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Influence of blood glucose fluctuations on chemotherapy efficacy and safety in type 2 diabetes mellitus patients complicated with lung carcinoma

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World Journal of Diabetes 2024年第4期15卷 645-653页

作者： Tian-Zheng Fang Xian-Qiao Wu ting-Qi Zhao Shan-Shan Wang Guo-Mei-Zhi Fu Qing-Long Wu c.eng-Wei Zhou Department of Thoracic Surgery The First Affiliated Hospital of Ningbo UniversityNingbo 315020Zhejiang ProvinceChina Department of endocrine The First Affiliated Hospital of Ningbo UniversityNingbo 315020Zhejiang ProvinceChina Department of Respiratory and critical care Medicine The First Affiliated Hospital of Ningbo UniversityNingbo 315020Zhejiang ProvinceChina

BAcKGROUND Patients with type 2 diabetes mellitus(T2DM)have large fluctuations in blood glucose(BG),abnormal metabolic function and low immunity to varying degrees,which increases the risk of malignant tumor diseases and affects the efficacy of tumor *** hyperglycemia may have important therapeutic implications for cancer *** To clarify the influence of BG fluctuations on chemotherapy efficacy and safety in T2DM patients complicated with lung carcinoma(Lc).METHODS The clinical data of 60 T2DM+Lc patients who presented to the First Affiliated Hospital of Ningbo University between January 2019 and January 2021 were retrospectively *** patients underwent chemotherapy and were grouped as a control group(cG;normal BG fluctuation with a mean fluctuationctuation with a mean fluctuation≥3.9 mmol/L)based on their BG fluctuations,with 30 cases *** indices,tumor markers,serum inflammatory cytokines and adverse reactions were comparatively *** correlation analysis was performed to analyze the correlation between BG fluctuations and tumor *** The fasting blood glucose and 2-hour postprandial blood glucose levels in the OG were notably elevated compared with those in the cG,together with markedly higher mean amplitude of glycemic excursions(MAGE),mean of daily differences,largest amplitude of glycemic excursions and standard deviation of blood glucose(Pently higher levels of carbohydrate antigen 19-9,carbohydrate antigen 125,carcinoembryonic antigen,neuron-specific.enolase,cytokeratin 19,tumor necrosis factor-α,interleukin-6,and highsensitivity c-reactive protein than the cG(Pciation of MAGE with serum tumor *** incidence of adverse reactions was significantly higher in the OG than in the cG(PcONcLUSION The greater the BG fluctuation in Lc patients after

关键词： Blood glucose fluctuation Type 2 diabetes mellitus Lung carcinoma Tumor markers

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Mechanistic research:Selenium regulates virulence factors,reducing adhesion ability and inflammatory damage of Helicobacter pylori

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World Journal of Gastroenterology 2024年第1期30卷 91-107页

作者： chun Qin Gan-Rong Huang Ai-Xing Guan Wen-ting Zhou Hao c.en Pei-Pei Luo Xian-Ke Luo Yan-Qiang Huang Zan-Song Huang Guangxi Technology Innovation cooperation Base of Prevention and control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Digestive Diseases Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Pathology Wannan Medical CollegeWuhu 241002Anhui ProvinceChina Department of Gastroenterology Wujin People’s Hospital affiliated to Jiangsu UniversityChangzhou 213004Jiangsu ProvinceChina Department of Gastroenterology Guangzhou Liwan District People's HospitalGuangzhou 510370Guangdong ProvinceChina

