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Summer extreme precipitation patterns and synoptic-scale circulation precursors over the Tibetan Plateau

Science China Earth Sciences 2024年第5期67卷 1625-1638页

作者： Zhiyuan DING Yao HA zhong zhong College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China Key Laboratory for Virtual Geographic Environment School of Geography ScienceNanjing Normal UniversityNanjing 210023China Jiangsu Collaborative Innovation Center for Climate Change School of Atmospheric SciencesNanjing UniversityNanjing 210023China

In the context of global warming,the extreme summer precipitation over the Tibetan Plateau(TP)has changed *** this study,the summer(June–August)extreme precipitation on the TP was classified into three spatial types by applying the K-means clustering method to the Third Pole Region long time-series high-resolution(1/30°)precipitation dataset(TPHi Pr,1979–2020).The characteristics of the circulation anomalies and precursors corresponding to the extreme precipitation on the TP in summer during 1979–2020 were *** results showed that the summer extreme precipitation of the TP can be categorized into northwestern(NW),southeastern(SE),and southern Himalayan(HS)types based on extreme precipitation *** NW and SE types are mainly influenced by anomalous signals in the mid-to-high latitude regions upstream of them,whereas the HS type is controlled by the localized subtropical anomalous *** the 8th day before the onset of the NW type,an anomalous cyclone was observed in the western Atlantic Ocean(60°W,50°N),which triggered the west-to-east quasi-latitudinal propagation of Rossby *** the onset day of the NW type,the upper troposphere showed positive-negative-positive geopotential height anomalies along the latitudinal 40°N from the Caspian Sea,the western part of Xinjiang,to the northeastern *** entered from the Arabian Sea along the southeastern edge of the anomalous cyclone on the southwestern TP and converged in the northwestern *** to the NW type,the precursors of the SE type appeared at higher latitudes and were more *** the 8th day before the onset of the SE type,an anomalous cyclone occurred near Greenland(60°W,70°N)and excited Rossby waves propagating *** the onset day of the SE type,the upper troposphere showed negative-positive-negative geopotential height anomalies across Eurasia from the Ural Mountains and the Iranian Plateau to the northern TP in the northwest-southeast directi

关键词： Tibetan Plateau Summer extreme precipitation Atmospheric circulation anomaly Precursor Teleconnection wave train

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Clathrin light chains negatively regulate plant immunity by hijacking the autophagy pathway

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Plant Communications 2024年第8期5卷 172-188页

作者： Hu-Jiao Lan Jie Ran Wen-Xu Wang Lei Zhang Ni-Ni Wu Ya-ting Zhao Min-Jun Huang Min Ni Fen Liu Ninghui Cheng Paul A.Nakata Jianwei Pan Steven A.Whitham Barbara J.Baker Jian-zhong Liu Zhejiang Provincial Key Laboratory of Biotechnology on Specialty Economic Plants Zhejiang Normal UniversityJinhua 321004China Institute of Plant Genetics and Developmental Biology College of Chemistry and Life SciencesZhejiang Normal UniversityJinhua 321004China College of Life Sciences Lanzhou UniversityLanzhou 730000China Department of Plant Pathology and Microbiology Iowa State UniversityAmesIA 50011USA Department of Plant and Microbial Biology University of CaliforniaBerkeleyBerkeleyCA 94720USA Plant Gene Expression Center U.S.Department of Agriculture-Agricultural Research ServiceAlbanyCA 94706USA Lushan Botanical Garden Chinese Academy of SciencesJiujiang 332000China U.S.Department of Agriculture-Agricultural Research Service Children’s Nutrition Research CenterDepartment of PediatricsBaylor College of MedicineHoustonTX 77030USA

