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Steroid for chronic subdural hematoma? A prospective phase IIB pilot randomized controlled trial on the use of dexamethasone with surgical drainage for the reduction of recurrence with reoperation

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Chinese Neurosurgical Journal 2015年第1期1卷 -页

作者： David Yuen chung Chan Tin Fung David Sun Wai Sang poon Division of Neurosurgery Department of Surgery Prince of Wales HospitalThe Chinese University of Hong Kong 30-32 Ngan Shing Street Shatin NTHong Kong

Background: Chronic subdural hematoma is a common neurosurgical condition especially in the aging *** hole for drainage is an effective treatment, yet recurrence is reported at 8 to 22 ％ worldwide, and 1-year mortality rates could be as high as 32 ％.Our previous study on the use of dexamethasone as a primary nonsurgical treatment showed good response in selected group of *** study aims to assess the efficacy of dexamethasone with surgical drainage in the reduction of recurrence requiring ***: From October 2000 to September 2006, patients with chronic subdural hematoma admitted to the Prince of Wales Hospital, The Chinese University of Hong Kong, were randomized to surgical drainage with steroid versus surgical drainage *** primary endpoint was symptomatic recurrence requiring ***: Two hundred forty-eight patients were recruited and consented for the randomization during the study *** hundred twenty-two received both surgery and steroid (the intervention arm) while 126 received surgery only (the control arm).The recurrence rate requiring reoperation was 6.6 ％ (8/122) and 13.5 ％ (17/126),respectively (p =0.109).There was no significant difference in complications such as chest infection (p =0.201) or wound infection (p =0.987).Favorable outcome (Glasgow Outcome Score 4-5) was 104/122 (85.2 ％) in the intervention group versus 105/126 (83.3 ％) in the control group, respectively (p =0.811).Based on the recurrence rate in our study, we generate a potential sample size of at least 594 patients (type Ⅰ error =5 ％, power =80 ％,two-sided test) to detect a significant ***, brief summary, and potential implications: In this prospective pilot phase IIB randomized controlled study, steroid with surgical drainage had a lower recurrence with reoperation though statistically *** was safe with no significant difference in complication *** pilot study generates a potential sample s

关键词： Chronic subdural hematoma Steroid Burr hole for drainage

Joint Applied Optics and Chinese Optics Letters Feature Introduction: Digital Holography and 3D Imaging

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Chinese Optics Letters 2011年第12期9卷 1-1页

作者： poon, ting-chung Zhou, Changhe Yatagai, Toyohiko Lee, Byoungho Zhai, Hongchen Virginia Tech Bradley Dept Elect & Comp Engn Blacksburg VA 24061 USA Chinese Acad Sci Shanghai Inst Opt & Fine Mech Shanghai 201800 Peoples R China Utsunomiya Univ Ctr Opt Res & Educ Utsunomiya Tochigi 3218585 Japan Seoul Natl Univ Sch Elect Engn Seoul 151744 South Korea Nankai Univ Inst Modern Opt Tianjin 300071 Peoples R China

This feature issue is the fifth installment on digital holography since its inception four years ago. The last four issues have been published after the conclusion of each Topical Meeting ＂Digital Holography and 3D imaging （DH）.＂ However, this feature issue includes a new key feature-Joint Applied Optics and Chinese Optics Letters Feature Issue.

关键词： Email Joint Applied Optics and Chinese Optics Letters Feature Introduction Digital Holography and 3D Imaging

Acute pancreatitis induced by transarterial chemoembolization:a single-center experience of over 1500 cases

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Hepatobiliary & Pancreatic Diseases International 2016年第1期15卷 93-98页

作者： Wong Hoi She Albert CY Chan Tan To Cheung Kenneth SH Chok See Ching Chan Ronnie TP poon chung Mau Lo Division of Hepatobiliary & Pancreatic Surgery and Liver Transplantation Department of SurgeryThe University of Hong Kong

