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Chinese Chemical Letters 2025年第2期36卷 412-416页

作者： Hong-Tao Ji Yu-Han Lu Yan-ting Liu Yu-Lin Huang jiang-Feng Tian Feng Liu Yan-Yan Zeng Hai-Yan Yang Yong-Hong Zhang Wei-Min He Department of Ophthalmology The Affiliated Nanhua Hospital Hengyang Medical School University of South China School of Chemistry and Chemical Engineering University of South China Department of Lung Cancer and Gastroenterology Hunan Cancer Hospital The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University

The first example of Nd@C3N4-photoredox/chlorine dual catalyzed alkylation with unactivated alkanes as the alkyl sources has been developed,which allows for the synthesis of various 4-alkylated cyclic sulfonyl *** this process,chlorine functions as both a redox and hydrogen atom transfer *** synergism of the reversible Nd2+/Nd3+and Clˉ/Cl˙redox pairs significantly enhances overall photocatalytic *** in vitro anticancer activity of 4-alkylated products was evaluated by using the CCK8assay against both human choroidal melanoma （MUM-2B） and lung cancer （A549） *** 3da showed approximately triple the potency of 5-fluorouracil.

关键词： Chlorine Dual catalysis Hydrogen atom transfer Redox catalyst Semiconductor

Effect of Co substitution for Fe on microstructure and magnetic properties of FeNiSiBCuNb alloy ribbons

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Chinese Physics B 2025年第2期34卷 438-446页

作者： Wen-Feng Liu Ya-ting Yuan Chang-jiang Yu Shu-Jie Kang Qian-Ke Zhu Zhe Chen Ke-Wei Zhang Min-Gang Zhang School of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China Laboratory of Magnetic and Electric Functional Materials and Applications The Key Laboratory of Shanxi ProvinceTaiyuan 030024China

This work investigated the microstructure,magnetic properties,and crystallization kinetics of the as-spun and annealed alloy ribbons of(Fe_(40-x)Co_xNi_(40)Si_(6.33)B_(12.66)Cu_1)_(0.97)Nb_(0.03),where x=0,6,7,8,9,prepared using the meltspinning *** results show that adding a moderate amount of Co can improve the glass forming ability(GFA),the first peak crystallization temperature,and thermal stability of the as-spun alloy *** x=7,the two-stage crystallization temperature interval△Tx=90 exhibits optimal thermal stability,and the alloy annealed at 673 K for 10 minutes shows the favorable combined magnetic properties,with H_(c)=0.12 A/m,M_(s)=88.7 A·m^(2)/kg,andμ_(e)=*** magnetic domain results show that annealing removes numerous pinning points in the magnetic domains of the alloy ribbons,making the domain walls smoother and effectively reducing the pinning effect.

关键词： amorphous alloys Co substitution for Fe glass formation ability magnetic properties crystallization kinetics

Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

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World Journal of Clinical Oncology 2025年第1期16卷 25-33页

作者： jiang-Yu Bian Yu-Fang Feng Wen-ting He Tong Zhang Department of Oncology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Oncology The Fourth Clinical Medical College of Xinjiang Medical UniversityUrumqi 830001China Department of Oncology Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830001China

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor *** the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal ***,we further explored the survival benefits in the population with BRAF V600E mutant *** To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal *** A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December *** patients were divided into two *** A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,*** analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

关键词： Metastatic colorectal cancer BRAF V600E mutation Integrated Chinese and Western medicine Cohort study

场景流动与消费重构:全域兴趣电商背景下图书出版业的营销赋能与破局进路

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出版发行研究 2025年第2期 62-69页

作者：范晓光姜帅浙江传媒学院播音主持艺术学院杭州师范大学文化创意与传媒学院

伴随“内容场景”与“货架场景”的融汇,数字消费市场呈现出新的变化。在此背景下,“全域兴趣电商”应运而生,成为兴趣电商升级优化后的全新电商模式。在图书出版业与电商关系微妙的当下,该模式对于图书出版业发展的意义,不仅在于消费... 详细信息

伴随“内容场景”与“货架场景”的融汇,数字消费市场呈现出新的变化。在此背景下,“全域兴趣电商”应运而生,成为兴趣电商升级优化后的全新电商模式。在图书出版业与电商关系微妙的当下,该模式对于图书出版业发展的意义,不仅在于消费端创新营销、扩大消费,也为从供给端促进图书出版业的转型升级提供了更多可能。该模式下的内容可见、关系建构、多域联动、细分运营、动线延长、多点做功等,在赋能图书出版业高效营销的同时,亦再次赋予图书业“内容”优先地位,有助于重申其文化产品的重要身份,反拨以往图书业浮躁的“价格战”。基于此,图书出版业应在该模式下深掘图书内容,打造自身IP,在洞察用户动线的基础上,对不同品类的图书进行分门别类的有效供给。

