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A novel fused bi-macrocyclic host for sensitive detection of Cr_(2)O_(7)^(2-)based on enrichment effect

Chinese Chemical Letters 2024年第7期35卷 291-295页

作者： ting-ting huang Jin-Fa Chen Juan Liu Tai-Bao Wei Hong Yao Bingbing Shi Qi Lin Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education Key Laboratory of Eco-environmental Polymer Materials of Gansu ProvinceCollege of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou 730070China Key Laboratory of Environment-Friendly Composite Materials of the State Ethnic Affairs Commission Gansu Provincial Biomass Function Composites Engineering Research CenterCollege of Chemical EngineeringNorthwest Minzu University(Northwest University for Nationalities)Lanzhou 730000China

Improving the highly selective and sensitive binding of chemosensor to target guest is always very *** order to solve this issue,herein,the enrichment effect was introduced into the design of chemosensor molecule.A novel bi-fused-macrocyclic host molecule BPN1 was synthesized by bridging a pillar[5]arene and a naphthalene diimide(NDI)group through hydrogen-bond-rich *** the BPN1,the naphthalimide side ring is outside the cavity of the pillar[5]*** addition,Cr(VI)greatly threat human health and the environment due to its severe toxicity,and it is very important to develop effective chemosensor for sensitive and selective detection of Cr_(2)O_(7)^(2-)or its ion *** this paper,the novel bi-fused-macrocyclic host molecule BPN1 can recognize Cr_(2)O_(7)^(2-)with high selectivity and *** mechanism of BPN1 recognition of Cr_(2)O_(7)^(2-)was studied through experiments and density functional theory(DFT),the results show that BPN1 could supply enrichment effect to bind Cr_(2)O_(7)^(2-)through multiple weak interactions such as hydrogen bonds and anion-π,and achieve highly sensitive and selective detection of Cr_(2)O_(7)^(2-).It is a significant and feasible strategy for improve high selectivity and sensitivity of host to specific objects by using the enrichment effect of fused bi-macrocyclic.

关键词： Pillararene Bi-macrocyclic Detection of Cr_(2)O_(7)^(2−) DFT The enrichment effect

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Tuning active sites in MoS_(2)-based catalysts via H_(2)O_(2)etching to enhance hydrodesulfurization performance

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Petroleum Science 2023年第6期20卷 3875-3886页

作者： Shui-Sen He ting-ting huang Chao Chen Yu Fan State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China State Key Laboratory Base for Eco-Chemical Engineering in College of Chemical Engineering Qingdao University of Science and TechnologyZhengzhou Road 53Qingdao266042ShandongChina

A H_(2)O_(2)etching strategy was adopted to introduce coordinatively unsaturated sites(CUS)on MoS_(2)-based catalysts for dibenzothiophene(DBT)hydrodesulfurization(HDS).The CUS concentrations on MoS_(2) slabs were finely regulated by changing the concentrations of H_(2)O_(2)*** the increasing H_(2)O_(2)concentrations(0.1–0.3 mol/L),The CUS concentrations on MoS_(2) slabs increased ***,the high-concentration H_(2)O_(2)etching(0.5 mol/L)increased the MoOxSy and MoO_(3) contents on MoS_(2) slabs compared to etching with the H_(2)O_(2)concentration of 0.3 mol/L,which led to the less CUS concentration in the sulfided Mo–H-0.5 catalyst than in the sulfided Mo–H-0.3 catalyst.A microstructure-activity correlation indicated that the CUS introduced by H_(2)O_(2)etching on MoS_(2) slabs significantly enhanced DBT *** Co loadings were further introduced into Mo–H-0.3,which had the most CUS concentration,and the corresponding 0.2-CoMo catalyst with the highest CoMoS content(3.853 wt%)exhibited the highest reaction rate constant of 6.95×10^(−6)mol g^(−1)s^(−1)among these CoMo catalysts.

