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Cerebral cysticercosis mimicking subarachnoid hemorrhage:a case report

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Chinese Neurosurgical Journal 2022年第1期8卷 60-64页

作者： Tao Liu tingzhong wang Yijun Bao Jinghua Du Yongchang Guan Department of Neurosurgery The Fourth Affiliated Hospital of China Medical UniversityShenyang 110032China Department of Neurology The Fourth Affiliated Hospital of China Medical UniversityShenyang 110032China

Background:Dense exudate during the calcification of cerebral cysticercosis in basal subarachnoid space was easy to be misdiagnosed as subarachnoid hemorrhage(SAH);clinical evaluation and MRI can help differentiate SAH from *** presentation:A case of ventricular expansion accompanied by high-density shadows in cisterna circinata cerebri was taken to the hospital for treatment due to sudden *** patient was diagnosed as subarachnoid hemorrhage according to computed tomography(CT)in another *** believe that the high density in cisterna circinata cerebri was misdiagnosed as subarachnoid hemorrhage(SAH)1 year *** main etiology of SAH is aneurysm;non-aneurysmal SAH associated with cerebral cysticercosis is extremely *** 5 patients have been ***:This case indicated that although the specificity of CT for SAH is very high,the physicians should be aware of rare false positive findings,called pseudo-SAH.

关键词： Cerebral cysticercosis Subarachnoid hemorrhage Computed tomography Magnetic resonance imaging Misdiagnosis

Bisoprolol reverses down-regulation of potassium channel proteins in ventricular tissues of rabbits with heart failure

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The Journal of Biomedical Research 2011年第4期25卷 274-279页

作者： Xi Li tingzhong wang Ke Han Xiaozhen Zhuo Qun Lu Aiqun Ma Department of Cardiovascular Medicine the First Affiliated Hospital of Medical School Xi＇an Jiaotong University Xi ＇an Shaanxi 710061 China Key Laboratory of Molecular Cardiology of Shaanxi Province Xi ＇an Shaanxi 710061 China Key Laboratory of Enwronment and Genes Related to Diseases Xi＇an Jiaotong University Xi＇an Shaanxi 710061 China Department of Cardiovascular Medicine the Second Affiliated Hospital of Medical School Ningxia Medical University Yinehuan Ningxia Hui Autonomous Region 750001 China

Remodeling of ion channels is an important mechanism of arrhythmia induced by heart failure （HF）. We investigated the expression of potassium channel encoding genes in the ventricles of rabbit established by volumeoverload operation followed with pressure-overload. The reversible effect of these changes with bisoprolol was also evaluated. The HF group exhibited left ventricular enlargement, systolic dysfunction, prolongation of corrected QT interval （QTc）, and increased plasma brain natriuretic peptide levels in the HF rabbits. Several potassium channel subunit encoding genes were consistently down-regulated in the HF rabbits. After bisoprolol treatment, heart function was improved significantly and QTc was shortened. Additionally, the mRNA expression of potassium channel subunit genes could be partially reversed. The down-regulated expression of potassium channel subunits Kv4.3, Kv1.4, KvLQT1, minK and Kir 2.1 may contribute to the prolongation of action potential duration in the heart of rabbits induced by volume combined with pressure overload HF. Bisoprolol could partially reverse these down-regulations and improve heart function.

关键词： heart failure potassium channel down-regulation animal models

Distribution of Soil Nutrients in Se-rich Areas of Hainan Island

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Agricultural Biotechnology 2018年第4期7卷 157-160,171页

作者： Qing MAI tingzhong wang Huande FENG Dengfeng wang Agricultural Science Institute of Tunchang Tunchang 571600China Hainan Soil and Fertilizer Station Haikou 570203China Tropical Crops Genetic Resources Institute CATASDanzhou 571737China

[Objectives] The aim was to reveal the distribution of soil nutrients in Se-rich area of Hainan and to clarify their specific contents, so as to provide references for the development of Se-rich area agriculture in Hainan.[Methods] With the se-rich area in Hainan as the object, field investigation and indoor analysis were combined to elucidate the nutrient status of cultivated soil in the area and analyze its nutrient distribution.[Results] The soil in the se-rich area in Hainan province was generally acidic with the average soil pH value of 5.0. The difference in soil pH between different landforms and different altitudes was not significant, ranging from 4.9 to 5.3. Soil available P and available K contents were low to intermediate, and the soil available N content was moderate. The farming system, chemical fertilizer application structure and meteorological factors were the main causes of the distribution of soil nutrient elements. The soil exchangeable calcium and magnesium content was rich, and the distribution of trace elements in the arable soil of different terrains and elevations was closely related to the distribution of soil parent material in the region. The increase of soil organic matter content in arable land could be achieved by increasing the application of organic fertilizer and guiding the farmers to enhance the application of straws to fields.[Conclusions] The application of soil N, P and K fertilizers should be combined with the application of soil organic fertilizers to improve the soil fertility of cultivated land.

