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Loss of GATA6-mediated up-regulation of UTX promotes pancreatic tumorigenesis and progression

Genes & Diseases 2024年第2期11卷 921-934页

作者： Hui-Qing Zhang Fanyang Kong Xiangyu Kong tingting Jiang Muyuan Ma Shaojiang Zheng Junli Guo Keping Xie The Third Department of Medical Oncology Jiangxi Cancer HospitalNanchangJiangxi 330006China Departments of Gastroenterology Changhai HospitalSecond Military Medical UniversityShanghai 200433China Center for Pancreatic Cancer Research The South China University of Technology School of MedicineGuangzhouGuangdong 510006China Hainan Clinical Medical Research Center of the First Affiliated Hospital Hainan Women and Children's Medical CenterHainan Medical UniversityHaikouHainan 570102China Key Laboratory of Tropical Cardiovascular Diseases Research of Hainan Province Key Laboratory of Emergency and Trauma of Ministry of EducationHainan Medical UniversityHaikouHainan 571199China

Ubiquitously transcribed tetratricopeptide repeat on chromosome X(UTX),also known as lysine(K)-specific demethylase 6A(KDM6A),functions as a tumor suppressor gene or oncogene depending on the tumor type and ***,its tumor-suppressive mechanisms remain largely ***,we investigated the clinical significance and biological effects of UTX expression in pancreatic ductal adenocarcinoma(PDA)and determined the potential mechanisms of its *** expression and its association with clinicopathologic characteristics of PDA patients were analyzed using *** mRNA and protein expression and their regulation in PDA cell lines were measured using quantitative polymerase chain reaction and western blot *** biological functions of UTX in PDA cell growth,migration,and invasion were determined using gain-and loss-of-function assays with both in vitro and in vivo animal *** expression was reduced in human PDA cell lines and *** UTX expression was associated with poor differentiation and prognosis in *** UTX expression inhibited PDA proliferation,migration,and invasion in vitro and PDA growth and metastasis in vivo,whereas knockdown of UTX expression did the ***,UTX expression was trans-activated by GATA6 ***6-mediated PDA progression could be blocked,at least partially,by silencing UTX *** conclusion,loss of GATA6-mediated UTX expression was evident in human PDA and restored UTX expression suppressed PDA growth and ***,UTX is a tumor suppressor in PDA and may serve as a prognostic biomarker and therapeutic target.

关键词： Growth Invasion Metastasis Pancreatic cancer UTX

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Development of a Multiplex Real-Time Quantitative PCR Assay for Detecting Vaginal Microbiota in Chinese women-China,2021-2022

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China CDC weekly 2024年第31期6卷 793-798,I0001,I0002页

作者： Xiaolei wang Yuanyuan Zhang tingting Liu Chuan Song Xiaoyu Xue Jun Liu Hongxin Zhao Clinical Center for HIV/AIDS Beijing Ditan HospitalCapital Medical UniversityBeijingChina Beijing Institute of Infectious Diseases BeijingChina Beijing Key Laboratory of Emerging Infectious Diseases Institute of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijingChina National Center for Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijingChina Beijing Ditan Hospital Peking UniversityBeijingChina Department of Gynecology Beijing Ditan HospitalCapital Medical UniversityBeijingChina

Introduction:The Nugent score,limited by subjectivity and personnel requirements,lacks *** a precise and simple molecular test is therefore essential for detecting vaginal microbiota compositions and evaluating vaginal ***:we evaluated the vaginal health of Chinese women using quantitative polymerase chain reaction(qPCR)to target Lactobacillus crispatus(***),***,Gardnerella vaginalis(***),Atopobium vaginae(***),and Megasphaera *** vaginosis(BV)-related bacteria shared a fluorescent *** 16S rDNA sequencing as a reference standard,we evaluated and validated the diagnostic accuracy of the qPCR ***:Both qPCR and 16S rDNA sequencing demonstrated 90.5%concordance in segregating vaginal community state type(CST),as visualized through heatmaps and ***’s correlation analysis revealed strong correlations between the two methods in calculating the RA of ***(CST I),***(CST III),and BV-related bacteria(CST IV),with coefficients of 0.865,0.837,and 0.827,*** operating characteristic analysis showed that qPCR had significant diagnostic accuracy for CST I,CST III,and CST IV(molecular BV),with area under the curve values of 0.967,0.815,and 0.950,respectively,indicating strong predictive ***:Vaginal health can be evaluated using a single qPCR amplification experiment,making the multiplex qPCR assay a highly accurate tool for this purpose.

