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Concomitant lung metastasis in patients with advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第20期18卷 2533-2539页

作者： Tian Yang Jun-Hua Lu Chuan Lin Song Shi ting-hao chen Rong-Hua Zhao Yi Wang Meng-Chao Wu Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China Department of Hepatobiliary Surgery the First People＇s Hospital of Ziyang Ziyang 641205 Sichuan Province China Department of Surgery Royal University Hospital College of Medicine University of Saskatchewan Saskatoon SK S7NOWS Canada

AIM:To investigate the clinical features and prognostic factors of advanced hepatocellular carcinoma (HCC)patients presenting with lung metastasis at initial diagnosis. METHODS:Between 2001 and 2010,we recruited 76 consecutive HCC patients initially presenting with lung metastasis,without co-existing metastasis from other *** patients were divided into three groups:untreated group(n=22),single treatment group(n= 19),and combined treatment group(n=35). RESULTS:Metastasis of bilateral lung lobes was common and noted in 35 patients(46.1%),and most of patients(59/76,77.6%)presented with multiple lung metastatic *** patients(25.0%) received single-method treatment,including hepatectomy in 4,transcatheter arterial chemoembolization in 6,radiotherapy in 5,and oral sorafenib in ***-five patients(46.1%)received combined treatment *** overall median survival of the all patients was 8.7±0.6 mo;4.1±0.3,6.3±2.5 and 18.6±3.9 mo, respectively in the untreated group,single treatment group and combined treatment group,respectively, with a significant difference(log-rank test,Pting survival of patients with advanced HCC and concomitant lung metastasis. CONCLUSION:Combined treatment modalities tend to result in a better survival as compared with the conservative treatment or single treatment modality for HCC patients initially presenting with lung metastasis.

关键词： Hepatocellular carcinoma Lung metastasis Prognosis Survival Prognostic factor

Spin chiral anisotropy of diamagnetic chiral mesostructured In_(2)O_(3) films

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Nano Research 2024年第8期17卷 7756-7761页

作者： ting Ji Quanzheng Deng hao chen Lu Han Zhibei Qu Shunai Che Yingying Duan Frontiers Science Center for Transformative Molecules State Key Laboratory of Metal Matrix CompositesShanghai Key Laboratory for Molecular Engineering of Chiral DrugsSchool of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China School of Chemical Science and Engineering Tongji UniversityShanghai 200092China Department of Medicinal Chemistry School of PharmacyFudan UniversityShanghai 201203China

Spin chiral anisotropy(SChA)refers to the occurrence of different spin polarization in antipodal chiral ***,we report the SChA in diamagnetic chiral mesostructured In2O3 films(CMIFs)with manifestation of chirality-dependent magnetic circular dichroism(MCD)*** were grown on fluorine-doped tin dioxide conductive glass(FTO)substrates,which were synthesized via a hydrothermal route,with malic acid used as the symmetry-breaking *** levels of chirality have been identified in CMIFs:primary nanoflakes with atomically twisted crystal lattices and secondary helical stacking of the *** exhibit chirality-dependent asymmetric MCD signals due to the different interactions of chirality-induced effective magnetic field and external magnetic field,which distinguish from the commonly observed external magnetic fielddependent symmetric MCD *** findings provide insights into spin manipulation of spin-paired diamagnets.

关键词： chiral inorganics mesostructure diamagnet spin chiral anisotropy(SChA) magnetic circular dichroism(MCD)

Novel Sum-of-Sinusoids Simulation Channel Modeling for 6G Multiple-Input Multiple-Output Vehicle-to-Everything Communications

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China Communications 2024年第1期21卷 242-259页

作者： hao Jiang Hongming Zhang ting Liu College of Artificial Intelligence Nanjing University of Information Science and Technology210044China National Mobile Communications Research Laboratory Southeast UniversityNanjing 210096China School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsChina

In this paper,a statistical cluster-based simulation channel model with a finite number of sinusoids is proposed for depicting the multiple-input multiple-output(MIMO)communications in vehicleto-everything(V2X)*** the proposed sum-of-sinusoids(SoS)channel model,the waves that emerge from the transmitter undergo line-of-sight(LoS)and non-line-of-sight(NLoS)propagation to the receiver,which makes the model suitable for describing numerous V2X wireless communication scenarios for sixth-generation(6G).We derive expressions for the real and imaginary parts of the complex channel impulse response(CIR),which characterize the physical propagation characteristics of V2X wireless *** statistical properties of the real and imaginary parts of the complex CIRs,i.e.,autocorrelation functions(ACFs),Doppler power spectral densities(PSDs),cross-correlation functions(CCFs),and variances of ACFs and CCFs,are derived and *** results are generated and match those predicted by the underlying theory,demonstrating the accuracy of our derivation and *** proposed framework and underlying theory arise as an efficient tool to investigate the statistical properties of 6G MIMO V2X communication systems.

关键词： complex CIRs LoS and NLoS propagation components MIMO V2X communication environments SoS simulation channel model statistical properties

Bacterial microcompartment-mimicking Pickering emulsion droplets for detoxification of chemical threats under sweet conditions

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Science China Chemistry 2024年第9期67卷 3039-3049页

作者： Xiao Xu Wenqi Xie ting Wu chen chen Xiaoning chen Yuheng Yang hao Lian hao chen Xiaofeng cheng Zhitong chen Guojun chen Chaoqun Liu Lanlan chen Yu He Zhaowei chen Bernard P.Binks Huanghao Yang New Cornerstone Science Laboratory MOE Key Laboratory for Analytical Science of Food Safety and BiologyCollege of ChemistryFuzhou UniversityFuzhou 350002China Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Biomedical Engineering and the Rosalind&Morris Goodman Cancer Research Institute McGill UniversityMontreal QC H3A 1A3Canada School of Pharmacy Henan UniversityKaifeng 475004China Department of Chemistry University of HullHull HU67RXUK

Chemical warfare agents represent a severe threat to mankind and their efficient decontamination is a global ***,traditional disposal strategies have limitations,including high energy consumption,use of aggressive reagents and generation of toxic ***,inspired by the compartmentalized architecture and detoxification mechanism of bacterial microcompartments,we constructed oil-in-water Pickering emulsion droplets stabilized by hydrogen-bonded organic framework immobilized cascade enzymes for decontaminating mustard gas simulant(2-chloroethyl ethyl sulfide,CEES)under sweet *** exemplified droplet systems were developed with two-enzyme(glucose oxidase/chloroperoxidase)and threeenzyme(invertase/glucose oxidase/chloroperoxidase)cascades,both achieving over 6-fold enhancement in decontamination efficiency compared with free enzymes and>99% selectivity towards non-toxic *** found that the favored mass transfer of sugars and CEES from their respective phases to approach the cascade enzymes located at the droplet surface and the facilitated substrate channeling between proximally immobilized enzymes were key factors in augmenting the decontamination *** importantly,the robustness of immobilized enzymes enabled easy reproduction of both the droplet formation and detoxification performance over 10 cycles,following long-term storage and in far-field locations.

关键词： Pickering emulsion biomimetics chemical warfare agent bacterial microcompartment biocatalysis

Movement of ACC oxidase 3 mRNA from seeds to flesh promotes fruit ripening in apple

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Molecular Plant 2024年第8期17卷 1221-1235页

作者： ting Wang Yi Zheng chen Xu Yulin Deng Xinyi hao Zicheng Chu Ji Tian Yi Wang Xinzhong Zhang Zhenhai Han ting Wu College of Horticulture China Agricultural UniversityBeijingChina Plant Science and Technology College Bioinformatics CenterBeijing University of AgricultureBeijingChina

