoseCA 95134USA Corporate Research Taiwan Semiconductor Manufacturing CompanyHsinchu 30078

A semiconductor/dielectric interface is one of the dominant factors in device characteristics,and a variety of oxides with high dielectric constants and low interface trap densities have been used in carbon nanotube *** the crystal structure of nanotubes with no dangling bonds,there remains room to investigate unconventional dielectric ***,we fabricate carbon nanotube transistors with boron nitride nanotubes as interfacial layers between channels and gate dielectrics,where a single semiconducting nanotube is used to focus on switching behaviors at the subthreshold *** subthreshold swing of 68 mV·dec^(−1)is obtained despite a 100-nm-thick Sio_(2)dielectric,corresponding to the effective interface trap density of 5.2×10^(11)cm^(−2)·eV^(−1),one order of magnitude lower than those of carbon nanotube devices without boron nitride *** interfacial layers also result in the mild suppression of threshold voltage variation and *** achieve Ohmic contacts through the selective etching of boron nitride nanotubes with XeF2 gas,overcoming the trade-off imposed by wrapping the inner *** impacts of fluorinating carbon nanotubes on device performances are also confirmed as long as the etching is applied exclusively at source/drain *** results represent an important step toward nanoelectronics that exploit the advantage of one-dimensional van der Waals heterostructures.

关键词： carbon nanotubes hexagonal boron nitride van der Waals interfaces field-effect transistors subthreshold swing selective etching

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Geochemical and Grain-Sized Implications for Provenance Variations of the Central Yellow Sea Muddy Area Since the Middle Holocene

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Journal of Ocean University of China 2020年第3期19卷 577-588页

作者： AI Lina HAN Zongzhu WU Xiao saito Yoshiki WANG Houjie College of Marine Geosciences/Key Laboratory of Submarine Geosciences and Prospecting Techniques MOEOcean University of ChinaQingdao 266100China Laboratory of Marine Geology Qingdao National Laboratory of Marine Science and TechnologyQingdao 266237China Estuary Research Center Shimane UniversityMatsue 690-8504Japan Geological Survey of Japan AISTTsukuba 305-8567Japan

Based on high-resolution analysis to a 280-cm long sediment core obtained from the muddy area in the central Yellow Sea, we examined the provenance of muddy sediments and discussed the changing marine sedimentary environment since the middle Holocene. The results indicated that fine-grained sediments in the muddy area were mainly derived from the Huanghe(Yellow River) and Changjiang(Yangtze River) with considerable stepwise variations during the past 6.6 kyr. The Yellow Sea Warm Current was initiated at 6 kyr when the sea level was high together with the enhanced East Asian Winter Monsoon. These in combination established the framework of shelf circulation in the Yellow Sea that began to trap the river-derived fine-grained sediments. From 4.9 kyr to 2.8 kyr, both the Kushiro Current and East Asian Monsoon were significantly weakened, reducing the delivery of Changjiang sediments to the muddy area. As a result, the sediments were mainly originated from the Huanghe. From 2.8 kyr to 1.5 kyr the continuously weakened East Asian Winter Monsoon and enhanced Yellow Sea Warm Current entrapped more fine-grain sediments. Whereas the enhanced East Asian Winter Monsoon and the human caused increase in sediment load of the Huanghe since 1.5 kyr, and direct delivery of Huanghe sediments to the Yellow Sea during 1128–1855 AD might dominated the sedimentation in the study area. The stepwise variations of the sediment provenance and composition of the Central Yellow Sea muddy sediments are of importance to understanding the formation of muddy deposit in the central Yellow Sea and the associated variations of marine environment since the middle Holocene.

关键词： sediment provenance rare earth elements grain size central Yellow Sea mud middle Holocene

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Successful Surgical Treatment of Bilateral Fibroepithelial Polyps in the Labia Minora of an Adolescent Female: A Case Report

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Open Journal of Obstetrics and Gynecology 2023年第4期13卷 775-779页

作者： Yutaka Kanamori Takeshi saito Tamotsu Kobayashi Takako Yoshioka Division of Surgery Department of Surgical Specialties National Center for Child Health and Development Tokyo Japan Department of Pathology National Center for Child Health and Development Tokyo Japan

