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Evaluation of epithelial-mesenchymal transitioned circulating tumor cells in patients with resectable gastric cancer: Relevance to therapy response

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World Journal of Gastroenterology 2015年第47期21卷 13259-13267页

作者： ting-ting Li Hao Liu Feng-Ping Li Yan-Feng Hu ting-yu mou Tian Lin Jiang yu Lei Zheng Guo-Xin Li Department of General Surgery Nanfang Hospital Southern Medical University Department of Laboratory Medicine Sino-UK Circulating Biomarkers’ Exploration and Detection Centre Nanfang Hospital Southern Medical University

AIM: To evaluate the epithelial-to-mesenchymal transition(EMT) of circulating tumor cells(CTCs) in gastric cancer ***: We detected tumor cells for expression of four epithelial(E^+) transcripts(keratins 8, 18, and 19 and epithelial cell adhesion molecule) and two mesenchymal(M^+) transcripts(Vimentin and Twist) by a quantifiable, dual-colorimetric RNA-in situ hybridization assay. Between July 2014 and October 2014, 44 patients with gastric cancer were recruited for CTC evaluation. Blood samples were obtained from selected patients during the treatment course [before surgery, after surgery and at the 6^(th) cycle of XELOX based chemotherapy(about 6 mo postoperatively)].RESULTS: We found the EMT phenomenon in which there were a few biphenotypic E^+/M^+ cells in primary human gastric cancer specimens. Of the 44 patients, the presence of CTCs was reported in 35(79.5%) patients at baseline. Five types of cells including from exclusively E^+ CTCs to intermediate CTCs and exclusively M^+ CTCs were identified(4 patients with M^+ CTCs and 10 patients with M^+ or M^+ > E^+ CTCs). Further, a chemotherapy patient having progressive disease showed a proportional increase of mesenchymal CTCs in the post-treatment blood specimens. We used NCI-N87 cells to analyze the linearity and sensitivity of Can Patrol^(TM) system and the correlation coefficient(R^2) was ***: The findings suggest that the EMT phenomenon was both in a few cells of primary tumors and abundantly in CTCs from the blood of gastric cancer patients, which might be used to monitor therapy response.

关键词： gastric cancer Epithelial-to-mesenchymaltransition circulating tumor cells Chemotherapy Therapy response

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Laparoscopic splenic hilum lymph node dissection for advanced proximal gastric cancer:A modified approach for pancreasand spleen-preserving total gastrectomy

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World Journal of Gastroenterology 2013年第30期19卷 4992-4999页

作者： ting-yu mou Yan-Feng Hu Jiang yu Hao Liu Ya-Nan Wang Guo-Xin Li Department of General Surgery Nanfang HospitalSouthern Medical University

AIM:To investigate the feasibility and optimal approach for laparoscopic pancreasand spleen-preserving splenic hilum lymph node dissection in advanced proximal gastric ***:Between August 2009 and August 2012,12 patients with advanced proximal gastric cancer treated in Nanfang Hospital,Southern Medical University,Guangzhou,China were enrolled and subsequently underwent laparoscopic total gastrectomy with pancreasand spleen-preserving splenic hilum lymph node(LN)*** clinicopathological characteristics,surgical outcomes,postoperative course and followup data of these patients were retrospectively collected and analyzed in the ***:Based on our anatomical understanding of peripancreatic structures,we combined the characteristics of laparoscopic surgery and developed a modified approach(combined supraand infra-pancreatic approaches)for laparoscopic pancreasand spleenpreserving splenic hilum LN *** was completed in all 12 patients laparoscopically without *** one patient experienced intraoperative bleeding when dissecting LNs along the splenic artery and was handled with laparoscopic *** mean operating time was 268.4 min and mean number of retrieved splenic hilum LNs was *** patient had splenic hilum LN metastasis(8.3%).Neither postoperative morbidity nor mortality was *** metastasis occurred in one patient and none of the other patients died or experienced recurrent disease during the follow-up ***:Laparoscopic total gastrectomy with pancreasand spleen-preserving splenic hilum LN dissection using the modified approach for advanced proximal gastric cancer could be safely achieved.