关键词： Hainan selenium-rich area soil nutrient spatial distribution

Spatial and Temporal Variability of Soil Organic Matters in Se-rich Areas of Hainan Island in Recent 30 Years

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Agricultural Biotechnology 2018年第4期7卷 242-245页

作者： Zhu CEN tingzhong wang Rongxiang wang Huande FENG Wuzhishan Agricultural Technology and Machinery Center Wuzhishan 572200China Hainan Soil and Fertilizer Station Haikou 570203China Tropical Crops Genetic Resources Institute CATASDanzhou 571737China

[Objectives] The aim was to reveal the distribution of soil organic matter content in cultivated land in the Se-rich areas of Hainan in 1980and 2010, so as to provide reference for the study on the evolution of soil organic matter content.[Methods] With the combination of field investigation with indoor analysis, the characteristics of organic matter content in the Se-rich areas of Hainan in 1980 and 2010 was revealed by means of spatial analysis, and the differences were analyzed.[Results] In the last 30 years, the proportion of 20-30 g/kg of soil organic matter content in the Se-rich areas of Hainan was reduced, but the content of soil organic matter in the area generally increased. The average value of the content of organic matter in the area was increased from 25.3 g/kg in the 1980s to 28.1 g/kg, but its spatial distribution was uneven.[Conclusions] The farmers should be guided to change the fertilization structure, and attention should be paid to the application of organic fertilizer, so as to improve the soil organic matter content.

关键词： Hainan Se-rich area Organic matter spatial distribution

Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-Ⅱa Window

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Nano-Micro Letters 2020年第3期12卷 129-141页

作者： Xunzhi Wu Yongkuan Suo Hui Shi Ruiqi Liu Fengxia Wu tingzhong wang Lina Ma Hongguang Liu Zhen Cheng Institute of Molecular Medicine College of Life and Health SciencesNortheastern UniversityShenyang 110000People’s Republic of China Department of Neurosurgery The Fourth Affiliated Hospital of China Medical UniversityShenyang 110000People’s Republic of China Changchun Institute of Applied Chemistry Chinese Academy of ScienceChangchun 130000People’s Republic of China Molecular Imaging Program at Stanford Stanford UniversityPalo AltoCA 94301USA

Photothermal therapy(PTT)using near-infrared(NIR)light for tumor treatment has triggered extensive attentions because of its advantages of noninvasion and *** current research on PTT usually uses lasers in the first NIR window(NIR-I;700–900 nm)as irradiation ***,the second NIR window(NIR-II;1000–1700 nm)especially NIRIIa window(1300–1400 nm)is considered much more promising in diagnosis and treatment as its superiority in penetration depth and maximum permissible exposure over NIR-I ***,we propose the use of laser excitation at 1275 nm,which is approved by Food and Drug Administration for physical therapy,as an attractive technique for PTT to balance of tissue absorption and scattering with water ***,CuS-PEG nanoparticles with similar absorption values at 1275 and 808 nm,a conventional NIR-I window for PTT,were synthesized as PTT agents and a comparison platform,to explore the potential of 1275 and 808 nm lasers for PTT,especially in deep-tissue *** results showed that 1275 nm laser was practicable in *** exhibited much more desirable outcomes in cell ablation in vitro and deep-tissue antitumor capabilities in vivo compared to that of 808 nm ***-IIa laser illumination is superior to NIR-I laser for deep-tissue PTT,and shows high potential to improve the PTT outcome.

关键词： Photothermal therapy Deep-tissue NIR-IIa 1275 nm laser Molecular imaging

胰岛素对人心肌细胞QT间期及诱发心律失常的影响

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西安交通大学学报（医学版） 2022年第2期43卷 196-201页

作者：谢学刚魏峰张玉顺王星烨霍建华王亭忠马爱群西安交通大学第一附属医院结构性心脏病科陕西西安710061 环境与疾病相关基因教育部重点实验室陕西西安710061 陕西省分子心脏病学重点实验室陕西西安710061 西安交通大学第一附属医院心血管内科陕西西安710061

目的探讨胰岛素对人诱导多潜能干细胞来源的心肌细胞(hiPSC-CMs)QT间期及诱发心律失常的影响。方法免疫荧光染色及流式细胞术分析hiPSC-CMs纯度,微电极阵列(MEA)检测胰岛素干预hiPSC-CMs前后的电生理改变,包括心率(HR)、阈电位时程(FPD... 详细信息