关键词： H_(2)O_(2)etching Coordinatively unsaturated site concentrations CoMoS Hydrodesulfurization

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Effect of early nutrition on intestine development of intrauterine growth retardation in rats and its correlation to leptin

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World Journal of Gastroenterology 2005年第28期11卷 4419-4422页

作者： Xiao-Shan Qiu ting-ting huang Zhen-Yu Shen Zhi-Yong Ke Hui-Ying Deng Pediatric Department the First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080Guangdong ProvinceChina Guangzhou Children’s Hospital Guangzhou 510120Guangdong ProvinceChina

AIM：To investigate the intestine and body development of intrauterine growth retardation（IUGR）rats under early different protein diet and to analyze the correlation between leptin and intestine and body development．METHODS：An IUGR rat model was established by food restriction of pregnant female ***-six neonatal IUGR rats and 24 neonatal normal rats were randomly divided into normal control group（Cgroup），IUGR model group （scgroup），low protein diet IUGR group（SL group），and high protein diet IUGR group（SH group）．Eight rats were killed per group at wk 0，4，and *** leptin，body weight（BW），body length（BL），intestinal weight（IW），intestinal length（IL），andintestinal disaccharidase（including lactase，maltase，and saccharase） were detected．RESULTS：BW（4．50±0．41g），BL（5．96±0．40cm），IW（0．05±0．01g），and IL（15.9±2．8cm）in neonatal IUGR rats were much lower than those in Cgroup（6．01±0．55g，6．26±0．44cm，0．10±0．02g，21.8±2．7cm，P〈0．05），while intestinal lactase and maltase activities were higher than those in *** group showed the fastest catch up growth and their BW，BL，IW，and IL reached the Cgroup level at wk *** group showed relatively slower catch up growth than SH group，and their BW，BL，IW did not reach the Cgroup level at wk *** group did not show intestine and body catch up *** maltase [344±33μmol／（min·q）]and saccharase activities[138±32μmol／（min·g）]in SL group were both markedly lower than nose in C group [751±102，258±271μmol／（min·g），P〈0．05]．There were no significant difierences in lactase activities at wk 4 and disaccharidase activities at wk 12 among all groups（P〈0．05）．The leptin level in SL group（0．58±0．12ng／mL） was the highest in all groups，and much lower in SH group（0．21±0．03ng／mL） than that in any other IUGR groups at wk 4（P〈0．05）．Leptin was negatively related to BW （r=-0．556，P=0．001），IW（r=-0．692，P=0．001） and IL（r=-0．738，P=0．000）at wk 4，while no correlation was found at wk 12．CONCLUSION：High protein diet is a reasonable early nutritional mode to IU

关键词： Intrauterine growth retardation Rat Intestine development Disaccharidase Leptin Nutritional intervention

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Influence of Monomers'Structure on the Assembly and Material Property of Pillar[5]arene-Based Supramolecular Polymer Gels

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Chinese Journal of Chemistry 2021年第12期39卷 3421-3428页

作者： Juan Liu Xiao-Wen Sun ting-ting huang You-Ming Zhang Hong Yao Tai-Bao Wei Qi Lin College of Chemical Engineering Northwest Minzu University(Northwest University for Nationalities)Xibei XincunLanzhouGansu 730000China Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education Key Laboratory of Eco-environmental Polymer Materials of Gansu ProvinceCollege of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhouGansu 730070China