The crosstalk between clathrin-mediated endocytosis(CME)and the autophagy pathway has been reported in mammals;however,the interconnection of CME with autophagy has not been established in ***,we report that the Arabidopsis CLATHRIN LIGHT CHAIN(CLC)subunit 2 and 3 double mutant,clc2-1 clc3-1,phenocopies Arabidopsis AUTOPHAGY-RELATED GENE(ATG)mutants in both autoimmunity and nutrient ***,the autophagy pathway is significantly compromised in the clc2-1 clc3-1 ***,multiple assays demonstrate that CLC2 directly interacts with ATG8h/ATG8i in a domain-specific *** expected,both GFP-ATG8h/GFP-ATG8i and CLC2-GFP are subjected to autophagic degradation,and degradation of GFP-ATG8h is significantly reduced in the clc2-1 clc3-1 ***,simultaneous knockout of ATG8h and ATG8i by CRISPR-Cas9 results in enhanced resistance against Golovinomyces cichoracearum,supporting the functional relevance of the CLC2-ATG8h/8i *** conclusion,our results reveal a link between the function of CLCs and the autophagy pathway in Arabidopsis.

关键词： autophagy clathrin light chain immunity clathrin-mediated endocytosis senescence cell death

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Complete Universal Scaling in First-Order Phase Transitions

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Chinese Physics Letters 2024年第10期41卷 8-13页

作者： Fan zhong School of Physics and State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-sen UniversityGuangzhou 510275China

Phase transitions and critical phenomena are among the most intriguing phenomena in nature and *** are classified into first-order phase transitions(FOPTs)and continuous *** the latter shows marvelous phenomena of scaling and universality,whether the former behaves similarly is a long-standing controversial *** we definitely demonstrate complete universal scaling in field driven FOPTs for Langevin equations in both zero and two spatial dimensions by rescaling all parameters and subtracting nonuniversal contributions with singular dimensions from an effective temperature and a special field according to an effective *** offers a perspective different from the usual nucleation and growth but conforming to continuous phase transitions to study FOPTs.

关键词： theory. transitions scaling

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Key issues on magnetic reconnection at Mercury

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Earth and Planetary Physics 2024年第5期8卷 673-685页

作者： Jun zhong Key Laboratory of Earth and Planetary Physics Institute of Geology and Geophysics Chinese Academy of Sciences

Magnetic reconnection processes and their impact on planetary magnetospheric dynamics exhibit significant differences due to differences in upstream solar wind conditions and internal planetary environments. Current understanding of reconnection phenomena at Mercury is rooted in the MESSENGER mission. However, direct detection of reconnection remains rare. Here, we aim to assess the limitations of MESSENGER in detecting reconnection in Mercury's space and to discuss key issues of reconnection that will be addressed by BepiColombo, including the dynamics of magnetic flux ropes, particle acceleration, density asymmetric reconnection,IMF-driven near-tail structures, and potential modes of magnetospheric convection.

关键词： magnetic reconnection Mercury MESSENGER BepiColombo

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Anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab for first-line treatment in advanced natural killer T cell lymphoma

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1665-1674页

作者： Jie Xiong Shu Cheng Xiao Gao Shan-He Yu Yu-ting Dai Xin-Yun Huang Hui-Juan zhong Chao-Fu Wang Hong-Mei Yi Hao Zhang Wei-Guo Cao Rong Li Wei Tang Yan Zhao Peng-Peng Xu Li Wang Wei-Li Zhao Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Nuclear Medicine Shanghai Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Pathology Shanghai Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Otolaryngology Shanghai Rujin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Radiation Shanghai Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Hematology Navy Medical Center of PLAShanghaiChina Pole de Recherches Sino-Francais en Science du Vivant et Genomique Laboratory of Molecular PathologyShanghaiChina

