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重组牛碱性成纤维细胞生长因子滴眼液治疗白内障术后干眼症的效果

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西北药学杂志 2024年第3期39卷 149-152页

作者：方琦琦吴婷婷邢健强海南爱尔新希望眼科医院综合眼科海口571100

目的探讨重组牛碱性成纤维细胞生长因子(recombinant bovine basic fibroblast growth factor,rb-bFGF)滴眼液对白内障术后干眼症患者泪液分泌、角膜损伤和氧化应激指标水平的影响。方法选取接受白内障手术并出现干眼症的患者120例作为... 详细信息

目的探讨重组牛碱性成纤维细胞生长因子(recombinant bovine basic fibroblast growth factor,rb-bFGF)滴眼液对白内障术后干眼症患者泪液分泌、角膜损伤和氧化应激指标水平的影响。方法选取接受白内障手术并出现干眼症的患者120例作为研究对象,用随机数字表法分为观察组和对照组,每组60例。对照组用聚乙二醇滴眼液治疗,观察组在此基础上加用rb-bFGF滴眼液治疗。比较2组治疗前和治疗后泪液分泌量[SchirmerⅠ试验(SchirmerⅠtest,SIT)]、角膜损伤程度[角膜荧光素染色(fluorescein staining of the cornea,FL)评分]、泪膜破裂时间(tear film break up time,BUT)和氧化应激指标[超氧化物歧化酶(superoxide dismutase,SOD)、丙二醛(malonaldehyde,MDA)和过氧化脂质(lipid peroxide,LPO)],并对临床疗效及安全性进行评价。结果观察组的总有效率高于对照组(P>0.05)。治疗后,2组SIT、FL评分、BUT和氧化应激指标均改善(P0.05)。结论rb-bFGF滴眼液治疗白内障手术后干眼症疗效确切,可显著促进患者泪液分泌,减轻角膜损伤,延长泪膜破裂时间,改善氧化应激指标的水平。

关键词：重组牛碱性成纤维细胞生长因子(rb-bFGF)滴眼液白内障干眼症泪液分泌角膜损伤氧化应激

两阶段轧制变形与时效下超细铁素体/马氏体双相钢的微观组织演变

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热加工工艺 2024年第1期53卷 90-94页

作者：邢磊王成猛高雪云马才女翟亭亭王海燕内蒙古科技大学材料与冶金学院内蒙古自治区新金属材料重点实验室内蒙古包头014010 北京科技大学材料科学与工程学院北京100083

对含铜低合金高强钢进行了两阶段轧制变形及时效处理,形成了超细晶铁素体/马氏体双相组织。利用扫描电子显微镜与电子背散射衍射技术分析了不同工艺下双相钢的微观组织演变规律,结合力学性能测试讨论了细晶强化与纳米相析出的协同强化... 详细信息

对含铜低合金高强钢进行了两阶段轧制变形及时效处理,形成了超细晶铁素体/马氏体双相组织。利用扫描电子显微镜与电子背散射衍射技术分析了不同工艺下双相钢的微观组织演变规律,结合力学性能测试讨论了细晶强化与纳米相析出的协同强化增韧机理。结果表明,经过上述变形和时效处理,得到具有良好的强塑性结合的超细晶铁素体/马氏体双相钢,其晶粒平均尺寸为1.23μm。随着时效时间延长,细小的第二相弥散析出并均匀分布,使得实验钢的屈服强度提高。

关键词：两阶段轧制变形双相钢超细晶析出相

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牧草混合青贮技术及其在动物生产中的应用

中国饲料 2024年第15期 150-154页

作者：吴婷婷周嘉欣黄浩展丘天珍邢哲炜马健广东海洋大学滨海农业学院广东湛江524088

牧草是草食动物重要的粗饲料来源,青贮可降低牧草体积,有利于贮藏。然而一些牧草存在水分高、可溶性碳水化合物含量低等问题,对牧草单一进行青贮发酵品质较差。混合青贮技术可发挥不同原料的特性,形成互补,有效改善牧草青贮品质。本文... 详细信息

