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Plasma Metabonomics of Human Adenovirus-infected Patients with Pneumonia and Upper Respiratory Tract Infection

Current Medical Science 2024年第1期44卷 121-133页

作者： ting-ting wei Wen XU Bo TU Wan-xue ZHANG Xin-xin YANG Yiguo ZHOU Shan-shan ZHANG Jun-lian YANG Ming-zhu XIE Juan DU wei-wei CHEN Qing-bin LU Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of Infectious Disease The Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Department of Laboratorial Science and Technology&Vaccine Research Center School of Public HealthPeking UniversityBeijing 100191China Department of Health Policy and Management School of Public HealthPeking UniversityBeijing 100191China Global Center for Infectious Disease and Policy Research&Global Health and Infectious Diseases Group Peking UniversityBeijing 100191China Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of EducationBeijing 100191China

Objective Human adenovirus(HAdV)infection is common and can develop to serious conditions with high mortality,yet the mechanism of HAdV infection remains *** the present study,the serum metabolite profiles of HAdV-7-infected patients with pneumonia or upper respiratory tract infection(URTI)were *** In total,35 patients were enrolled in the study following an outbreak of HAdV-7 in the army,of whom 14 had pneumonia and 21 had *** samples were collected at the acute stage and at the recovery stage and were analyzed by untargeted *** Over 90% of the differential metabolites identified between the pneumonia patients and URTI patients were lipids and lipid-like molecules,including glycerophospholipids,fatty acyls,and *** metabolic pathways that were significantly enriched were primarily the lipid metabolism pathways,including sphingolipid metabolism,glycerophospholipid metabolism,and linoleic acid *** sphingolipid metabolism was identified as a significantly differential pathway between the pneumonia patients and URTI patients and between the acute and recovery stages for the pneumonia patients,but not between the acute and recovery stages for the URTI *** and lactosylceramide,involved in sphingolipid metabolism,were significantly higher in the pneumonia patients than in the URTI patients with good discrimination abilities[area under curve(AUC)0.742 and 0.716,respectively;combination AUC 0.801].Conclusion Our results suggested that HAdV modulated lipid metabolism for both the patients with URTI and pneumonia,especially the sphingolipid metabolism involving ceramide and lactosylceramide,which might thus be a potential intervention target in the treatment of HAdV infection.

关键词： human adenovirus metabonomic lipids pneumonia upper respiratory tract infection

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Regulating the electrochemical activity of Fe-Mn-Cu-based layer oxides as cathode materials for high-performance Na-ion battery

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Journal of Energy Chemistry 2023年第5期80卷 603-613,I0014页

作者： ting-ting wei Xu Liu Shao-Jie Yang Peng-Fei Wang ting-Feng Yi School of Materials Science and Engineering Northeastern UniversityShenyang 110819LiaoningChina Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province School of Resources and MaterialsNortheastern University at Qinhuangdao066004HebeiChina

Fe-Mn based layer oxides cathode materials have attracted widespread attention as a potential candidate for sodium-ion batteries(SIBs)owing to the earth abundance,cost-effectiveness and acceptable specific ***,the irreversible phase transition often brings rapid capacity decay,which seriously hinders the practical application in large-scale energy ***,we design a nickel-doped Na_(0.70)Fe_(0.10)Cu_(0.20)Ni_(0.05)Mn_(0.65)O_(2)(NFCNM-0.05)cathode material of SIBs with activated anionic redox reaction,and then inhibit the harmful phase *** ex-situ X-ray diffraction patterns demonstrate the NFCNM-0.05 always keeps the P2 phase during the sodiation/desodiation process,indicating a high structure *** ex-situ X-ray photoelectron spectroscopy implies the redox reactions between O2-and O-occur in the charging process,which offers extra specific ***,the NFCNM-0.05 electrode delivers a high initial discharge capacity of 148 mA h g-1and remains a prominent cycling stability with an excellent capacity retention of 95.9%after 200 cycles at 1 *** addition,the electrochemical impedance spectroscopy and galvanostatic intermittent titration technique show the NFCNM-0.05 electrode possesses fast ion diffusion ability,which is beneficial for the enhancement of rate *** at 10 C,the NFCNM-0.05 can offer a reversible discharge capacity of 81 mA h *** calculation demonstrates the doping of appropriate amount of Ni ions is benefit for the enhancement of the electrochemical performance of the layer *** work provides an effective strategy to enhance the electrochemical performance of Fe-Mn based cathode materials of SIBs.