Xenia,the phenomenon in which the pollen genotype directly affects the phenotypic characteristics of maternal tissues(i.e.,fruit ripening),has applications in crop production and ***,the underlying molecular mechanism has yet to be ***,we investigated whether mobile mRNAs from the pollen affect the ripening and quality-related characteristics of the fruit using cross-pollination between distinct Malus domestica(apple)*** demonstrated that hundreds of mobile mRNAs originating fromthe seeds are deliveredto *** themovementof one of these mRNAs,AcC oxidase 3(MdAco3),is coordinated with fruit *** acid treatment,which can cause plasmodesmal closure,blocks MdAcO3 movement,indicating that MdAcO3 transcripts may move through the *** assess the role of mobile MdAcO3 transcripts in apple fruit,we created MdACO3-GFP-expressing apple seeds using MdACO3-GFP-overexpressing pollen for pollination and showed that MdACO3 transcripts in the transgenic seeds move to the flesh,where they promote fruit ***,we demonstrated that MdAco3 can be transported from the seeds to fruit in the fleshy-fruited species tomato and *** results underscore the potential of mobile mRNAs from seeds to influence fruit characteristics,providing an explanation for the xenia ***,our findings highlight the feasibility of leveraging diverse pollen genomic resources,without resorting to genome editing,to improve fruitquality.

关键词： fruit ripening xenia ACO3 mobile RNA seed(to flesh)

Research progresses and prospects of multi-sphere compound extremes from the Earth System perspective

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Science China Earth Sciences 2024年第2期67卷 343-374页

作者： Zengchao hao Yang chen College of Water Sciences Beijing Normal UniversityBeijing100875China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing100081China

Compound extremes,whose socioeconomic and ecological impacts are severer than that caused by each event occurring in isolation,have evolved into a hot topic in Earth Science in the past *** the context of climate change,many compound extremes have exhibited increasing frequency and intensity,and shown novel fashions of combinations,posing more pressing demands and tougher challenges to scientific research and disaster prevention and *** article,via a perspective of multi-sphere interactions within the Earth System,systematically reviews the status quo,new scientific understanding,and deficiencies regarding the definition,mechanism,change,attribution,and projection of compound *** study also sorts out existing challenges and outlines a potential roadmap in advancing the study on compound extremes with respect to data requirement,mechanistic diagnosis,numerical modeling,attribution and projection,risk assessment,and adaptive *** directions of compound extremes studies and key research topics that warrant multi-disciplinary and multisectoral coordinated efforts are also *** that climate change has reshaped the type of extremes,a transformation from the traditional single-event perspective to a compound-event perspective is needed for scientific research,disaster prevention and mitigation,and climate change adaptation,calling for bottom-up innovation in research objects,ideas,and *** article will add value to promoting the research on compound extremes and interdisciplinary cooperations.

关键词： Extremes Compound extremes Climate change and risk Multi-sphere interactions

Constraint on the focal mechanism of the 2011 Tohoku earthquake from the radial modes

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Geodesy and Geodynamics 2024年第1期15卷 27-32页

作者： Weikun chen hao Ding School of Geodesy and Geomatics Hubei LuoJia LaboratoryWuhan UniversityWuhan 430079China

Different from other normal modes of the Earth’s free oscillation that depend on all the six components(M_(rr),M_(tt),M_(pp),M_(rt),M_(rp),and M_(tp))of the centroid moment tensor,the amplitudes of the radial modes depend on the M_(rr)component(e.g.,scalar moment(M_(0)),dip(δ),and slip(λ))and hypocenter depth of the focal mechanism,and hence can be easily used to constrain these parameters of the focal *** this study,we use the superconducting gravimeter(SG)records after the 2011 Tohoku earthquake to analyze the radial modes_(0)S_(0)and_(1)S_(0).Based on the solutions of the focal mechanism provided by the GCMT and USGS,we can obtain the theoretical amplitudes of these two radial *** the theoretical amplitudes with the observation amplitudes,it is found that there are obvious differences between the former and the latter,which means that the GCMT and USGS focal mechanisms cannot well represent the real focal mechanism of the 2011 *** the GCMT solution as a reference and changing the depth and the three parameters of the M_(rr)moment,the scalar moment(M_(0))and the dip(δ)have significant influences,but the effects of the slip(λ)and the depth are *** comparisons,we provide a new constraint(M_(0)=5.8±0.09×10^(22)N·m,δ=10.1±0.08°,λ=88°,and depth=20 km)for the focal mechanism of the 2011 *** addition,we further determine the center frequency(1.631567±2.6e^(-6)mHz)and quality factor(2046.4±50.1)of the_(1)S_(0)mode.

