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老年急性冠脉综合征患者PCI术前血清miR-34a、miR-182水平与术后对比剂肾病发生的相关性

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天津医药 2024年第4期52卷 422-426页

作者：薛文平秦巍刘婷婷张爱文史菲承德医学院附属医院本部心脏内科 067020 承德医学院附属医院门诊部 067020

目的探究老年急性冠脉综合征(ACS)患者经皮冠状动脉介入治疗(PCI)术前血清微小RNA(miR)-34a、miR-182水平与术后对比剂肾病(CIN)发生的关系。方法纳入行PCI治疗的146例老年ACS患者。收集ACS患者临床资料;全自动生化分析仪检测术前血... 详细信息

目的探究老年急性冠脉综合征(ACS)患者经皮冠状动脉介入治疗(PCI)术前血清微小RNA(miR)-34a、miR-182水平与术后对比剂肾病(CIN)发生的关系。方法纳入行PCI治疗的146例老年ACS患者。收集ACS患者临床资料;全自动生化分析仪检测术前血脂、肾功能指标;实时荧光定量PCR法测定血清miR-34a、miR-182水平。根据患者PCI术后是否发生CIN分为CIN组(20例)和非CIN组(126例)。比较CIN组和非CIN组临床资料、术前血脂、肾功能指标、血清miR-34a、miR-182、术后血清肌酐(Scr)、肾小球滤过率(eGFR)水平;分析老年ACS患者术前血清miR-34a、miR-182、术后Scr、eGFR的相关性及影响老年ACS患者PCI术后发生CIN的因素,受试者工作特征(ROC)曲线评估术前血清miR-34a、miR-182水平对老年ACS患者PCI术后发生CIN的预测价值。结果 CIN组术前血清miR-34a和miR-182水平、术后Scr水平均高于非CIN组,术后eGFR水平低于非CIN组(P<0.05);ACS患者术前血清miR-34a、miR-182与术后Scr呈正相关,与术后eGFR呈负相关(P<0.05);术前血清miR-34a与miR-182呈正相关(P<0.05);术前血清miR-34a、miR-182水平升高是影响老年ACS患者PCI术后发生CIN的独立危险因素(P<0.05);术前血清miR-34a、miR-182及两者联合预测老年ACS患者PCI术后发生CIN的曲线下面积(AUC)分别为0.881、0.888、0.964,两者联合预测的AUC高于各自单独预测(P<0.05)。结论术前血清miR-34a、miR-182水平升高是老年ACS患者PCI术后发生CIN的危险因素,两者联合可有效预测CIN的发生。

关键词：急性冠状动脉综合征经皮冠状动脉介入治疗微小RNA-34a 微小RNA-182 对比剂肾病

一种实现任意窄带光谱检测的有机光电探测器通用策略

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Science China Materials 2024年第3期67卷 852-862页

作者：朱玉秦灏郭婷婷杨艳青张哲张京李明朋陈红滨吴思敏韩蕊蔓万相见李光辉陈永胜 The Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer Materials Institute of Polymer ChemistryTianjin Key Laboratory of Functional Polymer MaterialsCollege of Chemistryand Renewable Energy Conversion and Storage Center(RECAST)Nankai UniversityTianjin 300071China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China

窄带光电探测器因其优异的综合性能,在光谱仪、激光雷达、光通信和监控等关键应用领域广受欢迎.尽管窄带硅基探测器在当前市场上占据主导地位,但其本征刚性、光学带隙固定和尺寸大的特性极大地限制了其在新兴领域的应用,尤其是在柔性和... 详细信息