关键词： Proximal stomach Stomach neoplasm Laparoscopy Lymph node excision Splenic hilum

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Staging laparoscopy improves treatment decision-makingfor advanced gastric cancer

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World Journal of Gastroenterology 2016年第5期22卷 1859-1868页

作者： Yan-Feng Hu Zhen-Wei Deng Hao Liu ting-yu mou Tao Chen Xin Lu Da Wang Jiang yu Guo-Xin Li Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of General Surgery Dongguan People’s HospitalDongguan 523000Guangdong ProvinceChina

AIM To evaluate the clinical value of staging laparoscopyin treatment decision-making for advancedgastric cancer （GC）.METHODS： Clinical data of 582 patients with advancedGC were retrospectively analyzed. All patientsunderwent staging laparoscopy. The strength ofagreement between computed tomography （CT） stage,endoscopic ultrasound （EUS） stage, laparoscopic stage,and final stage were determined by weighted Kappastatistic （Kw）. The number of patients with treatmentdecision-changes was counted. A χ 2 test was used toanalyze the correlation between peritoneal metastasisor positive cytology and clinical ***： Among the 582 patients, the distributions ofpathological T classifications were T2/3 （153, 26.3%）,T4a （262, 45.0%）, and T4b （167, 28.7%）. Treatmentplans for 211 （36.3%） patients were changed after staging laparoscopy was performed. Two （10.5%） of19 patients in M1 regained the opportunity for potentialradical resection by staging laparoscopy. Unnecessarylaparotomy was avoided in 71 （12.2%） patients. Thestrength of agreement between preoperative T stageand final T stage was in almost perfect agreement （Kw= 0.838; 95% confidence interval （CI）： 0.803-0.872;P 〈 0.05） for staging laparoscopy; compared with CTand EUS, which was in fair agreement. The strengthof agreement between preoperative M stage andfinal M stage was in almost perfect agreement （Kw= 0.990; 95% CI： 0.977-1.000; P 〈 0.05） for staginglaparoscopy; compared with CT, which was in slightagreement. Multivariate analysis revealed that tumorsize （≥ 40 mm）, depth of tumor invasion （T4b）, andBorrmann type （Ⅲ or Ⅳ） were significantly correlatedwith either peritoneal metastasis or positive *** best performance in diagnosing P-positive wasobtained when two or three risk factors ***： Staging laparoscopy can improvetreatment decision-making for advanced GC anddecrease unnecessary exploratory laparotomy.

关键词： Staging laparoscopy Advanced gastriccancer Tumor staging Peritoneal metastasis Riskfactor

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Laparoscopic vs open D2 gastrectomy for locally advanced gastric cancer: A meta-analysis

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World Journal of Gastroenterology 2014年第44期20卷 16750-16764页

作者： Zhen-Hong Zou Li-Ying Zhao ting-yu mou Yan-Feng Hu Jiang yu Hao Liu Hao Chen Jia-Ming Wu Sheng-Li An Guo-Xin Li Department of General Surgery The Second Affiliated Hospital of Nanchang University Department of General Surgery Nanfang Hospital Southern Medical University Department of Biostatistics Southern Medical University

AIM: To conduct a meta-analysis comparing laparoscopic (LGD2) and open D2 gastrectomies (OGD2) for the treatment of advanced gastric cancer (AGC).

关键词： D2 lymph node dissection Gastrectomy Gastric cancer Laparoscopy Meta-analysis

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Survival outcomes following laparoscopic vs open surgery for non-metastatic rectal cancer:a two-center cohort study with propensity score matching

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Gastroenterology Report 2020年第4期8卷 319-325,I0002,I0003页

作者： Kang-Lian Tan Hai-Jun Deng Zhi-Qiang Chen ting-yu mou Hao Liu Run-Sheng Xie Xue-Min Liang Xiao-Hua Fan Guo-Xin Li Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Abdominal Pain Center Guangdong Provincial Hospital of Chinese MedicineThe Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhouGuangdongP.R.China

Background:Laparoscopic surgery for rectal cancer is commonly performed in ***,compared with open surgery,the effectiveness of laparoscopic surgery,especially the long-term survival,has not been sufficiently ***:Data of eligible patients with non-metastatic rectal cancer at Nanfang Hospital of Southern Medical University and Guangdong Provincial Hospital of Chinese Medicine between 2012 and 2014 were retrospectively ***-termsurvival outcomes and short-termsurgical safety were analysed with propensity score matching between ***:Of 430 cases collated from two institutes,103 matched pairs were analysed after propensity score *** estimated blood loss during laparoscopic surgerywas significantly less than that during open surgery(P=0.019)and the operative time and hospital staywere shorter in the laparoscopic group(both Pting overall survival and relapse-free ***:Our findings suggest that open surgery should still be the priority recommendation,but laparoscopic surgery is also an acceptable treatment for non-metastatic rectal cancer.