BAcKGROUND The pathogenicity of Helicobacter pylori is dependent on factors including the environment and the *** selenium is closely related to pathogenicity as an environmental factor,the specific correlation between them remains *** To investigate how selenium acts on virulence factors and reduces their *** *** strains were induced by sodium *** expression of cytotoxin-associated protein A(cagA)and vacuolating cytotoxin gene A(VacA)was determined by quantitative PcR and Western *** was used to analyze cagA,cagM,cagE,cag1,cag3,and cagT.c57BL/6A mice were infected with the attenuated strains subjected to sodium selenite induction,and *** colonization,inflammatory reactions,and the cell adhesion ability of *** were *** cagA and VacA expression was upregulated at first and then downregulated in the *** strains after sodium selenite *** expression was significantly and steadily downregulated after the 5th cycle(10 d).Transcriptome analysis revealed that sodium selenite altered the levels affect *** virulence factors such as cagA,cagM,cagE,cag1,cag3,and *** these factors,cagM and cagE expression was continuously downregulated and further downregulated after 2 h of induction with sodium ***,cagT expression was upregulated before the 3rd cycle(6 d)and significantly downregulated after the 5th ***1 and cag3 expression was upregulated and downregulated,respectively,but no significant change was observed by the 5th cycle.c57BL/6A mice were infected with the attenuated strains subjected to sodium selenite *** extent of *** colonization in the stomach increased;however,sodium selenite also induced a mild inflammatory reaction in the gastric mucosa of ***-infected mice,and the cell adhesion ability of *** was significantly *** These results demonstrate that *** displayed virulence attenuation after

关键词： Helicobacter pylori Sodium selenite Virulence factors Adherence Inflammation

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Advancing energy Systems with In-Situ and Operando Surface-enhanced Raman Scattering Spectroscopy

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ccS chemistry 2024年第6期6卷 1403-1421页

作者： Haoming Bao Shi Xuan Leong Jaslyn Ru ting c.en Zhenhai Shi Suli c.en Yan Lv Tianxi Liu In Yee Phang Xing Yi Ling Key Laboratory of Synthetic and Biological colloids Ministry of EducationInternational Joint Research Laboratory for Nano Energy CompositesSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122 School of chemistry Chemical Engineering and BiotechnologyNanyang Technological UniversitySingapore 637371

Surface-enhanced Raman scattering spectroscopy(SERS)has emerged as a powerful analytical technique to enable nanoscale investigations of energy *** mini-review focuses on the applications of in-situ and operando SERS in energy-related research,highlighting its unique capabilities and significant contributions to understanding energy storage and conversion *** first introduce the fundamental principles of SERS,key SERS-derived techniques,and commonly employed ***,we delve into the diverse applications of in-situ and operando SERS across various energy systems,encompassing photocatalytic and electrocatalytic systems,fuel cells,solar cells,and ***,we conclude with our perspective on the current challenges and prospects in this *** hope thismini-review serves as an essential overview to guide the design and implementation of in-situ and operando SERS studies of energy systems.

关键词： surface-enhanced Raman scattering spectroscopy in-situ operando energy systems photocatalysis electrocatalysis fuel cells solar cells batteries

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Elucidating ligand effects in rhodium(Ⅲ)-catalyzed arene-alkene coupling reactions

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chinese chemical Letters 2024年第5期35卷 130-134页

作者： Kongchuan Wu Dandan Lu Jianbin Lin ting-Bin Wen Wei Hao Kai Tan Hui-Jun Zhang Department of chemistry College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Beijing National Laboratory for Molecular Sc.ences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China

Rhodium(Ⅲ)-catalyzed c-H couplings of arenes with alkenes are among the most powerful methods for c-c bond *** these transformations,subtle manipulation of ancillary ligands can lead to dramatic changes in reactivity and ***,detailed mechanistic studies concerning the ligand effects are *** this study,we investigated the origin of ligand-controlled product-selectivity in rhodium(Ⅲ)-catalyzed c-H couplings of arenes with alkenes,using a series of well-defined[cpXRhⅢ]complexes that feature electronically or sterically distinct cp^(X)(cp(η^(5)-c_(5)H_(5)),cp^(cF3)(η^(5)-c_(5)Me_(4)cF_(3))and cp^(∗)(η^(5)-c_(5)Me_(5)))ligands.A combination of experimental and theoretical investigations showed that(i)rhodium hydride species containing the electron rich cp^(∗)ligand can undergo reinsertion of the alkene,thereby allowing rhodium-walking,(ii)rhodium hydride species involving the electron-defic.ent cp or cp^(cF3) ligands prefer reductive elimination rather than alkene *** findings offer valuable insights on future rational catalyst design for selective arene-alkene cross coupling reactions.