Natural killer T cell lymphoma(NKTCL)is highly aggressive,with advanced stage patients poorly responding to intensive *** explore effective and safe treatment for newly diagnosed advanced stage NKTCL,we conducted a phase ll study of anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab(NCT04096690).Twenty-two patients with a median age of 51 years(range,24-74)were enrolled and treated with induction treatment of pegaspargase 2500 IU/m2 intramuscularly on day 1 and sintilimab 200 mg intravenously on day 2 for 6 cycles of 21 days,followed by maintenance treatment of sintilimab 200 mg for 28 cycles of 21 *** complete response and overall response rate after induction treatment were 59%(95%Cl,43-79%)and 68%(95%Cl,47-84%),*** a median follow-up of 30 months,the 2 year progression-free and overall survival rates were 68%(95%Cl,45-83%)and 86%(95%Cl,63-95%),*** most frequently grade 3/4 adverse events were neutropenia(32%,n=7)and hypofibrinogenemia(18%,n=4),which were manageable and led to no discontinuation of *** proportion score of PD-L1,peripheral blood high-density lipoprotein cholesterol,and apolipoprotein A-l correlated with good response,while PD-1 on tumor infiltrating lymphocytes and peripheral Treg cells with poor response to pegaspargase plus sintilimab *** conclusion,the chemo-free regimen pegaspargase plus sintilimab was effective and safe in newly diagnosed,advanced stage *** lipid profle and immunosuppressive signature contributed to treatment resistance,providing an alternative therapeutic approach dual targeting fatty acid metabolism and CTLA-4 in NKTCL.

关键词： killer metabolism lymphoma

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乡村振兴背景下民族传统体育现代化发展研究

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体育文化导刊 2024年第2期 7-13,74页

作者：戴彬钟婷婷聂真新云南师范大学体育学院昆明650500 云南大学体育学院昆明650504 云南体育运动职业技术学院昆明650228

运用文献资料、逻辑分析等方法,审思乡村振兴背景下我国民族传统体育现代化发展价值和趋势,并提出发展路径。价值:助力产业兴旺,拉动乡村经济增长;赋能治理有效,增强乡村道德教化;优化乡风文明,丰富乡村文化生活;增进民生福祉,推进乡村... 详细信息

运用文献资料、逻辑分析等方法,审思乡村振兴背景下我国民族传统体育现代化发展价值和趋势,并提出发展路径。价值:助力产业兴旺,拉动乡村经济增长;赋能治理有效,增强乡村道德教化;优化乡风文明,丰富乡村文化生活;增进民生福祉,推进乡村社会建设;致力生态宜居,改善乡村生态环境。趋势:多产融合是实践路向,三治融合是创新举措,文明建设是核心导向,社会服务是必然要求,生态保护是应有之义。路径:促进产业延伸重组,打造产业体系;深化乡村治理改革,强固治理效能;盘活传统文化资源,释放文化储量;实施乡村建设行动,提升服务质量;坚守乡村生态本色,拓展发展空间。

关键词：民族传统体育乡村振兴现代化发展

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无人机遥感的多植被指数土壤水分反演模型

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光谱学与光谱分析 2024年第1期44卷 207-214页

作者：李虎钟韵冯雅婷林震朱士江三峡大学水利与环境学院湖北宜昌443002 三峡库区生态环境教育部工程研究中心湖北宜昌443002

土壤水分是影响农业生产的重要因素,在作物生长发育和最终产量上起着至关重要的作用,快速、高效地估算土壤水分已成为农林水资源监测的热点问题。利用高光谱反射率的特征波段计算植被指数、构建土壤水分反演模型已获得广泛的认可和应用... 详细信息

