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Magnetic endoscopic imaging vs standard colonoscopy:Meta-analysis of randomized controlled trials

World Journal of Gastroenterology 2013年第41期19卷 7197-7204页

作者： Yi Chen yu-ting duan Qin Xie Xian-Peng Qin Bo Chen Lin Xia Yong Zhou Ning-Ning Li Xiao-ting Wu Department of Gastrointestinal Surgery West China HospitalSichuan University Department of Radiology People’s Hospital Department of Gastroenterology West China HospitalSichuan University

AIM:To assess the theoretical advantages of magnetic endoscope imaging(MEI)over standard colonoscopies(SCs)and to compare their ***:Electronic databases,including PubMed,EMBASE,the Cochrane library and the Science Citation Index,were searched to retrieve relevant *** addition,abstracts from papers presented at professional meetings and the reference lists of retrieved articles were reviewed to identify additional *** metaanalyses were performed using RevMan 5.1.A random effect model with the Mantel-Haenszel method was used for pooling dichotomous and continuous data.A sensitivity analysis was performed by excluding the trials with a small number of patients and by excluding the trials performed by inexperienced ***:Eight randomized controlled trials(RCTs),including 2967 patients,were included in the metaanalysis to compare cecal intubation rates and times,sedation dose,abdominal pain scores and the use of ancillary maneuvers between MEI and *** overall OR was 1.92(95%CI:1.13-3.27,eight RCTs),as indicated by the cecal intubation rate of MEI compared with SC,but MEI did not have any distinct advantage over SC for cecal intubation time(MD=-0.07,95%CI:-0.16-0.02;three RCTs).MEI did not generally result in lower pain *** were also analyzed for the two subgroups based on the endoscopists’experience level to evaluate cecal intubation *** presented better outcomes for non-experienced colonoscopists than experienced ***:The real-time magnetic imaging system is of benefit in training and educating inexperienced endoscopists and improves the cecal intubation rate for experienced and inexperienced endoscopists.

关键词： Colonoscope Magnetic endoscope imaging Magnetic Standard colonoscope Meta-analysis

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MXene Hybridized Polymer with Enhanced Electromagnetic Energy Harvest for Sensitized Microwave Actuation and Self‑Powered Motion Sensing

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Nano-Micro Letters 2025年第3期17卷 265-279页

作者： yu‑Ze Wang yu‑Chang Wang ting‑ting Liu Quan‑Liang Zhao Chen‑Sha Li Mao‑Sheng Cao School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China School of Materials Science and Engineering Peking UniversityBeijing 100871People’s Republic of China School of Mechanical and Material Engineering North China University of TechnologyBeijing 100144People’s Republic of China Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080People’s Republic of China

Polymeric microwave actuators combining tissue-like softness with programmablemicrowave-responsive deformation hold great promise for mobile intelligentdevices and bionic soft robots. However, their application is challenged by restricted electromagneticsensitivity and intricate sensing coupling. In this study, a sensitized polymericmicrowave actuator is fabricated by hybridizing a liquid crystal polymer with Ti3C2Tx(MXene). Compared to the initial counterpart, the hybrid polymer exhibits unique spacechargepolarization and interfacial polarization, resulting in significant improvements of230% in the dielectric loss factor and 830% in the apparent efficiency of electromagneticenergy harvest. The sensitized microwave actuation demonstrates as the shortenedresponse time of nearly 10 s, which is merely 13% of that for the initial shape memory polymer. Moreover, the ultra-low content of MXene (upto 0.15 wt%) benefits for maintaining the actuation potential of the hybrid polymer. An innovative self-powered sensing prototype that combinesdriving and piezoelectric polymers is developed, which generates real-time electric potential feedback (open-circuit potential of ~ 3 mV) duringactuation. The polarization-dominant energy conversion mechanism observed in the MXene-polymer hybrid structure furnishes a new approachfor developing efficient electromagnetic dissipative structures and shows potential for advancing polymeric electromagnetic intelligent devices.