Pillar[5]arene-based supramolecular polymer gels(SPGs)show broad application *** investigate the influence of the supramolecular monomers'structure on the assembly and properties of corresponding pillar[5]arene-based SPGs,a series of monomers based on different functionalized pillar[5]arene derivatives with various structures were *** are per-methylated pillar[5]arene(H1),bromobutane-functionalized pillar[5]arene(H2),4-hydroxybenzaldehyde-functionalized pillar[5]arene(H3),ethyl thioglycolate-functionalized pillar[5]arene(H4),thioacetylhydrazine-functionalized pillar[5]arene(H5),bola-type bis-pillar[5]arene(H6)and tripodal-type tri-pillar[5]arene(H7).Meanwhile,a neutral tripodal-guest TG was also employed to co-assemble with these pillar[5]arene-based monomers by host-guest *** a result,under the same conditions(10%,DMSO-H_(2)O,w/v,10 mg·mL^(-1)=1%),H1 and H2 cannot assemble into SPGs with ***,mono-p[5]derivatives H3—H5 could assemble into SPGs with *** importantly,bis-p[5]H6 and tri-p[5]H7 could assemble into supramolecular polymer network gel(SPNG)and supramolecular polymer organic framework gel(SOFG)with TG,*** gels all show blue aggregation-induced emission(ALE)*** these SPGs,the SPNG shows the best viscoelastic behavior and self-healing *** result is attributed to the flexible network structure of *** addition,the xerogels of SOFG and SPNG have shown nice adsorption and separation properties for organic dyes in water solution.

关键词： Pillararerie Host-guest systems Self-assembly Aggregation Structure-activity relationships

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Novel compound heterozygous GPR56 gene mutation in a twin with lissencephaly:A case report

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World Journal of Clinical Cases 2022年第2期10卷 607-617页

作者： Wen-Xin Lin Ying-Ying Chai ting-ting huang Xia Zhang Guo Zheng Gang Zhang Fang Peng Yan-Jun huang Department of Neurology Children’s Hospital of Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina Department of Neurology Huashan HospitalFudan UniversityShanghai 200040China

BACKGROUND Lissencephaly(LIS)is a malformation of cortical development with broad gyri,shallow sulci and thickened cortex characterized by developmental delays and ***,20 genes have been implicated in ***,GRP56-related LIS has never been ***56 is considered one of the causative genes for bilateral frontoparietal ***,we report a twin infant with LIS and review the relevant *** twins both carried the novel compound heterozygous GPR56 *** SUMMARY A 5-mo-old female infant was hospitalized due to repeated convulsions for 1 *** patient had a flat head deformity that manifested as developmental delays and a sudden onset of generalized tonic-clonic seizures at 5 mo without any *** electroencephalography was *** magnetic resonance imaging revealed a simple brain structure with widened and thickened gyri and shallow *** white matter of the brain was significantly *** long T1 and T2 signals could be seen around the ventricles,which were expanded,and the extracerebral space was *** testing confirmed that the patient carried the GPR56 gene compound heterozygous mutations c.228delC(p.F76fs)and c.1820_1821delAT(p.H607fs).The unaffected father carried a heterozygous c.1820_1821delAT mutation,and the unaffected mother carried a heterozygous c.228delC *** twin sister carried the same mutations as the *** patient was diagnosed with *** This is the first case report of LIS that is likely caused by mutations of the GPR56 gene.

关键词： Lissencephaly Epilepsy GPR56 mutations Compound heterozygous mutations Case report

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Pillar[n]arenes-based materials for detection and separation of pesticides

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Chinese Chemical Letters 2023年第4期34卷 6-15页

作者： Zhong-Di Tang Xiao-Mei Sun ting-ting huang Juan Liu Bingbing Shi Hong Yao You-Ming Zhang Tai-Bao Wei Qi Lin Key Laboratory of Eco-Functional Polymer Materials of Ministry of Education Key laboratory of Polymer Materials of Gansu ProvinceCollege of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou 730070China Key Laboratory of Environment-Friendly Composite Materials of the State Ethnic Affairs Commission Gansu Provincial Biomass Function Composites Engineering Research CenterKey Laboratory for Utility of Environment-Friendly Composite Materials and Biomass in University of Gansu ProvinceCollege of Chemical EngineeringNorthwest Minzu University(Northwest University for Nationalities)Lanzhou 730000China

The effective materials and methods for detection and separation of pesticides are urgently needed because most of pesticides show very harmful influence on life and environment. As a new kind of macrocyclic host compound, pillar[n]arenes show very good performance in the detection and separation of pesticides, especially for paraquat(PQ). For the pesticide detection and separation materials, their structures determine performance. Therefore, this review summarizes the recent progress of pillar[n]arenes-based materials for detection and separation of pesticides covering single/multi-pillar[n]arenes, pillar[n]arenes-based polymers, frameworks, composites, nanomaterials, *** structure-performance relationships of these materials have been discussed according to the cavity size, the synergistic or collaboration effect, the structure of the polymer or framework, the substrate of the composites and the size of nanomaterials and so on. Based on these, we also look forward to the future and point out the possible way for improving the pesticides detection sensitivity and separation efficiency of this kind of materials.