关键词：全域兴趣电商图书营销内容需求多域联动动线延长

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-jiang Hao Key Laboratory of Phytochemistry and Natural Medicines(Chinese Academy of Sciences) Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical OncogenomicsPeking University Shenzhen Graduate SchoolShenzhen 518055China Shenzhen Bay Laboratory Shenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Microbial Metabolism School of Life Sciences&BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical UniversityGuiyang 550014China Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest ChinaKunming Institute of BotanyChinese Academy of SciencesKunming 650201China Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical SciencesBeijing 100730China

In the intricate process of natural product biosynthesis,a metabolon can enhance metabolic flux by associating sequential enzymes.A fungal metabolon,comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G,is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide *** notoamide E as a substance,Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation,followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium ***,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol *** provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

Synthesis of chiral phosphine derivatives through a copper（I）-catalyzed desymmetric SNAr reaction

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Science China Chemistry 2025年

作者： shuai Zhang Pei-Zhi Liu Yan-Bo Li Qi Zhang Jun-Zhao Xiao Yi-Fan Wang Tian-Yu Wei Jia-Wei jiang Ye Wang Qian Peng Liang Yin Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Biosensing and Molecular Recognition College of Chemistry Frontiers Science Center for New Organic Matter Nankai University Haihe Laboratory of Sustainable Chemical Transformations

Axially chiral phosphines are a class of extremely important ligands in asymmetric catalysis. Herein, an unprecedented copper（I）-catalyzed asymmetric SNAr reaction with HP（S）R2is uncovered, which delivers a series of axially chiral phosphine derivatives in high yields with excellent enantioselectivity. Furthermore, the diastereoselective reaction with the kinetic resolution of racemic HP（S）ArR proceeds smoothly, providing the products with moderate diastereoselectivity and excellent enantioselectivity. Control experiments indicate that HP（S）Ph2is much more active than HPPh2and HP（O）Ph2as the pronucleophile in the present reaction. It is found that the SNAr reaction （the first SNAr） proceeds in a desymmetric manner, providing the desired chiral products while a continued SNAr reaction （the second SNAr） slightly occurs in a kinetic resolution manner in the present catalytic system, which enhances the ee of the desired chiral products. DFTcalculations support a concerted reaction pathway rather than a step-wise mechanism. Finally, axially chiral olefin-phosphines produced by the present method work as suitable ligands in Pdcatalyzed asymmetric allylic substitution with C-, N-, and O-nucleophiles and Rh-catalyzed asymmetric addition of arylboronic acid to benzil.

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大鼠骨髓间充质干细胞体外可诱导分化为角膜上皮细胞

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国际眼科杂志 2007年第2期7卷 339-341页

作者：姜廷帅蔡莉惠延年闫峰第四军医大学西京医院眼科中国陕西省西安市710032

目的:探讨骨髓间充质干细胞(mesenchymal stem cell,MSC)分化为角膜上皮细胞的可塑性及其重建角膜上皮的可能性。方法:用密度梯度离心法结合贴壁培养法分离纯化大鼠骨髓MSC,经体外与角膜基质细胞共培养诱导分化,免疫荧光法检测角膜上皮... 详细信息

目的:探讨骨髓间充质干细胞(mesenchymal stem cell,MSC)分化为角膜上皮细胞的可塑性及其重建角膜上皮的可能性。方法:用密度梯度离心法结合贴壁培养法分离纯化大鼠骨髓MSC,经体外与角膜基质细胞共培养诱导分化,免疫荧光法检测角膜上皮细胞特异标志物K12的表达。结果:体外培养的大鼠骨髓MSC表现出很强的增殖潜能,原代培养的骨髓MSCCD29免疫荧光染色阳性,CD34和CD45为阴性,符合骨髓MSC的特征。MSC与角膜基质细胞共培养1wk后大部分细胞分化为间质细胞,少部分细胞形态上相对偏小,免疫荧光检测这部分细胞表达角膜上皮细胞特异性标志角蛋白K12。结论:体外培养的MSC在角膜基质细胞的诱导下可横向分化为角膜上皮细胞。

关键词：骨髓间充质干细胞角膜上皮细胞分化可塑性

复合MoO_(3)/g-C_(3)N_(4)催化剂氧化脱硫性能

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中国石油大学学报(自然科学版) 2025年第1期49卷 220-226页

作者：姜楠李健宇张琨宣谭智赫蒋博龙王帅东北石油大学黑龙江大庆163318 江苏洋井石化集团有限公司江苏连云港222000

为提高金属氧化物催化剂的氧化脱硫活性,通过两步焙烧法制备MoO_(3)(w)/g-C_(3)N_(4)复合催化剂,以噻吩为模拟油,评价催化材料的脱硫性能,优化反应温度、催化剂用量、氧化剂用量和萃取剂用量等反应条件。结果表明:与单一MoO_(3)氧化物相... 详细信息