窄带光电探测器因其优异的综合性能,在光谱仪、激光雷达、光通信和监控等关键应用领域广受欢迎.尽管窄带硅基探测器在当前市场上占据主导地位,但其本征刚性、光学带隙固定和尺寸大的特性极大地限制了其在新兴领域的应用,尤其是在柔性和可穿戴光电子领域.在本工作中,我们报道了一种构筑窄带有机光电探测器(OPD)的简单通用策略.该策略通过溶液法将活性层中的给体和受体材料制备成光学调制层(OAL),并集成在OPD上,可实现对任意光谱的检测.利用该策略,我们成功地构筑了以750 nm为中心的窄带OPD,其半峰宽(FWHM)为40 nm,光谱响应率为3667,-3 dB截止频率为927 kHz,打破了自驱动窄带OPD的性能记录.值得注意的是,这种新颖的OAL策略在OPD中具有良好的通用性,可以实现对600至1000 nm范围内的任意窄光谱检测,具有FWHM可调(最小步长为2 nm)、响应度和探测率高、响应速度快的优势.受益于有机半导体固有的柔性特性,我们构筑了一种柔性且可弯曲的窄带近红外OPD线性阵列,并应用于全向激光雷达上,在无需机械旋转的情况下实现了360°水平扫描.

关键词： organic photodetector narrowband organic photodetector LiDAR flexible photodetector visible-near-infrared narrowband organic photodetector

生物3D打印丹酚酸B⁃海藻酸钠⁃明胶皮肤支架促进糖尿病大鼠创面愈合

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南京医科大学学报（自然科学版） 2024年第3期44卷 297-304,328页

作者：秦立昊李静燕张嘉伟柏益飞刘婷婷唐蛰雨薛同庆贾中芝南京医科大学附属常州第二人民医院介入血管科江苏常州213003 大连医科大学研究生院辽宁大连116044 淮安市淮安医院(淮安市肿瘤医院)疼痛与介入血管外科江苏淮安223000

目的:探讨生物3D打印丹酚酸B(salvianolic acid B,SAB)⁃海藻酸钠⁃明胶皮肤支架对糖尿病大鼠创面的治疗作用。方法:按照SAB占海藻酸钠与明胶总重的百分比制成含0%、0.5%、1.0%、1.5%SAB的生物墨水,采用生物3D打印技术制备不同规格的皮肤... 详细信息

目的:探讨生物3D打印丹酚酸B(salvianolic acid B,SAB)⁃海藻酸钠⁃明胶皮肤支架对糖尿病大鼠创面的治疗作用。方法:按照SAB占海藻酸钠与明胶总重的百分比制成含0%、0.5%、1.0%、1.5%SAB的生物墨水,采用生物3D打印技术制备不同规格的皮肤支架。扫描电镜观察微观结构,高效液相色谱测定SAB体外累积释放浓度。皮肤支架用于治疗2型糖尿病大鼠创面,分为空白对照组、凡士林纱布组以及皮肤支架组(0%SAB、0.5%SAB、1.0%SAB、1.5%SAB组)。于第7、14天观察创面愈合、渗出情况,同时取创面组织进行HE、Masson、活性氧(reactive oxygen species,ROS)染色,并检测超氧化物歧化酶(super⁃oxide dismutase,SOD)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH⁃PX)、过氧化氢酶(catalase,CAT)及丙二醛(malondial⁃dehyde,MDA)水平。结果:扫描电镜下,4组皮肤支架均呈网孔状立体结构,孔隙分布均匀。SAB累积释放量随时间延长逐渐增加。各组创面均愈合良好,1.0%SAB组创面修复优于其他各组。第7天时,1.0%SAB组ROS水平均低于其他各组(P<0.05);第14天时,1.0%SAB组ROS水平低于除1.5%SAB组外的其他各组(P<0.01),1.0%SAB组和1.5%SAB组ROS表达水平差异无统计学意义(P=0.136)。第7天时,1.0%SAB组SOD、GSH⁃PX及CAT水平均高于其他各组(P<0.05),MDA水平低于空白对照组、凡士林纱布组及0%SAB组(P<0.05);第14天时,1.0%SAB组SOD、GSH⁃PX及CAT水平高于空白对照组、凡士林纱布组和0%SAB组(P<0.05),MDA水平低于空白对照组、凡士林纱布组(P<0.05)。HE染色显示,各组创面皮肤均修复较好,1.0%SAB组新生组织较多。Masson染色显示,第7、14天时,0.5%、1.0%、1.5%SAB组创面胶原蛋白沉积多于其他各组(P<0.05)。结论:1.0%SAB⁃海藻酸钠⁃明胶皮肤支架在第7、14天时不仅可以抑制ROS的产生,并上调各种抗氧化酶的表达,抑制创面组织内氧化应激反应,还可以促进胶原沉积,最终促进糖尿病大鼠的创面愈合。

