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Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

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World Journal of Clinical Oncology 2025年第1期16卷 25-33页

作者： Jiang-Yu bian Yu-Fang Feng Wen-ting He Tong Zhang Department of Oncology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Oncology The Fourth Clinical Medical College of Xinjiang Medical UniversityUrumqi 830001China Department of Oncology Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830001China

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor *** the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal ***,we further explored the survival benefits in the population with BRAF V600E mutant *** To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal *** A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December *** patients were divided into two *** A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,*** analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

关键词： Metastatic colorectal cancer BRAF V600E mutation Integrated Chinese and Western medicine Cohort study

ImSpiRE: image feature-aided spatial resolution enhancement method

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Science China Life Sciences 2025年第1期68卷 272-283页

作者： Yuwei Hua Yizhi Zhang Zhenming Guo Shan bian Yong Zhang State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center Institute for Regenerative MedicineDepartment of NeurosurgeryShanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji University

The resolution of most spatially resolved transcriptomic technologies usually cannot attain the single-cell level, limiting their applications in biological discoveries. Here, we introduce ImSpiRE, an image feature-aided spatial resolution enhancement method for in situ capturing spatial transcriptome. Taking the information stored in histological images, ImSpiRE solves an optimal transport problem to redistribute the expression profiles of spots to construct new transcriptional profiles with enhanced resolution, together with extending the gene expression profiles into unmeasured regions. Applications to multiple datasets confirm that ImSpiRE can enhance spatial resolution to the subspot level while contributing to the discovery of tissue domains, signaling communication patterns, and spatiotemporal characterization.

关键词： spatial transcriptome histological images spatial resolution enhancement

Numerical simulation of high-speed train induced ground vibrations using 2.5D finite element approach

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Science China(Physics,Mechanics & Astronomy) 2008年第6期51卷 632-650页

作者： bian XueCheng CHEN YunMin HU ting Department of Civil Engineering Zhejiang UniversityHangzhou 310027China

An efficient 2.5D finite element numerical modeling approach was developed to simulate wave motions generated in ground by high-speed train passages. Fourier transform with respect to the coordinate in the track direction was applied to re-ducing the three-dimensional dynamic problem to a plane strain problem which has been solved in a section perpendicular to the track direction. In this study, the track structure and supporting ballast layer were simplified as a composite Euler beam resting on the ground surface, while the ground with complicated geometry and physical properties was modeled by 2.5D quadrilateral elements. Wave dissipation into the far field was dealt with the transmitting boundary constructed with fre-quency-dependent dashpots. Three-dimensional responses of track structure and ground were obtained from the wavenumber expansion in the track direction. The simulated wave motions in ground were interpreted for train moving loads traveling at speeds below or above the critical velocity of a specific track-ground system. It is found that, in the soft ground area, the high-speed train operations can enter the transonic range, which can lead to resonances of the track structure and the sup-porting ground. The strong vibration will endanger the safe operations of high-speed train and accelerate the deterioration of railway structure.

关键词： high-speed train moving load ground vibration 2.5D finite element absorbing boundary

Cobalamin-dependent radical S-adenosyl-L-methionine protein functions with a partner to successively methylate tricyclic indole alkaloid for chuangxinmycin maturation and derivatization

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Science China Chemistry 2025年第1期68卷 308-316页

作者： Sili Wang Jiancheng Huang Yanan Du Wei Huang Yufeng Xue Xiaokun Xu Guannan Zhong Yuanyuan Shi Bin Hong Xiaoying bian Wen Liu State Key Laboratory of Chemical Biology Shanghai Institute of Organic Chemistry University of Chinese Academy of SciencesChinese Academy of Sciences State Key Laboratory of Microbial Technology Shandong University National Health Commission (NHC) Key Laboratory of Biotechnology for Microbial Drugs Institute of Medicinal BiotechnologyChinese Academy of Medical Science & Peking Union Medical College

