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Effectiveness and tolerability of programmed cell death protein-1 inhibitor+chemotherapy compared to chemotherapy for upper gastrointestinal tract cancers

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1613-1625页

作者： Xiao-Min Zhang ting Yang Ying-Ying Xu Bao-Zhong Li Wei Shen Wen-Qing Hu cai-Wen Yan Liang Zong Department of central Laboratory Changzhi People’s HospitalThe Affiliated Hospital of Changzhi Medical CollegeChangzhi 046000Shanxi ProvinceChina Department of Gastrointestinal Surgery Yizheng People’s HospitalThe Affiliated Hospital of Yangzhou UniversityYangzhou 225000Jiangsu ProvinceChina Department of General Surgery Anyang Tumor HospitalAnyang 455000Henan ProvinceChina Department of General Surgery Wuxi People’s Hospital Affiliated to Nanjing Medical UniversityWuxi 214023Jiangsu ProvinceChina Department of Gastrointestinal Surgery Changzhi People’s HospitalThe Affiliated Hospital of Changzhi Medical CollegeChangzhi 046000Shanxi ProvinceChina Department of Gastroenterology Changzhi People’s HospitalThe Affiliated Hospital of Changzhi Medical CollegeChangzhi 046000Shanxi ProvinceChina

BAcKGROUND The combination of programmed cell death protein-1(PD-1)inhibitor and che-motherapy is approved as a standard first-or second-line treatment in patients with advanced oesophageal or gastric ***,it is unclear whether this combination is superior to chemotherapy *** To assess the comparative effectiveness and tolerability of combining PD-1 inhibitors with chemotherapy vs chemotherapy alone in patients with advanced gastric cancer,gastroesophageal junction(GEJ)cancer,or oesophageal *** We searched the PubMed and Embase databases for studies that compared the efficacy and tolerance of PD-1 inhibitors in combination with chemotherapy vs chemotherapy alone in patients with advanced oesophageal or gastric *** employed either random or fixed models to analyze the outcomes of each clinical trial,en-compassing data on overall survival(OS),progression-free survival(PFS),objective response rate,and adverse events(AEs).RESULTS Nine phase 3 clinical trials(7016 advanced oesophageal and gastric cancer patients)met the inclusion *** meta-analysis demonstrated that the pooled PD-1 inhibitor+chemotherapy group had a significantly longer OS than the chemotherapy-alone group[hazard ratio(HR)=0.76,95%confidence interval(cI):0.71-0.81];the pooled PFS result was consistent with that of OS(HR=0.67,95%cI:0.61-0.74).The count of patients achieving an objective response in the PD-1 inhibitor+chemotherapy group surpassed that of the chemotherapy-alone group[odds ratio(OR)=1.86,95%cI:1.59-2.18].AE incidence was also higher in the combination-therapy group than in the chemotherapy-alone group,regardless of whether≥grade 3 only(OR=1.30,95%cI:1.07-1.57)or all AE grades(OR=1.88,95%cI:1.39-2.54)were *** performed a subgroup analysis based on the programmed death-ligand 1(PD-L1)combined positive score(cPS)and noted extended OS and PFS durations within the cPS≥1,cPS≥5,and cPS≥10 subgroups of the PD-1 inhibitor+chemotherapy ***

关键词： Programmed cell death protein-1 inhibitor chemotherapy Oesophageal squamous cell carcinoma Gastric/gastroesophageal junction adenocarcinoma Overall survival Progression-free survival Objective response rate Adverse event

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不同外源物质对盐、碱及干旱胁迫下草木樨种子萌发、幼苗生长及生理的影响

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草业学报 2024年第8期33卷 122-132页

作者：张婷婷刘宇乐陈红许凌欣陈祥伟王恩姮严俊鑫东北林业大学园林学院黑龙江哈尔滨150000 东北林业大学林学院黑龙江哈尔滨150000

为筛选出促进盐、碱及干旱胁迫下草木樨种子萌发和幼苗生长的最佳外源物质及其处理浓度,采用培养皿滤纸发芽法,研究不同浓度赤霉素(GA)和褪黑素(MT)浸种6 h对盐、碱及干旱胁迫下草木樨种子萌发及幼苗生长的影响。结果表明,盐胁迫下,200... 详细信息

