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Journal of Pharmaceutical Analysis 2024年第1期14卷 140-148页

作者： Jingxian Zhang Qinsheng chen Lianglong Zhang Biru Shi Men Yu Qingxia Huang Huiru Tang State Key Laboratory of Genetic Engineering School of Life SciencesHuman Phenome InstituteZhangjiang Fudan International Innovation CenterMetabonomics and Systems Biology Laboratory at Shanghai International Centre for Molecular PhenomicsZhongshan HospitalFudan UniversityShanghai200032China Wuhan Laboratory for Shanghai Metabolome Institute(SMI)Ltd. Wuhan430000China

Acylcarnitines are metabolic intermediates of fatty acids and branched-chain amino acids having vital biofunctions and pathophysiological significances. Here, we developed a high-throughput method for quantifying hundreds of acylcarnitines in one run using ultrahigh performance liquid chromatography and tandem mass spectrometry (UPLC-MS/MS). This enabled simultaneous quantification of 1136 acylcarnitines (C0–C26) within 10-min with good sensitivity (limit of detection 0.992), accuracy (relative error 0.998) for predicting retention time (tR) of acylcarnitines with no standards and built a database of their multiple reaction monitoring parameters (tR, ion-pairs, and collision energy). Furthermore, we quantified 514 acylcarnitines in human plasma and urine, mouse kidney, liver, heart, lung, and muscle. This provides a rapid method for quantifying acylcarnitines in multiple biological matrices.

关键词： Acylcarnitine UPLC-MS/MS Quantitative structure-retention relationship Molecular phenotype

Lipoic acid suppresses portal endotoxemia-induced steatohepatitis and pancreatic inflammation in rats

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World Journal of Gastroenterology 2013年第18期19卷 2761-2771页

作者： Yu-Feng Tian Chih-Tsueng He Yu-ting chen Po-Shiuan Hsieh Division of General Surgery Department of Surgery Yung Kung Campus Chi-Mei Medical Center Department of Health and Nutrition Chia Nan University of Pharmacy and Science Tainan 717 Taiwan Division of Endocrinology and Metabolism Department of Internal Medicine Tri-Service General Hospital Taipei 114 Taiwan Department of Physiology and Biophysics National Defense Medical Center Department of Medical Research Tri-Service General Hospital Taipei 114 Taiwan

AIM: To examine the effect of α-lipoic acid (LA) on mild portal endotoxemia-induced steatohepatitis and associated pancreatic abnormalities in fructose-fed rats. METHODS: Rats were randomly assigned into two groups with a regular or 60% fructose-enriched diet for 8 wk. After fructose feeding for 4 wk, rats were further divided into four subgroups: with intraportal saline (F PV ), with intraportal saline plus administration of LA (F PV + LA ), with lipopolysaccharide (LPS) infusion (F PLPS ), and with LPS infusion plus administration of LA (F PLPS + LA ). Rats were treated with LPS using intraportal infusion while LA was administered orally. Metabolite levels, superoxide levels, inflammatory markers, malondialdehyde content, glutathione content and toll-like receptor 4 (TLR4 ) gene expression were all measured using standard biochemical techniques. Pancreatic insulin secretion was evaluated by a hyperglycemic clamp technique. Histology of liver and pancreas tissues were evaluated using hematoxylin and eosin staining and immunohistochemistry. RESULTS: Fructose-induced elevation in plasma C-reactive protein, amylase, superoxide, white blood cell count as well as in hepatic and pancreatic contents of malondialdehyde, tumor necrosis factor alpha and interleukin-6 were increased in animals treated with LPS and reversed with LA administration. The augmented hepatic gene expression of TLR4 in fructose-fed rats was further increased in those with intraportal LPS infusion, which was partially reversed by LA administration. Pathological examination showed inflammatory changes and leukocyte infiltration in hepatic and pancreatic islets of animals treated with LPS but were rarely observed in those with LA treatment. In addition to affects on the liver, impaired pancreatic insulin secretion seen in fructose-fed rats was deteriorated in with LPS treatment and partially reversed with LA administration. CONCLUSION: These data suggest LA could significantly suppress mild portal-endot

关键词： Lipoic acid Oxidative stress Steatohepatitis Portal endotoxemia Insulin secretion Fructose

Alleviative effects of Bacillus coagulans strains on irritable bowel syndrome-unraveling strain specificity through physiological and genomic analysis

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Food Science and Human Wellness 2024年第4期13卷 1845-1855页

作者： Jiang Cao Leilei Yu Jianxin Zhao Hao Zhang Wei chen Yuzheng Xue Qixiao Zhai State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch Wuxi 214122China Department of Gastroenterology Affiliated Hospital of Jiangnan UniversityWuxi 214122China