关键词： Vaginal Assay precise

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Coordinatively unsaturated cobalt single-atom nanozymes for visual pesticides detection by smartphone-based platform

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Nano Research 2024年第4期17卷 2298-2307页

作者： Fangning Liu Zhe Li Hengya wei Peng Xu Ge Kang Shicheng Zhu tingting wang Ruxue He Chuanxia Chen Yizhong Lu School of Materials Science and Engineering University of JinanJinan 250022China

By adjusting the coordination environment of single-atom catalysts,the enzyme-like activity can be finely tuned for highly sensitive ***,we demonstrated that coordinatively unsaturated cobalt-nitrogen sites doped within porous carbon(SA-CoN_(3))could serve as highly efficient oxidase *** with the typical planar four-coordination structure(SA-CoN_(4)),the as-obtained single-atom Co nanozymes anchored by three nitrogen atoms are found to display much higher oxidase-like catalytic *** theoretical and experimental analysis revealed that the coordinatively unsaturated Co sites could facilitate adsorption and activation of O_(2) molecule and thus improve their oxidase-like *** on the enhanced oxidase-like activity of SA-CoN_(3),a paper/smartphone sensor for organophosphorus pesticides(OPs)was successfully constructed and used to quantify glyphosate in environmental and food samples with a low detection limit of 0.66μ*** work not only highlights the important role of coordination unsaturation of SA nanozymes for promoting oxidase-like activity,but also provides an easy and cost-effective way to conduct effective quantification of OPs in the field.

关键词： single-atom nanozymes asymmetric organophosphorus pesticides oxygen adsorption smartphone

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Nanomaterial‑Based Repurposing of Macrophage Metabolism and Its Applications

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Nano-Micro Letters 2024年第11期16卷 494-528页

作者： tingting Meng Danfeng He Zhuolei Han Rong Shi Yuhan wang Bibo Ren Cheng Zhang Zhengwei Mao Gaoxing Luo Jun Den Institute of Burn Research Southwest HospitalState Key Laboratory of Trauma and Chemical PoisoningArmy Medical UniversityChongqing 400038People’s Republic of China Department of Breast Surgery Gansu Provincial HospitalLanzhouGansu 730030People’s Republic of China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Macrophage immunotherapy represents an emerging therapeutic approach aimed at modulating the immune response to alleviate disease ***(NMs)have been engineered to monitor macrophage metabolism,enabling the evaluation of disease progression and the replication of intricate physiological signal *** achieve this either directly or by delivering regulatory signals,thereby mapping phenotype to effector functions through metabolic repurposing to customize macrophage fate for ***,a comprehensive summary regarding NM-mediated macrophage visualization and coordinated metabolic rewiring to maintain phenotypic equilibrium is currently *** review aims to address this gap by outlining recent advancements in NM-based metabolic *** initially explore the relationship between metabolism,polarization,and disease,before delving into recent NM innovations that visualize macrophage activity to elucidate disease onset and fine-tune its fate through metabolic remodeling for macrophage-centered ***,we discuss the prospects and challenges of NM-mediated metabolic immunotherapy,aiming to accelerate clinical *** anticipate that this review will serve as a valuable reference for researchers seeking to leverage novel metabolic intervention-matched immunomodulators in macrophages or other fields of immune engineering.

关键词： Immunomodulatory nanomaterial Macrophage polarization Macrophage metabolic reprogramming Immune engineering

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Exchanges,Mutual Learning and Looking Forward to the Future The Exhibition of Oil Paintings of China and Five Central Asian Countries

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China & The world Cultural Exchange 2024年第3期 28-33页

作者： Qin tingting 不详

Exchanges and mutual learning between the Chinese and foreign civilizations are an important part of human cultural *** Chinese civilization adopts an all-embracing,open and inclusive attitude to understand the different views of different civilizations on the connotation of *** ancient Silk Road has opened a new window of friendship between countries and written a new chapter in the development of mankind.