为筛选出促进盐、碱及干旱胁迫下草木樨种子萌发和幼苗生长的最佳外源物质及其处理浓度,采用培养皿滤纸发芽法,研究不同浓度赤霉素(GA)和褪黑素(MT)浸种6 h对盐、碱及干旱胁迫下草木樨种子萌发及幼苗生长的影响。结果表明,盐胁迫下,200 mg·L^(-1)的GA是促进种子萌发的最佳处理,50μmol·L^(-1)的MT是提高幼苗超氧化物歧化酶(SOD)、过氧化物酶(POD)和过氧化氢酶(cAT)活性的最佳处理。在碱胁迫下,200μmol·L^(-1)的MT则使幼苗胚轴长出现最大值。在干旱胁迫下,100 mg·L^(-1)的GA使草木樨种子发芽率和胚根长出现最大值。隶属函数综合评价得出,缓解盐胁迫的最佳外源物质是GA,最佳处理浓度是200 mg·L^(-1),缓解碱和干旱胁迫的最佳外源物质是MT,最佳处理浓度分别是50和100μmol·L^(-1)。综上所述,MT和GA浸种能够在盐、碱及干旱胁迫下促进草木樨种子萌发和幼苗生长,研究结果可为提高草木樨对盐、碱及干旱胁迫的耐受能力提供参考。

关键词：外源物质盐、碱、干旱胁迫草木樨种子萌发幼苗生长抗氧化酶活性

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Functional decoration on a regenerable bifunctional porous covalent organic framework probe for rapid detection and adsorption of copper ions

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Rare Metals 2024年第2期43卷 758-769页

作者： Yu-Long Li Xi-Lang Jin Yi-ting Ma Jing-Rui Liu Fazal Raziq Peng-Yuan Zhu Zhi-Feng Deng Hong-Wei Zhou Wei-Xing c.en Wen-Huan Huang School of Materials and chemical engineering Xi’an Technological UniversityXi’an710021China Yulin Boyi-Jingking Research Institute of Industrial Technology Development Research Yulin719054China KAUST catalysis center King Abdullah University of Science and Technology23955-6900ThuwalKingdom of Saudi Arabia Key Laboratory of chemical Additives for china National Light Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and TechnologyXi’an710021China National and Local Joint engineering Laboratory for Slag comprehensive Utilization and environmental Technology School of Materials Science and EngineeringShaanxi University of TechnologyHanzhong723001China

Developing fluorescence porous probe for detecting and eliminating cu^(2+) contamination in water or biosystem is an essential research project that has attracted considerable ***,improving the fluorescence detecting effic.ency while enhancing the adsorption capacity of the porous probe is of great ***,a bifunctional two-dimensional imine-based porous covalent organic framework(TTP-cOF)probe was designed and synthesized from 1,3,5-tris(4-aminophenyl)benzene(TAPB)and 2,4,6-Triformylphloroglucinol(TP)***-cOF displayed rapid detection of cu^(2+)(limit of detection(LOD)=10 nmol·L^(−1) while achieving a high adsorption capacity of 214 mg·g^(−1)(pH=6)at room temperature with high reusability(>5 cycles).The key roles and contributions of highπ-conjugate and delocalized electrons in TABP and functional–OH groups in TP were *** importantly,the fluorescence quenching mechanism of TTP-cOF was studied by density functional theory theoretical calculations,revealing the crucial role of intramolecular hydrogen bonds among c=N and–OH groups and the blocking of the excited state intramolecular proton transfer process in detecting process of cu^(2+).

关键词： covalent organic framework(cOF) Excited-state intramolecular proton transfer(ESIPT) copper ion detection copper ion adsorption Renewability

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Terpyridine-based metallo-cuboctahedron nanomaterials for effic.ent photocatalytic degradation of persistent organic pollutants

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Nano Research 2024年第8期17卷 6833-6840页

作者： Qixia Bai Yan Huang Zhihong c.en Yilin Pan Xiaohan Zhang Qingwu Long Qiaoan Yang Tun Wu ting-Zheng Xie Mingjian Wang Hongguang Luo chun Hu Pingshan Wang Zhe Zhang Key Laboratory for Water Quality and conservation of the Pearl River Delta(Ministry of Education) Institute of Environmental Research at Greater Bay AreaGuangzhou UniversityGuangzhou 510006China college of Light chemical Industry and Materials engineering Shunde PolytechnicFoshan 528333China Guangdong Guangye Inspection&Testing Group co. Ltd.Guangzhou 510006China