牧草是草食动物重要的粗饲料来源,青贮可降低牧草体积,有利于贮藏。然而一些牧草存在水分高、可溶性碳水化合物含量低等问题,对牧草单一进行青贮发酵品质较差。混合青贮技术可发挥不同原料的特性,形成互补,有效改善牧草青贮品质。本文分析了混合青贮品质的影响因素,归纳了牧草混合青贮技术的类型及其在动物生产中的应用。

关键词：牧草混合青贮发酵品质微生物多样性

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乳铁蛋白抗炎及美白功效的体外试验研究

香料香精化妆品 2020年第1期 24-28页

作者：邢婷婷王全宇施雁勤李学娇潘仙华王玥上海应用技术大学上海201418 天津银河伟业进出口有限公司天津100029

建立了丙二醇甲醚醋酸酯(PMA)诱导的人急性单核白血病细胞(THP-1)炎症模型,通过细胞毒性试验确定乳铁蛋白对THP-1的安全质量浓度,考察了乳铁蛋白对THP-1分泌白介素6(IL-6)的影响。研究结果表明:乳铁蛋白在最大安全质量浓度为0.1 g/L时... 详细信息

建立了丙二醇甲醚醋酸酯(PMA)诱导的人急性单核白血病细胞(THP-1)炎症模型,通过细胞毒性试验确定乳铁蛋白对THP-1的安全质量浓度,考察了乳铁蛋白对THP-1分泌白介素6(IL-6)的影响。研究结果表明:乳铁蛋白在最大安全质量浓度为0.1 g/L时能有效抑制IL-6的分泌,使IL-6的相对分泌量降至21.7%,抑制率为78.3%,具有明显的抗炎活性。建立小鼠皮肤黑色素瘤细胞(B16-F10)模型,考察了乳铁蛋白对黑色素分泌的影响。研究结果表明:在最大安全质量浓度为1 g/L时,乳铁蛋白对黑色素的抑制率可达28.39%,具有明显的的美白活性。相同质量浓度条件下,0.5 g/L的乳铁蛋白和熊果苷对黑色素生成的抑制率分别为26.26%和12.15%,乳铁蛋白对黑色素表达的抑制高于功效对照原料熊果苷。因此乳铁蛋白具有明显的抗炎和美白活性,在化妆品领域有较好的应用前景。

关键词：化妆品添加剂乳铁蛋白抗炎美白

Effects of RE(La,Ce)on fcc-bcc martensitic transformation of iron via Bain transformation path

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Journal of Rare Earths 2022年第11期40卷 1812-1818,I0006页

作者： Haiyan Wang Xueyun Gao Lei xing tingting Zhai Meng Lv Huiping Ren Huihui Wei Jianguo Zhi School of Materials and Metallurgy Inner Mongolia University of Science and TechnologyBaotou 014010China Key Laboratory of Integrated Exploitation of Bayan Obo Multi-Metal Resource Inner Mongolia University of Science and TechnologyBaotou 014010China Inner Mongolia Baotou Steel Union Co. Ltd. Inner Mongolia Enterprise Key Laboratory of Rare Earth Steel Products Research and Development Baotou 014010China

The fundamental understanding of the effects of rare earth(RE)on the phase transformation of Fe-based alloys is essential in the development of advanced RE-containing high strength *** this work,we investigated the effects of La and Ce on the martensitic phase transformation of Fe in terms of the driving force and minimum energy path(MEP)using the first-principles *** calculations of formation energy show that the RE substitution increases the stabilization of fcc-Fe and decreases that of bcc-Fe,thus decreasing the driving force of phase ***,the analysis based on the generalized solid-state nudged elastic band(G-SSNEB)method indicates that in the RE-containing systems,an additional energy barrier appears when the phase transformation proceeds along the Bain transition path to c/a ratio of 1.14 in the FM state,which is associated with a sudden decrease in magnetization due to the hybridization between the orbits of the RE atoms and those of the nearest neighbor Fe *** results of potential-energy surfaces(PES)confirm that magnetic ordering and lattice volume change simultaneously with the Bain transition,and in comparison to pure Fe,the variation between the onset and the end structural volumes of the phase transformation is slight for the REcontaining Fe systems.

