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Further discussion of CO_(2) huff-n-puff mechanisms in tight oil reservoirs based on NMR monitored fluids spatial distributions

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Petroleum Science 2023年第1期20卷 350-361页

作者： Wei-Yu Tang James J.Sheng ting-xue jiang Unconventional Petroleum Research Institute China University of PetroleumBeijing102249China Bob L.Herd Department of Petroleum Engineering Texas Tech UniversityLubbockTX79409USA Sinopec Research Institute of Petroleum Engineering Beijing100101China

Due to the poor physical properties of tight reservoirs,CO_(2) huff-n-puff(HNP)is considered a potential enhanced oil recovery(EOR)method after primary *** plays a critical role in the effective implementation of CO_(2) *** the optimization requires a good understanding of the EOR *** this work,the spatial distribution of oil saturation under different experimental conditions was analyzed by the NMR method to further discuss the HNP *** to the variation of 1D frequency signal amplitude,we divided the core into the hardly movable area and movable area,the region with the obvious signal decline was defined as the movable area,and the hardly movable area was the region with limited signal *** on that the recovery characteristics of different scenarios were ***,the necessity of the soaking stage was studied,where three scenarios with different soaking times were carried ***,the injection pressure was adjusted to investigate the effect of the pressure *** T_(2) spectra show that soaking has significantly improved the production of crude oil in small pores,and higher oil recovery in a single cycle is observed,but it is lower when the elapsed time(total operation time)is the same.31.03% of oil can be recovered after 3 cycles HNP,which increases to 33.8% and 37.06% for the 4 cycles and 6 cycles *** the pressure gradient increases,more oil is removed out of the matrix,and the oil in the deep part of the reservoir can be effectively *** the CO_(2) huff-n-puff process,the oil distributions are similar to the solution gas drive,the residual oil is distributed at the close end of the core and the range that the oil can be efficiently recovered is limited.

关键词： Tight reservoirs Low-field nuclear magnetic resonance (NMR) CO_(2)huff-n-puff Enhanced oil recovery

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Development of unconventional gas and technologies adopted in China

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Energy Geoscience 2020年第1期1卷 55-68页

作者： Yang Li De-Hua Zhou Wei-Hong Wang ting-xue jiang Zhao-Jie xue China Petroleum&Chemical Corporation Beijing100728China Sinopec Exploration&Production Research Institute Beijing100083China Sinopec Research Institute of Petroleum Engineering Beijing100101China

This study analyses the geological characteristics and development progress of unconventional gas in China,summarizes the development theories and technologies,discusses the prospects and challenges of unconventional gas development,and puts forward the future trends of development *** technologies of unconventional gas development are available in *** gas development technologies include comprehensive geological evaluation,volume fracturing of cluster horizontal wells under complex stress conditions,and factory-like operation of horizontal wells in complex mountainous area et *** gas development technologies include fluid identification and quantitative prediction,optimization of well patterns,multi-layer fracturing in vertical well,staged fracturing in horizontal well,and drainage gas *** methane(CBM)development technologies include the prediction of medium-high-and medium-low-rank CBM enrichment areas,rate-variable hydraulic fracturing,and quantitative drainage recovery with five stages,three pressures,and four *** economic and effective development of unconventional gas,further efforts should be ***,intensified studies should be conducted on high-precision prediction and fine characterization technologies of high-quality shale reservoirs in deep marine,continental,and transitional ***,key theories and technologies such as fast drilling and completion of wells with long laterals as well as large-scale volume fracturing should be developed to improve well ***,new technologies such as multiple well-type development,fluid injection,and nano-flooding should be developed to enhance the ***,effort should be made to identify the accumulation mechanism and large-scale effective development technologies for ***,the application of large amounts of data and artificial intelligence in the entire process of unconventional gas development should be considered to reduce the dev

关键词： Unconventional gas Geologic characteristics Development history Integrated development technology

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Mechanisms of fracture propagation from multi-cluster using a phase field based HMD coupling model in fractured reservoir

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Petroleum Science 2024年第3期21卷 1829-1851页

作者： Yun-Jin Wang Bo Wang Hang Su Tu Chang Ren-Cheng Dong Li-Zhe Li Wei-Yu Tang ting-xue jiang Fu-Jian Zhou State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum-BeijingBejing2249China China University of Petroleum-Beijing at Karamay Karamay834000XinjiangChina China National Oil and Gas Exploration and Development Corporation Ltd. Beijing100034China University of Texas at Austin United States SINOPEC Research Institute of Petroleum Engineering Beijing100101China