Cobalamin(Cbl)-dependent radical S-adenosyl-L-methionine(SAM) proteins constitute the largest collection of the radical SAM superfamily that has hundreds of thousands of individual members. Many of these proteins are involved in the biosynthesis of pharmaceutically important natural products to catalyze chemically demanding reactions. In the biosynthetic pathway of chuangxinmycin(CXM), a unique indole alkaloid antibiotic with potent anti-infective activity, functionalization of the characteristic thiopyrano[4,3,2-cd]indole scaffold by regio-and stereoselective C3-methylation is believed to rely on a Cbl-dependent radical process, which, however, remained to be reconstituted biochemically. We here report the dissection of this enzymatic process, which requires the incorporation of Cxm8, a Cbl-dependent radical SAM protein, with Cxm9, a DUF5825family protein that shares no homology to any proteins of known functions. Cxm8 and Cxm9 function together by forming an unexpected heterodimeric complex that selectively catalyzes C3-methylation of the tricyclic indole-S-hetero ring system in a successive manner, achieving CXM and a recently identified, C3-dimethylated congener. Detailed biochemical characterization,isotope labeling, structural simulation and bioinformatics analysis rationalized the catalysis of the Cxm8/Cxm9 complex and particularly the necessity of the DUF5825 protein for C3-methylase activity. This is the first example that a Cbl-dependent protein acts with a partner to exhibit radical SAM activity.

关键词： cbl-dependent radical SAM protein biosynthesis chuangxinmycin stereoselective methylation

Interannual variability in the onset of the South China Sea summer monsoon from 1997 to 2014

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Atmospheric and Oceanic Science Letters 2017年第1期10卷 73-81页

作者： HE bian ZHANG Ying LI ting HU Wen-ting State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesWeather StationSuqian Meteorological Administratio

Using observed and reanalysis datasets,the South China Sea summer monsoon（SCSSM） onset process is analyzed in each year from 1997 to *** mean（5-20°N,110-120°E） 850 hPa zonal wind,precipitation,and SST are used as indices to describe SCSSM *** distinct onset types are identified：among the 18 years studied,nine are normal onset years,which are characterized by a well-established westerly wind and associated precipitation over the South China Sea（SCS）;eight are intermittent onset years,in which monsoon precipitation does not occur continuously following the establishment of the westerly wind over the SCS;and one year,2014,is a delayed onset year,in which the western Pacific subtropical high dominates over the SCS after the seasonal transition and prevents the monsoon onset.A comparison of the first two types suggests that a positive SST gradient in the northern Indian Ocean and local SST warming in the SCS are two key factors in the normal SCSSM onset *** regard to the influence of the El Nino-Southern Oscillation background,there are four late onset years（1997,1998,2007,and 2010） that coincide with El Nino events,but only two early-onset years（1999 and 2012） out of the six years featuring La Nina *** analysis suggests that the zonal thermal contrast across the Indian and western Pacific oceans modulates monsoon onset in La Nina years.

关键词： South China Sea summer monsoon onset air-sea interaction

Assessment of the Summer South Asian High in Eighteen CMIP5 Models

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Atmospheric and Oceanic Science Letters 2015年第1期8卷 33-38页

作者： HE bian HU Wen-ting State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric Physics Chinese Academy of Sciences State Key Laboratory of Loess and Quaternary Geology Institute of Earth Environment Chinese Academy of Sciences

The South Asian High(SAH) is one of the most important components of the Asian summer monsoon system. To understand the ability of state-of-the-art general circulation models(GCMs) to capture the major characteristics of the SAH, the authors evaluate 18 atmospheric models that participated in the Coupled Model Intercomparison Project Phase 5/Atmospheric Model Intercomparison Project(CMIP5/AMIP). Results show that the multi-model ensemble(MME) mean is able to capture the climatological pattern of the SAH, although its intensity is slightly underestimated. For the interannual variability of the SAH, the MME exhibits good correlation with the reanalysis for the area and intensity index, but poor skill in capturing the east-west oscillation of the SAH. For the interdecadal trend, the MME shows pronounced increasing trends from 1985 to 2008 for the area and intensity indexes, which is consistent with the reanalysis, but fails to capture the westward shift of the SAH center. The individual models show different capacities for capturing climatological patterns, interannual variability, and interdecadal trends of the SAH. Several models fail to capture the climatological pattern, while one model overestimates the intensity of the SAH. Most of the models show good correlations for interannual variability, but nearly half exhibit high root-mean-square difference(RMSD) values. Six models successfully capture the westward shift of the SAH center in the interdecadal trends, while other models fail. The possible causes of the systematic biases involved in several models are also discussed.

