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Measurement of atmospheric non-reciprocity effects for satellite-based two-way time-frequency transfer

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Photonics Research 2024年第6期12卷 1274-1282页

作者： ting ZENG QI SHEN YUAN CAO JIAN-YU GUAN MENG-ZHE LIAN JIN-JIAN HAN LEI HOU JIAN LU XIN-XIN PENG MIN LI WEI-YUE LIU JIN-CAI WU YONG WANG JUAN YIN JI-GANG REN HAI-FENG JIANG QIANG ZHANG CHENG-ZHI PENG JIAN-WEI pan Hefei National Research Center for Physical Sciences at the Microscale and School of Physical Sciences University of Science and Technology of ChinaHefei 230026China Shanghai Research Center for Quantum Science and CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaShanghai 201315China Hefei National Laboratory University of Science and Technology of ChinaHefei 230094China Faculty of Information Science and Engineering Ningbo UniversityNingbo 315211China Key Laboratory of Space Active Opto-Electronic Technology Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China

Future optical clock networks will require high-precision optical time-frequency transfer between satellites and ground ***,due to atmospheric turbulence,satellite motion and time delay between the satellite–ground transmission links will cause spatial and temporal variations,respectively,resulting in the breakdown of the time-of-flight reciprocity on which optical two-way time-frequency transfer is ***,we experimentally simulate the atmospheric effects by two-way spatio-temporally separated links between two stationary terminals located 113 km apart and measure the effects for optical two-way time-frequency *** experiment shows that the effect on the link instability is less than 2.3×10^(−19) at 10,000 *** indicates that when the link instability of satellite-ground optical time-frequency transfer is on the order of 10^(−19),it is not necessary to consider the atmospheric non-reciprocity effects.

关键词： breakdown transfer satellite

Variable phenotypes and outcomes associated with the MMACHC c.482G>A mutation:follow-up in a large CblC disease cohort

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World Journal of Pediatrics 2024年第8期20卷 848-858页

作者： Sheng-Nan Wu Hui-Shu E Yue Yu Shi-Ying Ling Li-Li Liang Wen-Juan Qiu Hui-Wen Zhang Rui-Xue Shuai Hai-Yan Wei Chi-Ju Yang Peng Xu Xi-Gui Chen Hui Zou Ji-zhen Feng ting-ting Niu Hai-Li Hu Kai-Chuang Zhang De-Yun Lu Zhu-Wen Gong Xia Zhan Wen-Jun Ji Xue-Fan Gu Yong-Xing Chen Lian-Shu Han Department of Endocrinology and Metabolism Henan Key Laboratory of Children’s Genetics and Metabolic DiseasesChildren’s Hospital Affiliated to Zhengzhou UniversityHenan Children’s HospitalZhengzhou Children’s HospitalNo.255 Gangdu StreetZhengzhouChina Department of Pediatric Endocrinology and Genetics Fujian Children’s HospitalFuzhouChina The Center for Pediatric Liver Diseases Children’s HospitalFudan UniversityShanghaiChina Department of Pediatric Endocrinology/Genetics Shanghai Institute for Pediatric ResearchXinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityNo.1665 Kongjiang RoadShanghaiChina Department of Pediatrics Second Affiliated Hospital of Naval Medical UniversityShanghaiChina Center of Neonatal Disease Screening Jining Maternal and Child Health Care HospitalJiningChina Center of Neonatal Disease Screening Jinan Maternal and Child Health Care HospitalJinanChina Center of Neonatal Disease Screening Shijiazhuang Maternal and Child Health Care HospitalShijiazhuangChina Center of Neonatal Disease Screening Shandong Maternal and Child Health Care HospitalJinanChina Center of Neonatal Disease Screening Hefei Maternal and Child Health Care HospitalHefeiChina

