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Nine-year experience of doxorubicin-eluting beads chemoembolization for hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2016年第5期15卷 493-498页

作者： Alvin Ho-Kwan Cheung Colin Siu-Chi Lam Henry Shiu-Cheung Tam Tan-To Cheung Roberta Pang Ronnie Tung-Ping poon Department of Surgery University of Hong Kong and Queen Mary Hospital

BACKGROUND: Chemoembolization with doxorubucin-eluting beads (DEB) has been used to treat hepatocellular carcinoma (HCC) since 2007. This study compared the efifcacy and sur-vival between transarterial chemoembolization (TACE) with DEB and conventional approach (cTACE) in HCC treatment. METHODS: This retrospective case-control study compared the overall survival and tumor response of HCC patients to cTACE (n=190) and DEB (n=143) by the reassessment of com-puted tomography and serum alpha-fetoprotein (AFP). Mul-tivariate analysis was used to determine the factors affecting tumor response. RESULTS: The median post-treatment to pre-treatment AFP level was 0.8 for a DEB session (n=258) and 1.0 for a cTACE session (n=452), showing a signiifcantly greater decrease in AFP after DEB (P80 months after the ifrst TACE session in the DEB group. CONCLUSION: DEB is a safe alternative to cTACE in HCC pa-tients with better therapeutic efifcacy.

关键词： doxorubicin-eluting beads transarterial chemoembolization hepatocellular carcinoma

Repair of traumatic plasmalemmal damage to neurons and other eukaryotic cells

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Neural Regeneration Research 2016年第7期11卷 1033-1042页

作者： George D.Bittner Christopher S.Spaeth Andrew D.poon Zachary S.Burgess Christopher H.Mc Gill Department of Neuroscience The University of Texas at Austin

The repair（sealing） of plasmalemmal damage,consisting of small holes to complete transections,is critical for cell survival,especially for neurons that rarely regenerate cell *** first describe and evaluate different measures of cell *** measures,including morphological/ultra-structural observations,membrane potential,and input resistance,provide very ambiguous assessments of plasmalemmal *** contrast,measures of ionic current flow and dye barriers can,if appropriately used,provide more accurate *** describe the effects of various substances（calcium,calpains,cytoskeletal proteins,ESCRT proteins,m UNC-13,NSF,PEG） and biochemical pathways（PKA,PKC,PLC,Epac,cytosolic oxidation） on plasmalemmal sealing probability,and suggest that substances,pathways,and cellular events associated with plasmalemmal sealing have undergone a very conservative *** sealing,calcium ion influx mobilizes vesicles and other membranous structures（lysosomes,mitochondria,etc.） in a continuous fashion to form a vesicular plug that gradually restricts diffusion of increasingly smaller molecules and ions over a period of seconds to ***,we find no direct evidence that sealing occurs through the collapse and fusion of severed plasmalemmal leaflets,or in a single step involving the fusion of one large wound vesicle with the nearby,undamaged *** describe how increases in perikaryal calcium levels following axonal transection account for observations that cell body survival decreases the closer an axon is transected to the ***,we speculate on relationships between plasmalemmal sealing,Wallerian degeneration,and the ability of polyethylene glycol（PEG） to seal cell membranes and rejoin severed axonal ends – an important consideration for the future treatment of trauma to peripheral nerves.A better knowledge of biochemical pathways and cytoplasmic structures involved in plasmalemmal sealing might provide insights to develo

关键词： sealing traumatic eukaryotic vesicles axonal membranous closer biochemical vesicular muscular

Synthesis and enhanced piezoelectric response of CVD-grown SnSe layered nanosheets for flexible nanogenerators

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Nano Research 2023年第9期16卷 11839-11845页

作者： Fumei Yang Man-chung Wong Jianfeng Mao Zehan Wu Jianhua Hao Department of Applied Physics the Hong Kong Polytechnic UniversityHong Kong 999077China

Piezoelectricity is the electric charge which accumulates in certain materials in response to mechanical stimuli,while piezoelectric nanogenerators(PENGs)converting mechanical energy into electricity can be widely used for energy harvesting and self-powered *** group IV-VI monochalcogenides may exhibit strong piezoelectricity because of their puckered C_(2v)symmetry and electronic structure,making them promising for flexible ***,we investigated the synthesis and piezoelectric properties of multilayer SnSe nanosheets grown by chemical vapor deposition(CVD).The SnSe nanosheets exhibited high single-crystallinity,large area,and good *** strong layer-dependent in-plane piezoelectric coefficient of SnSe nanosheets showed a saturated trend to be~110 pm/V,which overcomes the weak piezoelectric response or odd-even effects in other layered nanosheets.A high energy conversion efficiency of 9.3%and a maximum power density of 538 mW/cm^(2)at 1.03%strain have been demonstrated in a SnSe-based *** on the enhanced piezoelectricity of SnSe and attractive output performance of the nanogenerator,a self-powered sensor for human motion monitoring is further *** results demonstrate the strong piezoelectricity in high quality CVD-grown SnSe nanosheets,allowing for application in flexible smart piezoelectric sensors and advanced microelectromechanical devices.