The high intraspecies heterogeneity of Baciillus coagulans leads to significant phenotypic differences among different ***,6 *** strains were tested in the present study using an irritable bowel syndrome(IBS)animal model to determine whether the IBS-alleviating effects of *** strains are *** results of this study showed that the ingestion of *** GBI-30,6086,and *** CCFM1041 significantly alleviated IBS symptoms in *** contrast,other *** strains showed no or limited alleviating effects on IBS *** to our experimental results,the two main common features of these strains were as follows:1)The resistance of vegetative cells to bile salts,and 2)ability to synthesize specific lipids and secondary *** strains based on these two indicators may greatly reduce costs and provide a basis for mining new functional *** *** results also suggest that administration of *** could significantly regulate microbiota dysbiosis in animal ***,the close relationships between the gut microbiota,gut microbiota metabolites,and IBS were further confirmed in this study.

关键词： Baciillus coagulans Irritable bowel syndrome Resistance to bile salts Comparative genomic analysis Gut microbiota

Hierarchical V_(3)S_(4)/C nanofibers with fast kinetics for superior alkali metal batteries

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Rare Metals 2024年第4期43卷 1836-1844页

作者： Li chen Zhi-Xin Rao Zhi chen Zhao-Hui Wu Shuai Yang Zhi-Jun Feng Hui-Yong Yang Fan-Yan Zeng Xi-Bao Li Jin-Yang Hu Jun-Tong Huang School of Materials Science and Engineering Nanchang Hangkong UniversityNanchang330063China School of Aeronautical Manufacturing Engineering Nanchang Hangkong UniversityNanchang330063China

Owing to the numerous benefits,including low cost and great theoretical capacity,V3S4 has been a research hotspot for Li^(+)/Na^(+)/K^(+) ***,the V_(3)S_(4) electrode with long cycling stability and high specific capacities continues to pose significant *** this work,vacuum vulcanization is combined with electrospinning to synthesize V_(3)S_(4)/C composite nanofibers(V_(3)S_(4)@CNF).

关键词： composite fibers kinetics

孟鲁司特钠片联合糠酸氟替卡松治疗支气管哮喘患儿的疗效及对miRNA-21、miRNA-26a水平的影响

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检验医学与临床 2024年第1期21卷 75-78,82页

作者：闫鲜鹏韩伟王洁英李婷陈蓉陕西省人民医院儿童病院陕西西安710068 陕西省人民医院干部体检中心陕西西安710068

目的探究孟鲁司特钠片联合糠酸氟替卡松治疗对支气管哮喘患儿血清微小RNA(miRNA)-21及miRNA-26a水平的影响。方法选择2020年3月至2022年3月陕西省人民医院儿童病院收治的支气管哮喘患儿120例,按照随机数字表法分为两组,每组60例。在常... 详细信息

目的探究孟鲁司特钠片联合糠酸氟替卡松治疗对支气管哮喘患儿血清微小RNA(miRNA)-21及miRNA-26a水平的影响。方法选择2020年3月至2022年3月陕西省人民医院儿童病院收治的支气管哮喘患儿120例,按照随机数字表法分为两组,每组60例。在常规方法的基础上,对照组使用布地奈德雾化吸入治疗,观察组使用孟鲁司特钠片联合糠酸氟替卡松治疗。比较两组治疗后临床疗效和不良反应。检测并比较两组患儿肺功能指标、血清炎症因子以及miRNA-21、miRNA-26a表达水平。结果治疗后两组第1秒用力呼气容积(FEV_(1))和最大呼气流量(PEF)均显著升高(P0.05)。结论糠酸氟替卡松联合孟鲁斯特钠片对儿童支气管哮喘具有更好的临床疗效,可提高肺功能,并具有一定的安全性。并且联合治疗可能通过下调miRNA-21和miRNA-26a的表达水平抑制炎症因子。

关键词：支气管哮喘孟鲁司特钠片糠酸氟替卡松微小RNA-21 微小RNA-26a

上市旅游企业财务风险评价分析的影响因素——以9家上市旅游企业为例

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科技和产业 2024年第13期24卷 180-188页

作者：王玲张薇薇徐舟红陈秋米林婷海南热带海洋学院商学院海南三亚572000

上市旅游企业的财务风险评价分析对企业的健康经营十分重要。企业的发展极易受市场环境、政策因素以及社会环境等影响,产生明显的财务风险和经营风险。基于财务风险评价理论,以9家上市旅游企业的财务数据为例,采用因子分析法实现对数据... 详细信息