关键词： 3D打印皮肤支架丹酚酸B 糖尿病创面

An Outbreak of SARS-CoV-2 Omicron Subvariant BA.2.76 in an Outdoor Park—Chongqing Municipality,China,August 2022

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China CDC weekly 2022年第46期4卷 1039-1042页

作者： Li Qi Wenge Tang Ju Wang Yu Xiong Yi Yuan Baisong Li Lin Yang tingting Li Lianjian Yang Xiaoyuan Su qin Li Lijie Zhang Chongqing Center for Disease Control and Prevention Chongqing MunicipalityChina Shapingba Center for Disease Control and Prevention Chongqing MunicipalityChina Yubei Center for Disease Control and Prevention Chongqing MunicipalityChina Chinese Center for Disease Control and Prevention BeijingChina

Summary What is already known about this topic?Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron subvariant has a stronger transmission capacity and faster transmission speed than the previous strain.

关键词： acute respiratory Chongqing

Interface electronic engineering of molybdenum sulfide/MXene hybrids for highly efficient biomimetic sensors

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Nano Research 2023年第1期16卷 1158-1164页

作者： Pengfei Wu tingting You qingyuan Ren Hongyan Xi qingqing Liu Fengjuan qin Hongfei Gu Yu Wang Wensheng Yan Yukun Gao Wenxing Chen Penggang Yin Key Laboratory of Bio-inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191China Energy&Catalysis Center School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Shanghai Synchrotron Radiation Facility Zhangjiang LaboratoryShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China

Interface regulation plays a key role in the electrochemical performance for biosensors.By controlling the interfacial interaction,the electronic structure of active species can be adjusted effectively at micro and nano-level,which results in the optimal reaction energy barrier.Herein,we propose an interface electronic engineering scheme to design a strongly coupled 1T phase molybdenum sulfide(1T-MoS2)/MXene hybrids for constructing an efficient electrocatalytic biomimetic sensor.The local electronic and atomic structures of the 1T-MoS2/Ti3C2TX are comprehensively studied by synchrotron radiation-based X-ray photoelectron spectroscopy(XPS),as well as X-ray absorption spectroscopy(XAS)at atomic level.Experiments and theoretical calculations show that there are interfacial stresses,atomic defects and adjustable bond-length between MoS2/MXene nanosheets,which can significantly promote biomolecular adsorption and rapid electron transfer to achieve excellent electrochemical activity and reaction kinetics.The 1T-MoS2/Ti3C2TX modified electrode shows ultra high sensitivity of 1.198μA/μM for dopamine detection with low limit of 0.05μM.We anticipate that the interface electronic engineering investigation could provide a basic idea for guiding the exploration of advanced biosensors with high sensitivity and low detection limit.

关键词： MXene molybdenum sulfide interface electronic effect biomimetic sensor X-ray absorption spectroscopy

Charge state modulation on boron site by carbon and nitrogen localized bonding microenvironment for two-electron electrocatalytic H_(2)O_(2)production

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Chinese Chemical Letters 2023年第5期34卷 598-603页

作者： tingting Zhang Yin Wang Xiangyang Li Quan Zhuang Zixuan Zhang Hong Zhou qin Ding Yingqi Wang Yuxin Dang Limei Duan Jinghai Liu Inner Mongolia Key Laboratory of Carbon Nanomaterials College of Chemistry and Materials ScienceNano Innovation InstituteInner Mongolia Minzu UniversityTongliao 028000China Tongliao Center for Disease Control and Prevention Tongliao 028000China