关键词： Fe-Mn-Cu based oxide Nickel-ion doping Reversible phase transition Cycling stability

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Rational construction and decoration of Li_(5)Cr_(7)Ti_(6)O_(25)@Cnanofibers as stable lithium storage materials

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Journal of Energy Chemistry 2022年第8期31卷 400-410,I0011页

作者： ting-ting wei Panpan Peng Yu-Rui Ji Yan-Rong Zhu ting-Feng Yi Ying Xie School of Materials Science and Engineering Northeastern UniversityShenyang 110819LiaoningChina Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150080HeilongjiangChina School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao 066004HebeiChina Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province Qinhuangdao 066004HebeiChina

Li_(5)Cr_(7)Ti_(6)O_(25) is regarded as a promising anode material for Li-ion batteries(LIBs)because of its low cost and high theoretical ***,the inherently poor conductivity significantly limits the enhancement of its rate capability and cycling stability,especially at high current *** this work,we construct one-dimensional Li_(5)Cr_(7)Ti_(6)O_(25)/C nanofibers by electrospinning method to enhance the kinetic,which realizes high cycling *** coating enhances the structure stability,insertion/extraction reversibility of Li-ions and electrochemical reaction activity,and facilitates the transfer of *** from the unique architecture and component,the Li_(5)Cr_(7)Ti_(6)O_(25)/C(6.6 wt%)nanofiber shows an excellent rate capability with a reversible de-lithiation capacity of 370.8,290.6,269.2,254.3 and 244.9 m Ah g^(-1) at 200,300,500,800 and 1000 m A g^(-1),*** at a higher current density of 1 A g^(-1),Li_(5)Cr_(7)Ti_(6)O_(25)/C(6.6 wt%)nanofiber shows high cycling stability with an initial de-lithiation capacity of 237.8 m Ah g^(-1) and a capacity retention rate of about 84%after 500 *** density functional theory calculation result confirms that the introduction of carbon on the surface of Li_(5)Cr_(7)Ti_(6)O_(25) changes the total density of states of Li_(5)Cr_(7)Ti_(6)O_(25),and thus improves electronic conductivity of the composite,resulting in a good electrochemical performance of Li_(5)Cr_(7)Ti_(6)O_(25)/C ***_(5)Cr_(7)Ti_(6)O_(25)/C nanofibers indicate a great potential as an anode material for the next generation of high-performance LIBs.

关键词： Lithium-ion battery Anode Li_(5)Cr_(7)Ti_(6)O_(25) Electrospinning Nanofibers

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Anesthetic management of a pregnant patient with Eisenmenger’s syndrome:A case report

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世界临床病例杂志 2023年第27期11卷 6597-6602页

作者： Ying Zhang ting-ting wei Gang Chen Department of Anesthesiology Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310006Zhejiang ProvinceChina

BACKGROUND Eisenmenger’s syndrome(ES)is a rare complication of congenital heart disease that includes pulmonary artery hypertension and reversed or bidirectional *** mortality rate of pregnant women with ES is 30%-70%due to pathophysiological *** perioperative management of a pregnant patient with ES is a challenge for *** SUMMARY A 38-year-old pregnant woman was admitted to the cardiology department of our hospital at 22 wk of gestation with complaints of chest tightness and shortness of breath for 3 *** echocardiography revealed a bidirectional shunt between the descending aorta and pulmonary artery after interventional closure of the patent ductus arteriosus and severe pulmonary *** in pregnancy was our primary *** patient elected to terminate the pregnancy under adequate preoperative preparation,rigorous intraoperative monitoring,and perfect epidural *** was discharged successfully on postoperative day *** Our experience in this case suggests that successful outcomes are possible in pregnant patients with ES for termination of pregnancy under epidural anesthesia and intensive monitoring.

关键词： Eisenmenger’s syndrome Pulmonary artery hypertension Pregnancy Monitoring Epidural anesthesia Case report

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Snap-through behaviors and nonlinear vibrations of a bistable composite laminated cantilever shell:an experimental and numerical study

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Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 779-794页

作者： Lele REN wei ZHANG ting DONG Yufei ZHANG State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200240China Department of Mechanics Guangxi UniversityNanning 530004China Beijing Key Laboratory of Nonlinear Vibrations and Strength of Mechanical Structures College of Mechanical EngineeringBeijing University of TechnologyBeijing 100124China School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China