关键词： composites separation pesticides

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p66Shc-mediated oxidative stress is involved in gestational diabetes mellitus

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World Journal of Diabetes 2021年第11期12卷 1894-1907页

作者： ting-ting huang Wen-Juan Sun Hai-Ying Liu Hong-Li Ma Bao-Xia Cui Cheeloo College of Medicine Shandong UniversityJinan 250000Shandong ProvinceChina Department of Obstetrics Taian City Central HospitalTaian 271000Shandong ProvinceChina Department of Obstetrics The Second HospitalCheeloo College of MedicineShandong UniversityJinan 250000Shandong ProvinceChina Department of Obstetrics and Gynecology Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityQingdao 266000Shandong ProvinceChina Department of Obstetrics and Gynecology Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250013Shandong ProvinceChina

BACKGROUND Gestational diabetes mellitus(GDM)is associated with a heightened level of oxidative stress,which is characterized by the overproduction of reactive oxygen species(ROS)from *** studies showed that mitochondrial dysfunction is regulated by dynamin-related protein 1(Drp1)and p66Shc in *** The aim was to investigate the expression of Drp1 and p66Shc and their possible mechanisms in the pathogenesis of *** A total of 30 pregnant women,15 with GDM and 15 without GDM,were *** blood mononuclear cells and placental tissue were *** human JEG3 trophoblast cell line was cultivated in 5.5 mmol/L or 30 mmol/L glucose and transfected with wild-type(wt)-p66Shc and p66Shc siRNA.P66Shc and Drp1 mRNA levels were detected by quantitative real-time polymerase chain *** expression of p66Shc and Drp1 was assayed by immunohistochemistry and western *** was assayed by dihydroethidium *** The p66Shc mRNA level was increased in the serum(P<0.01)and placentas(P<0.01)of women with GDM,and the expression of Drp1 mRNA and protein were also increased in placentas(P<0.05).In JEG3 cells treated with 30 mmol/L glucose,the mRNA and protein expression of p66Shc and Drp1 were increased at 24 h(both P<0.05),48 h(both P<0.01)and 72 h(both P<0.001).ROS expression was also *** levels of Drp1 and ROS expression were detected in JEG3 cells transfected with wt-p66Shc(P<0.01),and low levels were detected in JEG3 cells transfected with p66Shc siRNA(P<0.05).CONCLUSION The upregulated expression of Drp1 and p66shc may contribute to the occurrence and development of *** of the mitochondrial fusion-fission balance could be a novel strategy for GDM treatment.

关键词： p66Shc Dynamin-related protein 1 Gestational diabetes mellitus Oxidative stress Mitochondrial dysfunction

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Reshaping force for deformed casing repairing with hydraulic rolling reshaper and its influencing factors

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Petroleum Science 2024年第4期21卷 2745-2757页

作者： Hong-Fei Li Min Luo ting-ting Xu Qiao-Zhen Li Cong-Jian huang School of Mechanical Science and Engineering Northeast Petroleum University

Hydraulic rolling reshaper is an advanced reshaping tool to solve the problem of casing deformation,which has been widely used in recent years. When it is used for well repair operation, the reshaping force provided by ground devices is generally determined by experience. However, too large reshaping force may destroy the deformed casing, and too small reshaping force may also prolong the construction period and affect the repairing effect. In this paper, based on Hertz contact theory and elastic-plastic theory, combined with the process parameters of shaping, and considering the structural characteristics of the deformed casing and reshaper, we propose a mathematical model for calculating the reshaping force required for repairing deformed casing by hydraulic rolling reshaper. Meanwhile, the finite element model and numerical method of hydraulic rolling reshaper repairing deformed casing are established by using the finite element method, and the reliability of the mathematical model is verified by several examples. On this basis, the control variable method is used to investigate the influence of each parameter on the reshaping force, and the influence degree of each parameter is explored by orthogonal simulation test and Pearson correlation analysis. The research results not only provide an important theoretical basis for the prediction of reshaping force in on-site construction, but also provide a reference for the subsequent improvement of the shaping process.