关键词： Microwave absorption Electromagnetic response Energy harvest Self-sensing Soft actuator

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Diffusion of Innovative Behavior of the Public Toward Preparing FEMKs:From Innovative Characteristics to Personal Risk Perception and Behavioral Intention

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Psychosomatic Medicine Research 2021年第1期3卷 16-23页

作者： Shu-Xian Xu ting-yu duan Shu-ting Wei Xi-Zhe He Ru-Yi Hou Yi-Bo Wu School of pharmacy Shenyang pharmaceutical universityBenxi 117004China Department of humanities arts and mediaChangzhi Medical CollegeChangzhi 046000China Department of clinical medicine School of Basic MedicineShandong UniversityJinan 250100China School of pharmacy Jiangxi University of Traditional Chinese MedicineNanchang 330004China Key Research Base of Philosophy and Social Sciences in Shaanxi Province Health Culture Research Center of ShaanxiXi'an 712046China Peking University Health Science Center Beijing 100191China

Objective:The study aims to apply diffusion of innovation theory and structural equation modeling(SEM)to explore the current situation of personal risk perception and preparation of family emergency medicine kits(FEMKs)in Shanxi Province during the period of ***,the study intends to analyze the impact of innovation characteristics and risk perception to provide reference for the future popularization of FEMKs and the formulation of relevant ***:A total of 1,606 permanent residents in Shanxi Province were selected as *** was used to analyze the relationship among innovation characteristics,personal risk perception,and behavioral ***:The results demonstrate that only observability(λ=0.968)exerted a significant direct impact on the public's behavior of preparing *** risk perception(λ=0.334)can have a significant direct impact on behavioral *** advantage,compatibility,and convenience of use exerted significant impacts on behavioral intention by influencing individual perceived risk(mediating effects=0.237,0.892,and 1.044,respectively).Conclusion:Residents are undergoing a period of change(i.e.,from the contemplation to the preparation stage).Thus,innovative characteristics can directly influence the behavior or behavioral intention of preparing FEMKs by influencing the public's risk *** the future,studies should focus on publicity and education of the behavior of preparing FEMKs to increase the awareness of residents and effectively improve the FEMKs level of importance given to this behavior.

关键词： COVID-19 Emergency medicine kit Diffusion of innovations Structural equation model Psychosomatic medicine Affecting factors

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Bioinspired Ultrasensitive Flexible Strain Sensors for Real‑Time Wireless Detection of Liquid Leakage

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Nano-Micro Letters 2025年第3期17卷 310-327页

作者： Weilong Zhou yu Du Yingying Chen Congyuan Zhang Xiaowei Ning Heng Xie ting Wu Jinlian Hu Jinping Qu Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of EducationHubei Key Laboratory of Material Chemistry and Service Failure and Hubei Engineering Research Center for Biomaterials and Medical Protective MaterialsSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China School of Materials Science and Engineering Wuhan Institute of TechnologyWuhan 430205People’s Republic of China Department of Biomedical Engineering City University of Hong KongHong KongSAR 999077People’s Republic of China

Liquid leakage of pipeline networks not only results in considerableresource wastage but also leads to environmental pollution and ecological *** response to this global issue, a bioinspired superhydrophobic thermoplastic polyurethane/carbon nanotubes/graphene nanosheets flexible strain sensor (TCGS) hasbeen developed using a combination of micro-extrusion compression molding andsurface modification for real-time wireless detection of liquid leakage. The TCGSutilizes the synergistic effects of Archimedean spiral crack arrays and micropores,which are inspired by the remarkable sensory capabilities of scorpions. This designachieves a sensitivity of 218.13 at a strain of 2%, which is an increase of 4300%. Additionally, it demonstrates exceptional durability bywithstanding over 5000 usage cycles. The robust superhydrophobicity of the TCGS significantly enhances sensitivity and stability indetecting small-scale liquid leakage, enabling precise monitoring of liquid leakage across a wide range of sizes, velocities, and compositionswhile issuing prompt alerts. This provides critical early warnings for both industrial pipelines and potential liquid leakage scenariosin everyday life. The development and utilization of bioinspired ultrasensitive flexible strain sensors offer an innovative and effectivesolution for the early wireless detection of liquid leakage.