关键词： Looking mutual civilization

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Appropriate supply of irrigation and nitrogen produced higher yields of cherry tomatoes

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 149-158页

作者： Zelin Cai Mengchi Zhang Jiarui Xie tingting Kong Yuxuan Zhang Zhihao He Zhi Zhang College of Horticulture Northwest A&F UniversityYangling 712100ShaanxiChina Key Laboratory of Protected Horticultural Engineering in Northwest Ministry of Agriculture/Shaanxi Province Facility Agriculture Engineering CenterYangling 712100ShaanxiChina Key Laboratory for Agricultural Soil and water Engineering in Arid Area of Ministry of Education Northwest A&F UniversityYangling 712100ShaanxiChina

Accurate irrigation and nitrogen application are essential for promoting the growth and yield of cherry *** investigating the effects of irrigation and nitrogen on the growth,photosynthesis,and yield of cherry tomatoes,nine treatments including three levels of both irrigation and nitrogen were conducted over two growing *** stem diameter and horizontal stem diameter had the best performance at the irrigation level of 75%evaporation(E_(p)),although their responses to nitrogen were different for the two *** height increased with the increase of irrigation and *** dry matter(PDM)was significantly affected by irrigation and nitrogen *** lowest PDM was found in the highest proportion of root dry matter,which occurred under low nitrogen *** net photosynthetic rate(Pn)and transpiration rate enhanced with the increase of *** nitrogen showed promotion effect on all photosynthetic parameters in both growing *** of all fourteen indicators showed significant correlations with ***,single plant fruit number and PDM in 2018 Fall had significant positive direct effects on yield with the path coefficients of 0.648 and 1.159,while the significant direct path coefficients were 0.362 and 0.294 in Fruit dry matter and Pn for 2019 Spring,*** on the comprehensive evaluation of growth and yield by TOPSIS,the irrigation level of 75%E_(p) combined with medium nitrogen application produced higher yields by promoting the growth and photosynthesis of cherry *** provides a strategy for water and nitrogen management of cherry tomatoes in Northwest China.

关键词： cherry tomatoes yield growth irrigation nitrogen path analysis

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A Molecular-Sieving Interphase Towards Low-Concentrated Aqueous Sodium-Ion Batteries

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Nano-Micro Letters 2024年第8期16卷 51-63页

作者： tingting Liu Han wu Hao wang Yiran Jiao Xiaofan Du Jinzhi wang Guangying Fu Yaojian Zhang Jingwen Zhao Guanglei Cui Qingdao Industrial Energy Storage Research Institute Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101People’s Republic of China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049People’s Republic of China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaideSA 5005Australia Shandong Energy Institute Qingdao 266101People’s Republic of China Qingdao New Energy Shandong Laboratory Qingdao 266101People’s Republic of China

Aqueous sodium-ion batteries are known for poor rechargeability because of the competitive water decomposition reactions and the high electrode *** have been reported by saltconcentrated and organic-hybridized electrolyte designs,however,at the expense of cost and ***,we report the prolonged cycling of ASIBs in routine dilute electrolytes by employing artificial electrode coatings consisting of NaX zeolite and NaOH-neutralized perfluorinated sulfonic *** as-formed composite interphase exhibits a molecularsieving effect jointly played by zeolite channels and size-shrunken ionic domains in the polymer matrix,which enables high rejection of hydrated Na^(+)ions while allowing fast dehydrated Na^(+)*** this coating to electrode surfaces expands the electrochemical window of a practically feasible 2 mol kg^(-1) sodium trifluoromethanesulfonate aqueous electrolyte to 2.70 V and affords Na_(2)MnFe(CN)_(6)//NaTi_(2)(PO_(4))_(3) full cells with an unprecedented cycling stability of 94.9%capacity retention after 200 cycles at 1 *** with emerging electrolyte modifications,this molecular-sieving interphase brings amplified benefits in long-term operation of ASIBs.

关键词： Molecular sieving effect Electrode coatings Aqueous sodium ion batteries Dilute aqueous electrolytes

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Synergetic Control of Li^(+)Transport Ability and Solid Electrolyte Interphase by Boron-Rich Hexagonal Skeleton Structured All-Solid-State Polymer Electrolyte

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Energy & Environmental Materials 2024年第3期7卷 154-163页

作者： Yanan Li Shunchao Ma Yuehua Zhao Silin Chen tingting Xiao Hongxing Yin Huiyu Song Xiumei Pan Lina Cong Haiming Xie Department of Chemistry National&Local United Engineering Laboratory for Power BatteryNortheast Normal UniversityChangchun 130024China State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchun 130022China