关键词： South Asian High CMIP5 Asian summer monsoon AMIP

Influence of annealing on microstructure and hydrogen storage properties of V48Fe12Ti15Cr25 alloy

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Journal of Iron and Steel Research International 2020年第2期27卷 217-227页

作者： Long Luo Xuan bian Wen-yuan Wu Ze-ming Yuan Yong-zhi Li ting-ting Zhai Feng Hu School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina Analytical and Testing Center Inner Mongolia University of Science and Technology.Baotou 014010Inner MongoliaChina

V48Fe12Ti15Cr25 alloy was prepared using vacuum arc melting and was subsequently annealed for 10 h at 1273 *** effects of annealing on the hydrogen storage properties and microstructure of the V48Fe12Ti15Cr25 alloys were *** results indicated that the alloy consisted of main body-centered cubic,Ti-rich,and TiFe *** annealing,the kinetic properties of the alloy were improved but its hydrogen storage capacity was slightly *** kinetic mechanisms of the hydrogen absorption and desorption of the alloys were *** dehydrogenation enthalpy of the alloy was decreased by 2.57 kJ/mol after *** scanning calorimetry indicated that the hydride decomposition temperature of the annealed alloy was *** hydrogen desorption activation energies of the as-cast and annealed alloys were calculated to be 79.41 and 71.25 kJ/mol,*** results illustrated that annealing was a beneficial method of improving the kinetic and thermodynamic properties of the hydrogen absorption/desorption of the alloy.

关键词： V-based solid solution alloy Annealing Microstructure Hydrogen storage Kinetic mechanism

Early Rehabilitation of Orthopedic Internal Fixation Removal in DaytimeWard

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Computer Systems Science & Engineering 2022年第10期43卷 219-231页

作者： Lanlan Ni Lanzheng bian Rugang Lu ting Chen Jinyue Xia Department of Day Surgery Children's Hospital of Nanjing Medical UniversityNanjing210008China Department of Surgery Children's Hospital of Nanjing Medical UniversityNanjing210008China International Business Machines Corporation(IBM) NY10504USA

Children's fractures are very common,and many children's fractures need internal *** the children are treated and recovered,it needs to be internally fixed and then taken *** the development of internal fixation materials,the research of surgical methods and the improvement of surgical skills,postoperative removal of orthopedic surgery patients has gradually been included in daytime *** ensuring the safety of children's surgery,it is necessary to shorten the postoperative limb and joint function recovery time,promote the recovery of limb and joint function,the healing of wounds and bones,and reduce the occurrence of these *** order to reduce the occurrence of these complications,carry out early rehabilitation education and development early rehabilitation training is very *** paper puts forward the concept of early rehabilitation based on shared decision model,in which doctors,nurses,children and family members participate in the treatment of children before,during and after *** effect of early rehabilitation education in the daytime ward after removal of internal fixation was ***,through the analysis of the control trial also confirmed that the clinical effect of early rehabilitation in improving and optimizing the rehabilitation of fracture in children is significant.

关键词： Fractures internal fixation daytime surgery rehabilitation

Numerical Study on the Effect of Gap Diffraction on the Hydrodynamic Performance of A Floating Breakwater

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China Ocean Engineering 2024年第4期38卷 663-675页

作者： bian Xiang-qian JI Chun-yan XU Sheng GUO Jian-ting HUO Fa-li School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China

Two-dimensional(2D)flume experiments are useful in investigating the performances of floating breakwaters(FBs),including hydrodynamic performances,motion responses,and mooring *** a reasonable gap between the flume wall and the FBs is a critical step in 2D flume ***,research on the effect of the gap on the accuracy of 2D FB experimental results is *** address this issue,a numerical wave tank is developed using CFD to estimate the wave-FB interaction of a moored dual-cylindrical FB,and the results are compared to experimental data from a previously published *** is good agreement between them,indicating that the numerical model is sufficiently *** numerical model is then applied to explore the effect of gap diffraction on the performance of FBs in2D *** was discovered that the nondimensional gap length L_(Gap)/W_(Pool)should be smaller than 7.5%to ensure that the relative error of the transmission coefficient is smaller than 3%.The influence of the gap is also related to the entering wave properties,such as the wave height and period.

关键词： floating breakwater diffraction effect gap hydrodynamic performance model experiments CFD numerical simulation