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Integrated analyses of transcriptomics and network pharmacology reveal leukocyte characteristics and functional changes in subthreshold depression,elucidating the curative mechanism of Danzhi Xiaoyao powder

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Journal of Traditional Chinese Medical Sciences 2024年第1期11卷 3-20页

作者： Kunyu Li Leiming You Jianhua zhen Guangrui Huang ting Wang Yanan Cai Yunan Zhang Anlong Xu School of Life Sciences Bejing University of Chinese MedicineBeijing 102488China School of Life Sciences Sun Yat-Sen UniversityGuangzhou 510006Chin

Objective:To investigate the molecular mechanism and identify potential drugs for subthreshold depression(SD),and elucidate the detalied mechanism of Danzhi Xiaoyao powder(DZXY)in ***:Using RNA-sequencing,we identified differentially expressed genes(DEGs)in leukocytes of SD compared to healthy controls,deciphered their functions and pathways,and identified the hub genes of *** also assessed changes in leukocyte transcription factor activity in patients with SD using the TELis *** Connectivity Map database was retrieved to screen candidate drugs for *** on network pharmacology,we elucidated the"multi-component,multi-target,and multi-pathway"mechanism of DZXY in the treatment of ***:We identified 1080 DEGs(padj<0.05 and|log2(fold change)l≥1&protein coding)in the leukocytes of patients with *** DEGs,including hub genes,were primarily involved in immune and inflammatory response-related *** factor activity analysis revealed similarities between the leukocyte transcriptome profile in SD and the conserved transcriptional response to adversities in immune *** Map analysis identified 28 potential drugs for SD treatment,particularly SB-202190 and *** the"Direct Compounds-Direct Targets-Pathways"network for DZXY and SD revealed the curative mechanisms of DZXY in SD,primarily including inflammatory response,lipid metabolism,immune response,and other ***:These results provide new insights into the characteristics and functional changes of leukocytes in SD,partially illustrate the pathogenesis of SD,and suggest potential drugs for *** curative mechanisms of DZXY in SD are also partially elucidated.

关键词： Subthreshold depression Leukocyte mRNAbiomarker CTRA Transcription factor activity CMap Danzhi Xiaoyaopowder Networkpharmacology

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A crucial role of neutrophil extracellular traps in pulmonary infectious diseases

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第1期2卷 34-41页

作者： ting pan Jae Woo Lee Shanghai Key Laboratory of Lung Inflammation and Injury Department of Pulmonary MedicineZhongshan HospitalFudan UniversityShanghai 200032China Department of Anesthesiology University of California Los AngelesLos AngelesCA 90230USA

Neutrophil extracellular traps(NETs),extrusions of intracellular DNA with attached granular material that exert an antibacterial effect through entangling,isolating,and immobilizing microorganisms,have been extensively studied in recent *** primary role of NETs is to entrap and facilitate the killing of bacteria,fungi,viruses,and parasites,preventing bacterial and fungal *** formation has been described in many pulmonary diseases,including both infectious and *** are considered a double-edged *** innate immune cells,neutrophils release NETs to kill pathogens and remove cellular ***,the dele-terious effects of excessive NET release in lung disease are particularly important because NETs and by-products of NETosis can directly induce epithelial and endothelial cell death while simultaneously inducing inflammatory cytokine secretion and immune-mediated ***,NET formation must be tightly regulated to preserve the anti-microbial capability of NETs while minimizing damage to the *** this review,we summarized the recent updates on the mechanism of NETs formation and pathophysiology associated with excessive NETs,aiming to provide insights for research and treatment of pulmonary infectious diseases.

关键词： Pulmonary infectious diseases Neutrophils Neutrophil extracellular traps(NETs) NETosis

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Experimental study of the effects of a multistage pore-throat structure on the seepage characteristics of sandstones in the Beibuwan Basin:Insights into the flooding mode

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Petroleum Science 2024年第2期21卷 1044-1061页