Metal–organic cage photocatalysts with nanoscale dimensions have received wide attention in the field of photocatalytic.environmental pollutant treatment due to their large cavities,easy modification,high tunability,and enriched active ***,we prepared a series of dihydroanthracene-cored terpyridine-based metallo-cuboctahedron nanomaterials through a selfassembly method,which exhibited satisfactory degradation performance for persistent organic pollutants under visible light *** particular,under light conditions,S1-Zn,one of the prepared nanomaterials,produced photogenerated holes oxidizing water molecules to∙OH,which attacked ibuprofen(IBU)for up to 95% ***,the corresponding photogenerated electrons reduced the dissolved oxygen in water,producing 66.2μmol/L hydrogen *** obtained supramolecular photocatalytic materials have a stable structure with non-precious metals and do not require a sacrificial *** metal sites of metallo-cuboctahedrons adsorb pollutants and transfer captured holes to them,accelerating degradation and promoting simultaneous H_(2)O_(2) *** work not only proposes a simple and effic.ent synthesis method for supramolecular photocatalysts but also opens up opportunities for effic.ent,low-cost,and multifunctional materials for environmental persistent organic pollutants treatment.

关键词： supramolecular cages self-assembly photocatalytic pollutant degradation H2O2 production

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chromosome-level genome and population genomics of the intermediate horseshoe bat(Rhinolophus affinis)reveal the molecular basis of virus tolerance in Rhinolophus and echolocation call frequency variation

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Zoological Research 2024年第5期45卷 1147-1160页

作者： Le Zhao Jiaqing Yuan Guiqiang Wang Haohao Jing c.en Huang Lulu Xu Xiao Xu ting Sun Wu c.en Xiuguang Mao Gang Li college of Life Sc.ences Shaanxi Normal UniversityXi’anShaanxi 710119China QinLing-Bashan Mountains Bioresources comprehensive Development c.I.c. School of Bioscience and EngineeringShaanxi University of TechnologyHanzhongShaanxi 723001China Guangzhou Zoo GuangzhouGuangdong 510070China School of Ecological and environmental Sc.ences East China Normal UniversityShanghai 200241China

Horseshoe bats(genus Rhinolophus,family Rhinolophidae)represent an important group within chiropteran phylogeny due to their distinctive traits,including constant high-frequency echolocation,rapid karyotype evolution,and unique immune *** in evolutionary biology,supported by high-quality reference genomes and comprehensive whole-genome data,have significantly enhanced our understanding of species origins,speciation mechanisms,adaptive evolutionary processes,and phenotypic ***,genomic research and understanding of the evolutionary patterns of Rhinolophus are severely constrained by limited data,with only a single published genome of *** currently *** this study,we constructed a high-quality chromosome-level reference genome for the intermediate horseshoe bat(***).comparative genomic analyses revealed potential genetic characteristics associated with virus tolerance in ***,we observed expansions in several immune-related gene families and identified various genes functionally associated with the SARS-coV-2 signaling pathway,DNA repair,and apoptosis,which displayed signs of rapid *** addition,we observed an expansion of the major histocompatibility complex class II(MHc-II)region and a higher copy number of the HLA-DQB2 gene in horseshoe bats compared to other chiropteran *** on whole-genome resequencing and population genomic analyses,we identified multiple candidate loci(e.g.,GLI3)associated with variations in echolocation call frequency across *** *** research not only expands our understanding of the genetic characteristics of the Rhinolophus genus but also establishes a valuable foundation for future research.

关键词： Reference-quality genome comparative genomics Population genomics Positive selection Bats

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Tailorable Multi-Photoresponsive Behavior Triggered by Different Sulfur Oxidation States

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ccS chemistry 2024年第10期6卷 2465-2475页

作者： Jingjing Guo Xiaoluo Peng Shihuai Wang Shuai Bi ting He Yu c.eng Zujin Zhao Ben Zhong Tang Yanli Zhao School of chemistry Chemical Engineering and BiotechnologyNanyang Technological UniversitySingapore 637371 State Key Laboratory of Luminescent Materials and Devices Key Laboratory of Luminescence from Molecular Aggregates of Guangdong ProvinceSouth China University of TechnologyGuangzhou 510640 School of Sc.ence and engineering The Chinese University of Hong KongShenzhenGuangdong 518172

