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Convolutional neural network-based segmentation network applied to image recognition of angiodysplasias lesion under capsule endoscopy

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World Journal of Gastroenterology 2023年第5期29卷 879-889页

作者： Ye Chu Fang Huang Min Gao Duo-Wu Zou Jie Zhong Wei Wu Qi Wang Xiao-Nan Shen ting-ting gong Yuan-Yi Li Li-Fu Wang Department of Gastroenterology Shanghai Jiao Tong University School of MedicineRuijin HospitalShanghai 200025China Technology Platform Department Jinshan Science&Technology(Group)Co.Ltd.Chongqing 401120China

BACKGROUND Small intestinal vascular malformations(angiodysplasias)are common causes of small intestinal *** capsule endoscopy has become the primary diagnostic method for angiodysplasia,manual reading of the entire gastrointestinal tract is time-consuming and requires a heavy workload,which affects the accuracy of *** To evaluate whether artificial intelligence can assist the diagnosis and increase the detection rate of angiodysplasias in the small intestine,achieve automatic disease detection,and shorten the capsule endoscopy(CE)reading *** A convolutional neural network semantic segmentation model with a feature fusion method,which automatically recognizes the category of vascular dysplasia under CE and draws the lesion contour,thus improving the efficiency and accuracy of identifying small intestinal vascular malformation lesions,was ***-50 was used as the skeleton network to design the fusion mechanism,fuse the shallow and depth features,and classify the images at the pixel level to achieve the segmentation and recognition of vascular *** training set and test set were constructed and compared with PSPNet,Deeplab3+,and *** The test set constructed in the study achieved satisfactory results,where pixel accuracy was 99%,mean intersection over union was 0.69,negative predictive value was 98.74%,and positive predictive value was 94.27%.The model parameter was 46.38 M,the float calculation was 467.2 G,and the time length to segment and recognize a picture was 0.6 *** Constructing a segmentation network based on deep learning to segment and recognize angiodysplasias lesions is an effective and feasible method for diagnosing angiodysplasias lesions.

关键词： Artificial intelligence Image segmentation Capsule endoscopy Angiodysplasias

Does young feces make the elderly live better? Application of fecal microbiota transplantation in healthy aging

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BIOCELL 2024年第6期48卷 873-887页

作者： YUANYUAN LIAO XINSI LI QIAN LI YIZHONG WANG XIUJUN TAN ting gong Department of Endodontics Stomatological Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences ChongqingChina Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education ChongqingChina Department of Research&Development Zhejiang Charioteer Pharmaceutical Co.Ltd.TaizhouChina Department of Implantology Stomatological Hospital of Chongqing Medical UniversityChongqingChina

As we are facing an aging society,anti-aging strategies have been pursued to reduce the negative impacts of aging and increase the health span of human *** microbiota has become a key factor in the anti-aging *** of gut microbiota by fecal microbiota transplantation(FMT)to prevent frailty and unhealthy aging has been a hot topic of *** narrative review summarizes the beneﬁts of FMT for health span and lifespan,brains,eyes,productive systems,bones,and *** mechanisms of FMT in improving healthy aging are *** increased beneﬁcial bacteria and decreased pathological bacteria decreased gut permeability and systemic inﬂammation,increased short-chain fatty acid(SCFA)and SCFA-producing bacteria,and other factors are listed as mechanisms of FMT to improve healthy *** points that need to be considered to ensure the optimal outcomes of FMT are also discussed,such as recipients’age,sex,genetic background,and gut microbiota after *** thisﬁeld is still in its infancy,it has shown that FMT has great potential to improve healthy aging.

关键词： Gut microbiota Healthy aging Lifespan Fecal microbiota transplantation Co-housing Short-chain fatty acid Inﬂammaging

Porcine enteric alphacoronavirus infection increases lipid droplet accumulation to facilitate the virus replication

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Journal of Integrative Agriculture 2024年第3期23卷 988-1005页

作者： Qi Gao Yongzhi Feng ting gong Dongdong Wu Xiaoyu Zheng Yizhuo Luo Yunlong Yang Zebu Song Lang gong Guihong Zhang Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control College of Veterinary MedicineSouth China Agricultural UniversityGuangzhou 510642China Maoming Branch Guangdong Laboratory for Lingnan Modern AgricultureMaoming 525000China Key Laboratory of Animal Vaccine Development Ministry of Agriculture and Rural AffairsGuangzhou 510000China Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou 510642China