Background The aim of this study was to characterize the variable phenotypes and outcomes associated with the methylmalonic aciduria and homocystinuria type C protein gene(MMACHC)c.482G>A mutation in 195 Chinese cases with CblC *** We carried out a national,retrospective multicenter study of 195 Chinese patients with CblC disease attributable to the MMACHC c.482G>A variant either in a homozygous or compound heterozygous *** control group consisted of 200 patients diagnosed with CblC disease who did not possess the c.482G>A *** features,including disease onset,symptoms,biochemical metabolites,gene mutation,and follow-up outcomes were reviewed and analyzed in *** median follow-up period spanned 3 years and 8 months,with a range of 1 year and 2 months to 12 years and 10 *** Among 195 patients carrying the c.482G>A variant,125(64.1%)cases were diagnosed by newborn screening(NBS),60(30.8%)cases were detected due to disease onset,and 10(5.1%)cases were identified from sibling *** hundred and seventeen(93.6%)individuals who were diagnosed by NBS,and nine patients who came from sibling diagnoses remained asymptomatic in this *** 69 symptomatic patients of the c.482G>A group,more patients presented with later onset,and the top six common clinical symptoms at disease onset were developmental delay(59.4%),lower limb weakness and poor exercise tolerance(50.7%),cognitive decline(37.7%),gait instability and abnormal posture(36.2%),seizures(26.1%),and psychiatric and behavioral disturbances(24.6%).In the 159 symptomatic patients lacking c.482G>A variants,the most frequently observed clinical manifestations at disease onset included developmental delay(81.8%),lethargy and feeding difficulty(62.9%),lower limb weakness and poor exercise tolerance(54.7%),prolonged neonatal jaundice(51.6%),vomiting(47.2%),and seizures(32.7%).Before treatment,the levels of blood propionylcarnitine,propionylcarnitine/acetylcarnitine ratio

关键词： c.482G>A CblC disease MMACHC gene Newborn screening Outcome Use our pre-submission checklist Avoid common mistakes on your manuscript.

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MMC直流侧故障有源限流策略

电网技术 2024年第3期48卷 1235-1243页

作者：唐欣潘一彬岳雨霏黄晟李珍长沙理工大学电气与信息工程学院湖南省长沙市410114

为了避免直流短路故障威胁到模块化多电平换流器(modular multilevel converter,MMC)型柔性直流电网的安全可靠运行,该文提出了一种适用于半桥型MMC直流侧故障的有源限流策略,限制直流短路电流和桥臂电流的峰值及上升速率。首先,该文阐... 详细信息

为了避免直流短路故障威胁到模块化多电平换流器(modular multilevel converter,MMC)型柔性直流电网的安全可靠运行,该文提出了一种适用于半桥型MMC直流侧故障的有源限流策略,限制直流短路电流和桥臂电流的峰值及上升速率。首先,该文阐述了故障期间系统控制策略对故障电流的影响,然后通过反馈桥臂电流分别调整差、共模调制波,进而改变上、下桥臂中子模块的数量及分配,达到快速抑制交、直流侧故障电流的目的。其次,推导了考虑有源限流策略下的故障电流解析式,并分析了该限流策略对控制系统稳定性的影响,为有源阻尼参数选取提供理论依据。最后,在PSCAD/EMTDC中搭建四端柔性直流电网模型,仿真结果表明:有源限流策略不仅能够显著降低直流断路器开断故障电流,且能保证桥臂内器件的安全。

关键词：直流电网模块化多电平换流器直流侧故障有源阻尼限流策略

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我国民营医院集团的发展现状分析

中华医院管理杂志 2024年第2期40卷 136-141页

作者：李真潘伟田梦北京大学医学部公共卫生学院北京100191 首都医科大学国家医疗保障研究院科研组织与教育培训办公室北京100037 首都医科大学国家医疗保障研究院基金监管室北京100037

民营医院集团化被业界认为是提高民营医院综合实力及医疗服务品质的关键, 也是民营医疗行业发展的必然趋势。本研究分析了我国民营医院集团的发展现状, 并对3家上市民营医院集团进行典型案例剖析, 以此为基础探讨民营医院集团的发展困... 详细信息

民营医院集团化被业界认为是提高民营医院综合实力及医疗服务品质的关键, 也是民营医疗行业发展的必然趋势。本研究分析了我国民营医院集团的发展现状, 并对3家上市民营医院集团进行典型案例剖析, 以此为基础探讨民营医院集团的发展困境。研究发现, 当前我国民营医院集团的发展仍存在规范化管理能力薄弱、忽视内部资源整合的作用以及内部治理难度大等问题。作者认为民营医院集团应坚持价值医疗导向, 着重增强规范化管理能力, 并通过多样化手段优化内部治理机制, 推动集团内部资源的整合与优化配置, 以提升整体运营管理效率, 获得规模优势与协同效果;在外部治理方面, 应借助多方力量共同加强对民营医院集团经营行为的监管, 以促进集团整体的健康发展。

关键词：医院管理民营医院医院集团化内部治理资源整合

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老旧住宅区户外活动空间适老性现状研究

上海建设科技 2024年第3期 39-44页

作者：潘婷重庆科技大学重庆401331

旨在探究老旧住宅区户外活动空间适老性现状,采用行为标注法对某老旧住宅区内6个户外活动空间进行了分析,且选取参与人数较多的行为活动与空间要素进行对比研究,分析了每种行为与空间要素之间的关联性,得出影响老年人使用的空间要素,揭... 详细信息