关键词： Organometallics Transition metal catalysis Arene-alkene coupling β-H elimination Rhodium hydride

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Research p rogress on chinese herbal drugs in the TGF- β signaling pathway involved in epithelial-mesenchymal transition

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cancer Advances 2024年第17期7卷 1-12页

作者： Hui-Juan cao c.en-Xi Wu Xiao-Le Xian Yong-Sen Jia Yue-Yue Yu Shu Zhao ting-ting Fu Traditional chinese Medicine college North China University of Science and TechnologyTangshan 063210China.

Epithelial-mesenchymal transition is a well-defined,reversible process in which epithelial cells lose their epithelial phenotype and acquire mesenchymal-like ***-mesenchymal transition contributes significantly to the metastasis,invasion,and development of treatment resistance in cancer *** have been many studies on suppression of tumor epithelial-mesenchymal transition by chinese medicine in recent years,mainly based on chinese herbal drug monomers and *** this review,we aim to describe the research progress on chinese medicine in the t ransforming growth factor beta(T GF-β)sig naling pathway,we hope these will provide some guidance for further research on chinese medicine targeting epithelial-mesenchymal transition.

关键词： epithelial-mesenchymal transition cancer chinese medicine invasion metastasis

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Physicochemical characterization of Dendrobium officinale polysaccharides and regulation of immunometabolic homeostasis in Sub-health mice based on the cD4-Th17/Treg immunity axis

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Food Sc.ence and Human Wellness 2024年

作者： Bo Li Ze-Hua Zhang Hao-Ru Guan Xing-Li-Shang He Ning Wang Ying-Jie Dong Mei Rong Jiu-Jie Jia ting-ting c.en Zhi-Yuan Li Gui-Yuan Lv Lin-Nan Zhang Su-Hong c.en collaborative Innovation center of Yangtze River Delta Region Green Pharmaceuticals， Zhejiang University of Technology Zhejiang Provincial Key Laboratory of TcM for Innovative R & D and Digital Intelligent Manufacturing of TcM Great Health Products.Huzhou college of Pharmaceutical Sc.ence， Zhejiang chinese Medical University

The aim of this study was to investigate the role of DOPS and DOPS100 in attenuating immune dysfunction in subfertile mice. The results of the study revealed several noteworthy findings. First， DOPS and DOPS100 treatments led to significant improvement in weight gain and reversal of fatigue-related behaviors compared to the normal group. Second， both DOPS and DOPS100 showed effectiveness in reducing immune organ swelling， modulating immunoglobulin （IgA and IgM） levels， and restoring complement （c3c and c4） levels. In addition， they demonstrated a significant ability to enhance the integrity of the intestinal mechanical barrier by differentially upregulating the tight junction proteins Occludin and ZO-1. In addition， it was found that DOPS100 specifically enhanced the cD4+-Th17/Treg immune axis in the gut， as evidenced by increased expression of Foxp3 as well as decreased expression of RORγt， and further modulation of IL-10， IL-22， and IL-17A expression levels of inflammatory factors. These findings collectively suggest that DOPS100 holds significant potential in improving sub-healthy status by repairing the intestinal barrier， restoring local immune homeostasis， and activating the intestinal immune regulatory network. The study's outcomes provide valuable insights into the therapeutic implications of DOPS and DOPS100 in addressing immune dysfunction in sub-healthy conditions.

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分布式光纤测温系统在热风炉监测中的优化与应用

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科学与信息化 2024年第1期 63-65页

作者：侯恩华方挺印华安徽工业大学电气与信息工程学院安徽马鞍山 243032

针对传统的热风炉测温监测系统测量范围小、精度较差等问题,本文提出了将分布式光纤测温系统优化后应用于热风炉监测,给出了该系统的组成结构和流程设计,提出了螺旋式缠绕热风炉的布设方式.优化使用平移算法对光信号进行光纤色散补偿.... 详细信息

针对传统的热风炉测温监测系统测量范围小、精度较差等问题,本文提出了将分布式光纤测温系统优化后应用于热风炉监测,给出了该系统的组成结构和流程设计,提出了螺旋式缠绕热风炉的布设方式.优化使用平移算法对光信号进行光纤色散补偿.实验结果表明,使用优化算法后,去噪效果好且补偿了系统的光纤色散效应,系统平均误差由1.12下降到了0.35℃,测温精度有所提高.综上,优化后的分布式光纤测温系统能有效监测热风炉的连续温度,可以投入到实际测温中使用.