上市旅游企业的财务风险评价分析对企业的健康经营十分重要。企业的发展极易受市场环境、政策因素以及社会环境等影响,产生明显的财务风险和经营风险。基于财务风险评价理论,以9家上市旅游企业的财务数据为例,采用因子分析法实现对数据的降维提取。结果表明,企业的盈利能力对企业的财务风险影响最大。从风险评价的角度提出财务风险识别与控制措施。研究成果可为上市旅游企业有效地识别风险、合理地规避风险、妥善地处理风险提供有益的指导。

关键词：财务风险上市旅游企业因子分析法

Constructing a stable interface on Ni-rich LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2) cathode via lactic acid-assisted engineering strategy

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Journal of Energy Chemistry 2024年第3期90卷 412-422,I0010页

作者： Weijian Tang chengzhi Hu AFei Li Xiaoqin Huang Zhangxian chen Jianhui Su Weixin Zhang Institute of Energy Hefei Comprehensive National Science CenterHefei 230031AnhuiChina School of Chemistry and Chemical Engineering Hefei University of Technology and Anhui Key Laboratory of Controllable Chemical Reaction&Material Chemical EngineeringHefei 230009AnhuiChina School of Electrical Engineering and Automation Hefei University of TechnologyHefei 230009AnhuiChina

Ni-rich layered oxides are potential cathode materials for next-generation high energy density Li-ion batteries due to their high capacity and low ***,the inherently unstable surface properties,including high levels of residual Li compounds,dissolution of transition metal cations,and parasitic side reactions,have not been effectively addressed,leading to significant degradation in their electrochemical *** this study,we propose a simple and effective lactic acid-assisted interface engineering strategy to regulate the surface chemistry and properties of Ni-rich LiNi_(0.8)Co_(0.1)Mr_(0.1)O_(2) *** novel surface treatment method successfully eliminates surface residual Li compounds,inhibits structural collapse,and mitigates cathode-electrolyte interface film *** a result,the lactic acidtreated LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2) achieved a remarkable capacity retention of 91.7% after 100 cycles at 0.5 C(25℃) and outstanding rate capability of 149.5 mA h g^(-1) at 10 C,significantly outperforming the pristine ***,a pouch-type full cell incorporating the modified LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2) cathode demonstrates impressive long-term cycle life,retaining 81.5% of its capacity after 500 cycles at 1 *** importantly,the thermal stability of the modified cathode is also dramatically *** study offers a valuable surface modification strategy for enhancing the overall performance of Ni-rich cathode materials.

关键词： Residual Li Lactic acid Surface modification Carbon coating Layered cathode Ni-rich

基于OBE理念的BOPPPS教学方式联合3D打印及增强现实技术在留学生神经外科临床见习教学中的应用

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中国医学教育技术 2024年第5期38卷 684-689页

作者：梁晨魏婷张威李瑞春高珂于海西安交通大学第一附属医院神经外科西安710061 西安交通大学第一附属医院眼科西安710061

目的该研究基于以结果为导向教育(outcome-based education,OBE)理念的BOPPPS教学方式联合3D打印及增强现实(augmented reality,AR)技术运用于留学生神经外科临床见习教学中,旨在探索更加有效的留学生神经外科临床见习教学模式,提升留... 详细信息

目的该研究基于以结果为导向教育(outcome-based education,OBE)理念的BOPPPS教学方式联合3D打印及增强现实(augmented reality,AR)技术运用于留学生神经外科临床见习教学中,旨在探索更加有效的留学生神经外科临床见习教学模式,提升留学生神经外科临床见习的教学效果。方法将82名临床医学本科(MBBS)留学生随机以班级为单位分为试验组(40名)和对照组(42名),试验组采用基于OBE理念的BOPPPS教学方式联合3D打印及AR技术的教学模式,对照组采用传统教学模式,通过理论知识及临床思维考核、个人能力提升评价、教学满意度评价进行教学效果评估。结果试验组理论知识及临床思维考核平均成绩为(91.45±5.05)分,对照组为(85.83±8.30)分;试验组个人能力提升评价平均成绩为(90.10±6.04)分,对照组为(76.78±6.38)分;试验组中29名学生(72.5%)对教学效果非常满意,11名学生(27.5%)对教学效果比较满意,对照组中14名学生(33.3%)对教学效果非常满意,28名学生(66.7%)对教学效果比较满意。以上结果两组比较差异具有统计学意义(均P<0.05)。结论将基于OBE理念的BOPPPS教学方式联合3D打印及增强现实技术应用于留学生神经外科见习教学具有一定优势,可作为一种有益探索,为留学生神经外科临床见习教学改良提供新的思路。