High Li^(+)transference number electrolytes have long been understood to provide attractive candidates for realizing uniform deposition of Li^(+).However,such electrolytes with immobilized anions would result in incomplete solid electrolyte interphase(SEI)formation on the Li anode because it suffers from the absence of appropriate inorganic components entirely derived from anions ***,a boron-rich hexagonal polymer structured all-solid-state polymer electrolyte(BSPE+10%LiBOB)with regulated intermolecular interaction is proposed to trade off a high Li^(+)transference number against stable SEI *** Li^(+)transference number of the as-prepared electrolyte is increased from 0.23 to 0.83 owing to the boron-rich cross-linker(BC)*** intriguingly,for the first time,the experiments combined with theoretical calculation results reveal that BOB^(-)anions have stronger interaction with B atoms in polymer chain than TFSI^(-),which significantly induce the TFSI^(-)decomposition and consequently increase the amount of LiF and Li3N in the SEI ***,a LiFePO_(4)|BSPE+10%LiBOBlLi cell retains 96.7%after 400 cycles while the cell without BC-resisted electrolyte only retains 40.8%.BSPE+10%LiBOB also facilitates stable electrochemical cycling of solid-state Li-S *** study blazes a new trail in controlling the Li^(+)transport ability and SEI properties,synergistically.

关键词： all-solid-state electrolyte boron-rich polymer lithium metal batteries lithium-ion transference number solid electrolyte interphase layer

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Structure-guided isolation of anti-neuroinflammatory sesquiterpene coumarins from Ferula sinkiangensis

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Chinese Journal of Natural Medicines 2024年第7期22卷 643-653页

作者： DANG wen GUO tingting ZHOU Di MENG Qingqi FANG Mingxia CHEN Gang LIN Bin HOU Yue LI Ning School of Traditional Chinese Materia Medica Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning ProvinceKey Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang CityShenyang Pharmaceutical UniversityShenyang 110016China College of Life and Health Sciences Northeastern UniversityShenyang 110004China School of Pharmaceutical Engineering Shenyang Pharmaceutical UniversityShenyang 110016China

The resin of Ferula sinkiangensis has been traditionally utilized for treating gastrointestinal disorders,inflammation,tumors,various cancers,and alopecia *** primary bioactive constituents,sesquiterpene coumarins,have demonstrated notable therapeutic potential against *** this study,a structure-guided fractionation method was used to isolate nine novel sesquiterpene coumarins from the resin of *** compounds were characterized and structurally elucidated using comprehensive physicochemical and spectroscopic techniques,including calculated electronic circular dichroism(ECD).Anti-neuroinflammatory assays revealed that compounds 2,3,and 6 significantly inhibited nitric oxide(NO)production in lipopolysaccharide(LPS)-stimulated BV2 microglial cells,with IC_(50)values ranging from 1.63 to 12.25μmol·L^(−1).

关键词： Ferula sinkiangensis Sesquiterpene coumarins Structure elucidation Anti-neuroinflammatory activity

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The Effect of Standardized Nutritional Care Combined with Exercise Intervention in Patients with Gestational Diabetes Mellitus and Its Effect on FPG,2hPG,and HbA1c Levels

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Journal of Clinical and Nursing Research 2024年第7期8卷 73-78页

作者： tingting wang Lianyungang Maternal and Child Health Hospital Lianyungang 222000Jiangsu ProvinceChina

Objective:To study the application effect of standardized nutritional care combined with exercise intervention in patients with gestational diabetes mellitus and the effect on fasting blood glucose(FPG),2-hour postprandial blood glucose(2hPG),and glycated hemoglobin(HbA1c)***:Ninety cases of gestational diabetes mellitus diagnosed between June 2022 and June 2023 were selected and randomly divided into two groups of 45 cases *** control group received conventional intervention,while the observation group received combined standardized nutritional care and exercise *** glucose levels,adverse pregnancy outcomes,and adverse neonatal outcomes were ***:On the day before delivery,the FPG,2hPG,and HbA1c levels of patients in the observation group were lower than those of patients in the control group(Pwas lower than in the control group(P<0.05).Conclusion:The blood glucose levels of gestational diabetes mellitus patients can be controlled through standardized nutritional care and exercise interventions,leading to improved pregnancy and neonatal outcomes.

关键词： Gestational diabetes mellitus Standardized nutritional care Exercise intervention FPG 2hPG HbA1c

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