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Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige Jiang Dexiang liu tingting li Chengcheng Gai Danqing Xin Yijing Zhao Yan Song Yahong Cheng Tong li Zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

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黔桂地区20年间植被时空变化及其对地理环境的响应

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水土保持研究 2025年第2期32卷 255-262页

作者：冯达段亚锋李婷婷湖南省测绘科技研究所长沙410007 湖南省长沙生态环境监测中心长沙410000

[目的]研究黔桂地区植被时空变化及其对地理环境的响应,为区域生态恢复工程效益评估和进一步恢复提供科学参考。[方法]基于NDVI数据,结合植被本底值和变化趋势,将区域植被分为9种状态类型;利用均一化面积指数分析不同状态类型植被对岩... 详细信息

[目的]研究黔桂地区植被时空变化及其对地理环境的响应,为区域生态恢复工程效益评估和进一步恢复提供科学参考。[方法]基于NDVI数据,结合植被本底值和变化趋势,将区域植被分为9种状态类型;利用均一化面积指数分析不同状态类型植被对岩性、地貌、土壤和地形位指数等地理特征的响应。[结果](1) 2001—2020年NDVI年均值波动增加,平均趋势率为1.8×10^(-3)/a,恢复趋势、退化趋势和稳定状态的植被面积分别占30.8%,9.1%和60.1%;(2)稳定型植被在低、中、高覆盖植被中面积占比逐渐降低,而退化型和恢复型的面积占比均依次增加;(3)纯碳酸盐岩上高覆盖植被均一化面积指数低于均值、低覆盖植被高于均值,而碎屑岩正好相反;(4)植被对红壤和水稻土的响应与本底覆盖度相关;(5)低覆盖稳定型植被在岩溶峡谷区集中分布,峰丛洼地的高覆盖植被优势明显;(6)低覆盖植被与地形位的响应关系明显,中覆盖植被受地形位影响较小。[结论]黔桂地区植被总体呈改善趋势,不同植被状态类型空间分布不均,赤红壤和岩溶峡谷上的植被相对稳定,黄壤区和峰林平原的高覆盖植被单向退化较为明显,高覆盖和低覆盖植被分别集中分布于地形位中值和低值区。

关键词：黔桂地区喀斯特植被状态类型地理环境响应

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Development in oxide metallurgy for improving the weldability of high -strength low-alloy steel-Combined deoxidizers and microalloying elements

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1263-1284页

作者： tingting li Jian Yang State Key Laboratory of Advanced Special Steel School of Materials Science and EngineeringShanghai UniversityShanghai 200444China

The mechanisms of oxide metallurgy include inducing the formation of intragranular acicular ferrite(IAF)using micron-sized inclusions and restricting the growth of prior austenite grains(PAGs)by nanosized particles during *** chaotically oriented IAF and refined PAGs inhibit crack initiation and propagation in the steel,resulting in high impact *** work summarizes the com-bined effect of deoxidizers and alloying elements,with the aim to provide a new perspective for the research and practice related to im-proving the impact toughness of the heat affected zone(HAZ)during the high heat input *** complex deoxidation with other strong deoxidants,such as Mg,Ca,Zr,and rare earth metals(REMs),can improve the toughness of the heat-affected zone(HAZ)by re-fining PAGs or increasing IAF ***,it is difficult to identify the specific phase responsible for IAF nucleation because ef-fective inclusions formed by complex deoxidation are usually *** alloying elements,such as C,Si,Al,Nb,or Cr,con-tents can impair HAZ toughness.A high C content typically increases the number of coarse carbides and decreases the potency of IAF ***,Cr,or Al addition leads to the formation of undesirable *** reduces the high-temperature stability of the ***,V,and B can enhance HAZ ***-containing precipitates present good thermal *** or V(C,N)is ef-fective in promoting IAF nucleation due to its good coherent crystallographic relationship with *** formation of the B-depleted zone around the inclusion promotes IAF *** interactions between alloying elements are complex,and the effect of adding dif-ferent alloying elements remains to be *** the future,the interactions between various alloying elements and their effects on ox-ide metallurgy,as well as the calculation of the nucleation effects of effective inclusions using first principles calculations will become the focus of