The snap-through behaviors and nonlinear vibrations are investigated for a bistable composite laminated cantilever shell subjected to transversal foundation excitation based on experimental and theoretical *** improved experimental specimen is designed in order to satisfy the cantilever support boundary condition,which is composed of an asymmetric region and a symmetric *** symmetric region of the experimental specimen is entirely clamped,which is rigidly connected to an electromagnetic shaker,while the asymmetric region remains free of *** motion paths are realized for the bistable cantilever shell by changing the input signal levels of the electromagnetic shaker,and the displacement responses of the shell are collected by the laser displacement *** numerical simulation is conducted based on the established theoretical model of the bistable composite laminated cantilever shell,and an off-axis three-dimensional dynamic snap-through domain is *** numerical solutions are in good agreement with the experimental *** nonlinear stiffness characteristics,dynamic snap-through domain,and chaos and bifurcation behaviors of the shell are quantitatively *** to the asymmetry of the boundary condition and the shell,the upper stable-state of the shell exhibits an obvious soft spring stiffness characteristic,and the lower stable-state shows a linear stiffness characteristic of the shell.

关键词： bistable composite laminated cantilever shell snap-through behavior nonlinear vibration nonlinear stiffness characteristic chaos and bifurcation

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The High-order SPDEs Driven by Multi-parameter Fractional Noises

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Acta Mathematica Sinica,English Series 2010年第10期26卷 1943-1960页

作者： ting ting wei Schoole of Mathematics Nankai University Tianjin 300071 P. R. China

The existence and uniqueness of the solutions are proved for a class of fourth-order stochastic heat equations driven by multi-parameter fractional noises. Furthermore the regularity of the solutions is studied for th... 详细信息

关键词： Fourth-order stochastic heat equation multi-parameter fractional noise regularity

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Higher intakes of lysine,threonine and valine are inversely associated with non-alcoholic fatty liver disease risk:a community-based case-control study in the Chinese elderly

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Food Science and Human Wellness 2024年第1期13卷 191-197页

作者： Xueqi Li Wenjun Ma ting Yang Chong Wang wei Zhang Hui Li ting Zhao Xiaofei Guo Institute of Nutrition&Health School of Public HealthQingdao UniversityQingdao 260071China Affiliated Hospital of Qingdao University Qingdao 260071China

The associations of individual amino acid with non-alcoholic fatty liver disease(NAFLD)risk remained *** present study aimed to investigate the associations between the two in the Chinese ***:A community-based health check-up program was conducted in Qingdao,*** was diagnosed by ultrasonography accompanied by epidemiological *** dietary intakes of amino acids were investigated with 3-day,24-h dietary records and calculated by Nutrition Calculator *** cubic spline model was used to evaluate a nonlinear relationship between amino acid intake and NAFLD ***:400 NAFLD subjects were identified,and 400 participants were randomly selected as controls and matched by gender and age(±3 years)Dose-response analysis showed that 1000 mg increment of aromatic amino acids(AAAs)was associated with reduced 16%risk of *** increments of 750 mg/d threonine,950 mg/d valine,or 1700 mg/d lysine were associated with a 20%reduction in the NAFLD risk(all P for linearityting against NAFLD in the elderly.

关键词： Amino acid Non-alcoholic fatty liver disease Senior citizen Dose-response analysis

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Pathogen-induced methylglyoxal negatively regulates rice bacterial blight resistance by inhibiting OsCDR1 protease activity

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Molecular Plant 2024年第2期17卷 325-341页

作者： Zheng-wei Fu Jian-Hui Li Xiang Gao Shi-Jia Wang ting-ting Yuan Ying-Tang Lu State Key Laboratory of Hybrid Rice College of Life SciencesRenmin Hospital of Wuhan UniversityWuhan UniversityWuhan 430072China Key Laboratory of Biology and Genetic Improvement of OilCrops Ministry of Agriculture and Rural AffairsOilCrops Research Institute of the Chinese Academy of Agricultural SciencesWuhan 430062China