关键词： Thermoplastic polyurethane Bioinspired Cracks Liquid leakage Flexible strain sensor

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NIRF蛋白对妊娠早期绒毛滋养细胞增殖、凋亡的影响及其作用机制

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中国生物制品学杂志 2017年第6期30卷 613-617,622页

作者：钱冠华董晓静于廷和段昌柱重庆医科大学附属第二医院妇产科重庆400010 重庆医科大学细胞生物学及遗传学教研室重庆400016

目的观察NIRF蛋白对妊娠早期绒毛滋养细胞增殖、凋亡的影响及其作用机制。方法取正常妊娠妇女人工流产绒毛组织(8~10周),按常规分离方法获得滋养细胞,进行原代培养。通过上/下调NIRF在滋养细胞中的表达后,采用qRT-PCR法检测p53基因mRNA... 详细信息

目的观察NIRF蛋白对妊娠早期绒毛滋养细胞增殖、凋亡的影响及其作用机制。方法取正常妊娠妇女人工流产绒毛组织(8~10周),按常规分离方法获得滋养细胞,进行原代培养。通过上/下调NIRF在滋养细胞中的表达后,采用qRT-PCR法检测p53基因mRNA的转录水平;Western blot法检测p53蛋白的表达水平;MTT法检测滋养细胞的增殖能力;Annexin V/PI双染色法检测细胞凋亡情况。结果与未转染组比较,NIRF上/下调后,p53基因m RNA转录水平差异无统计学意义(P>0.05);NIRF上调,p53蛋白表达水平明显下降(P0.05);NIRF下调,p53蛋白的表达水平明显升高(P<0.05),早期绒毛滋养细胞增殖能力明显减弱(P<0.05),凋亡率明显上升(P<0.05)。结论 NIRF在蛋白水平上抑制了p53的表达,促进了滋养细胞的增殖。

关键词： NIRF蛋白 p53蛋白滋养细胞细胞增殖细胞凋亡

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Direct Photolithography of WO_(x)Nanoparticles for High‑Resolution Non‑Emissive Displays

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Nano-Micro Letters 2025年第3期17卷 297-309页

作者： Chang Gu Guojian Yang Wenxuan Wang Aiyan Shi Wenjuan Fang Lei Qian Xiaofei Hu ting Zhang Chaoyu Xiang yu‑Mo Zhang Laboratory of Optoelectronic Information Technology and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201People’s Republic of China Hangzhou Bay Laboratory of Advanced Nano‑Optoelectronic Materials and Devices Qianwan Institute of CNITECHNingbo 315336People’s Republic of China Smart Materials for Architecture Research Lab Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100People’s Republic of China University of Science and Technology of China Hefei 230026People’s Republic of China State Key Lab of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012People’s Republic of China

High-resolution non-emissive displays based on electrochromic tungsten oxides(WOx)are crucial for future near-eye virtual/augmented reality interactions,given their impressive attributes such as high environmental stability,ideal outdoor readability,and low energy ***,the limited intrinsic structure of inorganic materials has presented a significant challenge in achieving precise patterning/pixelation at the micron ***,we successfully developed the direct photolithography for WOx nanoparticles based on in situ photo-induced ligand *** strategy enabled us to achieve ultra-high resolution efficiently(line widthting device exhibited impressive electrochromic performance,such as fast response(3600 cycles),as well as promising applications in electronic logos,pixelated displays,flexible electronics,*** success and advancements presented here are expected to inspire and accelerate research and development(R&D)in high-resolution non-emissive displays and other ultra-fine micro-electronics.

关键词： Electrochromic Direct photolithography WOx nanoparticles In situ photo-induced ligand exchange High-resolution displays

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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan yu Xiao-Li Li Xiao-ting Sun Li-ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

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World Journal of Clinical Oncology 2025年第1期16卷 25-33页

作者： Jiang-yu Bian yu-Fang Feng Wen-ting He Tong Zhang Department of Oncology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Oncology The Fourth Clinical Medical College of Xinjiang Medical UniversityUrumqi 830001China Department of Oncology Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830001China

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor *** the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal ***,we further explored the survival benefits in the population with BRAF V600E mutant *** To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal *** A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December *** patients were divided into two *** A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,*** analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

关键词： Metastatic colorectal cancer BRAF V600E mutation Integrated Chinese and Western medicine Cohort study