关键词： SnSe piezotronics piezoresponse force microscope piezoelectric nanogenerator self-powered device

Chronic subdural haematoma during the COVID-19 lockdown period:late presentation with a longer interval from the initial head injury to the final presentation and diagnosis

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Chinese Neurosurgical Journal 2022年第1期8卷 31-35页

作者： David Yuen chung Chan Wai Sang poon Danny Tat Ming Chan Wai Kit Mak George Kwok Chu Wong Division of Neurosurgery Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongPrince of Wales HospitalHong Kong SARChina

Background:The COVID-19 novel coronavirus is contagious,and the mortality is higher in the elderly *** in different parts of the world has been imposed since January *** subdural haematoma (cSDH) has a unique natural history in which symptoms can be non-specific,and the onset is *** study aims to evaluate the impact of the COVID-19 pandemic on the presentation of ***:Consecutive adult cSDH patients admitted from 1 March 2020 to 30 April 2020 were *** criteria including those who had no definite history of head injury or the diagnosis of cSDH were made from a scheduled follow-up *** data during the same period in 2019 were reviewed for *** primary outcome was the interval between the initial head injury and the final radiological diagnosis of *** outcomes include Markwalder chronic subdural haematoma grade upon admission,length of stay in the acute hospital,and the modified Rankin scale (mRS) upon ***:For the primary outcome,the average interval between head injury and the diagnosis of cSDH was significantly longer at 56.6 days (49 to 74 days,SD 9.83 days) during the period from March to April 2020,versus 29.4 days (17 to 42 days,SD 8.59 days) in 2019 for the corresponding period (p = 0.00703).There was no significant difference in the functional outcome upon ***:cSDH patients can present late during the COVID-19 lockdown *** functional outcome was comparable when operations for drainage were timely performed.

关键词： Chronic subdural haematoma Novel coronavirus COVID-19 Head injury

First Trimester Preeclampsia Screening and Prevention:Perspective in Chinese Mainland

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Maternal-Fetal Medicine 2024年第2期6卷 84-91页

作者： Jiao Liu Yunyu Chen Sin ting Tai Long Nguyen-Hoang Kunping Li Jing Lin Xiaohong Lu Liona C.poon Department of Obstetrics and Gynecology The Chinese University of Hong KongShatinHong Kong 999077China

Preeclampsia(PE),a multisystem disorder in pregnancy,is one of the leading causes of perinatal morbidity and mortality that poses financial and physical burdens *** PE with delivery atting PE in patients at high-risk of the *** this article,we will summarize the existing literature on the different screening methods,different components of risk assessment,therapeutic interventions,and clinical implementation of the first trimester screening and prevention program for PE with specific considerations for Chinese mainland.

关键词： Preeclampsia Chinese population First trimester Screening Prevention

Hybrid AlGaInAs/Si Fabry–Pérot lasers with near-total mode confinements

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Journal of Semiconductors 2018年第8期39卷 41-46页

作者： Yuede Yang Shaoshuai Sui Mingying Tang Jinlong Xiao Yun Du Andrew W.poon Yongzhen Huang State Key Laboratory of Integrated Optoelectronics Institute of Semiconductors Chinese Academy of Sciences College of Materials Science and Opto-Electronic Technology University of Chinese Academy of Sciences Photonic Device Laboratory Department of Electronic and Computer Engineering The Hong Kong University of Science and Technology

We have proposed and demonstrated hybrid Al Ga In As/Si Fabry–Pérot(FP) lasers, with the FP cavity facet covered by the p-electrode metal for enhancing mode confinement. Continuous-wave lasing is obtained at room temperature with a threshold current of 45 m A for the hybrid FP laser with a cavity length of 415 μm and a width of 7 μm. Near-field optical microscope images indicate an efficient output emission from the underneath evanescently-coupled silicon waveguide. Furthermore, single-mode lasing with a side-mode suppression-ratio of29 d B and a threshold current of 16 m A is realized for the 150 μm-long hybrid FP laser.