BACKGROUND： Acute pancreatitis is a relatively rare but po- tentially lethal complication after transarterial chemotherapy. This study aimed to review the complications such as acute pancreatitis after transarterial chemotherapy with or without embolization for hepatocellular carcinoma. METHODS： A total of 1632 patients with hepatocellular car- cinoma who had undergone transarterial chemoembolization from ]anuary 2000 to February 2014 in a single-center were reviewed retrospectively. We investigated the potential com- plications of transarterial chemoembolization, such as acute pancreatitis and acute pancreatitis-related complications. RESULTS： Of the 1632 patients with hepatocellular carcinoma who had undergone 5434 transarterial chemoembolizations, 1328 were male and 304 female. The median age of these pa- tients was 61 years. Most （79.6%） of the patients suffered from HBV-related hepatoceUular carcinoma. The median tumor size was 5.2 cm. Of the 1632 patients, 145 patients underwent transarterial chemoembolization with doxorubicin elut- ing bead, making up a total of 538 episodes. The remaining patients underwent transarterial chemoembolization with cisplatin. Seven （0.4%） patients suffered from acute pancre- atitis post-chemoembolization. Six patients had chemoembo- lization with doxorubicin and one had chemoembolization with cisplatin. Patients who received doxornbicin eluting bead had a higher risk of acute pancreatitis [6/145 （4.1%） vs 1/1487 （0.1%）, P〈0.0001]. Two patients had anatomical arterial variations. Four patients developed acute pancreatitis- related complications including necrotizing pancreatitis （n=3） and pseudocyst formation （n=1）. All of the 4 patients resolved after the use of antibiotics and other conservative treatment. Three patients had further transarterial chemoembolization without any complication. CONCLUSIONS： Acute pancreatitis after transarterial chemo- embolization could result in serious complications, especially after treatment wit

关键词： transarterial chemoembolization acute pancreatitis hepatocellular carcinoma

Recent studies on mechanical properties of recycled aggregate concrete in China-A review

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Science China(Technological Sciences) 2012年第6期55卷 1463-1480页

作者： XIAO JianZhuang LI WenGui poon ChiSun Department of Building Engineering Tongji UniversityShanghai 200092China Department of Civil and Structural Engineering Hong Kong Polytechnic UniversityHong KongChina Committee of Recycled Aggregate Concrete Civil Engineering SocietyShanghai 200092China

Numerous experimental and theoretical studies on recycled aggregate concrete have been carried out in China in the past 10 *** paper provides a comprehensive review of the related findings of research on the mechanical properties of RAC in *** influences of the RCA on the strength and deformation characteristics of concrete,the statistical characteristics for the strength of RAC,fracture energy,stress-strain relationships under uniaxial compression,uniaxial tension as well as pure shear,and the residual strength of RAC after exposure to high temperatures,the bond between RAC and different kinds of steel rebar were also ***,some recent studies on the numerical simulation of the failure mechanism for RAC at the meso-structure level were discussed.

关键词： construction and demolition (C&D) wastes recycled coarse aggregate (RCA) recycled aggregate concrete (RAC) me-chanical property test numerical simulation

Artificial intelligence in gastroenterology:where are we heading?

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Frontiers of Medicine 2020年第4期14卷 511-517页

作者： Joseph JY Sung Nicholas CH poon Institute of Digestive Disease Faculty of MedicineThe Chinese University of Hong KongHong KongChina Big Data Decision Analytic Cancer The Chinese University of Hong KongHong KongChina

Artificial intelligence(AI)is coming to medicine in a big *** making diagnosis in various medical conditions,following the latest advancements in scientific literature,suggesting appropriate therapies,to predicting prognosis and outcome of diseases and conditions,AI is offering unprecedented possibilities to improve care for *** is a field that AI can make a significant *** is partly because the diagnosis of gastrointestinal conditions relies a lot on image-based investigations and procedures(endoscopy and radiology).AI-assisted image analysis can make accurate assessment and provide more information than conventional *** integration of genomic,epigenetic,and metagenomic data may offer new classifications of gastrointestinal cancers and suggest optimal personalized *** managing relapsing and remitting diseases such as inflammatory bowel disease,irritable bowel syndrome,and peptic ulcer bleeding,convoluted neural network may formulate models to predict disease outcome,enhancing treatment *** and surgical robots can also assist surgeons in conducting gastrointestinal *** the advancement and new opportunities are exciting,the responsibility and liability issues of AI-assisted diagnosis and management need much deliberations.