Photoresponsive materials are considered as promising systems for intelligent technology applications owing to the contactless spatial and temporal ***,controllable multi-photoresponsive behaviors are realized in benzo[b]thiophene derivatives(o-DMP-S,o-DMP-SO,and o-DMP-SO_(2))by modulating the sulfur oxidation *** them,o-DMP-S is photo-unreactive but possesses denser molecular packing upon ultraviolet(UV)light irradiation,exhibiting photoenhanced room-temperature phosphorescence *** stoichiometric oxidation of the sulfur atom in o-DMP-S,the resulting sulfoxide compound o-DMP-SO undergoes a radical photolysis reaction involving photodeoxygenation and photochemical rearrangement,thereby leading to the photomechanical *** sulfone compound o-DMP-SO_(2)displays prominent reversible photochromism,resulting from the radical photocyclization under 365 nm UV light *** on comprehensive experimental and computational investigations,the diverse photoresponsive behaviors of these benzo[b]thiophene derivatives are demonstrated to depend on the intersystem crossing effic.ency and radical-mediated photochemical reaction activity in excited states due to the different sulfur oxidation *** work provides an insightful understanding of the relationship between molecular structure and photoresponsive behavior and opens up the opportunity for the development of photoresponsive materials with potential applications.

关键词： photoenhanced room-temperature phosphorescence photomechanical effect radicalmediated photochemical reaction reversible photochromism sulfur oxidation state

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Fusobacterium nucleatum-induced imbalance in microbiome-derived butyric acid levels promotes the occurrence and development of colorectal cancer

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World Journal of Gastroenterology 2024年第14期30卷 2018-2037页

作者： Qi-Long Wu Xiao-ting Fang Xin-Xin Wan Qing-Yong Ding Yan-Jun Zhang Ling Ji Yong-Liang Lou Xiang Li School of Laboratory Medicine and Life Sc.ences Wenzhou Medical UniversityKey Laboratory of Laboratory MedicineMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of Health Inspection and Quarantine School of Laboratory Medicine and Life SciencesWenzhou 325035Zhejiang ProvinceChina School of Laboratory Medicine and Life Sc.ences Wenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of General Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina School of Laboratory Medicine and Life Sc.ences Institute of One HealthWenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of Health Inspection and Quarantine School of Laboratory Medicine and Life SciencesInstitute of One HealthWenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina

BAcKGROUND colorectal cancer(cRc)ranks among the most prevalent malignant tumors *** reports suggest that Fusobacterium nucleatum(***)contributes to the initiation,progression,and prognosis of ***,a short-chain fatty acid derived from the bacterial fermentation of soluble dietary fiber,is known to inhibit various *** study is designed to explore whether *** influences the onset and progression of cRc by impacting the intestinal metabolite butyric *** To investigate the mechanism by which *** affects cRc occurrence and *** Alterations in the gut microbiota of BALB/c mice were observed following the oral administration of ***,DLD-1 and HcT116 cell lines were exposed to sodium butyrate(NaB)and *** in vitro to examine the effects on proliferative proteins and mitochondrial *** Our research indicates that the prevalence of *** in fecal samples from cRc patients is significantly greater than in healthy counterparts,while the prevalence of butyrate-producing bacteria is notably *** mice colonized with ***,the population of butyrate-producing bacteria decreased,resulting in altered levels of butyric acid,a key intestinal metabolite of *** to NaB can impair mitochondrial morphology and diminish mitochondrial membrane potential in DLD-1 and HcT116 cRc ***,this leads to modulated production of adenosine triphosphate and reactive oxygen species,thereby inhibiting cancer cell ***,NaB triggers the adenosine monophosphate-activated protein kinase(AMPK)signaling pathway,blocks the cell cycle in HcT116 and DLD-1 cells,and curtails the proliferation of cRc *** combined presence of *** and NaB attenuated the effects of the *** employing small interfering RNA to suppress AMPK,it was demonstrated that AMPK is essential for NaB’s inhibition of cRc cell *** F.n

关键词： colorectal cancer Fusobacterium nucleatum Butyric acid Gut microbiota Adenosine monophosphate-activated protein kinase signal pathway

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Binder-induced ultrafast ■-intercalation toward a high-voltage,high-power and long-cycling zinc–graphite dual-ion battery