作者： Lei Wang Xiao Lei Qiao-Liang Zhang Guang-Qing Yao Bo Sui Xiao-Jun Chen Ming-Wei Wang zhen-Yu Zhou pan-Rong Wang Xiao-Dong Peng Zhanjiang Branch China National Offshore Oil Corporation(CNOOC)LimitedZhanjiang524057GuangdongChina Faculty of Earth Resources China University of Geosciences(Wuhan)Wuhan430074HubeiChina School of Resources and Safety Engineering Chongqing UniversityChongqing400044China School of Engineering University of ManchesterManchester M139WJUK Hainan Branch China National Offshore Oil Corporation(CNOOC)LimitedHaikou570311HainanChina

To investigate the relationship between grain sizes, seepage capacity, and oil-displacement efficiency in the Liushagang Formation of the Beibuwan Basin, this study identifies the multistage pore-throat structure as a crucial factor through a comparison of oil displacement in microscopic pore-throat experiments. The two-phase flow evaluation method based on the Li-Horne model is utilized to effectively characterize and quantify the seepage characteristics of different reservoirs, closely relating them to the distribution of microscopic pores and throats. It is observed that conglomerate sandstones at different stages exhibit significant heterogeneity and noticeable differences in seepage capacity, highlighting the crucial role played by certain large pore throats in determining seepage capacity and oil displacement efficiency. Furthermore, it was found that the displacement effects of conglomeratic sandstones with strong heterogeneity were inferior to those of conventional homogeneous sandstone, as evidenced by multiple displacement experiments conducted on core samples with varying granularities and flooding systems. Subsequently, core-based experiments on associated gas flooding after water flooding were conducted to address the challenge of achieving satisfactory results in a single displacement mode for reservoirs with significant heterogeneity. The results indicate that the oil recovery rates for associated gas flooding after water flooding increased by 7.3%-16.4% compared with water flooding alone at a gas-oil ratio of approximately 7000 m^(3)/m^(3). Therefore, considering the advantages of gas flooding in terms of seepage capacity, oil exchange ratio, and the potential for two-phase production, gas flooding is recommended as an energy supplement mode for homogeneous reservoirs in the presence of sufficient gas source and appropriate tectonic angle. On the other hand, associated gas flooding after water flooding is suggested to achieve a more favorable develop

关键词： Beibuwan Basin Multistage pore-throat structure Multistage seepage characteristics Microscopic visualization Heterogeneity Gas/water flooding Flooding mode

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Prevention and control strategies for antibiotic resistance:from species to community level

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Soil Ecology Letters 2024年第3期6卷 17-34页

作者： Yan-Zi Wang Hu Li Qing-Lin Chen ting pan Yong-Guan Zhu Dirk Springael Jian-Qiang Su Key Laboratory of Urban Environment and Health Ningbo Observation and Research StationInstitute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Division of Soil and Water Management KU LeuvenKasteelpark Arenberg 20 Box 24593001 HeverleeBelgium

Antibiotic resistance genes(ARGs)and antibiotic resistant bacteria(ARB)in the environment pose serious threats to environmental security and public *** is an urgent need for methods to specifically and effectively control environmental pollution or pathogen infection associated with ARGs and *** review aims to provide an overview of methods abating the prevalence and spread of ARGs and ARB from species to community *** the species level,species-specific technologies,such as nanoparticle-,photosensitizer-,CRISPR-Cas-,and phage-related technology can be utilized to clear a particular class of ARGs or ARB,and in combination with low-dose antibiotics,a higher removal efficiency can be ***,the combination of antibiotics can be used to reverse microbial resistance and treat recurrent antibiotic resistant pathogen *** the community level,community-specific strategies,such as biochar,hyperthermophilic compost,and fecal microbiota transplantation can eradicate most types of ARGs or ARB in one shot,reducing the probability of resistance *** some progress has been made to eliminate ARGs and ARB in disease treatment or decontamination scenarios,further research is still needed to elucidate their mechanisms of action and scopes of application,and efforts should be made to explore novel strategies to counter the prevalence of antibiotic resistance.