关键词： oxide metallurgy technology heat affected zone high-strength low-alloy steel intragranular acicular ferrite microalloying element

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Barotropic Processes Associated with the Development of the Mei-yu Precipitation System

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Advances in Atmospheric Sciences 2016年第5期33卷 593-598页

作者： tingting li Xiaofan li School of Earth Sciences Zhejiang University

The barotropic processes associated with the development of a precipitation system are investigated through analysis of cloud-resolving model simulations of Mei-yu torrential rainfall events over eastern China in mid-June 2011. During the model integration period, there were three major heavy rainfall events： 9–12, 13–16 and 16–20 June. The kinetic energy is converted from perturbation to mean circulations in the first and second period, whereas it is converted from mean to perturbation circulations in the third period. Further analysis shows that kinetic energy conversion is determined by vertical transport of zonal momentum. Thus, the prognostic equation of vertical transport of zonal momentum is derived, in which its tendency is associated with dynamic, pressure gradient and buoyancy processes. The kinetic energy conversion from perturbation to mean circulations in the first period is mainly associated with the dynamic processes. The kinetic energy conversion from mean to perturbation circulations in the third period is generally related to the pressure gradient processes.

关键词： tropical cyclone–trough interaction upper troposphere eddy momentum flux convergence

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Mechanically Strong Heterogeneous Catalysts via Immobilization of Powderous Catalysts to Porous Plastic Tablets

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Chinese Journal of Chemistry 2021年第10期39卷 2673-2678页

作者： tingting li Bo Xu Key Laboratory of Science and Technology of Eco-Textiles Ministry of EducationCollege of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai201620 China

Main observation and conclusion We describe a practical and general protocol for immobilization of heterogeneous catalysts to mechanically robust porous ultra-high molecular weight polyethylene tablets using inter-facial lifshitz-van der Waals *** types of powderous catalysts,including Cu,Pd/C,Pd/Al2O3,Pt/C,and Rh/C have been immobilized *** immobilized catalysts are mechanistically robust towards stirring in solutions,and they worked well in diverse synthetic *** immobilized catalyst tablets are easy to handle and ***,the metal leaching of immobilized catalysts was reduced significantly.

关键词： Heterogeneous catalysts Solution-phase chemistry Immobilization Porous plastic tablets Metal leaching Main observation

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MULTIRATE TIME ITERATIVE SCHEME WITH MULTIPHYSICS FINITE ELEMENT METHOD FOR A NONliNEAR POROELASTICITY

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Journal of Computational Mathematics 2024年第2期42卷 597-616页

作者： Zhihao Ge Hairun li tingting li School of Mathematics and Statistics Henan UniversityKaifengHenan 475004China

In this paper,a multirate time iterative scheme with multiphysics finite element method is proposed and analyzed for the nonlinear poroelasticity *** original problem is reformulated into a generalized nonlinear Stokes problem coupled with a diffusion problem of a pseudo pressure field by a new multiphysics approach.A multiphysics finite element method is adopted for the spatial discretization,and the generalized nonlinear Stokes problem is solved in a coarse time step and the diffusion problem is solved in a finer time *** proposed algorithm is a decoupled algorithm,which is easily implemented in computation and reduces greatly computation *** stability analysis and the convergence analysis for the multirate iterative scheme with multiphysics finite element method are *** numerical tests are shown to demonstrate and validate the analysis results.

关键词： Nonlinear poroelasticity model Multiphysics finite element method Multirate iterative scheme

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N-heterocyclic carbene-catalyzed arene formation reactions

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Science China Chemistry 2022年第2期65卷 210-223页

作者： tingting li Zhichao Jin Yonggui Robin Chi State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityGuiyang 550025China Division of Chemistry&Biological Chemistry School of Physical&Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore

N-heterocyclic carbene-catalyzed reactions for the formation of aromatic compounds are *** reactions are subdivided into 4 types based on their activation modes.A brief summary on the achievements and the challenges remaining in Nheterocyclic carbene(NHC)-catalyzed arene construction processes is provided at the end of this *** outlook into the future research direction within this field is also given based on our own opinion and knowledge on the trends of the development of NHC organocatalysis.