Background: Fibroepithelial polyp in the vulva is a rare disease mainly seen in female adolescents and young adults, and several reports were published in the past. Some cases showed large polyps that might be misinterpreted as malignant tumors such as aggressive angiomyxoma. Aim: We report a case of bilateral fibroepithelial polyps in the labia minora in an adolescent age girl. Case Presentation: A 16 year-old-girl was referred to our department for the treatment of an enlarged skin-tag appearance lesion at the right sided labia minora. The lesion was resected and the microscopic finding was a fibroepithelial polyp. One year after the first operation the patient was again referred to our department for the treatment of a skin-tag lesion at the left sided labia minora. It was again resected and the pathological diagnosis was a fibroepithelial polyp. Conclusion: Fibroepithelial polyp of the labia minora is not common and it is often seen in adolescent girls and in young adults. Bilateral lesions and skin-tag appearance are especially rare. The lesion should be excised for obtaining the correct diagnosis.

关键词： Fibroepithelial Polyp Labia Minora Skin Tag

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Dedifferentiated chondrosarcoma of the middle finger arising from a solitary enchondroma:A case report

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World Journal of Clinical Cases 2022年第10期10卷 3297-3305页

作者： Hirotaka Yonezawa Norio Yamamoto Katsuhiro Hayashi Akihiko Takeuchi Shinji Miwa Kentaro Igarashi Sei Morinaga Yohei Asano Shiro saito Yasunori Tome Hiroko Ikeda Takayuki Nojima Hiroyuki Tsuchiya Department of Orthopaedic Surgery Graduate School of Medical SciencesKanazawa UniversityKanazawa 920-8641IshikawaJapan Department of Orthopedic Surgery Graduate School of MedicineUniversity of the RyukyusNishihara 903-0215OkinawaJapan Department of Diagnostic Pathology Kanazawa University HospitalKanazawa 920-8641IshikawaJapan

BACKGROUND Dedifferentiated chondrosarcoma(DDCS)accounts for 10%of all chondrosarcomas and has the poorest outcome,with a 5-year survival rate of 7%-25%.DDCS commonly occurs in the femur and pelvis,whereas DDCS of the finger is extremely ***,the histological findings of preexisting solitary enchondroma samples are important and valuable for diagnosing malignant *** SUMMARY We report our experience with DDCS in the proximal phalanx of the left middle finger of an 87-year-old *** had undergone surgery for enchondroma,with curettage and artificial bone grafting,11 years ago,in the same *** years after the primary surgery,the left middle finger gradually started to enlarge,and the growth speed increased in the past *** radiographs showed an expansive osteolytic lesion with calcifications and residual grafting *** to the suspicion of malignancy,we performed ray *** findings revealed an abrupt transition between the low-grade chondrosarcoma and dedifferentiated sarcoma *** dedifferentiated components showed the features of a high-grade undifferentiated pleomorphic *** patient was diagnosed with DDCS arising from a preexisting *** had no local recurrence or distant metastasis and died of pneumonia 6 years and 10 months after the second *** The histological findings of a precursor lesion showed a typical enchondroma,suggesting that DDCS can arise from enchondroma.

关键词： Dedifferentiated chondrosarcoma Enchondroma Finger Phalanx Ray amputation Case report

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Endoscopic diagnosis of cytomegalovirus gastritis after allogeneic hematopoietic stem cell transplantation

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World Journal of Gastroenterology 2010年第23期16卷 2907-2912页

作者： Yasuo Kakugawa Masahiro Kami Takahisa Matsuda Yutaka saito Sung-Won Kim Takahiro Fukuda Shin-ichiro Mori Tadakazu Shimoda Ryuji Tanosaki Daizo saito Division of Endoscopy National Cancer Center Hospital(Japan) Division of Exploratory Research Institute of Medical ScienceUniversity of Tokyo Division of Hematopoietic Stem Cell Transplantation National Cancer Center Hospital(Japan) Clinical Laboratory Division National Cancer Center Hospital(Japan)