关键词： antibiotic resistance genes antibiotic resistant bacteria treatment strategy disinfection

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Suppressing Wnt signaling of the blood-tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2716-2731页

作者： Yang Tong Pei An Puxian Tang Rui Mu Yuteng Zeng Hang Sun Mei Zhao Ziyan Lv pan Wang Wanjun Han Chunshan Gui Xuechu zhen Liang Han Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development Soochow UniversitySuzhou 215123China

Lipogenesis is often highly upregulated in breast cancer brain metastases to adapt to intracranial low lipid *** inhibitors hold therapeutic potential but their intra-tumoral distribution is often blocked by the blood-tumor barrier(BTB).BTB activates its Wnt signaling to maintain barrier properties,e.g.,Mfsd2a-mediated BTB low ***,we reported VCAM-1-targeting nano-wogonin(W@V-NPs)as an adjuvant of nano-orlistat(O@V-NPs)to intensify drug delivery and inhibit lipogenesis of brain metastases.W@V-NPs were proven to be able to inactivate BTB Wnt signaling,downregulate BTB Mfsd2a,accelerate BTB vesicular transport,and enhance tumor accumulation of O@*** the ability to specifically kill cancer cells in a lipid-deprived environment with IC_(50) at 48 ng/mL,W@V-NPs plus O@V-NPs inhibited the progression of brain metastases with prolonged survival of model *** combination did not induce brain edema,cognitive impairment,and systemic toxicity in healthy *** Wnt signaling could safely modulate the BTB to improve drug delivery and metabolic therapy against brain metastases.

关键词： Lipogenesis Brain metastases Blood-tumor barrier Wnt signaling Drug delivery Fatty acid synthase Nanoparticles Combination therapy

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Inferring Mycobacterium Tuberculosis Drug Resistance and Transmission using Whole-genome Sequencing in a High TB-burden Setting in China

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Biomedical and Environmental Sciences 2024年第2期37卷 157-169页

作者： FAN Yu Feng LIU Dong Xin CHEN Yi Wang OU Xi Chao MAO Qi Zhi YANG ting ting WANG Xi Jiang HE Wen Cong ZHAO Bing LIU zhen Jiang ABULIMITI Maiweilanjiang AIHEMUTI Maimaitiaili GAO Qian ZHAO Yan Lin Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghai 200032China National Tuberculosis Reference Laboratory Chinese Center for Disease Control and PreventionBeijing 102206China Hangzhou Red Cross Hospital Hangzhou 310005ZhejiangChina Xinjiang Uygur Autonomous Region Center for Disease Control and Prevention Urumqi 830026XinjiangChina Tuberculosis Dispensary of Kashgar Prefecture Kashgar 844099XinjiangChina

Objective China is among the 30 countries with a high burden of tuberculosis(TB)worldwide,and TB remains a public health *** Prefecture in the southern Xinjiang Autonomous Region is considered as one of the highest TB burden regions in ***,molecular epidemiological studies of Kashgar are *** A population-based retrospective study was conducted using whole-genome sequencing(WGS)to determine the characteristics of drug resistance and the transmission *** A total of 1,668 isolates collected in 2020 were classified into lineages 2(46.0%),3(27.5%),and 4(26.5%).The drug resistance rates revealed by WGS showed that the top three drugs in terms of the resistance rate were isoniazid(7.4%,124/1,668),streptomycin(6.0%,100/1,668),and rifampicin(3.3%,55/1,668).The rate of rifampicin resistance was 1.8%(23/1,290)in the new cases and 9.4%(32/340)in the previously treated *** resistance mutations were detected more frequently in lineage 2 strains than in lineage 3 or 4 strains,respectively:18.6%vs.8.7 or 9%,P<*** estimated proportion of recent transmissions was 25.9%(432/1,668).Multivariate logistic analyses indicated that sex,age,occupation,lineage,and drug resistance were the risk factors for recent *** the low rate of drug resistance,drug-resistant strains had a higher risk of recent transmission than the susceptible strains(adjusted odds ratio,1.414;95%CI,1.023–1.954;P=0.036).Among all patients with drug-resistant tuberculosis(DR-TB),78.4%(171/218)were attributed to the transmission of DR-TB *** Our results suggest that drug-resistant strains are more transmissible than susceptible strains and that transmission is the major driving force of the current DR-TB epidemic in Kashgar.

