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Silencing of Jumonji domain-containing 1C inhibits the osteogenic differentiation of bone marrow mesenchymal stem cells via nuclear factor-κB signaling

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World Journal of Stem Cells 2024年第2期16卷 151-162页

作者： Jing-Yi Li ting-ting wang Li Ma Yu Zhang Di Zhu Department of Medical Cosmetology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of General Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Plastic Surgery China-Japan Friendship HospitalBeijing 100029China Senior Department of Hematology The Fifth Medical CentreGeneral Hospital of Chinese People’s Liberation ArmyBeijing 100071China Department of Orthopaedic Surgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

BACKGROUND Osteoporosis is a common metabolic bone disorder induced by an imbalance between osteoclastic activity and osteogenic *** osteoporosis,bone mesenchymal stem cells(BMSCs)exhibit an increased ability to differentiate into adipocytes and a decreased ability to differentiate into osteoblasts,resulting in bone *** domain-containing 1C(JMJD1C)has been demonstrated to suppress *** To examine the effect of JMJD1C on the osteogenesis of BMSCs and the potential underlying *** BMSCs were isolated from mouse bone marrow *** Red O staining,Alizarin red staining,alkaline phosphatase staining and the expression of adipo-genic and osteogenic-associated genes were assessed to determine the differen-tiation of *** marrow-derived macrophages(BMMs)were incubated with receptor activator of nuclear factor-kappaΒligand to induce osteoclast differentiation,and osteoclast differen-tiation was confirmed by tartrate-resistant acid phosphatase *** related genes were measured via reverse transcription coupled to the quantitative polymerase chain reaction and western ***-linked immunosorbent assays were used to measure the levels of inflammatory cytokines,including tumor necrosis factor alpha,interleukin-6 and interleukin-1 *** The osteogenic and adipogenic differentiation potential of BMSCs isolated from mouse bone marrow samples was ***1C mRNA and protein expression was upregulated in BMSCs after osteoblast induction,while p-nuclear factor-κB(NF-κB)and inflammatory cytokines were not significantly *** of JMJD1C repressed osteogenic differentiation and enhanced NF-κB activation and inflammatory cytokine release in ***,JMJD1C expression decreased during BMM osteoclast *** The JMJD1C/NF-κB signaling pathway is potentially involved in BMSC osteogenic differentiation and may play vital roles in the pathogenesis of osteoporosis.

关键词： Osteoporosis Mesenchymal stem cells Osteogenesis Jumonji domain-containing 1C Nuclear factor-κB

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Endoscopic ultrasound-guided biliary drainage vs percutaneous transhepatic bile duct drainage in the management of malignant obstructive jaundice

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1592-1600页

作者： Qin-Qin Zhu Bing-Fang Chen Yue Yang Xue-Yong Zuo Wen-Hui Liu ting-ting wang Yin Zhang Department of Gastroenterology The Third Affiliated Hospital of Soochow University(The First People’s Hospital of Changzhou)Changzhou 213000Jiangsu ProvinceChina Department of Hepatobiliary and Pancreatic Surgery The Third Affiliated Hospital of Soochow University(The First People’s Hospital of Changzhou)Changzhou 213000Jiangsu ProvinceChina