目的探讨胰岛素对人诱导多潜能干细胞来源的心肌细胞(hiPSC-CMs)QT间期及诱发心律失常的影响。方法免疫荧光染色及流式细胞术分析hiPSC-CMs纯度,微电极阵列(MEA)检测胰岛素干预hiPSC-CMs前后的电生理改变,包括心率(HR)、阈电位时程(FPD,类似心电图QT间期)、FPDc(经HR校正的FPD)、锋电位与传导速率(CV);观察E4031干预hiPSC-CMs诱发FPDc延长及心律失常的情况;在胰岛素干预hiPSC-CMs基础上,再给予E4031处理,观察胰岛素对E4031诱发FPDc延长及心律失常的改善情况。结果hiPSC-CMs高表达心肌特异性标志物cTnT,hiPSC-CMs纯度为97.1%;胰岛素干预hiPSC-CMs 5 d后,与未干预组比较,干预组HR增快(11.9±3.3)%,FPD缩短(22.7±2.8)%,FPDc缩短(15.6±1.6)%,锋电位增加了(39.1±7.9)%,CV无明显变化;10 nmol/L的E4031可使hiPSC-CMs的FPDc延长(37.8±9.0)%,30 nmol/L的E4031可诱发心律失常;经胰岛素预处理后,10 nmol/L的E4031使hiPSC-CMs的FPDc延长(21.8±3.1)%(与胰岛素未处理组相比,FPDc缩短,P<0.05),30 nmol/L的E4031未诱发出心律失常。结论胰岛素可缩短hiPSC-CMs的QT间期,并显著降低药物诱发hiPSCCMs的QT间期延长及心律失常风险。

关键词：人诱导多潜能干细胞心肌细胞 QT间期心律失常胰岛素

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外源甘氨酸促进火龙果根系生长和养分吸收

热带作物学报 2022年第7期43卷 1440-1449页

作者：杨永志高伟高翔钟龙李菊王朝弼王汀忠张珂阮云泽海南大学热带作物学院海南海口570228 海南省土壤肥料总站海南海口570203

根是植物的重要营养器官,控制水分和养分的吸收,很大程度上影响了作物的产量,因此,健康庞大根系网络的建成,对促进作物生产具有决定性意义。火龙果(Hylocereus polyrhizus)属于仙人掌科量天尺属,是热带地区重要的经济作物,具有很高的食... 详细信息

根是植物的重要营养器官,控制水分和养分的吸收,很大程度上影响了作物的产量,因此,健康庞大根系网络的建成,对促进作物生产具有决定性意义。火龙果(Hylocereus polyrhizus)属于仙人掌科量天尺属,是热带地区重要的经济作物,具有很高的食用价值和工业价值,近年来其在热带和亚热带地区的种植面积呈现出急剧扩大的趋势。火龙果是浅根系作物,而关于如何促进火龙果根系生长的研究依然非常匮乏。氨基酸态氮是植物重要氮源,对改善根系生长和作物品质有重要作用,而外源氨基酸态氮如何影响火龙果根系生长以及养分吸收尚无相关报道。本研究以‘软枝大红’火龙果为研究对象,在水培条件下,分析了不同外源氨基酸态氮(甘氨酸、谷氨酸、精氨酸)对火龙果幼苗根系和养分吸收的影响,探究适合火龙果生长所需的外源氨基酸类型。结果表明:甘氨酸处理条件下,火龙果幼苗地上部分生物量和侧枝长度分别为18.12 g/株和59.0 cm,显著高于无机氮(NH_(4)^(+)+NO^(3)^(-))、谷氨酸或精氨酸等处理。地上部养分吸收量也显著受氨基酸类型的影响,甘氨酸处理氮、磷、钾以及中微量元素的吸收量均显著高于其他氨基酸处理。同谷氨酸和精氨酸相比,甘氨酸处理显著促进了根系的生长,幼苗总根长和根表面积分别达到2578 cm/株、401 cm^(2)/株,但低于对照无机氮处理。甘氨酸处理火龙果幼苗根系FTIR光谱在1604 cm^(-1)和1380 cm^(-1)波数附近的透射率均高于其他处理,表明甘氨酸处理降低了火龙果根系氨基酸等物质的含量,可能由于含氮素等物质更多向地上部分配引起。综上所述,同谷氨酸和精氨酸相比,甘氨酸能显著促进火龙果幼苗根系生长,并提高地上部生物量以及养分吸收。