关键词： N-heterocyclic carbene arene construction cycloaddition organocatalysis

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An attention-based prototypical network for forest fire smoke few-shot detection

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Journal of Forestry Research 2022年第5期33卷 1493-1504页

作者： tingting li Haowei Zhu Chunhe Hu Junguo Zhang School of Technology Beijing Forestry UniversityBeijing 100083People’s Republic of China Key Lab of State Forestry and Grassland Administration for Forestry Equipment and Automation Beijing 100083People’s Republic of China

Existing almost deep learning methods rely on a large amount of annotated data, so they are inappropriate for forest fire smoke detection with limited data. In this paper, a novel hybrid attention-based few-shot learning method, named Attention-Based Prototypical Network, is proposed for forest fire smoke detection. Specifically, feature extraction network, which consists of convolutional block attention module, could extract high-level and discriminative features and further decrease the false alarm rate resulting from suspected smoke areas. Moreover, we design a metalearning module to alleviate the overfitting issue caused by limited smoke images, and the meta-learning network enables achieving effective detection via comparing the distance between the class prototype of support images and the features of query images. A series of experiments on forest fire smoke datasets and miniImageNet dataset testify that the proposed method is superior to state-of-the-art few-shot learning approaches.

关键词： Forest fire smoke detection Few-shot learning Channel attention module Spatial attention module Prototypical network

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SWARM-LLM:基于大语言模型的无人集群任务规划系统

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计算机科学 2025年第1期52卷 72-79页

作者：李婷婷王琪王嘉康徐勇军中国科学院计算技术研究所北京100190 中国科学院大学北京100049

针对无人集群系统自主智能性不足、异构无人集群协同效率低、任务分配不均衡等问题,文中面向无人集群自主规划、高效协作、智能决策的需求,首先提出了一种新的基于大语言模型的无人集群任务规划系统框架(SWARM-LLM)。该框架利用大语言... 详细信息

针对无人集群系统自主智能性不足、异构无人集群协同效率低、任务分配不均衡等问题,文中面向无人集群自主规划、高效协作、智能决策的需求,首先提出了一种新的基于大语言模型的无人集群任务规划系统框架(SWARM-LLM)。该框架利用大语言模型将高层次的任务指令转化为具体的智能无人集群任务规划方案,通过任务分解、任务分配、任务执行等多个阶段来实现无人集群协同任务。进一步地,设计了一套适用于无人集群规划的提示工程方法-规划链(Planning Chain, PC),用来指导和优化上述各阶段的实施。最终,在无人集群仿真环境(AirSim)中构建了不同类别和复杂度的任务,并进行了评估实验。与其他基于优化算法和机器学习的算法相比,实验结果证明了SWARM-LLM框架的有效性,并在任务成功率上展现出了显著的优势,平均性能提升了47.8%。

关键词：任务规划无人集群大语言模型协同策略智能决策

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An assessment of the effectiveness and impact of electrokinetic remediation for pyrene-contaminated soil

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Journal of Environmental Sciences 2014年第11期26卷 2290-2297页

作者： Sujuan Xu Shuhai Guo Bo Wu Fengmei li tingting li Institute of Applied Ecology Chinese Academy of Sciences Graduate School of Chinese Academy of Sciences

The effectiveness of electrokinetic remediation for pyrene-contaminated soil was investigated by an anode-cathode separated system using a salt bridge. The applied constant voltage was 24 V and the electrode gap was 24 cm. Two types of soil （sandy soil and loam soil） were selected because of their different conductive capabilities. The initial concentrations of pyrene in these soil samples were 261.3 mg/kg sandy soil and 259.8 mg/kg loam soil After treatment of the sandy soil and loam soil for seven days, 56.8% and 20.1% of the pyrene had been removed respectively. Under the same power supply voltage, the removal of the pollutant from the sandy soil was greater than that from the loam soil, due to the higher current and lower pH. Further analysis revealed that the effectiveness of electrokinetic remediation was affected by the energy expenditure, and was associated with changes in soil properties.

关键词： Electrokinetie remediation Anode-cathode separated system Electrochemical oxidation Soil Pyrene

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