关键词： First-principles calculations Rare earth Fe Generalized solid-state nudged elastic band Martensitic transformation

Simulated photo-degradation of dissolved organic matter in lakes revealed by three-dimensional excitation-emission matrix with regional integration and parallel factor analysis

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Journal of Environmental Sciences 2020年第4期32卷 310-320页

作者： Jin Zhang Fanhao Song tingting Li Kefu Xie Huiying Yao Baoshan xing Zhongyu Li Yingchen Bai School of Environmental and Safety Engineering Changzhou UniversityJiangsu 213164China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China College of Water Sciences Beijing Normal UniversityBeijing 100875China Department of Chemistry Beijing Normal UniversityBeijing 100875China Stockbridge School of Agriculture University of MassachusettsAmherstMA01003USA

Simulated photo-degradation of fluorescent dissolved organic matter(FDOM) in Lake Baihua(BH) and Lake Hongfeng(HF) was investigated with three-dimensional excitationemission matrix(3 DEEM) fluorescence combined with the fluorescence regional integration(FRI),parallel factor(PARAFAC) analysis,and multi-order kinetic *** the FRI analysis,fulvic-like and humic-like materials were the main constituents for both BH-FDOM and *** individual components were identified by use of PARAFAC analysis as humic-like components(C1),fulvic-like components(C2),protein-like components(C3) and unidentified components(C4).The maximum 3 DEEM fluorescence intensity of PARAFAC components C1-C3 decreased by about 60%,70% and 90%,respectively after *** multi-order kinetic model was acceptable to represent the photo-degradation of FDOM with correlation coefficient(Radj2)(0.963-0.998).The photo-degradation rate constants(kn) showed differences of three orders of magnitude,from 1.09 × 10-6 to 4.02 × 10-4 min-1,and half-life of multi-order model(T1/2n)ranged from 5.26 to 64.01 *** decreased values of fluorescence index(FI) and biogenic index(BI),the fact that of percent fluorescence response parameter of Region I(PⅠ,n) showed the greatest change ratio,followed by percent fluorescence response parameter of Region II(PⅡ,n,while the largest decrease ratio was found for C3 components,and the lowest T1/2n was observed for C3,indicated preferential degradation of protein-like materials/components derived from biological sources during *** research on the degradation of FDOM by 3 DEEM/FRI-PARAFAC would be beneficial to understanding the photo-degradation of FD OM in natural environments and accurately predicting the environmental behaviors of contaminants in the presence of FDOM.

关键词： Fluorescent dissolved organic matter Photo-degradation Fluorescence regional integration Parallel factor analysis Three-dimensional excitationemission matrix Multi-order kinetic models

Systematic characterization of transport and thermoelectric properties of a macroscopic graphene fiber

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Nano Research 2016年第11期9卷 3536-3546页

作者： Weigang Ma Yingjun Liu Shen Yan tingting Miao Shaoyi Shi Mincheng Yang xing Zhang Chao Gao Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Engineering Mechanics Tsinghua University Beijing 100084 China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Key Laboratory of Adsorption and Separation Materials & Technologies of Zhejiang Province Zhejiang University Hangzhou 310027 China Department of Thermal Engineering Tsinghua University Beijing 100084 China Key Laboratory of Process Fluid Filtration and Separation College of Mechanical and Transportation Engineering China University ot Petroleum Beijing Beijing 102249 China