BACKGROUND Malignant obstructive jaundice(MOJ)is a condition characterized by varying degrees of bile duct stenosis and obstruction,accompanied by the progressive development of malignant tumors,leading to high morbidity and mortality ***,the two most commonly employed methods for its management are percutaneous transhepatic bile duct drainage(PTBD)and endoscopic ultrasound-guided biliary drainage(EUS-BD).While both methods have demonstrated favorable outcomes,additional research needs to be performed to determine their relative *** compare the therapeutic effectiveness of EUS-BD and PTBD in treating *** This retrospective analysis,conducted between September 2015 and April 2023 at The Third Affiliated Hospital of Soochow University(The First People’s Hospital of Changzhou),involved 68 patients with *** patients were divided into two groups on the basis of surgical procedure received:EUS-BD subgroup(n=33)and PTBD subgroup(n=35).Variables such as general data,preoperative and postoperative indices,blood routine,liver function indices,myocardial function indices,operative success rate,clinical effectiveness,and complication rate were analyzed and compared between the *** In the EUS-BD subgroup,hospital stay duration,bile drainage volume,effective catheter time,and clinical effect-iveness rate were superior to those in the PTBD subgroup,although the differences were not statistically significant(P>0.05).The puncture time for the EUS-BD subgroup was shorter than that for the PTBD subgroup(P<0.05).Postoperative blood routine,liver function index,and myocardial function index in the EUS-BD subgroup were significantly lower than those in the PTBD subgroup(P<0.05).Additionally,the complication rate in the EUS-BD subgroup was lower than in the PTBD subgroup(P<0.05).CONCLUSION EUS-BD may reduce the number of punctures,improve liver and myocardial functions,alleviate traumatic stress,and decrease complication rates in MOJ treatment

关键词： Percutaneous hepatic biliary drainage Endoscopic ultrasound-guided biliary drainage Malignant obstructive jaundice Clinical effect Liver function Postoperative complications

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Acatulides A-G,neuroprotective macrolides from Acaulium album H-JQSF

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Chinese Chemical Letters 2024年第3期35卷 379-383页

作者： Zhi-Wu Tong ting-ting wang Pei Yang Jia-Lin Sun Chen-Peng Zhang Salman Khan Xin-Cun wang Rui-Hua Jiao Hui-Ming Ge Wen-Ying Zhuang Gang Hu Ren Xiang Tan State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional BiomoleculesNanjing UniversityNanjing 210023China State Key Laboratory Cultivation Base for TCM Quality and Efficacy Nanjing University of Chinese MedicineNanjing 210023China Insitute of Microbiology Chinese Academy of SciencesBeijing 100101China

Fungal symbionts co-evolve with hosts and microbial co-inhabitants to acquire an unpredictable potential for producing novel bioactive metabolites,but the knowledge about the topic remains patchy and *** we present the chemical characterization of acatulides A-G(1-7)as architecturally unprecedented macrolides from the solid-state culture of Acaulium album H-JQSF,an arthropod-associated *** acatulide structures were elucidated by spectroscopic analysis,modified Mosher's method and single-crystal X-ray *** plausible biosynthetic pathways for compounds 1-4 are ***,acatulides B-D(2-4)and G(7)were demonstrated to be neuroprotective against the 1-methyl-4-phenylpyridinium(MPP+)-induced damage to SH-SY5Y cells and nematode Caenorhabditis elegans(***).

关键词： Acaulium album Macrolides Acatulides A–G Mosher’s method Neuroprotective

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Perianesthesia emergency repair of a cut endotracheal tube’s inflatable tube:A case report

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World Journal of Clinical Cases 2022年第14期10卷 4594-4600页

作者： ting-ting wang Jiang wang ting-ting Sun Yu-ting Hou Yao Lu Shan-Gui Chen Department of Anesthesiology The First Affiliated Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina Department of Infectious Disease The First Affiliated Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina

BACKGROUND During the perianesthesia period,emergency situations threatening the life and safety of patients can occur at any *** dealing with some emergencies,occasional confusion is *** SUMMARY This case report describes the rare situation wherein a surgeon inadvertently detached the inflatable tube of an endotracheal tube during a tonsillectomy,and positive pressure ventilation could not be *** reintubation may increase the risk of respiratory tract infection and aspiration,patients with a difficult airway might die due to *** best treatment method is to optimize the damaged tracheal tube junction to avoid secondary intubation and ensure patient *** intravenous needle and cannula were used to repair the damaged gap in the current *** the repair,the anesthesia machine showed no indication of low tidal volume,and there was no deflation of the endotracheal tube ***,the patient was transferred to the postanesthesia recovery room,and the tracheal tube was removed with satisfactory *** Using an intravenous needle to repair a break in the inflatable tube surrounding an endotracheal tube is safe and reliable.