Coronaviruses are widely transmissible between humans and animals, causing diseases of varying severity. Porcine enteric alphacoronavirus(PEAV) is a newly-discovered pathogenic porcine enteric coronavirus in recent years, which causes watery diarrhea in newborn piglets. The host inflammatory responses to PEAV and its metabolic regulation mechanisms remain unclear, and no antiviral studies have been reported. Therefore, we investigated the pathogenic mechanism and antiviral drugs of PEAV. The transcriptomic analysis of PEAV-infected host cells revealed that PEAV could upregulate lipid metabolism pathways. In lipid metabolism, steady-state energy processes, which can be mediated by lipid droplets(LDs), are the main functions of organelles. LDs are also important in viral infection and inflammation. In infected cells, PEAV increased LD accumulation, upregulated NF-κB signaling, promoted the production of the inflammatory cytokines IL-1β and IL-8, and induced cell death. Inhibiting LD accumulation with a DGAT-1 inhibitor significantly inhibited PEAV replication, downregulated the NF-κB signaling pathway, reduced the production of IL-1β and IL-8, and inhibited cell death. The NF-κB signaling pathway inhibitor BAY11-7082 significantly inhibited LD accumulation and PEAV replication. Metformin hydrochloride also exerted anti-PEAV effects and significantly inhibited LD accumulation, downregulated the NF-κB signaling pathway, reduced the production of IL-1β and IL-8, and inhibited cell death. LD accumulation in the lipid metabolism pathway therefore plays an important role in the replication and pathogenesis of PEAV, and metformin hydrochloride inhibits LD accumulation and the inflammatory response to exert anti-PEAV activity and reducing pathological injury. These findings contribute new targets for developing treatments for PEAV infections.

关键词： porcine enteric alphacoronavirus NF-κB inflammatory pathway lipid droplet metformin hydrochloride

Bilayer Compounded Polytetrafluoroethylene Membrane for Enhanced Oil-Water Emulsion Separation

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Chinese Journal of Polymer Science 2024年第6期42卷 838-850页

作者： Yu-Liang Yang Tai-Ran Zhang Yan-ting Han Shao-Yun Guo Qin-gong Rong Jia-Bin Shen State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan UniversitySichuan Provincial Engineering Laboratory of Plastic/Rubber Complex Processing TechnologyChengdu610065China West China Hospital/West China School of Nursing Sichuan UniversityChengdu610041China Shandong Senrong New Materials Co. Ltd.Zibo256401China

In order to achieve efficient and durable oil-water emulsion separation,the membranes possessing high separation efficiency and mechanical strength attract extensive attention and are in great *** present study,a kind of polytetrafluoroethylene(PTFE)-based bilayer membrane was fabricated by electrospinning fibrous PTFE(fPTFE)on an expanded PTFE(ePTFE)*** morphological observation revealed that the fibrous structure of the fPTFE layer could be tailored by controlling the formulation of spinning *** addition of appropriate polyoxyethylene(PEO)would make the fibers in the fPTFE layer finer and more *** a result,the compounded membrane exhibited a small pore size of approximately 1.25µm and a substantial porosity nearing 80%.This led to super-hydrophobicity,characterized by a high water contact angle(WCA)of 149.8°,and facilitated rapid oil *** water-in-oil emulsion separation experiment further confirmed that the compounded membrane not only had a high separation efficiency closing 100%,but such an outstanding separation capacity could be largely retained,either through multiple cycles of use or through strong acid(pH=1),strong alkali(pH=12),or high-temperature(100°C)***,the mechanical behavior of the bilayer membrane was basically contributed by that of each layer in terms of their volume *** significantly,the poor creep resistance of fPTFE layer was suppressed by compounding with ePTFE ***,this study has laid the groundwork for a novel approach to create PTFE-based compounded membranes with exceptional overall characteristics,showing promise for applications in the realm of emulsion separation.

