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Immunotherapy as maintenance treatment in metastatic triple negative breast cancer

journal of Cancer Metastasis and Treatment 2021年第1期7卷 315-322页

作者： tira j.tan jack j.Chan Rebecca A.Dent Division of Medical Oncology National Cancer CentreSingapore 169610Singapore.

Metastatic triple negative breast cancer(mTNBC)is an aggressive disease associated with a poor prognosis as compared to other subtypes of breast *** advances have been made in recent years with new approvals for PARP inhibitors for those patients who harbor germline BRCA mutations and immune checkpoint inhibitors for patients with programmed death ligand-1(PD-L1)expressing *** therapies are associated with favorable toxicity profiles and improved health-related quality of life when compared with *** therapy,now recognized as the mainstay for patients with ovarian malignancies,takes advantage of the benefit of low-intensity therapies to suppress a disease over a prolonged period of time following maximal response to induction *** strategy has been little explored in the treatment of ***,we briefly discuss the evidence to date lending credence to this treatment paradigm and examine the potential role of immunotherapy as maintenance in the management of mTNBC.

关键词： Triple negative breast cancer maintenance therapy immunotherapy PARP inhibitor

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权力距离的影响是否会调节个人-工作匹配与组织承诺之间的关系，从而导致留任意愿？（来自印尼千禧一代工人的证据）

权力距离的影响是否会调节个人-工作匹配与组织承诺之间的关系，...

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作者： Revi tira Oktavianto 浙江工商大学

学位级别：硕士

Previous studies have found that Generation Y（Millennial）has a higher turnover rate compared to Generation *** Indonesia,there has been a phenomenon called job hopping which reflects how Millennial workers change their jobs after a short period of *** research aims to analyse the relationship between person-job fit（P-j fit）with organizational commitment（OC）and intention to stay（ITS）of Indonesian Millennial workers,and how power distance（PD）may influence the *** data were collected through self-reported questionnaires and were tested following the Andrew *** moderated mediation procedures in SPSS with sample size of *** current study contends that OC fully mediates the relationship between P-j fit and ITS,and PD does not moderate the relationship between P-j fit and *** research contributes to the literature by examining the moderating role of PD with Millennial generation as the objects,of which only few empirical studies have been based on samples from this particular generational group,especially in non-Western work culture.

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