关键词：分布式光纤螺旋式缠绕光纤色散补偿

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GIPc1 promotes tumor growth and migration in gastric cancer via activating PDGFR/PI3K/AKT signaling

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Oncology Research 2024年第2期32卷 361-371页

作者： tingting LI WEI ZHONG LIU YANG ZHIYU ZHAO LI WANG cONG LIU WANYUN LI HAIYAN LV SHenGYU WANG JIANGHUA YAN ting WU GANG SONG FANGHONG LUO cancer Research center School of MedicineXiamen UniversityXiamen361000China Department of Pharmacy Xiamen Mental Health CenterXiamen Xianyue HospitalXiamen361000China

The high mortality rate associated with gastric cancer(Gc)has resulted in an urgent need to identify novel therapeutic targets for *** study aimed to investigate whether GAIP interacting protein,c terminus 1(GIPc1)represents a therapeutic target and its regulating mechanism in ***1 expression was elevated in Gc tissues,liver metastasis tissues,and lymph node ***1 knockdown or GIPc1 blocking peptide blocked the platelet-derived growth factor receptor(PDGFR)/PI3K/AKT signaling pathway,and inhibited the proliferation and migration of Gc ***,GIPc1 overexpression markedly activated the PDGFR/PI3K/AKT signaling pathway,and promoted Gc cell proliferation and ***,platelet-derived growth factor subunit BB(PDGF-BB)cytokines and the AKT inhibitor attenuated the effect of differential GIPc1 ***,GIPc1 silencing decreased tumor growth and migration in BALB/c nude mice,while GIPc1 overexpression had contrasting *** together,our findings suggest that GIPc1 functions as an oncogene in Gc and plays a central role in regulating cell proliferation and migration via the PDGFR/PI3K/AKT signaling pathway.

关键词： GIPc1 PDGFR Gastric cancer Proliferation Migration

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chromosome-level genome assembly of the glass catfish(Kryptopterus vitreolus)reveals molecular clues to its transparent phenotype

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Zoological Research 2024年第5期45卷 1027-1036页

作者： chao Bian Rui-Han Li Zhi-Qiang Ruan Wei-ting c.en Yu Huang Li-Yue Liu Hong-Ling Zhou cheong-Meng chong Xi-Dong Mu Qiong Shi Laboratory of Aquatic Genomics College of Life Sciences and OceanographyShenzhen UniversityShenzhenGuangdong 518057China Key Laboratory of Prevention and control for Aquatic Invasive Alien Species Ministry of Agriculture and Rural AffairsGuangdong Modern.Recreational Fisheries Engineering Technology CenterPearl River Fisheries Research InstituteChinese Academy of Fishery SciencesGuangzhouGuangdong 510380China Shenzhen Key Lab of Marine Genomics Guangdong Provincial Key Lab of Molecular Breeding in Marine Economic AnimalsBGI Academy of Marine SciencesBGI MarineShenzhenGuangdong 518081China cAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization&Ecological Restoration and Biodiversity conservation Key Laboratory of Sichuan Province Chengdu Institute of BiologyChinese Academy of SciencesChengduSichuan 610041China School of Life Sc.ences Jiaying UniversityMeizhouGuangdong 514015China china Zebrafish Resource center National Aquatic Biological Resource CenterState Key Laboratory of Freshwater Ecology and BiotechnologyInstitute of HydrobiologyChinese Academy of ScienceWuhanHubei 430072China Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong 518116China State Key Laboratory of Quality Research in chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacaoMacao 999078China center for Aquatic Genomics College of Life SciencesNeijiang Normal UniversityNeijiangSichuan 641100China