土壤水分是影响农业生产的重要因素,在作物生长发育和最终产量上起着至关重要的作用,快速、高效地估算土壤水分已成为农林水资源监测的热点问题。利用高光谱反射率的特征波段计算植被指数、构建土壤水分反演模型已获得广泛的认可和应用。针对反演土壤水分受植被覆盖度影响较大的问题,提出用多种植被指数组合削弱植被覆盖度对土壤水分反演的影响。在宜昌市仓屋榜试验基地选取30组柑橘树,在果树滴落线处收集土壤,通过烘干法测定土壤质量含水率,采样4次,共计120组土壤含水率;并利用ASD Field Spectral FR光谱仪(波长范围325~1 075 nm)及大疆精灵4多光谱版无人机获取了120组试验区蓝、绿、红、红边、近红外及短波红外波段光谱反射率,采用移动平均法对光谱数据进行降噪预处理,通过灰色关联法对9种植被指数进行比较分析,筛选出与土壤水分极显著相关的4种植被指数(p<0.01),各指数与土壤水分的相关性从高到低依次为裸土指数(BSI)、归一化蓝绿差异植被指数(NGBDI)、绿色归一化指数(GNDVI)、归一化差异植被指数(NDVI),其中BSI与土壤水分的相关性最高,相关系数为-0.687(N=120)。采用线性逐步回归法和非线性BP神经网络法建立了基于多种植被指数的土壤水分反演模型,依据决定系数(R^(2))、相对误差绝对值(ARE)、均方根误差(RMSE)作为反演模型的精度评价指标。结果表明:逐步回归模型和BP神经网络模型的土壤水分反演值与实测值之间的R^(2)分别为0.816、 0.889, RMSE分别为2.54%、 1.53%, ARE分别为21.13%、 8.88%,利用多植被指数组合的非线性BP神经网络算法基于植被指数建模对土壤水分反演的精度更高,在一定程度上可以克服植被覆盖度不同对土壤水分反演精度的影响,作为直接测定土壤水分的有效替代方法,为农业灌溉定量决策及科学管理提供科学参数。

关键词：土壤水分多光谱遥感植被指数逐步回归 BP神经网络

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Modeling and Simulation of Lithium Vacuum Evaporation Process Using COMSOL Multiphysics

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Journal of Thermal Science 2024年第1期33卷 86-100页

作者： LIAN Xuexin zhong Dawen Beijing Key Laboratory of Passive Nuclear Power Safety and Technology North China Electric Power UniversityBeijing 102206China

Based on the COMSOL Multiphysics simulation software,this study carried out modeling and numerical simulation for the evaporation process of liquid metal lithium in the vacuum free molecular flow *** motion of lithium atoms in the evaporation process was analyzed through a succession of *** on the available experimental values of the saturated vapor pressure of liquid metal lithium,the relationship between saturated vapor pressure and temperature of liquid lithium in the range of 600 K-900 K was obtained.A two-dimensional symmetric model(3.5 mm×20 mm) was established to simulate the transient evaporation process of liquid lithium at wall temperatures of 750 K,780 K,800 K,810 K,825 K,and 850 K,*** effects of temperature,the evaporation coefficient,back pressure,and length-to-diameter ratio on the evaporation process were studied;the variation trends and reasons of the molecular flux and the pressure during the evaporation process were *** the same time,the evaporation process under variable wall temperature conditions was *** research made the evaporation process of liquid lithium in vacuum molecular flow clearer,and provided theoretical support for the space reactor and nuclear fusion related fields.

关键词： free molecular flow saturated vapor pressure vacuum evaporation liquid lithium metal

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基于转录组学研究白头翁汤正丁醇提取物经EGFR/MAPK通路对光滑念珠菌刺激下阴道上皮细胞的保护作用机制

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中国中药杂志 2024年第11期49卷 3021-3030页

作者：张佳萍张婷吴惠吴大强邵菁刘婷婷汪天明汪长中安徽中医药大学药学院安徽合肥230012 安徽中医药大学中西医结合学院安徽合肥230012 安徽省农村与社会科技发展中心安徽合肥230088 安徽医科大学第一附属医院药剂科安徽合肥230022

基于转录组学研究白头翁汤正丁醇提取物(n-butanol extract of Pulsatilla Decoction, BEPD)含药血清通过调控表皮生长因子受体(EGFR)/丝裂原活化蛋白激酶(MAPK)通路对光滑念珠菌刺激下阴道上皮细胞的保护作用及机制。首先构建外阴阴道... 详细信息

