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Engineering Analysis of Strong Motion Data from Recent Earthquakes in Sichuan, China

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工程科学与技术 2018年第3期50卷 112-124页

作者： HUANG Chen galasso Carmine Department of Civil Environmental and Geomatic Engineering University College London (UCL) London WC1E 6BT UK

Recent earthquakes in the Sichuan Province have contributed to significantly expand the existing ground-motion database for China with new,high-quality ground-motion *** study investigated the compatibility of ground-motion prediction equations(GMPEs)established by the NGA-West2 project in the US and local GMPEs for China,with respect to magnitude scaling,distance scaling,and site scaling implied by recent Chinese strong-motion *** NGA-West2 GMPEs for shallow crustal earthquakes in tectonically active regions are considerably more sophisticated than widely used previous models,particularly in *** a mixed-effects procedure,the study evaluated event terms(inter-event residuals)and intra-event residuals of Chinese data relative to the NGA-West2 *** scaling was investigated by examining trends of intra-event residuals with source-to-site *** with respect to site conditions was investigated by examining trends of intra-event residuals with soil *** study also investigated other engineering characteristics of Chinese strong ground *** particular,the records were analyzed for evidence of pulse-like forward-directivity *** elastic median response spectra of the selected stations were compared to code-mandated design spectra for various mean return *** showed that international and local GMPEs can be applied for seismic hazard analysis in Sichuan with minor modification of the regression coefficients related to the source-to-site distance and soil ***,the Chinese data attenuated faster than implied by the considered GMPEs and the differences were statistically significant in some ***-source,pulse-like ground motions were identified at two recording stations for the 2008 Wenchuan earthquake,possibly implying rupture *** median recorded spectra were consistent with the code-based spectra in terms of amplitude and *** new ground-motion data can be used to deve

关键词： ground motion prediction equations NGA-West2 project code-based spectrum pulse-like ground motions

Interpretability and spatial efficacy of a deep-learning-based on-site early warning framework using explainable artificial intelligence and geographically weighted random forests

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Geoscience Frontiers 2024年第5期15卷 182-196页

作者： Jawad Fayaz Carmine galasso Department of Computer Science University of ExeterUK Department of Civil Environmentaland Geomatic EngineeringUniversity College London(UCL)LondonUK

Earthquakes pose significant risks globally,necessitating effective seismic risk mitigation strategies like earthquake early warning(EEW)***,developing and optimizing such systems requires thoroughly understanding their internal procedures and coverage *** study examines a deep-learning-based on-site EEW framework known as ROSERS(Real-time On-Site Estimation of Response Spectra)proposed by the authors,which constructs response spectra from early recorded ground motion waveforms at a target *** study has three primary goals:(1)evaluating the effectiveness and applicability of ROSERS to subduction seismic sources;(2)providing a detailed interpretation of the trained deep neural network(DNN)and surrogate latent variables(LVs)implemented in ROSERS;and(3)analyzing the spatial efficacy of the framework to assess the coverage area of on-site EEW *** is retrained and tested on a dataset of around 11,000 unprocessed Japanese subduction ground ***-of-fit testing shows that the ROSERS framework achieves good performance on this database,especially given the peculiarities of the subduction seismic *** trained DNN and LVs are then interpreted using game theory-based Shapley additive explanations to establish cause-effect ***,the study explores the coverage area of ROSERS by training a novel spatial regression model that estimates the LVs using geographically weighted random forest and determining the radius of *** results indicate that on-site predictions can be considered reliable within a 2–9 km radius,varying based on the magnitude and distance from the earthquake *** information can assist end-users in strategically placing sensors,minimizing blind spots,and reducing errors from regional extrapolation.