旨在探究老旧住宅区户外活动空间适老性现状,采用行为标注法对某老旧住宅区内6个户外活动空间进行了分析,且选取参与人数较多的行为活动与空间要素进行对比研究,分析了每种行为与空间要素之间的关联性,得出影响老年人使用的空间要素,揭示了老年人行为与环境要素之间的联系,并基于此总结了老旧住宅区户外活动空间适老性存在的主要问题,为今后老旧住宅区户外活动空间优化提供参考。

关键词：老旧住宅区户外活动空间适老性

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乡村振兴背景下民族传统体育现代化发展研究

体育文化导刊 2024年第2期 7-13,74页

作者：戴彬钟婷婷聂真新云南师范大学体育学院昆明650500 云南大学体育学院昆明650504 云南体育运动职业技术学院昆明650228

运用文献资料、逻辑分析等方法,审思乡村振兴背景下我国民族传统体育现代化发展价值和趋势,并提出发展路径。价值:助力产业兴旺,拉动乡村经济增长;赋能治理有效,增强乡村道德教化;优化乡风文明,丰富乡村文化生活;增进民生福祉,推进乡村... 详细信息

运用文献资料、逻辑分析等方法,审思乡村振兴背景下我国民族传统体育现代化发展价值和趋势,并提出发展路径。价值:助力产业兴旺,拉动乡村经济增长;赋能治理有效,增强乡村道德教化;优化乡风文明,丰富乡村文化生活;增进民生福祉,推进乡村社会建设;致力生态宜居,改善乡村生态环境。趋势:多产融合是实践路向,三治融合是创新举措,文明建设是核心导向,社会服务是必然要求,生态保护是应有之义。路径:促进产业延伸重组,打造产业体系;深化乡村治理改革,强固治理效能;盘活传统文化资源,释放文化储量;实施乡村建设行动,提升服务质量;坚守乡村生态本色,拓展发展空间。

关键词：民族传统体育乡村振兴现代化发展

Supramolecular systems for bioapplications:recent research progress in China

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Science China Chemistry 2024年第5期67卷 1397-1441页

作者： Yue-Yang Liu Xiao-Yong Yu Yu-Chen pan Hang Yin Shuang Chao Yujie Li He Ma Minzan Zuo Kun-Xu Teng Jun-Li Hou Yong Chen Dong-Sheng Guo Ruibing Wang Yuxin Pei Zhichao Pei Jiang-Fei Xu Xiao-Yu Hu Chunju Li Qing-zheng Yang Leyong Wang Yu Liu Zhan-ting Li State Key Laboratory of Organometallic Chemistry Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional MoleculesShanghai Institute of Organic ChemistryChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200032China Department of Chemistry Fudan UniversityShanghai 200438China College of Chemistry State Key Laboratory of Elemento-Organic ChemistryCollaborative Innovation Center of Chemical Science and EngineeringNankai UniversityTianjin 300071China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China College of Chemistry&Pharmacy Northwest A&F UniversityYangling 712100China Key Lab of Organic Optoelectronics&Molecular Engineering Department of ChemistryTsinghua UniversityBeijing 100084China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China Key Laboratory of Radiopharmaceuticals Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing 100875China Tianjin Key Laboratory of Structure and Performance for Functional Molecules College of ChemistryTianjin Normal UniversityTianjin 300387China State Key Laboratory of Analytical Chemistry for Life Science Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Supramolecular systems feature dynamic,reversible and stimuli-responsive characteristics,which are not easily achieved by molecular *** last decade has witnessed tremendous advances in the investigations of supramolecular systems for various bioapplications,which include drug delivery,anticancer therapy,antibacterial therapy,photodynamic therapy,photothermal therapy,combination therapy,antidotes for residual drugs or toxins,and bioimaging and ***-guest chemistry has played a key role in the development of such bioactive supramolecular systems,and natural macrocycles(such as cyclodextrins),synthetic macrocycles(such as calixarenes,cucurbit[n]urils,and pillararenes),and porous framework polymers(such as supramolecular organic frameworks and flexible organic frameworks)have been most successfully used as hosts to build different kinds of host-guest systems for attaining designed *** self-assembly of rationally designed amphiphilic molecules,macromolecules and polymers represent another important approach for the construction of supramolecular architectures with advanced *** this review,we summarize the important contributions made by Chinese researchers in this field,with emphasis on those reported in the past five years.