AIM:To clarify the endoscopic and clinical findings of cytomegalovirus(CMV) gastritis after allogeneic hematopoietic stem cell transplantation(allo-SCT).METHODS:Between 1999 and 2005,523 patients underwent allo-SCT at our hospital,and 115 of these patients with gastrointestinal symptoms underwent ***:CMV gastritis was diagnosed pathologically in seven patients(1.3%) with the other 108 patients serving as *** of the seven patients developed positive CMV antigenemia,and five complained of abdominal *** of abdominal pain preceded CMV antigenemia in four of the f ive *** examination showed oozing(n=2),erosion(n=6),and redness(n=5) in the seven patients with CMV gastritis,while the control patients showed oozing(n=3),erosion(n=24),and redness(n=100).Erosion and oozing were more frequently documented in patients with CMV gastritis compared with the controls,and the differences were statistically significant(P=0.0012 and 0.029,respectively).CMV inclusion bodies were documented in 12 of 14 biopsy specimens obtained from erosive lesions,while they were identif ied in 4 of 15 biopsy specimens obtained from lesions other than erosions(P=0.0025).CONCLUSION:This study suggests that erosion and oozing,as well as abdominal pain,are useful indicators in the diagnosis of CMV gastritis following allo-SCT.

关键词： Cytomegalovirus gastritis Hematopoietic stem cell transplantation Cytomegalovirus antigenemia Esophagogastroduodenoscopy Graft-versus-host disease

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Reduction behaviors of permanganate by microbial cells and concomitant accumulation of divalent cations of Mg2+, Zn2+, and Co2+

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Journal of Environmental Sciences 2019年第12期31卷 78-86页

作者： Tomoaki Kato Qianqian Yu Kazuya Tanaka Naofumi Kozai Takumi saito Toshihiko Ohnuki School of Environment and Society Tokyo Institute of Technology2-12-1 OofcayamaMeguro-fcuTokyo 152-8550Japan School of Earth Science China University of GeosciencesWuhan 430074China Advanced Science Research Center Japan Atomic Energy AgencyTokaiIbaraki 319-1195Japan Institute of Innovative Research Tokyo Institute of Technology2-12-1 OokayamaMeguro-kuTokyo 152-8550Japan The University of Tokyo 7-3-1 HongoBunkyo-kuTokyo 113-8654Japan

Permanganate treatment is widely used for disinfection of bacteria in surface-contaminated *** this paper,the fate of the dissolved permanganate in aqueous solution after contact with cells of Pseudomonas fluorescens was *** accumulation of divalent cations of Mg2+,Zn2+,and Co2+during precipitation of Mn oxides was also *** time course of the Mn concentration in solution showed an abrupt decrease after contact of Mn(VII)with microbial cells,followed by an increase after^24 *** analysis of the precipitated Mn oxides,called biomass Mn oxides,showed the formation of low-crystalline *** spectroscopy and X-ray absorption near edge structure(XANES)analyses indicated that dissolved Mn(VII)was reduced to form biomass Mn oxides involving Mn(IV)and Mn(III),followed by reduction to soluble Mn(II).The numbers of electron transferred from microbial cells to permanganate and to biomass Mn oxides for 24 hr after the contact indicated that the numbers of electron transfer from microbial cell was approximately 50 times higher to dissolved permanganate than to the biomass Mn oxides in present experimental *** 24 hr accumulation of divalent cations during formation of biomass Mn oxides was in the order of Co2+>Zn2+>Mg2+.XANES analysis of Co showed that oxidation of Co2+to Co3+resulted in higher accumulation of Co than Zn and ***,treatment of surface water by KMnO4 solution is effective not only for disinfection of microorganisms,but also for the elimination of metal cations from surface water.

关键词： Permanganate Cobalt Zinc Biomass Mn oxides Bimessite XANES

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Estimating harvest costs and projecting quantities of logging residues for small-scale forestry in Nasushiobara, Tochigi Prefecture, Japan

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Journal of Forestry Research 2014年第4期25卷 965-974页

作者： Chikara Nakahata Ryo Uemura Masashi saito Kanae Kanetsuki Kazuhiro Aruga Department of Forest Science Faculty of Agriculture Utsunomiya University 350 Mine Utsunomiya 321-8505 Japan Frontier Agriscience and Technology Center Faculty of Agriculture Shinshu University Nagano 399-4598 Japan Nasunogahara Land Improvement Districts Tochigi 329-2807 Japan