关键词： Mycobacterium tuberculosis Whole-genome sequencing(WGS) Transmission Drug resistance Xinjiang

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Genome-wide analysis of panonychus citrimicro RNAs witha focus on potential insecticidal activity of 4 micro RNAs toeggs and nymphs

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Insect Science 2024年第2期31卷 354-370页

作者： Chuan-zhen Li Yu-Hang Liu Deng pan Meng-Hao Xia Qiang Zhang Yu-Chuang Li Guo-Rui Yuan Jin-Jun Wang Wei Dou Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionAcademy of Agricultural SciencesSouthwestUniversityChongqingChina Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River(Ministry of Education) Academy of Agricultural SciencesSouthwest UniversityChongqingChina

panonychus citriMcGregor(Acari:Tetranychidae),a destructive citrus pest,causes considerable annual economic losses due to its short lifespan and rapid ***(miRNA)-induced RNA interference is a promising approachfor pest control because of endogenous regulation of pest growth and *** for miRNAs with potential insecticidal activity ***,genome-wide analysis ofmiRNAs at different developmental stages was conducted,resulting in the identificationof 136 miRNAs,including 73 known and 63 novel miRNAs.A total of 17 isomiRNAsand 12 duplicated miRNAs were ***-1 and miR-252-5p were identified asreference miRNAs *** *** on differential expressionanalysis,treatments with miR-let-7a and miR-315 mimics and the miR-let-7a antagomirsignificantly reduced the egg hatch rate and resulted in abnormal egg ***-expression or downregulation of miR-34-5p and miR-305-5p through feeding significantlydecreased the adult eclosion rate and caused molting *** 4 miRNAs,miR-let-7a,miR-315,miR-34-5p,and miR-305-5p,had important regulatory functions and insectici-dal properties in egg hatching and adult *** general,these data advance our un-derstanding of miRNAs in mite biology,which can assist future studies on insect-specificmiRNA-based green pest control technology.

关键词： growth and development microRNAs panonychus citri referencemiRNAs regulation small RNA libraries

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Application of ^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography imaging in recurrent anastomotic tumors after surgery in digestive tract tumors

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2474-2483页

作者： Deng-Feng Ge Hao Ren Zi-Chen Yang Shou-Xiang Zhao zhen-ting Cheng Da-Da Wu Bin Zhang Department of Cardiothoracic Surgery Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Gastrointestinal Surgery Shanghai Sixth People’s HospitalShanghai 250063China

BACKGROUND This study was to investigate the application value of whole-body dynamic ^(18)F-fluorodeoxyglucose(FDG)positron emission tomography/computed tomogra-phy(PET/CT)imaging in recurrent anastomotic tumors of digestive tract after gastric and esophageal cancer *** patients with gastric and esophageal cancer have a high risk of tumor recurrence,and traditional imaging methods have certain limitations in early detection of recurrent ***-body dynamic ^(18)F-FDG PET/CT imaging,due to its high sensitivity and specifi-city,can provide comprehensive information on tumor metabolic activity,which is expected to improve the early diagnosis rate of postoperative recurrent tumors,and provide an important reference for clinical treatment *** A retrospective analysis was performed on 53 patients with upper digestive tract tumors after operation and systemic dynamic ^(18)F-FDG PET/CT imaging indi-cating abnormal FDG uptake by anastomosis,including 29 cases of gastric cancer and 24 cases of esophageal *** to the follow-up results of gas-troscopy and other imaging examinations before and after PET/CT examination,the patients were divided into an anastomotic recurrence group and anastomotic inflammation *** multi-parameter analysis software was used to obtain the metabolic rate(MRFDG),volume of distribution maximum(DVmax)of anastomotic lesions,and MRmean and DVmean of normal liver *** lesion/background ratio(LBR)was calculated by dividing the MRFDG and DVmax of the anastomotic lesion by the MRmean and DVmean of the normal liver tissue,respectively,to obtain LBR-MRFDG and *** independent sample t test was used for statistical analysis,and a receiver operating characteristic curve was used to analyze the differential diagnostic efficacy of each parameter for anastomotic recurrence and *** The dynamic ^(18)F-FDG PET/CT imaging parameters MRFDG,DVmax,LBR-MRFDG,and LBR-DVmax of post

关键词： Gastric cancer Esophageal cancer Anastomosis Dynamic positron emission tomography Differential diagnosis Metabolic rate

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Preparation of tungsten-particle-reinforced Zr-based bulk metallic glass composites by two-step spark plasma sintering:microstructure evolution,densification mechanism and mechanical properties