关键词： host-guest chemistry drug delivery anticancer and antibacterial photodynamic therapy photothermal therapy antidote transmembrane channel bioimaging and biosensing

外源性硫化氢对肾小球系膜细胞缺氧/复氧损伤的影响及其机制

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中国药理学通报 2024年第1期40卷 133-138页

作者：林真亭田华李鸿珠厦门医学院基础医学部福建厦门361023 厦门大学医学院基础部福建厦门361102

目的探讨外源性硫化氢(hydrogen sulfide,H_(2)S)对肾小球系膜细胞缺氧/复氧(hypoxia/reoxygenation,H/R)损伤的影响,并阐明其相关作用机制。方法H/R诱导小鼠肾小球系膜细胞系(SV40MES13)建立细胞损伤模型。细胞增殖试剂盒(CCK8)检测细... 详细信息

目的探讨外源性硫化氢(hydrogen sulfide,H_(2)S)对肾小球系膜细胞缺氧/复氧(hypoxia/reoxygenation,H/R)损伤的影响,并阐明其相关作用机制。方法H/R诱导小鼠肾小球系膜细胞系(SV40MES13)建立细胞损伤模型。细胞增殖试剂盒(CCK8)检测细胞活力,荧光探针技术分别检测H_(2)S和活性氧(ROS)含量,生化试剂盒检测超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量,Hoechst 33342染色检测细胞凋亡率;Western blot检测胱硫醚-γ-裂解酶(cystathione-gamma-lyase,CSE)、细胞凋亡相关蛋白(cleaved-caspase-3、Cyt c和Bcl-2)表达及信号通路相关蛋白(ERK1/2、Phospho-ERK1/2)活性。结果与对照(Control)组相比,缺氧/复氧(H/R)组细胞活力、内源性H_(2)S含量CSE蛋白表达、SOD活性及Bcl-2蛋白表达均明显降低;细胞凋亡率、MDA和ROS含量、Cyt c及cleaved caspase-3蛋白表达均显著升高;同时,磷酸化ERK1/2(p-ERK1/2)活性明显降低。与H/R比较,H/R+NaHS(外源性H_(2)S供体)逆转了H/R对上述指标的影响。另外,PD98059(ERK1/2抑制剂)减弱了NaHS对磷酸化ERK1/2的作用。结论肾小球系膜细胞H/R损伤与内源性CSE/H_(2)S系统下调有关;外源性H_(2)S通过上调ERK1/2通路抑制氧化应激和细胞凋亡,减轻肾小球系膜细胞H/R损伤。

关键词：硫化氢缺氧/复氧肾小球系膜细胞 ERK1/2通路细胞凋亡 CSE/H_(2)S系统

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产热脂肪细胞中线粒体代谢适应的调节

中国生物化学与分子生物学报 2024年第7期40卷 897-906页

作者：崔轩施亭潘东宁上海交通大学医学院附属第一人民医院临床研究院上海200080 复旦大学基础医学院代谢分子医学教育部重点实验室上海200030

伴随经济的快速发展和人类生活水平的提高,肥胖、2型糖尿病、非酒精性脂肪肝等各种代谢功能紊乱疾病已成为我国重要的公共卫生问题。产热脂肪细胞含有丰富的线粒体以及解偶联蛋白1(uncoupling protein 1,UCP1),可通过消耗甘油三酯和葡... 详细信息

伴随经济的快速发展和人类生活水平的提高,肥胖、2型糖尿病、非酒精性脂肪肝等各种代谢功能紊乱疾病已成为我国重要的公共卫生问题。产热脂肪细胞含有丰富的线粒体以及解偶联蛋白1(uncoupling protein 1,UCP1),可通过消耗甘油三酯和葡萄糖并以非颤抖性产热的方式来维持哺乳动物核心体温,鉴于产热过程增加体内能量消耗,因此,激活产热脂肪成为防治糖脂代谢紊乱性疾病的重要研究方向。线粒体作为产热脂肪细胞中功能高度保守的细胞器,在产热激活和失活过程中出现代谢适应性的改变以响应产热能力的变化,而产热脂肪细胞中线粒体代谢适应的失调则可能造成产热能力损伤,甚至全身代谢紊乱。本文概述了近年来报道的产热脂肪细胞线粒体多方面的灵活重塑,包括线粒体动力学变化、磷脂和嵴的重塑以及线粒体活性氧水平和氧化应激等方面,全面地总结了相关的调控因子,最后对脂肪细胞产热能力的维持提供了深入的见解,展望了未来有关产热脂肪细胞线粒体的研究方向,以期为开发靶向新药以激活脂肪产热来对抗代谢性疾病提供理论参考。

关键词：产热脂肪组织线粒体动力学蛋白质质量控制嵴线粒体应激