We used GIS on a regional scale to estimate and compare supply potentials and costs of small-scale logging systems, a mini-forwarder and a 4-ton truck operated by private logging contractors, and manual logging and a light truck operated by individual forest own- ers, with the mechanized operational system of the Forest Owners＇ Asso- ciation. Total potential yields of timber and logging residues were esti- mated as 418,895 m3 and 254,962 m3, respectively. The economic bal- ances were estimated and available amounts were projected as supply potentials from profitable sub-compartments. As a result, available amounts of timber and logging residues were estimated at 375,466 m3 （89.9%） and 203,850 m3 （80.0%）, respectively. Because their transport expenses were lower than for other systems the most profitable sub-compartments were operated by private logging contractors who sold logging residues at a plant. The profitable sub-compartments operated by individual forest owners were few because the extracting distances were usually greater than 20 m. Raising logging residue prices from 3,000 yen·m-3 to 4,080 yen·m-3 or 6,800 yen·m-3, and establishing forest roads, which reduced some extracting distances to less than 20 m, increased the number and area of profitable sub＊compartments, and increased available amounts of logging residues.

关键词： GIS supply potentials private logging contractor individual

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Clearance of the liver remnant predicts short-term outcome in patients undergoing resection of hepatocellular carcinoma

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World Journal of Gastroenterology 2022年第38期28卷 5614-5625页

作者： Atsushi Miki Yasunaru Sakuma Hideyuki Ohzawa Akira saito Yoshiyuki Meguro Jun Watanabe Kazue Morishima Kazuhiro Endo Hideki Sasanuma Atsushi Shimizu Alan Kawarai Lefor Yoshikazu Yasuda Naohiro Sata Department of Surgery Jichi Medical UniversityShimotsuke 329-0498TochigiJapan

BACKGROUND Estimation of the functional reserve of the remnant liver is important to reduce morbidity and *** To estimate the functional reserve of the remnant liver in patients with hepatocellular carcinoma(HCC).METHODS We reviewed the medical records of 199 patients who underwent resection of *** clearance of the remnant liver was calculated using fusion images of 99mTc-labelled galactosyl-human serum albumin liver scintigraphy and computed *** liver failure(PHLF)was classified according to the International Study Group of Liver *** was classified according to Clavien–Dindo *** analyzed by the risk factors for PHLF,morbidity and mortality with multivariate *** Twenty-seven(30%)patients had major complications and 23(12%)developed *** incidence of major complications increased with increasing albumin–bilirubin(ALBI)*** area under the curve values for hepatic clearance of the remnant liver,liver to heart-plus-liver radioactivity at 15 min(LHL15),and ALBI score predicting PHLF were 0.868,0.629,and 0.655,*** area under the curve for hepatic clearance of the remnant liver,LHL15,and ALBI score predicting major complications were 0.758,0.594,and 0.647,*** risk factors for PHLF and major complications were hepatic clearance of the remnant liver and intraoperative *** The measurement of hepatic clearance may predict PHLF and major complications for patients undergoing resection of HCC.

关键词： Liver function Hepatectomy Cirrhosis Fusion image Complication Mortality

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Modeling simulation and experimental validation for mold filling process

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中国有色金属学会会刊：英文版 2006年第A2期16卷 335-338,339页

作者：侯华巨东英毛红奎 D．saito College of Materials Science and Technology North University of China Taiyuan 030051 China Department of Mechanical Engineering Saitama Institute of Technology Fusaiji Saitama369-0239 Japan

Based on the continuum equation, momentum conservation and energy conservation equations, the numerical model of turbulent flow filling was introduced; the 3-D free surface vof method was improved. Whether or not the numerical simulation results are reasonable, it needs corresponding experimental validations. General experimental techniques for casting fluid flow process include: thermocouple tracking location method, hydraulic simulating method, heat-resistant glass window method and X-ray observation etc. The hydraulic analogue experiment with DPIV technique is arranged to validate the fluent flow program for low-pressure casting with 0.1 X 10(5) Pa and 0.6 X 10(5) Pa pressure visually. By comparing the flow head, liquid surface, flow velocity, it is found that the filling pressure value influences the flow state strongly. With the increase of the filling pressure, the fluid flow state becomes'unstable, the flow head becomes higher, and the filling time is reduced. The simulated results are accordant with the observed results approximately, which can prove the reasonability of our numerical program for filling process further.

关键词：铸模浇注过程数学模型数值模拟实验验证

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