基于转录组学研究白头翁汤正丁醇提取物(n-butanol extract of Pulsatilla Decoction, BEPD)含药血清通过调控表皮生长因子受体(EGFR)/丝裂原活化蛋白激酶(MAPK)通路对光滑念珠菌刺激下阴道上皮细胞的保护作用及机制。首先构建外阴阴道念珠菌病(VVC)模型小鼠,然后将该组小鼠连同空白对照组与BEPD干预组小鼠的阴道黏膜组织进行转录组测序分析基因表达差异,同时制备BEPD含药血清与氟康唑含药血清。将人阴道上皮细胞系(A431细胞)分为对照组、模型组、空白血清组、氟康唑含药血清组、BEPD含药血清组、EGFR激动剂组、EGFR抑制剂组。以细胞增殖与活性检测(CCK-8)法分别确定光滑念珠菌、含药血清及药物对A431细胞的安全浓度;酶联免疫吸附法(ELISA)检测细胞上清液白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、粒细胞-巨噬细胞集落刺激因子(GM-CSF)、粒细胞集落刺激因子(G-CSF)、趋化因子配体20(CCL20)和乳酸脱氢酶(LDH)的水平;革兰染色观察光滑念珠菌黏附阴道上皮细胞;流式细胞术检测光滑念珠菌对A431细胞凋亡的影响;根据转录组学结果,以免疫荧光检测细胞p-EGFR、p-ERK1/2蛋白的表达,免疫印迹法检测细胞中p-EGFR、p-ERK1/2、p-CFos、p-P38、Bax、Bcl-2蛋白的表达。转录组测序显示,相对于模型组,BEPD治疗后出现1 075个基因上调和927基因下调,主要富集于包括MAPK等在内的免疫炎症相关通路。细胞学实验显示,BEPD含药血清能够降低细胞上清液中IL-1β、IL-6、GMCSF、G-CSF、CCL20炎症因子的水平,缓解由光滑念珠菌引起的细胞中LDH的释放,减少光滑念珠菌对A431细胞的黏附,降低光滑念珠菌诱导的细胞凋亡,下调促凋亡相关蛋白Bax和上调抗凋亡相关蛋白Bcl-2的表达,并显著下调p-EGFR、p-ERK1/2、p-C-Fos与p-P38的表达。该研究提示,BEPD对光滑念珠菌所致VVC的干预效应可能与其通过调节EGFR/MAPK通路保护阴道上皮细胞有关。

关键词：白头翁汤正丁醇提取物含药血清光滑念珠菌阴道上皮细胞 EGFR/MAPK通路凋亡

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Cardiovascular computed tomography in cardiovascular disease:An overview of its applications from diagnosis to prediction

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Journal of Geriatric Cardiology 2024年第5期21卷 550-576页

作者： zhong-Hua SUN Discipline of Medical Radiation Science Curtin Medical SchoolCurtin UniversityPerthAustralia Curtin Health Innovation Research Institute(CHIRI) Curtin UniversityPerth 6012Australia

Cardiovascular computed tomography angiography(CTA)is a widely used imaging modality in the diagnosis of cardiovascular *** in CT imaging technology have further advanced its applications from high diagnostic value to minimising radiation exposure to *** addition to the standard application of assessing vascular lumen changes,CTA-derived applications including 3D printed personalised models,3D visualisations such as virtual endoscopy,virtual reality,augmented reality and mixed reality,as well as CT-derived hemodynamic flow analysis and fractional flow reserve(FFRCT)greatly enhance the diagnostic performance of CTA in cardiovascular *** widespread application of artificial intelligence in medicine also significantly contributes to the clinical value of CTA in cardiovascular *** value of CTA has extended from the initial diagnosis to identification of vulnerable lesions,and prediction of disease extent,hence improving patient care and *** this review article,as an active researcher in cardiovascular imaging for more than 20 years,I will provide an overview of cardiovascular CTA in cardiovascular *** is expected that this review will provide readers with an update of CTA applications,from the initial lumen assessment to recent developments utilising latest novel imaging and visualisation *** will serve as a useful resource for researchers and clinicians to judiciously use the cardiovascular CT in clinical practice.

关键词： diagnosis cardiovascular prediction

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