Natural fractures(NFs)are common in shale and tight reservoirs,where staged multi-cluster fracturing of horizontal wells is a prevalent technique for reservoir *** NFs and stress interference are recognized as significant factors affecting hydraulic fracture(HF)propagation,the combined influence of these factors remains poorly *** address this knowledge gap,a novel coupled hydromechanical-damage(HMD)model based on the phase field method is developed to investigate the propagation of multi-cluster HFs in fractured *** comprehensive energy functional and control functions are established,while incorporating dynamic fluid distribution between multiple perforation clusters and refined changes in rock mechanical parameters during hydraulic *** HMD coupled multi-cluster HF propagation model investigates various scenarios,including single HF and single NF,reservoir heterogeneity,single HF and NF clusters,and multi-cluster HFs with NF *** results show that the HMD coupling model can accurately capture the impact of approach angle(θ),stress difference and cementation strength on the interaction of HF and *** criterion of the open and cross zones is not *** NF angle(a)is not a decisive parameter to discriminate the *** to the relationship between approach angle(θ)and NF angle(a),the contact relationship of HF can be divided into three categories(θ=a,θa).The connected NF can increase the complexity of HF by inducing it to form branch fracture,resulting in a fractal dimension of HF as high as2.1280 at angles of±45°.Inter-fracture interference from the heel to the toe of HF shows the phenomenon of no,strong and weak ***,under the influence of NFs,distant HFs from the injection can become dominant ***,as a gradually increases,inter-fracture stress interference becomes the primary factor influencing HF propagation,gradually superseding the dominance of NF

关键词： HMD coupling Phase field Natural fracture Flow distribution Hydraulic fracturing Inter-fracture interference

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Preparation of Co/S co-doped carbon catalysts for excellent methylene blue degradation

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 169-181页

作者： Haixu Li Haobo He Tiannan jiang Yunfei Du Zhichen Wu Liang Xu Xinjie Wang Xiaoguang Liu Wanhua Yu Wendong xue School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Beijing Jinyu Tongda Refractory Technologies Co. Ltd.Beijing 100085China

S and Co co-doped carbon catalysts were prepared via pyrolysis of MOF-71 and thiourea mixtures at 800℃at a mass ratio of MOF-71 to thiourea of 1:0.1 to effectively activate peroxymonosulfate(PMS)for methylene blue(MB)*** effects of two different mixing routes were identified on the MB degradation ***,the catalyst obtained by the alcohol solvent evaporation(MOF-AEP)mixing route could degrade 95.60%MB(50 mg/L)within 4 min(degradation rate:K=0.78 min^(-1)),which was faster than that derived from the direct grinding method(MOF-DGP,80.97%,K=0.39 min^(-1)).X-ray photoelectron spectroscopy revealed that the Co-S content of MOF-AEP(43.39at%)was less than that of MOF-DGP(54.73at%),and the proportion of C-S-C in MOF-AEP(13.56at%)was higher than that of MOF-DGP(10.67at%).Density functional theory calculations revealed that the adsorption energy of Co for PMS was -2.94 eV when sulfur was doped as C-S-C on the carbon skeleton,which was higher than that when sulfur was doped next to cobalt in the form of Co-S bond(-2.86 eV).Thus,the C-S-C sites might provide more contributions to activate PMS compared with ***,the degradation parameters,including pH and MOF-AEP dosage,were ***,radical quenching experiments and electron paramagnetic resonance(EPR)measurements revealed that ^(1)O_(2)might be the primary catalytic species,whereas·O~(2-)might be the secondary one in degrading MB.

关键词： advanced oxidation process alcohol solvent evaporation hydrogen bond S and Co co-doped carbon catalysts wastewater remediation

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人骨髓间充质干细胞过表达白细胞介素-34对THP-1细胞的调节作用

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生物工程学报 2017年第4期33卷 642-652页

作者：高雪明张顺许兆军单艳王子鸿蔡挺江雪宁波市第二医院浙江宁波315010

构建人IL-34真核表达载体并将其转染到人骨髓间充质干细胞,观察高表达IL-34的骨髓间充质干细胞对THP-1细胞的影响。PCR扩增IL-34 DNA,并将其克隆到真核表达载体pIRES2-EGFP;将构建成功的重组体转染到骨髓间充质干细胞,Western blotting... 详细信息

构建人IL-34真核表达载体并将其转染到人骨髓间充质干细胞,观察高表达IL-34的骨髓间充质干细胞对THP-1细胞的影响。PCR扩增IL-34 DNA,并将其克隆到真核表达载体pIRES2-EGFP;将构建成功的重组体转染到骨髓间充质干细胞,Western blotting和ELISA分析IL-34在细胞中的表达;用高表达IL-34的骨髓间充质干细胞培养上清液来培养THP-1细胞,Real-time PCR分析THP-1细胞中IL-10和TNFα的表达变化。经双酶切和测序鉴定,成功构建了pIRES2-EGFP-IL-34重组体;转染至骨髓间充质干细胞的IL-34可以促进THP-1细胞表达IL-10和TNFα。结果表明,骨髓间充质干细胞表达分泌的IL-34对THP-1有调节作用。