为提高金属氧化物催化剂的氧化脱硫活性,通过两步焙烧法制备MoO_(3)(w)/g-C_(3)N_(4)复合催化剂,以噻吩为模拟油,评价催化材料的脱硫性能,优化反应温度、催化剂用量、氧化剂用量和萃取剂用量等反应条件。结果表明:与单一MoO_(3)氧化物相比,MoO_(3)/g-C_(3)N_(4)复合材料具有大的比表面积,对难以脱除的噻吩类含硫化合物具有优异的脱硫效果;在催化剂用量0.06 g,氧硫物质的量比为10∶1、萃取剂用量1 mL、噻吩模拟油用量10 mL以及温度为70℃的反应条件下,在复合和负载的协同作用下,120 min后MoO_(3)(0.5)/g-C_(3)N_(4)复合催化剂对噻吩的脱硫率高达94.5%,远高于单一MoO_(3)催化剂的78.2%;MoO_(3)(0.5)/g-C_(3)N_(4)催化剂具备良好的催化稳定性,在经过5次重复性试验后,材料催化活性仅下降4.0%;具有高催化活性的MoO_(3)与高比表面积g-C_(3)N_(4)的协同作用提高了催化剂的活性,在脱硫的过程中,噻吩被氧化为砜,并溶解在萃取剂或部分吸附在MoO_(3)(0.5)/g-C_(3)N_(4)表面而被脱除。

关键词：复合催化剂金属氧化物氧化脱硫

Effect of Na^(+)and Sr^(2+)Substitution on the Formation of the Oxygen Vacancies in Y_(3)Al_(2)Ga_(3)O_(12):Ce^(3+)Phosphor

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Journal of Wuhan University of Technology(Materials Science) 2023年第5期38卷 1221-1230页

作者： YANG ting jiang Hongyi DONG Ye GAO shuai LIU Shuning School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China

The low-valence cations Na^(+)and Sr^(2+)were selected as the co-dopants to increase the vacancies concentration in the Y_(2.982)Ce_(0.018)Al_(2)Ga_(3)O_(12)*** successful incorporation of Na^(+)and Sr^(2+)was confirmed by the X-Ray Difiraction(XRD)*** the samples show 5d-4f green persistent luminescence of Ce^(3+)after 450 nm *** decay curves demonstrate that the persistent luminescence is efiectively enhanced with Na+and Sr2+*** thermoluminescence glow curves also show not only does the trap concentration increase,but also the distribution of trap depths is *** addition,the air-and H_(2)/Ar-annealing treatments were conducted on every as-made *** experimental results prove that the increased traps after the Na^(+)/Sr^(2+)doping are mainly attributed to the oxygen vacancies,and the traps have a continuous and broad distribution of trap *** hope this work could give new inspiration for designing a high-performance persistent phosphor.

关键词： persistent luminescence YAGG Na^(+) Sr^(2+) oxygen vacancy charge compensation solidstate reaction

铁锰改性不同原料生物炭对镉污染碱性农田土壤修复

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环境科学 2025年第1期46卷 461-469页

作者：杨婷婷江胜国梁凯杨宗政徐应明天津市地质研究和海洋地质中心天津300170 山东司南检测技术有限公司济南250001 天津科技大学化工与材料学院天津300457 农业农村部环境保护科研监测所天津300191

为探讨铁锰改性不同原料生物炭(FM-BC)对Cd污染碱性农田土壤修复效应的影响,以树枝、榴莲壳和玉米秸秆为原料制备FM-BC,通过水体吸附试验和土壤培养试验研究了FM-BC性质,及其对水体Cd(Ⅱ)的吸附性能和碱性土壤有效态Cd含量(DTPA-Cd)和C... 详细信息

为探讨铁锰改性不同原料生物炭(FM-BC)对Cd污染碱性农田土壤修复效应的影响,以树枝、榴莲壳和玉米秸秆为原料制备FM-BC,通过水体吸附试验和土壤培养试验研究了FM-BC性质,及其对水体Cd(Ⅱ)的吸附性能和碱性土壤有效态Cd含量(DTPA-Cd)和Cd形态分布的影响.结果表明,铁锰改性后,生物炭的比表面积、总孔体积和氧含量得到了显著改善和提升. FMBC对水体Cd(Ⅱ)最大吸附量为50.71~98.09 mg·g^(−1),较BC提高了1.61~4.27倍.添加0.5%~3%FM-BC使土壤DTPA-Cd含量显著降低了11.77%~37.73%,碳酸盐结合态和铁锰氧化物结合态组分增加了8.61%~13.72%和6.74%~35.05%,降低了土壤中Cd的活性.铁锰改性榴莲壳生物炭(FM-DBC)对土壤DTPA-Cd的钝化效果显著优于铁锰改性树枝生物炭(FM-RBC)和铁锰改性玉米秸秆壳生物炭(FM-YBC).表征结果表明,FM-DBC含有大量CO_(3)^(2-)、C—O、Fe—O和Mn—O等吸附位点,主要通过沉淀和络合反应吸附镉,在镉污染碱性农田土壤修复方面具有较大的应用潜力.

关键词：铁锰改性生物炭原料镉污染土壤修复