关键词：留学生神经外科临床见习 BOPPPS教学方式 3D打印增强现实

Changes in global land surface frozen ground and freeze-thaw processes during 1950-2020 based on ERA5-Land data

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Advances in Climate Change Research 2024年第2期15卷 265-274页

作者： Yong YANG Ren-Sheng chen Yong-Jian DING Hong-Yuan LI Zhang-Wen LIU Qilian Alpine Ecology and Hydrology Research Station Key Laboratory of Ecological Safety and Sustainable Development in Arid LandsNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 73000China State Key Laboratory of Cryospheric Sciences Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 73000China Shandong Provincial Key Laboratory of Water and Soil Conservation and Environmental Protection College of Resources and EnvironmentLinyi UniversityLinyi 276000China

Frozen ground(FG)plays an important role in global and regional climates and environments through changes in land freeze-thaw processes,which have been conducted mainly in different ***,the changes in land surface freeze-thaw processes under climate change on a global scale are still *** on ERA5-Land hourly land skin temperature data,this study evaluated changes in the global FG area,global land surface first freeze date(FFD),last freeze date(LFD)and frost-free period(FFP)from 1950 to *** results show that the current FG areas(1991-2020 mean)in the Northern Hemisphere(NH),Southern Hemisphere(SH),and globe are 68.50×10^(6),9.03×10^(6),and 77.53×10^(6)km^(2),which account for 72.4%,26.8%,and 60.4%of the exposed land(excluding glaciers,ice sheets,and water bodies)in the NH,SH and the globe,respectively;further,relative to 1951-1980,the FG area decreased by 1.9%,8.8%,and 2.8%,*** FG at lower latitudes degrades to intermittently FG,and intermittently FG degrades to non-frozen ground,which caused the global FG boundary to retreat to higher latitudes from 1950 to *** annual FG areas in the NH,SH,and globe all show significant decreasing trends(p<0.05)from 1950 to 2020 at-0.32×10^(6),-0.22×10^(6),and-0.54×10^(6)km^(2)per decade,*** FFP prolongation in the NH is mainly influenced by LFD advance,while in the SH it is mainly controlled by FFD *** prolongation trend of FFP in the NH(1.34 d per decade)is larger than that in the SH(1.15 d per decade).

关键词： Frozen ground Freeze-thaw processes Frost-free period First freeze date Global warming

A Physics-informed Deep-learning Intensity Prediction Scheme for Tropical Cyclones over the Western North Pacific

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Advances in Atmospheric Sciences 2024年第7期41卷 1391-1402页

作者： Yitian ZHOU Ruifen ZHAN Yuqing WANG Peiyan chen Zhemin TAN Zhipeng XIE Xiuwen NIE Department of Atmospheric and Oceanic Sciences&Institute of Atmospheric Sciences Fudan UniversityShanghai 200438China Shanghai Typhoon Institute of China Meteorological Administration Shanghai 200030China Department of Atmospheric Sciences and International Pacific Research Center University of Hawaii at ManoaHonolulu 96822USA Key Laboratory of Mesoscale Severe Weather/MOE and School of the Atmospheric SciencesNanjing UniversityNanjing 210023China School of Computer Science Fudan UniversityShanghai 200438China

Accurate prediction of tropical cyclone(TC)intensity is challenging due to the complex physical processes ***,we introduce a new TC intensity prediction scheme for the western North Pacific(WNP)based on a time-dependent theory of TC intensification,termed the energetically based dynamical system(EBDS)model,together with the use of a long short-term memory(LSTM)neural *** time-dependent theory,TC intensity change is controlled by both the internal dynamics of the TC system and various environmental factors,expressed as environmental dynamical *** LSTM neural network is used to predict the environmental dynamical efficiency in the EBDS model trained using besttrack TC data and global reanalysis data during 1982–*** transfer learning and ensemble methods are used to retrain the scheme using the environmental factors predicted by the Global Forecast System(GFS)of the National Centers for Environmental Prediction during 2017–*** predicted environmental dynamical efficiency is finally iterated into the EBDS equations to predict TC *** new scheme is evaluated for TC intensity prediction using both reanalysis data and the GFS prediction *** intensity prediction by the new scheme shows better skill than the official prediction from the China Meteorological Administration(CMA)and those by other state-of-art statistical and dynamical forecast systems,except for the 72-h *** at the longer lead times of 96 h and 120 h,the new scheme has smaller forecast errors,with a more than 30%improvement over the official forecasts.

关键词： tropical cyclones western North Pacific intensity prediction EBDS LSTM