关键词： Focal mechanism Radial modes Gravity observation

Multimodal Machine Learning Guides Low Carbon Aeration Strategies in Urban Wastewater Treatment

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Engineering 2024年第5期36卷 51-62页

作者： Hong-cheng Wang Yu-Qi Wang Xu Wang Wan-Xin Yin ting-Chao Yu chen-hao Xue Ai-Jie Wang State Key Laboratory of Urban Water Resource and Environment School of Civil and Environmental EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China Key Laboratory of Drinking Water Safety and Distribution Technology of Zhejiang Province College of Civil Engineering and ArchitectureZhejiang UniversityHangzhou 310058China

The potential for reducing greenhouse gas(GHG)emissions and energy consumption in wastewater treatment can be realized through intelligent control,with machine learning(ML)and multimodality emerging as a promising ***,we introduce an ML technique based on multimodal strategies,focusing specifically on intelligent aeration control in wastewater treatment plants(WWTPs).The generalization of the multimodal strategy is demonstrated on eight ML *** results demonstrate that this multimodal strategy significantly enhances model indicators for ML in environmental science and the efficiency of aeration control,exhibiting exceptional performance and *** random forest with visual models achieves the highest accuracy in forecasting aeration quantity in multimodal models,with a mean absolute percentage error of 4.4%and a coefficient of determination of *** testing in a full-scale plant reveals that the multimodal model can reduce operation costs by 19.8%compared to traditional fuzzy control *** potential application of these strategies in critical water science domains is *** foster accessibility and promote widespread adoption,the multimodal ML models are freely available on GitHub,thereby eliminating technical barriers and encouraging the application of artificial intelligence in urban wastewater treatment.

关键词： Wastewater treatment Multimodal machine learning Deep learning Aeration control Interpretable machine learning

Very long wave infrared quantum dot photodetector up to 18μm

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Light(Science & Applications) 2024年第4期13卷 772-782页

作者： Xiaomeng Xue Qun hao Menglu chen School of Optics and Photonics Beijing Institute of TechnologyBeijing 100081China. Westlake Institute for Optoelectronics FuyangHangzhou 311421China. Physics Department Changchun University of Science and TechnologyChangchun 130022China

Colloidal quantum dots(CQDs)are of interest for optoelectronic devices because of the possibility of high-throughput solution processing and the wide energy gap tunability from ultraviolet to infrared *** may question about the upper limit on the CQD wavelength *** date,although the CQD absorption already reaches terahertz,the practical photodetection wavelength is limited within mid-wave *** figure out challenges on CQD photoresponse in longer wavelength,would reveal the ultimate property on these ***’s more,it motivates interest in bottom-up infrared photodetection with less than 10%cost compared with epitaxial growth semiconductor *** this work,developing a re-growth method and ionic doping modification,we demonstrate photodetection up to 18μm wavelength on HgTe *** liquid nitrogen temperature,the responsivity reaches 0.3 A/W and 0.13 A/W,with specific detectivity 6.6×108 Jones and 2.3×109 Jones for 18μm and 10μm CQD photoconductors,*** work is a step toward answering the general question on the CQD photodetection wavelength limitation.

关键词： quantum wave ultraviolet