Design of electrochemical active boron(B)site at solid materials to understand the relationships between the localized structure,charge state at the B site and electrocatalytic activity plays a crucial role in boosting the green electrochemical synthesis of hydrogen peroxide(H_(2)O_(2))via two-electron oxygen reduction(2eORR)pathway.Herein,we demonstrate a carbon(C)and nitrogen(N)localized bonding microenvironment to modulate the charge state of B site at the boron-carbon nitride solid(BCNs)to realize the efficient selective electrocatalytic H_(2)O_(2)production.The localized chemical structure of N-B-N,N-B-C and C-B-C bonds at B site can be regulated through solid-state reaction between boron nitride(BN)and porous carbon(C)at variable temperatures.The optimized BCN-1100 achieves an outstanding H_(2)O_(2)selectivity of 89%and electron transfer number of 2.2(at 0.55 V vs.RHE),with the production of 10.55mmol/L during 2.5 h and the catalytic stability duration for 15000 cycles.Further first-principles calculations identified the dependency of localized bonding microenvironment on the OOH~*adsorption energies and relevant charge states at the boron site.The localized structure of B site with BNC_(2)-Gr configuration is predicted to be the highest 2eORR activity.

关键词： Solid boron site Charge state modulation Localized bonding microenvironment Two-electron oxygen reduction H_(2)O_(2)electrosynthesis

Pore-Fracture Distribution Heterogeneity of Shale Reservoirs Determined by using HPMI and LPN_(2 )GA Tests

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Acta Geologica Sinica(English Edition) 2022年第5期96卷 1659-1672页

作者： ZHANG Junjian qin Zhengyuan HAN Yanning WANG Huaimeng HOU Maoguo YAN Gaoyuan FENG Guangjun ZHANG Xiaoyang YIN tingting ZHANG Hainan WEN Shupeng College of Earth Sciences&Engineering Shandong University of Science and TechnologyQingdaoShandong 266590China School of Resources and Earth Science China University of Mining and TechnologyXuzhouJiangsu 221116China Nottingham Geospatial Institute Faculty of EngineeringUniversity of NottinghamNottinghamNG72TUUK The First Exploration Team of Shandong Province Coal Geology Bureau ShandongQingdaoShandong 266000 General Institute of Chemical Geology Survey of CCGMB Beijing 100013China School of Geosciences China’s University of Petroleum(East China)QingdaoShandong 266580China 113 Team of Guizhou Coal Geology Bureau Guiyang 550000China

The compressibility of shale matrix reflects the effects of reservoir lithology, material composition, pore structure and tectonic deformation. It is important to understand the factors that influence shale matrix compressibility(SMC) and their effects on pore size distribution(PSD) heterogeneity in order to evaluate the properties of unconventional reservoirs.In this study, the volumes of pores whose diameters were in the range 6–100 nm were corrected for SMC for 17 shale samples from basins in China using high-pressure mercury intrusion and low-temperature nitrogen gas adsorption analyses,in order to investigate the factors influencing the SMC values. In addition, the variations in fractal dimensions before and after pore volume correction were determined, using single and multifractal models to explain the effects of SMC on PSD heterogeneity. In this process, the applicability of each fractal model for characterizing PSD heterogeneity was determined using statistical analyses. The Menger and Sierpinski single fractal models, the thermodynamic fractal model and a multifractal model were all used in this study. The results showed the following. The matrix compression restricts the segmentation of the fractal dimension curves for the single fractal Menger and Sierpinski models, which leads to a uniformity of PSD heterogeneity for different pore diameters. However, matrix compression has only a weak influence on the results calculated using a thermodynamic model. The SMC clearly affects the multifractal value variations, showing that the fractal dimension values of shale samples under matrix compression are small. Overall PSD heterogeneity becomes small for pores with diameters below 100 nm and the SMC primarily affects the PSD heterogeneity of higher pore volume areas. The comparison of fractal curves before and after correction and the variance analysis indicate that the thermodynamic model is applicable to quantitatively characterize PSD heterogeneity of shale collected from this sampling area. The results show

