检索结果-南通市图书馆

联合应用卡铂与紫杉醇治疗进展性和复发性宫颈癌:英国哥伦比亚癌症中心的治疗经验

世界核心医学期刊文摘（妇产科学分册） 2005年第11期1卷 38-38页

作者： tinker a.v. Bhagat K. Swenerton K.D. Hoskins P.J. 王颖 Peter MacCallum Cancer Centre St. Andrew' s Place East Melbourne Vic. 3002 Australia

Background. One of the most active chemotherapy combinations in a.v.nced or recurrent cervical cancer is cis-platin-paclitaxel. However, this palliative regimen is associated with significant toxicity. Carboplatin-paclitaxel is thus an attractive option. Methods. Patients with a.v.nced or recurrent carcinoma of the cervix treated with carboplatin-paclitaxel from April 2000 were included in the study. Starting doses of carboplatin-paclitaxel were: AUC 5-6 and 155-175 mg/m2, respectively, repeated every 28 days. Results. Twenty-five women treated with this combination were identified. Twenty-three women (92% ) had prior treatment with pelvic radiotherapy and 14 (56% ) had had concurrent radio-sensitizing cisplatin. There was a 20% PR and a 20% CR rate (10/25). The median progression-free survival for the entire group was 3 months. Responders had a median PFS of 16 months. Fourteen patients (56% ) had died of disease progression. The median overall survival (OS) was 21 months. Common toxicities included: grade 1 or 2 anemia, 68% ; grade 3 or 4 anemia, 32% ; grade 3 or 4 neutropenia, 32% ; and grade 1 or 2 peripheral neuropathy, 24% . ECOG PS did not change significantly while on treatment. Eighty-four percent of treatments were delivered on time, and 96% at full dose. Conclusions. Carboplatinpaclitaxel is an active combination in a.v.nced and recurrent cervical cancer. In this predominantly pre-irradiated group, the combination was deliverable, well tolerated, and the most commonly observed toxicity was anemia.1078. A phase Ⅱ evaluation of flavopiridol as second-line chemotherapy of endometrial carcinoma: A Gynecologic Oncology Group study Grendys Jr. E.C./Blessing J.A./Burger R./Hoffman J. E.C. Grendys Jr., Florida Gynecologic Oncology, 2780 Cleveland Avenue, Fort Myers, FL 33901, United States -GYNECOL. ONCOL. 2005, 98/2 (249-253) Objective. A phase Ⅱ study was conducted to determine the efficacy of single agent flavopiridol therapy in patients with recurrent or pers

关键词：癌症中心联合方案放疗史毒性反应增敏剂存活期联合用药反应率癌症进展

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bianchi Type-v Bulk viscous Barotropic Fluid Cosmological Model with variable G and A

引用

Chinese Physics Letters 2008年第8期25卷 3090-3093页

作者： Raj Bali Seema tinker Department of Mathematics University of Rajasthan 3aipur-302004 India

We investigate the Bianchi type-v bulk viscous barotropic fluid cosmological model with variable gravitational constant G and the cosmological constant A, assuming the condition on metric A/A=B/B=C/C=m/tn potential aswhere A, B, and C are functions of time t, while m and n are constants. To obtain the deterministic mo del, we also assume the relations P = p - 3η H, p = 7P, η = ηop^s, where p is the isotropic pressure, η the bulk viscosity,0≤r≤1 H the Hubble constant, ηo and s are constants. various physical aspects of the model are *** case of n = 1 is also discussed to compare the results with the actual universe.

关键词： the power-law exponents precipitation durative abrupt precipitation change

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Enabling intercalation-type TiNb_(24)O_(62)anode for sodiumand potassium-ion batteries via a synergetic strategy of oxygen vacancy and carbon incorporation

引用

SusMat 2023年第2期3卷 222-234页

作者： Ajay Piriya.v.jaya Kumar Saroja Zhipeng Wang Henry R.tinker Feng RyanWang Paul R.Shearing Yang Xu Department of Chemistry University College LondonLondonUK Materials and Catalysis Laboratory Department of Chemical EngineeringUniversity College LondonLondonUK Electrochemical Innovation Lab Department of Chemical EngineeringUniversity College LondonLondonUK