关键词： Hydraulic rolling reshaper Reshaping force Deformed casing Casing reshaping Hertz contact theory

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Structure-property relationship on aggregation-induced emission properties of simple azine-based AIEgens and its application in metal ions detection

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Chinese Chemical Letters 2023年第5期34卷 200-204页

作者： Xiao-Mei Sun Juan Liu Zhao-Hui Li Yong-Peng Fu ting-ting huang Zhong-Di Tang Bingbing Shi Hong Yao Tai-Bao Wei Qi Lin College of Chemistry and Chemical Engineering Northwest Normal UniversityLanzhou 730070China Key Laboratory of Environment-Friendly Composite Materials of the State Ethnic Affairs Commission College of Chemical EngineeringNorthwest Minzu UniversityLanzhou 730000 China Department of Pharmacy Jiangxi Medical College Shangrao 334000China Longnan Ecological and Environmental Monitoring Centre of Gansu Province Longnan 746000China

In recent twenty years,aggregation-induced emission(AIE),due to its excellent application prospect,has aroused widespread *** development of novel and easy to make AIE luminogens(AIEgens)is an attractive *** this purpose,it is very important to study the structure-property relationship of *** azine derivatives are easy to synthesis and some of them have nice AIE properties,herein,a series of azine derivatives(ADs)were employed as models to study the influence of different functional groups,electronic effects and structures on the AIE properties of azine *** AIE mechanism were studied by single crystal analysis,density functional theory(DFT)calculations and so *** results indicated that the o-hydroxyl aryl substituted azine compounds could show good AIE ***,the AIE properties of o-hydroxyl aryl substituted azine compounds were also influenced by the electronic effects of the aryl groups in the azine *** o-hydroxyl groups could form intramolecular hydrogen bond with imine group,which play key role to restrict the intramolecular rotation of the aryl groups and act as base stone for the AIE process of this kind *** HOMO-LUMO energy gaps of o-hydroxyl substituted azine are smaller than other homologous compounds,which is agree with the proposed AIE ***,thanks to the AIE properties,the o-hydroxy-substituted azines could be used as efficient Al^(3+)and Cu^(2+)fluorescent chemosensors in different *** addition,test strips based on AD10 has been prepared,which can conveniently detect Cu^(2+)in industrial *** research supplied a way for the design of novel easy to make AIEgens through simple azine derivatives.

关键词： AIEgens Structure-property relationship Fluorescent chemosensor Azine derivatives Calculations

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Cancer statistics and trends in China:the potential of natural product application

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Chinese Journal of Natural Medicines 2024年第8期22卷 673-675页

作者： LI ting huang Muyang LU Jinjian State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SAR 999078China MoE Frontiers Science Center for Precision Oncology University of MacaoMacao SAR 999078China Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoMacao SAR 999078China

Cancer presents a significant global challenge,impacting individuals,communities,and healthcare systems worldwide[1,2].Fundamentally,cancer involves the uncontrolled growth and proliferation of cells,driven by genetic and epigenetic alterations orchestrated by a complex array of molecular entities,including oncogenes,tumor suppressor genes,and various regulatory factors[3-5].This intricate interplay complicates early detection,often resulting in a significant mortality *** for nearly 30%of premature deaths globally,cancer is a major barrier to increasing human life expectancy[6,7].The urgent need for continued research,innovation,and collaborative efforts highlights the importance of combating this relentless disease.

关键词： Cancer incidence Mortality Increasing trends Natural products

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