关键词： shale reservoirs matrix compressibility pore structure fractal dimension multifractal

新型α-萘巯基氨基酸乙酯类LSD1抑制剂的构建、活性评价与分子模拟研究

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中国现代应用药学 2024年第3期41卷 295-302页

作者：李中华王真真秦婷婷王潘胡锴谢治深李立新张效威宋军营任伟宏马金莲河南中医药大学中医药科学院郑州450046 河南中医药大学第一附属医院检验科郑州450046

目的设计合成结构新颖的萘巯基氨基酸乙酯类组蛋白赖氨酸特异性去甲基化酶1(lysine specific demethylase 1,LSD1)抑制剂,评价其LSD1抑制活性与选择性,并通过分子对接和动力学模拟探讨结合机制。方法基于先导化合物3a与LSD1蛋白的结合模... 详细信息

目的设计合成结构新颖的萘巯基氨基酸乙酯类组蛋白赖氨酸特异性去甲基化酶1(lysine specific demethylase 1,LSD1)抑制剂,评价其LSD1抑制活性与选择性,并通过分子对接和动力学模拟探讨结合机制。方法基于先导化合物3a与LSD1蛋白的结合模式,在化合物结构中固定平面疏水性的萘环,同时引入具有亲水性的氨基片段,采用三组份一锅法构建α-萘巯基氨基酸乙酯小分子化合物。采用课题组自主构建的LSD1筛选平台测试化合物在5.0,1.0μmol·L^(-1)浓度下对LSD1的抑制率,测试活性最好的化合物的IC_(50)值及对MAO-A和MAO-B的抑制活性,并通过分子对接和动力学模拟研究其结合机制。结果共合成13个目标化合物,均对LSD1有很好的抑制作用,其中有9个化合物在1.0μmol·L^(-1)浓度下对LSD1抑制率>50.0%,且化合物3l活性最佳,IC_(50)值为0.17μmol·L^(-1),是阳性对照的174倍,对MAO-A和MAO-B有很好的选择性。分子对接和动力学模拟表明化合物3l通过多重作用与LSD1结合来抑制其活性。结论α-萘巯基氨基酸乙酯类结构可作为先导化合物或活性片段,为基于结构的药物设计进行后续LSD1抑制剂的设计打下良好基础。

关键词：组蛋白赖氨酸特异性去甲基化酶1(LSD1) 抑制剂分子对接动力学模拟

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高校院级分析测试平台构建与管理探讨

实验室科学 2024年第1期27卷 185-188页

作者：王磊张磊李大鹏秦宏兵周晓吉刘婷婷苏州科技大学、江苏省环境科学与工程重点实验室、环境科学与工程学院江苏苏州215000

仪器设备使用与管理的信息化是当前高校院所实现开放共享服务的重要途径。结合以江苏省环境科学与工程重点实验室为依托的环境科学与工程学院分析测试平台预约系统的构建案例,介绍了系统的构建思路、组成模块、运行方式及管理模式等内容... 详细信息

仪器设备使用与管理的信息化是当前高校院所实现开放共享服务的重要途径。结合以江苏省环境科学与工程重点实验室为依托的环境科学与工程学院分析测试平台预约系统的构建案例,介绍了系统的构建思路、组成模块、运行方式及管理模式等内容,介绍了院级仪器设备管理平台现状、院级分析测试系统的构建、管理运行模式探索等内容。院级系统的建立实现了对校级仪器设备信息化管理的补充,实现了不同教研室和科研课题组对仪器使用与管理的细化,有效促进了科研基础设施和仪器设备共享使用的全面化施行。

关键词：仪器设备预约管理开放共享二级学院