关键词： ePTFE Electrospinning membrane Bilayer compounding Emulsion separation

Versatile oxidized variants derived from TMDs by various oxidation strategies and their applications

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Chinese Chemical Letters 2024年第6期35卷 14-25页

作者： Gu gong Mengzhu Li Ning Sun ting Zhi Yuhao He Junan Pan Yuntao Cai Longlu Wang College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology) Nanjing University of Posts&Telecommunications(NUPT)Nanjing 210023China

The physicochemical properties of transition metal dichalcogenides(TMDs)are highly related to their structures and usually stable in ***,under certain conditions they could be transformed into different structures due to *** this,various materials with fascinating structures have been explored by oxidation strategies,which possess novel properties and great potential in various applications such as solar batteries,hydrogen evolution reaction(HER)catalysts,and field effect transistors(FET).In this review,we systematically summarize the atomic structures of TMD oxidized variants and the corresponding fabrication *** various characterization methods,the chemical components of TMD oxidized variants are ***,we expound the promising applications of the oxidized *** review is expected to provide a new insight for preparing precise materials at the atomic level through corresponding oxidation strategies.

关键词： Transition metal dichalcogenides Oxidation strategies Oxidized variants Hydrogen evolution reaction Physicochemical properties

Recent progress in co-detection of single-cell transcripts and proteins

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Nano Research 2024年第1期17卷 132-150页

作者： Shanqing Huang Qian Fan Yidi Wang Zhi Huang Weixiong Shi Yanli gong ting Yang Jie Wang Lingling Wu Chaoyong Yang Discipline of Intelligent Instrument and Equipment College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Institute of Molecular Medicine Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of General Surgery Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361101China Research Center for Analytical Sciences Department of ChemistryCollege of SciencesNortheastern UniversityShenyang 110819China

Cellular heterogeneity is a universal property of living systems,and the interrogation of single cells facilitates in-depth understanding of distinct cellular states and functions in various biological ***-analysis of transcripts and proteins from the same single cells opens the way to decipher complex RNA regulatory frameworks and phenotypes,facilitating the understanding of cellular fate and function regulations,discovery of novel cell types,and construction of a high-resolution cell ***,we review the state-of-art advances in the development of methodologies for co-analysis of single-cell transcripts and ***,imaging-based methods are summarized with particular emphasis on optical and mass spectrometry ***,sequencing-based approaches for high-throughput and sensitive co-analysis of single-cell transcripts and proteins are described,including droplet-,microwell-,and split-pool-based ***,combined methods with more flexibility and universality are *** methods commonly employ different strategies or reactions to convert transcripts and proteins of single cells into distinct signals simultaneously,which can be detected by different instruments or ***,some perspectives on the future challenges and development trends in this field are presented.

关键词： single cell optical imaging mass spectrometry imaging single-cell RNA sequencing(scRNA-seq) co-detection

A fungal CYP from Beauveria bassiana with promiscuous steroid hydroxylation capabilities

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Chinese Chemical Letters 2024年第5期35卷 218-222页

作者： Yu Peng Yue Wang Tian-Jiao Chen Jing-Jing Chen Jin-Ling Yang ting gong Ping Zhu State Key Laboratory of Bioactive Substance and Function of Natural Medicines NHC Key Laboratory of Biosynthesis of Natural ProductsCAMS Key Laboratory of Enzyme and Biocatalysis of Natural DrugsInstitute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Hydroxylation of steroid core is critical to the synthesis of steroid *** sp^(3) C-H hydroxylation is challenging through chemical catalysis,alternatively,fungal biotransformation offers a possible solution to this ***,mining and metabolic engineering of cytochrome P450 monooxygenases(CYPs)is usually regarded as a more eco-friendly and efficient ***,we report the mining and identification of a new steroid CYP(CYP68BE1)from Beauveria bassiana by transcriptomics,heterologous expression,in vivo and in vitro functional *** catalytic promiscuity of CYP68BE1 was explored,and CYP68BE1 showed promiscuously and catalytically versatile,which is qualified for monohydroxylation on C11α,C1α,C6βand dihydroxylation on C1β,11αand C6β,11αof six steroids,leading to the production of key steroid intermediates required in the industrial synthesis of some indispensable steroid *** dynamics simulations were performed,revealing the molecular basis of different binding orientations of CYP68BE1 with different *** discovery of CYP68BE1 offers a promising biocatalyst for enriching the steroid structural and functional diversity,which also can be applied to biosynthesize valuable steroid drug intermediates.