关键词： hybrid AlGaInAs/Si laser Fabry–Pérot cavity mode Q factor metal confinement

Resection of hepatocellular carcinoma after combined treatment with transarterial chemoembolization and sorafenib:a case report and literature review

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Hepatoma Research 2015年第1期1卷 104-106页

作者： Kenneth Siu Ho Chok Ian Yu Hong Wong See Ching Chan Ronnie Tung Ping poon chung Mau Lo Department of Surgery Queen Mary HospitalThe University of Hong KongHong KongChina

Hepatocellular carcinoma(HCC)with inferior vena cava(IVC)invasion and metastatic lymph node metastases has a poor prognosis,and surgical resection is seldom *** report how an initially unresectable HCC in a 36-year-old Chinese male with distant lymph node metastases and tumor thrombosis in the IVC was successfully downstaged and ultimately resected together with the *** the disease had been downstaged,curative resection of the tumor and IVC was conducted with immediate reconstruction of the *** patient has survived for more than 2 years after the *** conclusion,tumor and IVC resection can cure metastatic HCC after downstaging treatment combining sorafenib and transarterial chemoembolization.

关键词： Downstaging hepatocellular carcinoma lymph node metastases sorafenib vascular resection

Heterogeneous Cu_(x)O Nano‑Skeletons from Waste Electronics for Enhanced Glucose Detection

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Nano-Micro Letters 2024年第11期16卷 554-568页

作者： Yexin Pan Ruohan Yu Yalong Jiang Haosong Zhong Qiaoyaxiao Yuan Connie Kong Wai Lee Rongliang Yang Siyu Chen Yi Chen Wing Yan poon Mitch Guijun Li Center on Smart Manufacturing Division of Integrative Systems and DesignThe Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SAR 999077People’s Republic of China The Sanya Science and Education Innovation Park of Wuhan University of Technology Sanya 572000People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China

Electronic waste(e-waste)and diabetes are global challenges to modern ***,solving these two challenges together has been challenging until ***,we propose a laser-induced transfer method to fabricate portable glucose sensors by recycling copper from *** bring up a laser-induced full-automatic fabrication method for synthesizing continuous heterogeneous Cu_(x)O(h-Cu_(x)O)nano-skeletons electrode for glucose sensing,offering rapid(<1 min),clean,air-compatible,and continuous fabrication,applicable to a wide range of Cu-containing *** this approach,h-Cu_(x)O nanoskeletons,with an inner core predominantly composed of Cu_(2)O with lower oxygen content,juxtaposed with an outer layer rich in amorphous Cu_(x)O(a-Cu_(x)O)with higher oxygen content,are derived from discarded printed circuit *** employed in glucose detection,the h-Cu_(x)O nano-skeletons undergo a structural evolution process,transitioning into rigid Cu_(2)O@CuO nano-skeletons prompted by electrochemical *** transformation yields exceptional glucose-sensing performance(sensitivity:9.893 mA mM^(-1) cm^(-2);detection limit:0.34μM),outperforming most previously reported glucose *** functional theory analysis elucidates that the heterogeneous structure facilitates gluconolactone *** glucose detection device has also been downsized to optimize its scalability and portability for convenient integration into people’s everyday lives.

关键词： Copper oxide Electron 3D tomography E-waste Glucose detection Electrochemical activation

Long-term survival after intraluminal brachytherapy for inoperable hilar cholangiocarcinoma: A case report

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World Journal of Gastroenterology 2005年第20期11卷 3161-3164页

作者： Siu-Yin Chan Ronnie T. poon Kelvin K. Ng Chi-Leung Liu Raymond T. Chan Sheung-Tat Fan Centre for the Study of Liver Disease and Department of Surgery The University of Hong Kong PokfulamHong Kong China Department of Clinical Oncology The University of Hong Kong Pokfulam Hong Kong China

Surgical resection with a tumor-free margin is the onlycurative treatment for hilar cholangiocarcinoma (Klatskin tumor). However, over half of the patients present late with unresectable tumors. Radiotherapy using external beamirradiation or intraluminal brachytherapy (ILBT) has been used to treat unresectable hilar cholangiocarcinoma with satisfactory outcome. We reported a patient with unresectable hilar cholangiocarcinoma surviving more than 6 years after combined external beam irradiation and ILBT.

关键词： Brachytherapy Hilar cholangiocarcinoma