关键词： artificial intelligence endoscopy robotics gastrointestinal diseases

Tendency to Avoid Physical Activity and Sport:Associations with Weight Stigma,and Psychological Distress in a Two-Wave Longitudinal Study

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International Journal of Mental Health Promotion 2024年第8期26卷 633-641页

作者： Saffari Mohsen Yi-Ching Lin Po-Ching Huang Yu-ting Huang Ru-Yi Huang Chi Hsien Huang Jung-Sheng Chen Wai Chuen poon Mark D.Griffiths chung-Ying Lin Health Research Center Life Style InstituteBaqiyatallah University of Medical SciencesTehran***Iran Health Education Department Faculty of HealthBaqiyatallah University of Medical SciencesTehran***Iran Department of Early Childhood and Family Education National Taipei University of EducationTaipei106TaiwanChina School of Physical Therapy Graduate Institute of Rehabilitation ScienceCollege of MedicineChang Gung UniversityTaoyuan333TaiwanChina Institute of Allied Health Sciences College of MedicineNational Cheng Kung UniversityTainan701TaiwanChina Division of Family Medicine Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical Foundationand School of MedicineTzu Chi UniversityHualienTaiwanChina Data Science Degree Program National Taiwan University and Academia SinicaTaipeiTaiwanChina Department of Family Medicine and Community Medicine E-Da HospitalI-Shou UniversityKaohsiung824TaiwanChina College of Medicine I-Shou UniversityKaohsiung840Taiwan Department of Medical Research E-Da HospitalI-Shou UniversityKaohsiung840TaiwanChina Sunway Business School Sunway UniversitySelangor47500Malaysia International Gaming Research Unit Psychology DepartmentNottingham Trent UniversityNottinghamNG14BUUK Department of Public Health College of MedicineNational Cheng Kung UniversityTainan701TaiwanChina Biostatistics Consulting Center National Cheng Kung University HospitalCollege of MedicineNational Cheng Kung UniversityTainan704TaiwanChina Department of Occupational Therapy College of MedicineNational Cheng Kung UniversityTainan701TaiwanChina

Background:Physical inactivity is a major public health problem worldwide that results in physical and mental health *** major issue for physical inactivity is weight stigma(WS),especially perceived WS,which could lead to a tendency to avoid physical activity(PA).To better understand the association between perceived WS and PA,knowledge of the likely mediators in this association such as weight bias internalization(WBI)and psychological distress were investigated in the present ***:Using a two-wave longitudinal study and convenient sampling,388 Taiwan residents participants(55%females;mean age=29.7 years[SD±6.3])completed two surveys six months *** mass index(BMI),Perceived Weight Stigma Scale(PWSS),Weight Bias Internalization Scale(WBIS),Depression,Anxiety,Stress Scale(DASS-21),and Tendency to Avoid Physical Activity and Sport Scale(TAPAS)were ***:A mediation model controlling for age,gender,and BMI with 5000 bootstrapping resamples was *** WS exerted significant direct effects on WBI(β=0.25;pting role of WBI in this association,interventions addressing perceived WS and WBI may contribute to promoting ***,health interventionists(both when planning and executing PA programs)need to consider weight stigmawhen encouraging physical activity.

关键词： Mediation model physical activity psychological distress weight stigma young adults

Model investigation of the low-carbon MgO-treated soil foundation based on CO_(2) overall carbonation

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第11期15卷 2901-2916页

作者： Guanghua Cai Songyu Liu Yuqing Zhong Chisun poon Jiangshan Li School of Civil Engineering Nanjing Forestry UniversityNanjing210037China Institute of Geotechnical Engineering School of TransportationSoutheast UniversityNanjing211189China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong Kong999077China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China

The overall carbonation of MgO-admixed soil provides not only an efficient and environmentally friendly technique for improving soft ground but also a permanently safe solution for CO_(2) *** evaluate the carbon sequestration potential and promote the carbonation application in soil improvement,a laboratory-scale model investigation is designed under pressurized carbonation considering the influences of MgO dosage and CO_(2) ventilation mode(way).The temperature,dynamic resilience modulus,and dynamic cone penetration(DCP)were tested to assess the carbonation treatment *** physical,strength,and microscopic tests were also undertaken to reveal the evolution mechanisms of CO_(2) migration in the MgO-carbonated *** results indicate that the temperature peaks of MgO-treated foundation emerge at w20 h during hydration,but occur at a distance of 0e25 cm from the gas source within 6 h during *** dynamic resilience moduli of the model foundation increase by more than two times after carbonation and the DCP indices reduce *** the distance from the gas inlet increases,the bearing capacity,strength,and carbon sequestration decrease,whereas the moisture content *** to the end ventilation,the middle ventilation produces a higher carbonation degree and a wider carbonation *** cementation and filling of nesquehonite and dypingite/hydromagnesite are verified to be critical factors for carbonation evolution and enhancing mechanical ***,the overall carbonation model is described schematically in three stages of CO_(2) *** outcomes would help to facilitate the practical application of CO_(2) sequestration in soil treatment.