关键词： Earthquake early warning systems Spatial regression Neural networks Japanese subduction Explainable artificial intelligence

Antiplatelet therapy in very elderly and comorbid patients with acute coronary syndromes

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Journal of Geriatric Cardiology 2019年第2期16卷 103-113页

作者： Roberta De Rosa Federico Piscione Gennaro galasso Stefano De Servi Stefano Savonitto Department of Medicine Surgery and DentistrySchola Medica SalemitanaUniversity of SalernoItaly IRCCS Multimedica Sesto San Giovanni(MI)Italy Cardiovascular Department Alessandro Manzoni HospitalLeccoItaly

With population ageing and rise of life expectancy,a progressively increasing proportion of patients presenting with an acute coronary syndrome(ACS)are older adults,including those at extreme chronological *** amounts of data,including randomized clinical trials,have shown that the benefits of an early revascularization are maintained also at very old age,resulting in improved outcome after an acute coronary *** the contrary,the optimal antiplatelet therapy(APT)remains unclear in these patients,because of both safety and efficacy ***,age-related multiple organ dysfunction and high prevalence of comorbidities may on the one hand reduce the therapeutic effects of administered drugs;on the other hand,it leads to increased vulnerability to drug toxicity and side ***,management of APT is particularly challenging in elderly patients because of higher risk of both ischemic and bleeding *** aim of the present paper is to review the current evidence,gaps in knowledge and ongoing research regarding APT in the setting of an ACS in elderly and very elderly patients,and in those with significant comorbidities including chronic kidney disease,diabetes mellitus and frailty.

关键词： Acute coronary syndrome Antiplatelet therapy The elderly

A Likert Scale-Based Model for Benchmarking Operational Capacity,Organizational Resilience,and Disaster Risk Reduction

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International Journal of Disaster Risk Science 2020年第3期11卷 404-409页

作者： Gianluca Pescaroli Omar Velazquez Irasema Alcántara-Ayala Carmine galasso Patty Kostkova David Alexander Institute for Risk and Disaster Reduction University College London(UCL)London WC1E 6BTUK Institute of Geography National Autonomous University of Mexico(UNAM)Mexico CityMexico Department of Civil Environmental and Geomatic EngineeringUniversity College London(UCL)London WC1E 6BTUK

Likert scales are a common methodological tool for data collection used in quantitative or mixed-method approaches in multiple *** are often employed in surveys or questionnaires,for benchmarking answers in the fields of disaster risk reduction,business continuity management,and organizational ***,both scholars and practitioners may lack a simple scale of reference to assure consistency across disciplinary *** article introduces a simple-to-use rating tool that can be used for benchmarking responses in questionnaires,for example,for assessing disaster risk reduction,gaps in operational capacity,and organizational *** aim,in particular,to support applications in contexts in which the target groups,due to cultural,social,or political reasons,may be unsuitable for in-depth analyses that use,for example,scales from 1 to 7 or from 1 to *** methodology is derived from the needs emerged in our recent fieldwork on interdisciplinary projects and from dialogue with the stakeholders *** output is a replicable scale from 0 to 3 presented in a table that includes category labels with qualitative attributes and descriptive equivalents to be used in the formulation of model *** include examples of levels of resilience,capacity,and *** are connected to other tools that could be used for in-depth *** advantage of our Likert scale-based response model is that it can be applied in a wide variety of disciplines,from social science to engineering.

关键词： Assessment Disaster risk reduction Interdisciplinary Likert scale Questionnaires Scales

Shear-wave elastography to predict hepatocellular carcinoma after hepatitis C virus eradication:A systematic review and meta-analysis

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World Journal of Gastroenterology 2024年第10期30卷 1450-1460页

作者： Giorgio Esposto Paolo Santini Linda galasso Irene Mignini Maria Elena Ainora Antonio Gasbarrini Maria Assunta Zocco CEMAD Digestive Disease Center Fondazione Policlinico Universitario“A.Gemelli”IRCCSCatholic University of RomeRome 00168Italy Fondazione Policlinico Universitario Agostino Gemelli IRCCS Fondazione Policlinico Universitario Agostino Gemelli IRCCS-UniversitàCattolica del Sacro CuoreRome 00168Italy Medicina Interna e Gastroenterologia CEMAD Digestive Disease CenterUniversitàCattolica del Sacro CuoreFondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy

BACKGROUND Direct-acting antiviral agents(DAAs)are highly effective treatment for chronic hepatitis C(CHC)with a significant rate of sustained virologic response(SVR).The achievement of SVR is crucial to prevent additional liver damage and slow down fibrosis *** assessment of fibrosis degree can be performed with transient elastography,magnetic resonance elastography or shear-wave elastography(SWE).Liver elastography could function as a predictor for hepato-cellular carcinoma(HCC)in CHC patients treated with *** To explore the predictive value of SWE for HCC development after complete clearance of hepatitis C virus(HCV).METHODS A comprehensive literature search of clinical studies was performed to identify the ability of SWE to predict HCC occurrence after HCV *** accordance with the study protocol,a qualitative and quantitative analysis of the evidence was *** At baseline and after 12 wk of follow-up,a trend was shown towards greater liver stiffness(LS)in those who go on to develop HCC compared to those who do not[baseline LS standardized mean difference(SMD):1.15,95%confidence interval(95%CI):020-2.50;LS SMD after 12 wk:0.83,95%CI:0.33-1.98].The absence of a statistically significant difference between the mean LS in those who developed HCC or not may be related to the inability to correct for confounding factors and the absence of raw source *** was a statist-ically significant LS SMD at 24 wk of follow-up between patients who developed HCC vs not(0.64;95%CI:0.04-1.24).CONCLUSION SWE could be a promising tool for prediction of HCC occurrence in patients treated with *** studies with larger cohorts and standardized timing of elastographic evaluation are needed to confirm these data.

关键词： Shear-wave elastography Hepatocellular carcinoma Hepatitis C virus Sustained virologic response

<i>In Silico</i>Exploration of <i>Cannabis sativa</i>L. Genome for Simple Sequence Repeats (SSRs)

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American Journal of Plant Sciences 2015年第19期6卷 3244-3250页

作者： Incoronata galasso Elena Ponzoni Istituto di Biologia e Biotecnologia Agraria (IBBA-CNR) Milan Italy

Simple sequence repeat (SSR) or microsatellite markers, are a valuable tool for several purposes such as evaluation of genetic diversity, fingerprinting, marker assisted selection, and breeding. Recent developments in sequencing technologies and bioinformatics analyses provide new opportunity to produce a high number of less costly SSRs. Here, we used for the first time a wholegenome shotgun sequencing of the nuclear genome and transcriptome of hemp to develop microsatellite markers for C. sativa L. (hemp). Hemp is an ancient crop that is widely cultivated as a source of fiber, seeds and medicine. The analysis using the MISA program revealed a total of 407,491 SSRs (from mono-nucleotide to deca-nucleotide) in the hemp genome and 15,655 SSRs in the transcriptome. Analysis of the frequency and distribution of SSRs showed that the mono-nucleotide repeats were the most abundant (55.4%) in the genome whereas the tri-nucleotide motifs (30.4%) resulted highly predominant in the transcriptome. Poly A/T was predominant over poly G/C in both genome and transcriptome sequences. Among the tri-nucleotide repeats AAG/CTT (34.5%) resulted the most abundant in the transcriptome. Repeats larger than tri-nucleotide were also observed in the hemp genome and transcriptome. Dinucleotide and tri-nucleotide repeat expansion of 8605 and 1401 times iteration were observed however, other SSR expansion more than 387 times repetition was not found. Primers were designed for amplification of few long microsatellite sequences which could be used to identify polymorphism and to study genetic diversity among hemp cultivars.

关键词： Microsatellite Relative Density Relative Abundance PCR Amplification

Dynamic contrast enhanced ultrasound in differential diagnosis of hepatocellular carcinoma: A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2804-2815页

作者： Giorgio Esposto Paolo Santini Fabrizio Termite Linda galasso Irene Mignini Maria Elena Ainora Antonio Gasbarrini Maria Assunta Zocco Department of CEMAD Digestive Disease Center Fondazione Policlinico Universitario A Gemelli IRCCSCatholic University of RomeRome 00168Italy Department of Fondazione Policlinico Universitario Agostino Gemelli IRCCS UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Medicina Interna e Gastroenterologia CEMAD Digestive Disease CenterFondazione Policlinico Universitario A Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy

BACKGROUND Non-invasive differential diagnosis between hepatocellular carcinoma(HCC)and other liver cancer(*** or metastasis)is highly challenging and definitive diagnosis still relies on histological *** patterns of enhancement and wash-out of liver nodules can be used to stratify the risk of malignancy only in cirrhotic patients and HCC frequently shows atypical *** contrast-enhanced ultrasound(DCEUS)with standardized software could help to overcome these obstacles,providing functional and quantitative parameters and potentially improving accuracy in the evaluation of tumor *** To explore clinical evidence regarding the application of DCEUS in the differential diagnosis of liver *** A comprehensive literature search of clinical studies was performed to identify the parameters of DCEUS that could relate to histological *** accordance with the study protocol,a qualitative and quantitative analysis of the evidence was *** Rise time was significantly higher in HCC patients with a standardized mean difference(SMD)of 0.83(95%CI:0.48-1.18).Similarly,other statistically significant parameters were mean transit time local with a SMD of 0.73(95%CI:0.20-1.27),peak enhancement with a SMD of 0.37(95%CI:0.03-0.70),area wash-in area under the curve with a SMD of 0.47(95%CI:0.13-0.81),wash-out area under the curve with a SMD of 0.55(95%CI:0.21-0.89)and wash-in and wash-out area under the curve with SMD of 0.51(95%CI:0.17-0.85).SMD resulted not significant in fall time and wash-in rate,but the latter presented a trend towards greater values in HCC compared to intrahepatic *** DCEUS could improve non-invasive diagnosis of HCC,leading to less liver biopsy and early *** quantitative analysis needs to be applied on larger cohorts to confirm these preliminary results.

关键词： Dynamic contrast enhanced ultrasound Hepatocellular carcinoma Intracellular cholangiocarcinoma Quantitative ultrasound Liver cancer Time-intensity curve

Breast cancer stem cells: The role of sex steroid receptors

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World Journal of Stem Cells 2019年第9期11卷 594-603页

作者： Pia Giovannelli Marzia Di Donato Giovanni galasso Erika Di Zazzo Nicola Medici Antonio Bilancio Antimo Migliaccio Gabriella Castoria Department of Precision Medicine University of Campania "L.Vanvitelli"

Breast cancer(BC)is the most common cancer among women,and current available therapies often have high success ***,BC might acquire drug resistance and sometimes *** knowledge about the most aggressive forms of BC points to the role of specific cells with stem properties located within BC,the so-called“BC stem cells”(BCSCs).The role of BCSCs in cancer formation,growth,invasiveness,therapy resistance and tumor recurrence is becoming increasingly *** growth and metastatic properties of BCSCs are regulated by different pathways,which are only partially *** steroid receptors(SSRs),which are involved in BC etiology and progression,promote BCSC proliferation,dedifferentiation and ***,in the literature,there is incomplete information about their ***,there are contrasting conclusions about the expression and role of the classical BC hormonal biomarkers,such as estrogen receptor alpha(ERα),together with scant,albeit promising information concerning ER beta(ERβ)and androgen receptor(AR)properties that control different transduction pathways in *** this review,we will discuss the role that SRs expressed in BCSCs play to BC progression and recurrence and how these findings have opened new therapeutic possibilities.

关键词： Breast cancer Steroids Sex steroid receptors Cancer stem cells Therapeutic implications

Treatment options for irreparable postero-superior cuff tears in young patients

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World Journal of Orthopedics 2015年第10期6卷 770-775页

作者： Olimpio galasso Filippo Familiari Giorgio Gasparini Department of Orthopaedic and Trauma Surgery "Magna Graecia" University of Catanzaro

Rotator cuff tears(RCTs) occur more commonly with advanced age,with most rotator cuff abnormalities in patients less than 30 years old being painful tendinoses or partial-thickness *** postero-superior cuff tears has been reported as frequent as 7% to 10% in the general population,and the incidence of irreparable RCTs in young patients is still *** surgical procedures have been proposed for young patients with irreparable postero-superior RCTs,such as rotator cuff debridement,partial rotator cuff repair,biceps tenotomy/tenodesis,rotator cuff grafting,latissimus dorsi tendon transfer,and reverse shoulder *** being thoroughly investigated in open surgery,arthroscopic techniques for latissimus dorsi tendon transfer have been recently *** have been shown to be an adequate option to open surgery for managing irreparable postero-superior RCTs refractory to conservative management.

关键词： Postero-superior rotator cuff tears Young patients Irreparable Latissimus dorsi Tendon transfer