关键词： Perianesthesia accident Emergency situation Endotracheal tube Inflatable tube Tonsillectomy Mechanical ventilation Case report

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Effects of combined spinal-epidural anesthesia on anxiety,labor analgesia and motor blocks in women during natural delivery

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World Journal of Psychiatry 2023年第11期13卷 838-847页

作者： Ling Cai Jiao-Jiao Jiang ting-ting wang Shuang Cao Department of Anesthesiology Shanghai Changning Maternity&Infant Health HospitalShanghai 200050China

BACKGROUND The background of this study was analgesia in natural *** combined spinal-epidural anesthesia has obvious analgesic effect on the parturients in natural labor,and combined spinal-epidural anesthesia has been widely used in anesthesia for various *** To study the effects of combined spinal-epidural anesthesia on anxiety,labor analgesia,and motor blocks in parturients during natural *** A total of 120 women who gave birth at Changning District Maternal and Child Health Hospital between December 2021 to December 2022 were included;a random number table approach was employed to divide the women into a control group and a joint group,with each group consisting of 60 *** control group was given epidural anesthesia,while the joint group was given combined spinal-epidural *** visual analog scale(VAS)was used to evaluate the degree of maternal *** were made between the two groups’conditions of childbirth and the duration of *** scores were used to evaluate the status of the newborns at birth;Self-rating Anxiety Scale(SAS)and General Self-Efficacy Scale(GSES)scores,umbilical artery blood gas analysis indices and stress indices were compared between the two groups;and the frequencies of motor block and postpartum complications were *** In comparison to the control group,in the joint group,the VAS scores for the first,second,and third stages of labor were lower(P0.05).The second and third stages of labor in the joint group were shorter than those in the control group(P<0.05).When compared to the control group,the postpartum SAS score of the joint group was lower,while the GSES score was g

关键词： Combined spinal-epidural anesthesia Natural delivery Anxiety level Labor analgesia Motor block

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Recent advances of emerging tin disulfide for room temperature gas sensing

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Rare Metals 2023年第12期42卷 3897-3913页

作者： ting-ting wang Bao-Shuai Xing Chuan-Yu Guo Juan-Yuan Hao You wang Li-Hua Huo Xiao-Li Cheng Ying-Ming Xu Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of ChemistryChemical Engineering and MaterialsHeilongjiang UniversityHarbin 150080China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China

Effectively monitoring of hazardous gases has become increasingly important for ecological environment and human *** an emerging component of two-dimensional materials,layered metal dichalcogenides are gaining significant attention due to their unique physical and chemical properties,thus catering well to the gas sensing ***,tin disulfide(SnS_(2))has been widely examined recently owing to its low-cost,earth-abundant,and environmental friendliness features,which meet the requirements of advanced sensing ***,the booming research advancements of SnS_(2)-based gas sensors have been ***,the basic attributes of SnS_(2) and its ability to detect various hazardous gases are ***,innovative approaches that have demonstrated the effectiveness of improving the room temperature sensing performance of SnS_(2) are ***,the major challenges and future opportunities of SnS_(2) are also *** is ultimately expected that this timely review could offer guidance for designing high-performance gas sensing materials and further push forward their potential applications.

关键词： Gas sensors Tin disulfide Advanced approaches Room temperature sensing

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Molecular Chaperone-Dependent Polymer Translocation through Nanopores: The Effects of Chaperone Concentration and Chaperone-Polymer Interaction

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Chinese Journal of Polymer Science 2024年第1期42卷 125-132,I0011页

作者： Chang-Sheng Zuo Kang wang Li-Zhen Sun ting-ting Sun Department of Physics Zhejiang University of Science and TechnologyHangzhou 310023China Department of Applied Physics Zhejiang University of TechnologyHangzhou 310014China