Graphene, a two-dimensional material with extraordinary electrical, thermal, and elastic performance, is a potential candidate for future technologies. However, the superior properties of graphene have not yet been realized for graphenederived macroscopic structures such as graphene fibers. In this study, we systematically investigated the temperature （T ）-dependent transport and thermoelectric properties of graphene fiber, including the thermal conductivity （A）, electrical conductivity （o）, and Seebeck coefficient （S）. A increases from 45.8 to 149.7 W·m^-1·K^-1 and then decreases as T increases from 80 to 290 K, indicating the boundary-scattering and three-phonon Umklapp scattering processes. σ increases with T from 7.1 × 10^4 to 1.18 × 10^5 S·m^-1, which can be best explained by the hopping mechanism. S ranges from -3.9 to 0.8 μV·K^-1 and undergoes a sign transition at approximately 100 K.

关键词： macroscopic graphene fiber thermoelectric properties thermal conductivity electrical conductivity Seebeck coefficient

A QoE-based cell range expansion scheme in heterogeneous cellular networks

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Science China(Information Sciences) 2015年第8期58卷 157-167页

作者： YUAN tingting FEI Ze Song LI Na WANG Ni Wei xing Cheng Wen LIU Jia Kang School of Information Science and Engineering Beijing Institute of Technology The Research Institution of China Mobile

Deploying low-power nodes(LPNs) overlaid with Macro cells is a promising strategy to improve the coverage and capacity of cellular systems. Meanwhile, cell range expansion(CRE) scheme is proposed to select a proper serving base station(BS) for users between Macro e Node Bs and LPNs, and then offloading of traffic from Macro cell is made. In this paper, first, we introduce the LPNs deployment strategy and its activation criteria in the heterogeneous system. Then, a quality of experience(Qo E)-based CRE scheme to adjust the coverage area of LPNs adaptively is proposed. Different from the existing CRE schemes, the Qo E values for different users with different services are considered when the users try to select an appropriate serving BS. Finally, simulation results demonstrate that the proposed scheme can improve cell edge user experience for various services as well as overall system performance.

关键词： low power nodes heterogeneous networks cell range expansion quality of experience LTEadvanced

Chemically doped macroscopic graphene fibers with significantly enhanced thermoelectric properties

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Nano Research 2018年第2期11卷 741-750页

作者： Weigang Ma Yingjun Liu Shen Yan tingting Miao Shaoyi Shi Zhen Xu xing Zhang Chao Gao Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Engineering Mechanics Tsinghua University Beijing China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Key Laboratory of Adsorption and Separation Materials & Technologies of Zhejiang Province Zhejiang University Hangzhou China Department of Thermal Engineering Tsinghua University Beijing China Key Laboratory of Process Fluid Filtration and Separation College of Mechanical and Transportation Engineering China University of Petroleum-Beijing Beijing China

Flexible wearable electronics, when combined with outstanding thermoelectric properties, are promising candidates for future energy harvesting systems. Graphene and its macroscopic assemblies （e.g., graphene-based fibers and films） have thus been the subject of numerous studies because of their extraordinary electrical and mechanical properties. However, these assemblies have not been considered suitable for thermoelectric applications owing to their high intrinsic thermal conductivity. In this study, bromine doping is demonstrated to be an effective method for significantly enhancing the thermoelectric properties of graphene fibers. Doping enhances phonon scattering due to the increased defects and thus decreases the thermal conductivity, while the electrical conductivity and Seebeck coefficient are increased by the Fermi level downshift. As a result, the maximum figure of merit is 2.76 ~ 10~, which is approximately four orders of magnitude larger than that of the undoped fibers throughout the temperature range. Moreover, the room temperature power factor is shown to increase up to 624 btW.m-l.K-2, which is higher than that of any other material solely composed of carbon nanotubes and graphene. The enhanced thermoelectric properties indicate the promising potential for graphene fibers in wearable energy harvesting systems.

关键词： macroscopic graphene fiber bromine doping thermoelectric properties thermal conductivity electrical conductivity Seebeck coefficient