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Rare Metals 2024年第4期43卷 1793-1808页

作者： Yun-Fei Ma pan Gong Mao Zhang Hui-EHu zhen Peng Xiao Xu Xin Wang Mehdi Malekan Xue-Feng Tang Lei Deng Jun-Song Jin Xin-Yun Wang State Key Laboratory of Materials Processing and Die and Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan430074China Research Institute of Huazhong University of Science and Technology in Shenzhen Shenzhen518057China Department of Chemistry and Materials Naval University of EngineeringWuhan430032China School of Materials Science and Engineering Jiangsu UniversityZhenjiang212013China College of Machine Shanghai Dianji UniversityShanghai201306China School of Metallurgy and Materials Engineering College of EngineeringUniversity of TehranTehran 11155-4563Iran

A new two-step spark plasma sintering(TSS)process with low-temperature pre-sintering and high-temperature final sintering has been successfully applied to prepare the tungsten-particle(Wp)-reinforced bulk metallic glass composites(Wp/BMGCs).Compared to normal spark plasma sintering(NS),the densification rate and relative density of Wp/BMGCs can be improved by selecting TSS with appropriate sintering pressure in the low temperature pre-sintering ***,the compressive strength and plastic strain of 30%Wp/BMGCs prepared by TSS are both higher than those of the samples prepared by *** TSS process can significantly enhance the compressive strength of 30%Wp/BMGCs by 12%and remarkably increase the plastic strain by 50%,while the trend is completely opposite for 50%Wp/***-in situ experiments and finite element simulations reveal that uneven temperature distribution among particles during low-temperature pre-sintering causes local overheating at contact points between particles,accelerating formation of sintering neck between particles and plastic deformation of *** the volume fraction of Wp is low,TSS can improve the interface bonding between particles by increasing the number of sintering *** makes the fracture mode of Wp/BMGCs being predominantly transgranular ***,as the volume fraction of Wp increases,the adverse effects of Wp plastic deformation are becoming more and more *** aggregated Wp tends to form a solid"cage structure"that hinders the bonding between particles at the interface;correspondingly,the fracture behavior of Wp/BMGCs is mainly dominated by intergranular ***,reducing the sintering pressure during the low-temperature pre-sintering stage of TSS has been shown to effectively decrease plastic deformation in Wp,resulting in a higher degree of densification and better mechanical properties.

关键词： Bulk metallic glass composites Tungsten particle Two-step spark plasma sintering Densification mechanism Mechanical properties

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Recent advances in Ir/Ru-based perovskite electrocatalysts for oxygen evolution reaction

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Rare Metals 2024年第7期43卷 2891-2912页

作者： Zhi-Qi Jiang Cheng-zhen Fan Jun-Yu pan Li Shao Hao Chen Erum Pervaiz Yan Dong Tong-Zhou Wang Xue-Rong zheng Ji-Hong Li Yi-Da Deng School of Materials Science and Engineering Hainan UniversityHaikou570228Chin Department of Chemical Engineering School of Chemical and Materials Engineering(SCME)National University of Sciences&Technology(NUST)Islamabad 44000Pakistan Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071Chin

Oxygen evolution reaction(OER)is a kinetically harsh four-electron anode reaction that requires a large overpotential to provide current and is of great importance in renewable electrochemical ***/Rubased perovskite oxides hold great significance for application as OER electrocatalysts,due to that their multimetal-oxide forms can reduce the use of noble metals,and their compositional tunability can modulate the electronic structure and optimize OER ***,high operating potentials and corrosive environments pose a serious challenge to the development of durable Ir-based and Ru-based perovskite *** efforts have been dedicated to improving the Ir/Ru-based perovskite activity to enhance the efficiency;however,progress in improving the durability of Ir/Ru-based perovskite electrocatalysts has been rather *** this review,the recent research progress of Ir/Ru-based perovskites is reviewed from the perspective of heteroatom doping,structural modulation,and formation of *** dissolution mechanism studies of Ir/Ru and experimental attempts to improve the durability of Ir/Ru-based perovskite electrocatalysts are *** and outlooks for further developing Ru-and Irbased perovskite oxygen electrocatalysts are also presented.

关键词： Oxygen evolution reaction Ir/Ru-based perovskites Stability Electrocatalysts

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