The polymer translocation through a nanopore from a donor space(or named cis side) to a receiver space(trans side) in the chaperone-induced crowded environment has attracted increasing attention in recent years due to its significance in biological systems and technological applications. In this work, we mainly focus on the effects of chaperone concentration and chaperone-polymer interaction on the polymer translocation. By assuming the polymer translocation to be a quasi-equilibrium process, the free energy F of the polymer can be estimated by Rosenbluth-Rosenbluth method and then the translocation time τ can be calculated by Fokker-Plank equation based on the obtained free energy landscape. Our calculation results show that the translocation time can be controlled by independently tuning the chaperone concentration and chaperone-polymer interaction at the cis side or the trans side. There exists a critical chaperone-polymer attraction ε~*=-0.2 at which the volume exclusion and interaction effects of the chaperone can balance each other. Additionally, we also find that at large chaperone-polymer attraction, the translocation time is mainly governed by the diffusion coefficient of the polymer.

关键词： Polymer translocation Rosenbluth-Rosenbluth method Fokker-Plank equation Free energy landscapes

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Er_(2)O_(3) nanospheres with fast response to humidity for non-contact sensing

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Rare Metals 2023年第1期42卷 56-63页

作者： Yi-Fan Jiang Chuan-Yu Guo Xian-Fa Zhang Xiao-Li Cheng Li-Hua Huo ting-ting wang Ying-Ming Xu Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin150080China

As a kind of lanthanide oxide functional material,Er_(2)O_(3) as aroused widespread scientific interest due to its exceptional properties;however,its humidity sensing performance remains to be ***,the rational designed Er_(2)O_(3) anospheres were prepared by one-step solvothermal and high-temperature calcined *** structure and morphology of the samples were analyzed by X-ray diffractometer(XRD),scanning electron microscope(SEM)and transmission electron microscope(TEM),and the effect of calcination temperatures on humidity sensing characteristics was also investigated.

关键词： method. spheres diffractometer

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Open-Shell Oligomers and Polymers: Theory, Characterization Methods, Molecular Design, and Applications

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Chinese Journal of Polymer Science 2024年第4期42卷 417-436页

作者： Xue-Qing wang Cheng Song ting Lei Key Laboratory of Polymer Chemistry and Physics(Ministry of Education) School of Materials Science and EngineeringPeking UniversityBeijing100871China

Open-shell oligomers and polymers have exhibited intriguing electronic and magnetic properties, making them highly desirable for a wide range of applications, including ambipolar organic field-effect transistors (OFETs), photodetectors, organic thermoelectrics, and spintronics. Although open-shell ground states have been observed in certain small molecules and doped organic semiconductors, the exploration of open-shell ground-state conjugated polymers is still limited, and the strategies for designing these polymers remain obscure. This review aims to briefly introduce the theory and characterization methods of open-shell conjugated polymers, along with an overview of recent progress and applications. The objective is to stimulate further advancements and investigations in this promising area by shedding light on the potential of open-shell conjugated polymers and the challenges that lie ahead.

关键词： Conjugated polymers Open-shell molecules High-spin ground state Donor-acceptor(D-A)polymers Optoelectronic and magnetic properties

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One more step to realistic CO_(2) reduction reactions——geometric structures evolutions at gas-solid interface

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Rare Metals 2024年第2期43卷 849-852页

作者： Ya-Qiang Xie Xin Yu ting wang College of the Environment and Ecology Xiamen UniversityXiamen361102China

A rational design of copper(Cu)nanocatalyst is critical to the efficient carbon dioxide(CO_(2))conversion toward C1/C2 chemical ***,the lack of actual information on the vicinal Cu interfaces hinders the intrinsic activitystructure correlation *** with atomic-scale in situ characterizations(AP-STM and synchrotron-based AP-XPS),Park and co-workers study and identify the adsorbate-driven morphological evolution of Cu nanoclusters on the Cu(997)surface,providing real-space evidence for the critical role of vicinal structures on Cu *** observed surface roughening trends caused by dissociated atomic oxygen and CO adsorbates subsequently affect the result of successive catalytic reactions to produce critical intermediates,such as carbonate and formate,during the CO_(2)reduction reaction.

关键词： reaction critical rational

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