关键词： Model investigation Overall carbonation Reactive MgO Engineering properties Microscopic characteristics

Rapid measurement of indocyanine green retention by pulse spectrophotometry: a validation study in 70 patients with Child-Pugh A cirrhosis before hepatectomy for hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2012年第3期11卷 267-271页

作者： Tan To Cheung See Ching Chan Kenneth SH Chok Albert CY Chan Wan Ching Yu Ronnie TP poon chung Mau Lo Sheung Tat Fan Department of Surgery the University of Hong Kong Department of Surgery and State Key Laboratory for Liver Research the University of Hong Kong

BACKGROUND: The indocyanine green (ICG) retention test is the most popular liver function test for selecting patients for major hepatectomy. Traditionally, it is done using spectrophotometry with serial blood sampling. The newly- developed pulse spectrophotometry is a faster alternative, but its accuracy on Child-Pugh A cirrhotic patients undergoing hepatectomy for hepatocellular carcinoma has not been well documented. This study aimed to assess the accuracy of the LiMON , one of the pulse spectrophotometry systems, in measuring preoperative ICG retention in these patients and to devise an easy formula for conversion of the results so that they can be compared with classical literature records where ICG retention was measured by the traditional method. METHODS: We measured the liver function of 70 Child-Pugh A cirrhotic patients before hepatectomy for hepatocellular carcinoma from September 2008 to January 2009. ICG retention at 15 minutes measured by traditional spectrophotometry (ICGR15) was compared with ICG retention at 15 minutes measured by the LiMON (ICGR15(L)). RESULTS: The median ICGR15 was 14.7% (5.6%-32%) and the median ICGR15(L) was 10.4% (1.2%-28%). The mean difference between them was -4.3606. There was a strong correlation between ICGR15 and ICGR15(L) (correlation coefficient, 0.844; 95% confidence interval, 0.762-0.899). The following formula was devised: ICGR15=1.16×ICGR15(L)+***: The LiMON provides a fast and repeatable way to measure ICG retention at 15 minutes, but with constant underestimation of the real value. Therefore, when comparing results obtained by traditional spectrophotometry and the LiMON, adjustment of results from the latter is necessary, and this can be done with a simple mathematical calculation using the above formula.

关键词： Child-Pugh A liver cirrhosis hepatocellular carcinoma indocyanine green clearance LiMON pulse spectrophotometry

Spreadsheet quality assurance:a literature review

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Frontiers of Computer Science 2024年第2期18卷 61-82页

作者： Pak-Lok poon Man Fai LAU Yuen Tak YU Sau-Fun TANG School of Engineering and Technology Central Queensland UniversityMelbourne 3000Australia Department of Computing Technologies Swinburne University of TechnologyHawthorn 3122Australia Department of Computer Science City University of Hong KongHong Kong SAR 999077China The Royal Victorian Eye and Ear Hospital East Melbourne 3002Australia

Spreadsheets are very common for information processing to support decision making by both professional developers and non-technical end ***,business intelligence and artificial intelligence are increasingly popular in the industry nowadays,where spreadsheets have been used as,or integrated into,intelligent or expert systems in various application ***,it has been repeatedly reported that faults often exist in operational spreadsheets,which could severely compromise the quality of conclusions and decisions based on the *** a view to systematically examining this problem via survey of existing work,we have conducted a comprehensive literature review on the quality issues and related techniques of spreadsheets over a 35.5-year period(from January 1987 to June 2022)for target journals and a 10.5-year period(from January 2012 to June 2022)for target *** other findings,two major ones are:(a)Spreadsheet quality is best addressed throughout the whole spreadsheet life cycle,rather than just focusing on a few specific stages of the life cycle.(b)Relatively more studies focus on spreadsheet testing and debugging(related to fault detection and removal)when compared with spreadsheet specification,modeling,and design(related to development).As prevention is better than cure,more research should be performed on the early stages of the spreadsheet life *** by our comprehensive review,we have identified the major research gaps as well as highlighted key research directions for future work in the area.

关键词： decision support system end-user computing end-user programming Excel spreadsheet