Glass catfish(Kryptopterus vitreolus)are notable in the aquarium trade for their highly transparent body *** transparency is due to the loss of most reflective iridophores and light-absorbing melanophores in the main body,although certain black and silver pigments remain in the face and *** date,however,the molecular mechanisms underlying this transparent phenotype remain largely *** explore the genetic basis of this transparency,we constructed a chromosome-level haplotypic genome assembly for the glass catfish,encompassing 32 chromosomes and 23344 protein-coding genes,using PacBio and Hi-c sequencing technologies and standard assembly and annotation *** revealed a premature stop codon in the putative albinism-related tyrp1b gene,encoding tyrosinase-related protein 1,rendering it a nonfunctional ***,a synteny comparison with over 30 other fish species identified the loss of the endothelin-3(edn3b)gene in the glass catfish *** investigate the role of edn3b,we generated edn3b^(−/−)mutant zebrafish,which exhibited a remarkable reduction in black pigments in body surface stripes compared to wild-type *** findings indicate that edn3b loss contributes to the transparent phenotype of the glass *** high-quality chromosome-scale genome assembly and identification of key genes provide important molecular insights into the transparent phenotype of glass *** findings not only enhance our understanding of the molecular mechanisms underlying transparency in glass catfish,but also offer a valuable genetic resource for further research on pigmentation in various animal species.

关键词： Glass catfish Whole-genome sequencing edn3b−/−mutant Transparent phenotype

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composition analysis of compound Shenhua Tablet,a seven-herb chinese medicine for IgA nephropathy:evaluation of analyte-capacity of the assays

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chinese Journal of Natural Medicines 2024年第2期22卷 178-192页

作者： ZHANG Haiyan WANG Qiuyue WANG Jianan ZHANG Sichao JIA Weiwei HE Ning XIA Xiaoyan WANG ting LAI Liyu LI Jiaying DU Jing OLALEYE Olajide E c.en Xiangmei YANG Junling LI chuan Graduate School Tianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmacy University of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100049China Department of Nephrology First Medical Center of Chinese PLA General HospitalNephrology Institute of the Chinese People’s Liberation ArmyNational Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney Disease ResearchBeijing 100853China Zhongshan Institute for Drug Discovery Zhongshan 528400China Haihe Laboratory of Modern chinese Medicine Tianjin 301617China

compound Shenhua Tablet,a medicine comprising seven herbs,is employed in treating IgA *** study aimed to meticulously analyze its chemical *** on a list of candidate compounds,identified through extensive literature review pertinent to the tablet’s herbal components,the composition analysis entailed the systematic identification,characterization,and quantification of the *** analyte-capacity of Lc/ESI-MS-based and Gc/EI-MS-based assays was *** identified and characterized constituents were quantified to determine their content levels and were ranked based on the constituents’daily doses.A total of 283 constituents,classified into 12 distinct categories,were identified and characterized in the compound Shenhua *** constituents exhibited content levels of 1−10982μg·g^(−1),with daily doses of 0.01−395μmol·d^(−1).The predominant constituents,with daily doses of≥10μmol·d^(−1),include nine organic acids(citric acid,quinic acid,chlorogenic acid,cryptochlorogenic acid,gallic acid,neochlorogenic acid,isochlorogenic acid c,isochlorogenic acid B,and linoleic acid),five iridoids(specnuezhenide,nuezhenoside G13,nuezhenidic acid,secoxyloganin,and secologanoside),two monoterpene glycosides(paeoniflorin and albiflorin),a sesquiterpenoid(curzerenone),a triterpenoid(oleanolic acid),and a phenylethanoid(salidroside).Additionally,there were 83,126,and 55 constituents detected in the medicine with daily doses of 1–10,0.1–1,and 0.01–0.1μmol·d^(−1),*** combination of the Lc/ESI-MS-based and Gc/EI-MS-based assays demonstrated a complementary relationship in their analyte-capacity for detecting the constituents present in the *** comprehensive composition analysis establishes a solid foundation for further pharmacological research on compound Shenhua Tablet and facilitates the quality evaluation of this complex herbal medicine.

关键词： compound Shenhua Tablet composition analysis Analyte-capacity

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