关键词： laparoscopic surgery open surgery propensity score matching rectal cancer

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Atomically precise nickel-sulfur clusters for efficient electrochemical 2,5-hydroxymethylfurfural oxidation

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Nano Research 2025年第1期18卷 140-148页

作者： Fen Wang Lu-yu Liu Sha-Sha Cui ting-ting Li Xiao-Meng Yang Zhijuan Liu Yanyong Wang Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China State Key Laboratory of Chem/Bio-sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Nickel sulfide exhibits excellent catalytic activity in the electrochemical 2,5-hydroxymethylfurfural oxidation reaction(HMFOR).However,due to the polydispersity of nanoparticles,it is difficult to establish a clear structure-activity relationship at the atomic *** this work,we have successfully synthesized atomically precise Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)clusters(PET:2-phenylethanethiol)for ***^(2+)and S_(2)-with atomic ratio of 1:2 was mainly existed in Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)to form Ni-S *** electrochemical test results have suggested both Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)displayed outstanding electrocatalytic ability for *** Ni_(6)(PET)_(12)exhibited better electrocatalytic ability than Ni_(4)(PET)_(8)with higher current density,lower overpotential and faster reaction *** superior electrochemical ability of Ni_(6)(PET)_(12)may be due to the enhanced adsorption towards HMF molecule with strong interaction towards hydroxyl group and furan ***,it found that the Ni^(2+)species in Ni_(6)(PET)_(12)could rapidly oxidized into Ni^(3+)species,which could spontaneously capture electron and proton from HMF for *** theoretical calculation demonstrated that the Ni_(6)(PET)_(12)process lower free energy barrier than Ni_(4)(PET)_(8)to display excellent electrocatalytic *** work is of great significance for designing efficient electrocatalysts for HMFOR.

关键词： atomically precise nickel nanoclusters 2 5-hydroxymethylfurfural electro-oxidation Ni3+species

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Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

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World Journal of Clinical Oncology 2025年第1期16卷 25-33页

作者： Jiang-yu Bian yu-Fang Feng Wen-ting He Tong Zhang Department of Oncology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Oncology The Fourth Clinical Medical College of Xinjiang Medical UniversityUrumqi 830001China Department of Oncology Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830001China

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor *** the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal ***,we further explored the survival benefits in the population with BRAF V600E mutant *** To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal *** A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December *** patients were divided into two *** A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,*** analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

关键词： Metastatic colorectal cancer BRAF V600E mutation Integrated Chinese and Western medicine Cohort study

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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan yu Xiao-Li Li Xiao-ting Sun Li-ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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Endoscopic polidocanol foam sclerobanding for treatment of internal hemorrhoids:A novel outpatient procedure

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World Journal of Gastroenterology 2024年第42期30卷 4583-4586页

作者： An-Na mou yu-ting Wang Department of Radiology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina

In the study,we comment on the article by Qu et *** hemorrhoids are the most common anorectal disorders worldwide with bleeding,prolapse,and difficulty in *** rubber band ligation(ERBL)is a safe,convenient,quick,and economical outpatient *** main goal of ERBL is to alleviate prolapse,but the high incidence of recurrence and post-procedural pain are of clinical *** foam as a local hemostatic and anesthetic agent could reduce the rates of post-procedural pain and *** polidocanol foam sclerobanding(EFSB)is a novel approach that could lift the mucosa for easy ligation and promote increased scarring in the submucosal tissue which translates into long-term relief from prolapse recurrence and reduced 24-h postprocedural *** study by Qu et al is a novel multi-center prospective randomized study to compare ERBL and EFSB in patients with grades II and III internal hemorrhoids with one-year *** showed that EFSB is a novel therapy for internal hemorrhoids,but future studies with a larger sample,multiple treatment sessions,and long-term follow-up are required to confirm these findings.

关键词： Internal hemorrhoids Goligher classification Rubber band ligation Sclerotherapy Polidocanol foam

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Adaptive dynamic surface control of NSVs with input saturation using a disturbance observer

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Chinese Journal of Aeronautics 2015年第3期28卷 853-864页

作者： Chen mou yu Jing College of Automation Engineering Nanjing University of Aeronautics and Astronautics

Abstract An adaptive dynamic surface control （DSC） scheme is proposed for the multiinput and multioutput （MIMO） attitude motion of nearspace vehicles （NSVs） in the presence of external dis turbance, system uncertainty and input saturation. The external disturbance and the system uncer tainty are efficiently tackled using a Nussbaum disturbance observer （NDO）, and the adaptive controller is constructed by combining the dynamic surface control technique to handle the problem of ＂explosion of complexity＂ inherent in the conventional backstepping methodl For handling the input saturation, an auxiliary system is designed with the same order as that of the studied MIMO attitude system. Using the error between the saturation input and the desired control input as the input of the designed auxiliary system, a series of signals are generated to compensate for the effect of the saturation in the dynamic surface control design. It is proved that the developed control scheme can guarantee that all signals of the closedloop control system are semiglobally uniformly bounded. Finally, simulation results illustrate that the proposed control scheme can achieve satis factory tracking performance under the composite effects of the input saturation and the external disturbance.

关键词： Auxiliary system Disturbance observer Dynamic surface controlInput saturation Near-space vehicle

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