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Unveiling phosphofructokinase as the key target: an innovative strategy combining pull-down assays with optical imaging for snail-killing mechanism exploration

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Science China Chemistry 2025年

作者： yuxun Lu Weisi Wang Le yu yuqiang Zhao Ying Chen yunhai Guo Bingrong Luo yuhua Liu Shizhu Li Liping duan Ying Zhou yunnan Characteristic Plant Extraction Laboratory College of Chemical Science and Technology Yunnan University College of Biological and Chemical Engineering Guangxi University of Science and Technology National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector Biology WHO Collaborating Centre for Tropical Diseases National Center for International Research on Tropical Diseases School of Chemistry and Environment Yunnan Minzu University Dali Institute of Schistosomiasis Control

The Pomacea canaliculata, also known as apple snail, is an invasive species in China, posing a serious threat to agricultural production and public health. To prevent its rampant infestation, we developed a highly efficient snail-killing lead compound, 1-(4-chlorophenyl)-3-(pyridin-3-yl)urea (PBQ). However, the killing mechanism of PBQ remains unclear. To elucidate this, two novel compounds, B-PBQ and J-PBQ, were developed through structural modification of PBQ and were used, through both protein pull-down assay and confocal laser scanning microscopy imaging, to identify and confirm that phosphofructokinase(PFK) in the apple snail is the primary target protein of PBQ. Further studies revealed that PBQ successfully inhibits the activity,content, and expression of PFK in apple snail, disrupting the glycolysis pathway and leading to abnormal energy *** disruptions impair the snail’s tolerance to low oxygen, resulting in its efficient eradication. These findings offer a promising direction for developing next-generation PFK-targeted snail-killing pesticides. Furthermore, the strategy of combining pull-down assays with optical imaging used in this work provides a novel approach for the exploration of mechanisms of other pesticide candidates.

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在血液肿瘤患者肺部侵袭性真菌感染中CT影像学检查的诊断价值

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中华医院感染学杂志 2017年第5期27卷 1043-1046页

作者：刘宇亭段早晖夏瑞明姚克林赵森绍兴文理学院附属医院放射科浙江绍兴312030 上饶市肿瘤医院放射科江西上饶334000

目的研究CT影像学检查在血液肿瘤患者发生肺部侵袭性真菌感染的诊断价值。方法选取2012年1月-2016年5月选择医院接诊的68例血液肿瘤患者,所有患者采用CT影像学进行检查。分析X线胸片诊断与CT诊断发生肺部侵袭性真菌感染率比较、肺部真... 详细信息

目的研究CT影像学检查在血液肿瘤患者发生肺部侵袭性真菌感染的诊断价值。方法选取2012年1月-2016年5月选择医院接诊的68例血液肿瘤患者,所有患者采用CT影像学进行检查。分析X线胸片诊断与CT诊断发生肺部侵袭性真菌感染率比较、肺部真菌感染类型、病原菌分布构成比、患者的CT影像学特征表现。结果 35例患者发生肺部侵袭性真菌感染,感染率为51.47%;肺部真菌感染患者经CT影像学检测,肺部真菌感染的类型主要有弥漫型、曲菌球型、实变型和结节型,分别占37.14%、25.71%、22.86%和14.29%;35例患者按照《全国临床检查操作规程》进行病原学诊断,均呈现阳性,阳性率为100.00%;X线胸片诊断8例呈阳性,阳性率22.85%;CT影像诊断31例,阳性率88.57%,CT影像诊断阳性率明显高于X线胸片诊断,两组比较差异有统计学意义(P<0.05);病原菌分布主要是以曲霉菌属为主,其次为假丝酵母菌属、隐球酵母菌属;CT影像学特征包括结节或肿块影、晕征、空洞。结论 CT影像学检查在肺部侵袭性真菌感染的诊断具有非常重要的意义,能够提供有效的诊断依据,特别是在肺部真菌感染的早期治疗中,结合患者临床的基础疾病,可以初步的诊断肺部真菌感染,具有良好的临床参考价值,值得在临床上广泛推广。

关键词： CT影像学检查血液肿瘤肺部侵袭性真菌感染诊断价值

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