关键词： Fungal CYPs Steroid hydroxylase Beauveria bassiana Promiscuous biocatalyst Molecular dynamics

Pre-existing orthorhombic embryos-induced hexagonal-orthorhombic martensitic transformation in MnNiSi_(1-x)(CoNiGe)_x alloy

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Chinese Physics B 2024年第4期33卷 691-699页

作者：张婷婷龚元元鲁子骞徐锋 MIIT Key Laboratory of Advanced Metallic and Intermetallic Materials Technology School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China

The thermal-elastic martensitic transformation from high-temperature Ni_(2)In-type hexagonal structure to low-temperature TiNiSi-type orthorhombic structure has been widely studied in MnMX(M=Ni or Co,and X=Ge or Si)***,the answer to how the orthorhombic martensite nucleates and grows within the hexagonal parent is still *** this work,the hexagonal-orthorhombic martensitic transformation in a Co and Ge co-substituted MnNiSi is *** can find some orthorhombic laths embedded in the hexagonal parent at a temperature above the martensitic transformation start temperature(M_(s)).With the the sample cooing to M_(s),the laths turn broader,indicating that the martensitic transformation starts from these pre-existing orthorhombic *** observation suggests that these pre-existing orthorhombic laths do not originate from the hexagonal-orthorhombic martensitic transformation because of the difference between atomic occupations of doping elements in the hexagonal parent and those in the preexisting orthorhombic *** phenomenological crystallographic theory and experimental investigations prove that the pre-existing orthorhombic lath and generated orthorhombic martensite have the same crystallography relationship to the hexagonal ***,the orthorhombic martensite can take these pre-existing laths as embryos and grow *** work implies that the martensitic transformation in MnNiSi_(1-x)(CoNiGe)_(x) alloy is initiated by orthorhombic embryos.

关键词： martensitic transformation MnMX alloy orthorhombic embryo crystallography relationship

Cross section determination of^(27)Al(n,2n)^(26)Al reaction induced by 14-MeV neutrons uniting with D-T neutron activation and AMS techniques

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Nuclear Science and Techniques 2024年第6期35卷 78-89页

作者： Xian-Lin Yang Chang-Lin Lan Yu-ting Wei Yi Zhang gong Jiang Bo Xie Yu Liu Hong-Tao Shen Xiao-Jun Sun School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China MOE Frontiers Science Center for Rare Isotopes Lanzhou UniversityLanzhou 730000China State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China Guangxi Key Laboratory of Nuclear Physics and Nuclear Technology Guangxi Normal UniversityGuilin 541004China

Aluminum is the primary structural material in nuclear engineering,and its cross section induced by 14-MeV neutrons is of great *** address the issue of insufficient accuracy for the^(27)Al(n,2n)^(26)Al reaction cross section,the activation method and accelerator mass spectrometry(AMS)technique were used to determine the^(27)Al(n,2n)^(26)Al cross section,which could be used as a D-T plasma ion temperature monitor in fusion *** the China Academy of Engineering Physics,neutron activation was performed using a K-400 neutron generator produced by the T(d,n)4He ***^(26)Al∕^(27)Al isotope ratios were measured using the newly installed GYIG 1 MV AMS at the Institute of Geochemistry,Chinese Academy of *** neutron flux was monitored by measuring the activity of 92mNb produced by the 93Nb(n,2n)92mNb *** measured results were compared with available data in the experimental nuclear reaction database,and the measured values showed a reasonable degree of consistency with partially available literature *** newly acquired cross-sectional data at 12 neutron energy points through systematic measurements clarified the divergence,which has two different growth trends from the existing experimental *** obtained results are also compared with the corresponding evaluated database,and the newly calculated excitation functions with TALYS−1.95 and EMPIRE−3.2 codes,the agreement with CENDL−3.2,TENDL-2021 and EMPIRE−3.2 results are generally acceptable.A substantial improvement in the knowledge of the^(27)Al(n,2n)^(26)Al reaction excitation function was obtained in the present work,which will lay the foundation for the diagnosis of the fusion ion temperature,testing of the nuclear physics model,evaluation of nuclear data,etc.

关键词： 14-MeV neutron ^(27)Al(n,2n)^(26)Al Cross section AMS