Xanthomonas oryzae ***(Xoo)causes bacterial blight(BB),a globally devastating disease of rice(Oryza sativa)that is responsible for significant crop *** and sugar metabolites are important for pathogen infection,providing energy and regulating events associated with defense responses;howev-er,the mechanisms by which they regulate such events in BB are *** an inevitable sugar metabolite,methylglyoxal(MG)is involved in plant growth and responses to various abiotic stresses,but the underlying mechanisms remain *** and how MG functions in plant biotic stress responses is almost completely ***,we report that the Xoo strain PXO99 induces OsWRKY62.1 to repress transcrip-tion of OsGLY Il genes by directly binding to their promoters,resulting in overaccumulation of *** negatively regulates rice resistance against Pxo99:osglyll2 mutants with higher MG levels are more sus-ceptible to the pathogen,whereas OsGLYIl2-overexpressing plants with lower MG content show greater resistance than the wild *** of OsGLYll2 to prevent excessive MG accumulation confers broad-spectrum resistance against the biotrophic bacterial pathogens Xoo and Xanthomonas oryzae *** and the necrotrophic fungal pathogen Rhizoctonia solani,which causes rice sheath *** evidence shows that MG reduces rice resistance against PXO99 through CONSTITUTIVE DISEASE RESISTANCE 1(OsCDR1).MGmodifies the Arg97 residue of OsCDR1to inhibit its aspartic protease activ-ity,which is essential for OsCDR1-enhanced *** together,these findings illustrate how Xoo promotes infection by hijacking a sugar metabolite in the host plant.

关键词： Oryza sativa bacterial blight OsWRKY62.1 methylglyoxal OsCDR1

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Advancement of technology towards high-performance non-aqueous aluminum-ion batteries

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Journal of Energy Chemistry 2021年第6期30卷 169-188,I0005页

作者： ting-ting wei Panpan Peng Si-Yu Qi Yan-Rong Zhu ting-Feng Yi School of Materials Science and Engineering Northeastern UniversityShenyang 110819LiaoningChina School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao 066004HebeiChina Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province Qinhuangdao 066004HebeiChina

Al-ion batteries(AIBs) have been identified as one of the most hopeful energy storage systems after Li-ion batteries on account for the ultrahigh volumetric capacity,high safety and low cost from the rich abundance of ***,some inevitable shortcomings,such as the formation of passive oxide film,hydrogen side reactions and anode corrosion,finally limit the large-scale application of aqueous *** nonaqueous AIBs have been considered as one of most hopeful alternatives for high-powered electrochemical energy storage ***,various technical and scientific obstacles should be resolved because nonaqueous AIBs are still *** significant efforts have aimed to resolve these issues towards large-scale applications,and some important advancement has been *** the present review,we mainly intended to offer an overview of non-aqueous AIBs systems,and we comprehensively reviewed the recent research advancement of the cathode materials,anode materials electrolyte and collectors as well as the fundamental understanding of the functional *** addition,we have also analyzed several technical challenges and summarized the strategies used for overcoming the challenges in improving the electrochemical properties,including morphology control,surface engineering,doping and construction of composite electrodes as well as the charge storage mechanisms of the materials with different crystal *** last,future research orientation and development prospect of the AIBs are proposed.

关键词： Al-ion batteries Electrode Electrolyte Collector Electrochemical performance

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An improved deep dilated convolutional neural network for seismic facies interpretation

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Petroleum Science 2024年第3期21卷 1569-1583页

作者： Na-Xia Yang Guo-Fa Li ting-Hui Li Dong-Feng Zhao wei-wei Gu State Key Laboratory of Petroleum Resources and Engineering CNPC Key Lab of Geophysical Exploration China University of Petroleum (Beijing) Dagang Branch Research InstituteBGP

With the successful application and breakthrough of deep learning technology in image segmentation,there has been continuous development in the field of seismic facies interpretation using convolutional neural networks. These intelligent and automated methods significantly reduce manual labor, particularly in the laborious task of manually labeling seismic facies. However, the extensive demand for training data imposes limitations on their wider application. To overcome this challenge, we adopt the UNet architecture as the foundational network structure for seismic facies classification, which has demonstrated effective segmentation results even with small-sample training data. Additionally, we integrate spatial pyramid pooling and dilated convolution modules into the network architecture to enhance the perception of spatial information across a broader range. The seismic facies classification test on the public data from the F3 block verifies the superior performance of our proposed improved network structure in delineating seismic facies boundaries. Comparative analysis against the traditional UNet model reveals that our method achieves more accurate predictive classification results, as evidenced by various evaluation metrics for image segmentation. Obviously, the classification accuracy reaches an impressive 96%. Furthermore, the results of seismic facies classification in the seismic slice dimension provide further confirmation of the superior performance of our proposed method, which accurately defines the range of different seismic facies. This approach holds significant potential for analyzing geological patterns and extracting valuable depositional information.

关键词： Seismic facies interpretation Dilated convolution Spatial pyramid pooling Internal feature maps Compound loss function

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