关键词：火龙果氮氨基酸根系形态养分吸收

1990-2019年中国心房颤动和心房扑动疾病负担及危险因素变化情况的分析

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中华心律失常学杂志 2023年第1期27卷 38-43页

作者：王怀根胡甲木王亭忠马爱群西安交通大学第一附属医院心血管内科西安710061 西安交通大学医学部西安710061

目的系统分析1990—2019年中国心房颤动和心房扑动疾病负担及危险因素的变化情况,为疾病的治疗和管理提供参考。方法提取全球疾病负担研究2019(GBD 2019)的数据,使用死亡及伤残致病寿命年(DALYs)的总数及年龄标准化率(ASR)来评估疾病负... 详细信息

目的系统分析1990—2019年中国心房颤动和心房扑动疾病负担及危险因素的变化情况,为疾病的治疗和管理提供参考。方法提取全球疾病负担研究2019(GBD 2019)的数据,使用死亡及伤残致病寿命年(DALYs)的总数及年龄标准化率(ASR)来评估疾病负担情况,并进一步分析其在不同时间、性别、年龄的差异以及危险因素的变化。结果1990—2019年中国心房颤动/心房扑动导致的死亡数增加了3.55倍,DALYs数增加了3.12倍。死亡的ASR从1.49每10万人增加到1.66每10万人,DALYs的ASR则从43.34每10万人年增加到50.59每10万人年。归因于代谢性危险因素(收缩压和体重指数升高)的死亡数从0.55万人增加到2.02万人,DALYs数从23.55万人年增加到了79.49万人年。结论1990—2019年中国心房颤动/心房扑动疾病负担不断加重,代谢性危险因素是其最主要的危险因素。

关键词：心房颤动心房扑动疾病负担危险因素伤残致病寿命年

不同施肥模式对热带地区菠萝生长发育及产量品质的影响

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热带作物学报 2022年第11期43卷 2294-2303页

作者：梁正灏张汉英金鑫翟鹏飞赵艳李长江阮云泽王朝弼王汀忠海南大学热带作物学院海南海口570228 海南省热带生物资源可持续利用重点实验室海南海口570228 国际镁营养研究所福建福州350002 海南省土壤肥料总站海南海口570203

本研究探究了不同施肥模式对菠萝(Ananas comosus)生长发育、养分吸收及产量品质的影响,旨在筛选出高产优质高效的施肥方案。以‘台农17号’菠萝为材料,采用田间小区试验,设置不施肥(CK)、农户常规施肥(NPK)、减量施肥(INF)、有机无机... 详细信息

本研究探究了不同施肥模式对菠萝(Ananas comosus)生长发育、养分吸收及产量品质的影响,旨在筛选出高产优质高效的施肥方案。以‘台农17号’菠萝为材料,采用田间小区试验,设置不施肥(CK)、农户常规施肥(NPK)、减量施肥(INF)、有机无机肥配施(INF+M)和有机无机缓控释肥配施(INF+M+S)5组处理,每组3次重复,比较不同施肥模式下菠萝叶片数、干物质量、产量品质和氮、磷、钾积累与分配的差异。结果表明:快速生长期后,NPK处理叶片数高于其他处理,约为84片。INF+M和INF+M+S处理收获期干物质积累量分别提高20.28%和23.16%,而INF与NPK处理间无显著差异。INF+M+S处理氮、磷积累量分别较NPK处理提高8.33%、2.77%,钾积累量无显著差异,而INF和INF+M处理对氮积累量无显著影响,但降低了磷、钾积累量。此外,INF+M+S处理显著提高了氮、磷、钾转运量,增幅依次为62.32%、189.83%和30.79%,INF+M处理氮、磷、钾转运量也有不同程度提高,而INF处理则降低了磷、钾转运量。相较于CK处理,施肥处理显著降低了冠芽养分分配率,3种减量施肥处理较NPK均提高了收获期菠萝果实养分分配率,减少了叶片等营养器官养分分配率,其中INF+M+S处理果实氮、磷、钾分配率分别较NPK处理提高131.43%、66.60%和147.33%。INF、INF+M和INF+M+S处理产量较NPK处理分别提高1.64%、19.35%和37.09%,且INF+M+S显著高于其他处理;施肥处理较CK显著提高可溶性糖的含量,降低可滴定酸和维生素C含量。但施肥处理间可溶性糖、可滴定酸和维生素C含量之间无显著差异。综上所述,INF+M+S处理下菠萝产量最高,且能提高养分积累量、养分转运量和果实养分分配率,为菠萝最优施肥模式。

关键词：养分积累有机肥缓控释肥菠萝