关键词：人骨髓间充质干细胞白细胞介素-34 THP-1细胞白细胞介素-10 肿瘤坏死因子-α

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Impacts of the annual cycle of background SST in the tropical Pacific on the phase and amplitude of ENSO

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 12-17页

作者： Song jiang Congwen Zhu Ning jiang State Key Laboratory of Severe Weather(LASW) Chinese Academy of Meteorological SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina

The dominant annual cycle of sea surface temperature(SST)in the tropical Pacific exhibits an antisymmetric mode,which explains 83.4%total variance,and serves as a background of El Niño-Southern Oscillation(ENSO).However,there is no consensus yet on its anomalous impacts on the phase and amplitude of *** on data during 1982-2022,results show that anomalies of the antisymmetric mode can affect the evolution of ENSO on the interannual scale via Bjerknes feedback,in which the positive(negative)phase of the antisymmetric mode can strengthen El Niño(La Niña)in boreal winter via an earlier(delayed)seasonal cycle transition and larger(smaller)annual *** magnitude of the SST anomalies in the equatorial eastern Pacific can reach more than±0.3◦C,regulated by the changes in the antisymmetric mode based on random sensitivity *** reveal the spatial pattern of the annual cycle associated with the seasonal phase-locking of ENSO evolution and provide new insight into the impact of the annual cycle of background SST on ENSO,which possibly carries important implications for forecasting ENSO.

关键词： Annual cycle SST anomaly Antisymmetric mode ENSO

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Staged dendrite suppression for high safe and stable lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： Jun jiang Zhenjie Lu Yanwen Ding Shujun Liu Zhijie Qi Tian Tang Yunfan Zhang Zhiyuan Ma Jingwen Sun Liang xue Wenyao Zhang Pan Xiong Xin Wang Junwu Zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Ductility

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Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

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World Journal of Clinical Oncology 2025年第1期16卷 25-33页

作者： jiang-Yu Bian Yu-Fang Feng Wen-ting He Tong Zhang Department of Oncology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Oncology The Fourth Clinical Medical College of Xinjiang Medical UniversityUrumqi 830001China Department of Oncology Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830001China

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor *** the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal ***,we further explored the survival benefits in the population with BRAF V600E mutant *** To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal *** A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December *** patients were divided into two *** A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,*** analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

关键词： Metastatic colorectal cancer BRAF V600E mutation Integrated Chinese and Western medicine Cohort study

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Toward understanding the role of genomic repeat elements in neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 646-659页

作者： Zhengyu An Aidi jiang Jingqi Chen Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan UniversityShanghaiChina Zhangjiang Fudan International Innovation Center ShanghaiChina

Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage sequencing technology, researchers have started to notice that genomic repeat regions, previously neglected in search of disease culprits, are active contributors to multiple neurodegenerative diseases. In this review, we describe the association between repeat element variants and multiple degenerative diseases through genome-wide association studies and targeted sequencing. We discuss the identification of disease-relevant repeat element variants, further powered by the advancement of long-read sequencing technologies and their related tools, and summarize recent findings in the molecular mechanisms of repeat element variants in brain degeneration, such as those causing transcriptional silencing or RNA-mediated gain of toxic function. Furthermore, we describe how in silico predictions using innovative computational models, such as deep learning language models, could enhance and accelerate our understanding of the functional impact of repeat element variants. Finally, we discuss future directions to advance current findings for a better understanding of neurodegenerative diseases and the clinical applications of genomic repeat elements.

关键词： Alzheimer's disease ataxia deep learning long-read sequencing neurodegeneration neurodegenerative diseases Parkinson's disease repeat element structural variant

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Optimal Scheduling of an Independent Electro-Hydrogen System with Hybrid Energy Storage Using a Multi-Objective Standardization Fusion Method

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Energy Engineering 2025年第1期122卷 63-84页

作者： SuliangMa ZeqingMeng Mingxuan Chen Yuan jiang School of Electrical and Control Engineering North China University of TechnologyBeijing100144China ChinaThree Gorges Technology Co. Ltd.Beijing100032China School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing100083China

In the independent electro-hydrogen system(IEHS)with hybrid energy storage(HESS),achieving optimal scheduling is ***,it presents a challenge due to the significant deviations in values ofmultiple optimization objective functions caused by their physical *** deviations seriously affect the scheduling process.A novel standardization fusion method has been established to address this issue by analyzing the variation process of each objective function’s *** optimal scheduling results of IEHS with HESS indicate that the economy and overall energy loss can be improved 2–3 times under different optimization *** proposed method better balances all optimization objective functions and reduces the impact of their *** the cost of BESS decreases by approximately 30%,its participation deepens by about 1 ***,if the price of the electrolyzer is less than 15￥/kWh or if the cost of the fuel cell drops below 4￥/kWh,their participation will increase *** study aims to provide a more reasonable approach to solving multi-objective optimization problems.

关键词： Electro-hydrogen system multi-objective optimization standardization method hybrid energy storage system

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