The key to develop earth-abundant energy storage technologies sodium-and potassium-ion batteries(SIBs and PIBs)is to identify low-cost electrode materials that allow fast and reversible Na^(+)/K^(+)***,we report an intercalation-type material TiNb_(24)O_(62)as a.v.rsatile anode for SIBs and PIBs,via a synergistic strategy of oxygen vacancy and carbon incorporation to enhance ion and electron *** TiNb_(24)O_(62-x)/reduced graphene oxide(rGO)composite anode delivers high reversible capacities(130 mA h g^(-1)for SIBs and 178 mA h g^(-1)for PIBs),great rate performance(54 mA h g^(-1)for SIBs and 37 mA h g^(-1)for PIBs at 1 A g^(-1)),and superior cycle stability(73.7%after 500 cycles for SIBs and 84%after 300 cycles for PIBs).The performance is among the best results of intercalation-typemetal oxide anodes for SIBs and *** better performance of TiNb_(24)O_(62-x)/rGO in SIBs than PIBs is due to the better reaction kinetics of the ***,mechanistic study confirms that the redox activity of Nb4+/5+is responsible for the reversible intercalation of Na^(+)/K^(+).Our results suggest that TiNb_(24)O_(62-x)/rGO is a promising anode for SIBs and PIBs and may stimulate further research on intercalation-type compounds as candidate anodes for large ion batteries.

关键词： anode defects intercalation potassium-ion battery sodium-ion battery sustainability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An integrated framework reinstating the environmental dimension for GWAS and genomic selection in crops

引用

Molecular Plant 2021年第6期14卷 874-887页

作者： Xianran Li Tingting Guo Jinyu Wang Wubishet ABekele Sivakumar Sukumaran Adam Evanous James PMcNellie Laura Tibbs Cortes Marta SLopes Kendall RLamkey Mark EWestgate John KMcKay Sotirios vArchontoulis Matthew PReynolds Nicholas Atinker Patrick SSchnable Jianming Yu Department of Agronomy Iowa State UniversityAmesIA 50011USA Ottawa Research and Development Centre Agriculture and Agri-Food CanadaOttawaONCanada International Maize and Wheat Improvement Center(CIMMYT) Mexico CityMexico Department of Bioagricultural Sciences and Pest Management Colorado State UniversityFort CollinsCO 80523USA

Identifying mechanisms and pathways involved in gene–environment interplay and phenotypic plasticity is a long-standing *** is highly desirable to establish an integrated framework with an environmental dimension for complex trait dissection and prediction.A critical step is to identify an environmental index that is both biologically relevant and estimable for new *** extensive field-observed complex traits,environmental profiles,and genome-wide single nucleotide polymorphisms for three major crops(maize,wheat,and oat),we demonstrated that identifying such an environmental index(i.e.,a combination of environmental parameter and growth window)enables genome-wide association studies and genomic selection of complex traits to be conducted with an explicit environmental ***,genes identified for two reaction-norm parameters(i.e.,intercept and slope)derived from flowering time values along the environmental index were less colocalized for a diverse maize panel than for wheat and oat breeding panels,agreeing with the different diversity levels and genetic constitutions of the *** addition,we showcased the usefulness of this framework for systematically forecasting the performance of diverse germplasm panels in new *** general framework and the companion CERIS-JGRA analytical package should facilitate biologically informed dissection of complex traits,enhanced performance prediction in breeding for future climates,and coordinated efforts to enrich our understanding of mechanisms underlying phenotypic variation.

关键词： phenotypic plasticity genotype by environment interaction gene-environment interplay genomewide association studies genomic selection flowering time reaction norm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

细菌***光合反应中心与醌分子QB相关质子转移机理的QM/MM研究

引用

中国化学会第九届全国量子化学学术会议

作者：孙扬张启元艾希成张建平 B．L．Grigorenko a.v.Nemukhin 中国科学院化学研究所分子动态与稳态国家重点实验室中国科学院化学研究所分子动态与稳态国家重点实验室中国科学院化学研究所分子动态与稳态国家重点实验室中国科学院化学研究所分子动态与稳态国家重点实验室 Chemistry DepartmentM．v.Lomonosov Moscow State University Moscow119899 Chemistry DepartmentM．v.Lomonosov Moscow State University Moscow119899

＜正＞本文应用GAMESS及EFP（Effective Fragment Potential有效片段势）模型与tinker程序包中的分子力场相结合而发展的QM/MM方法,对紫色细菌***光合反应中心内电子及质子转移到泛醌分子的机理进行了理论研究。在光合反应中心内,质体...

＜正＞本文应用GAMESS及EFP（Effective Fragment Potential有效片段势）模型与tinker程序包中的分子力场相结合而发展的QM/MM方法,对紫色细菌***光合反应中心内电子及质子转移到泛醌分子的机理进行了理论研究。在光合反应中心内,质体醌分子QA到泛醌分子 QB间的电子转移伴随质子转移过程是光能向化学能转化的关键反应步骤之一,但光合反应中心复杂的结构和庞大的分子对于通常方法下的理论计算构成了挑战。本文在计算模型的构建

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：