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Rare Metals 2024年第10期43卷 5017-5029页

作者： Gen Li Xiao-Jun Shi ting Dong Qian Yu Zhi-Fei Mao Xin-Hua Liu Rui Wang Bei-Bei He Jun Jin Yan-Sheng Gong Huan-Wen Wang engineering Research center of Nano-Geomaterials of Ministry of Education Faculty of Material Science and ChemistryChina University of Geosciences college of Resources and environment South-Central Minzu University School of Transportation Sc.ence and engineering Beihang University

Metallic zinc is an ideal anode material owing to its high theoretical capacity (819 mAh·g-1),ecofriendliness,low cost and high safety,which have driven fast development of Zn-ion batteries （ZIBs）.However,the practical application of current ZIBs is significantly restricted by irregular dendrite growth of zinc anode and the low working voltage （usuallycathode ***,we report a high-voltage Zn-based dualion battery （DIB）,which is constructed by a graphite cathode,a Zn anode,and 3 M LiPF6in the ethyl methyl carbonate （EMc） *** the corrosion interaction of Li+ions,Zn2+can be easily dissolved from Zn anode into the electrolyte to enable dendrite-free Zn2+plating/stripping at the ***,an aqueous carboxymethyl cellulose （cMc） binder is employed to generate a robust cathode electrolyte interface （cEI） layer on the graphite cathode,which renders ultrafast PF6--de-/intercalation into *** resultant Zn–graphite DIB operates stably at a high cut off voltage of 3.2 V,corresponding to an average output voltage of 2.2 *** 9000cycles at 5c,the high capacity retention of 95.9% can be achieved with～100%coulomb *** on the mass of cathode material,our Zn–graphite battery exhibits ultrafast rate capability （60 c,a discharge time of 44 s） and high energy/power densities (208 Wh·kg-1at 214 W·kg-1;142 Wh·kg-1at 8692 W·kg-1),which holds great promise for large-scale energy storage.

关键词： Binder Graphite High-voltage PF6−-de-/intercalation Zn-ion batteries

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Bioinspired anti-freezing 3D-printable conductive hydrogel microfibers for highly-sensitive and wide-range detection of ultralow and high strains

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Green chemical engineering 2024年第1期5卷 132-143页

作者： Yi-Min Yang ting-Yuan Hu Haidong Fan Lu Shi Shi-Yuan Zhang Zhuang Liu Xiao-Jie Ju Rui Xie Wei Wang Liang-Yin chu School of chemical engineering Sichuan UniversityChengdu610065China Department of Mechanics Sichuan UniversityChengdu610065China State Key Laboratory of Polymer Materials engineering Sichuan UniversityChengdu610065China

Soft strain sensors that can transduce stretch stimuli into electrical readouts are promising as sustainable wearable ***,most strain sensors cannot achieve highly-sensitive and wide-range detection of ultralow and high *** by bamboo structures,anti-freezing microfibers made of conductive poly(vinyl alcohol)hydrogel with poly(3,4-ethylenedioxythiphene)-poly(styrenesulfonate)are developed via continuous microfluidic *** microfibers provide unique bamboo-like structures with enhanced local stress to improve both their length change and resistance change upon stretching for effic.ent signal *** microfibers allow highlysensitive(detection limit:0.05%strain)and wide-range(0%-400%strain)detection of ultralow and high strains,as well as features of good stretchability(485%strain)and anti-freezing property(freezing temperature:-41.1°c),fast response(200 ms),and good *** experimental results,together with theoretical foundation analysis and finite element analysis,prove their enhanced length and resistance changes upon stretching for effic.ent signal *** integrating microfluidic spinning with 3D-printing technique,the textiles of the microfibers can be flexibly *** microfibers and their 3D-printed textiles enable highperformance monitoring of human motions including finger bending and throat vibrating during *** work provides an effic.ent and general strategy for developing advanced conductive hydrogel microfibers as highperformance wearable strain sensors.

关键词： conductive hydrogel microfibers Microfluidics Sensitive detection Wide detection range Anti-freezing

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Artificial intelligence-driven radiomics study in cancer:the role of feature engineering and modeling

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Military Medical Research 2024年第1期11卷 115-147页

作者： Yuan-Peng Zhang Xin-Yun Zhang Yu-ting c.eng Bing Li Xin-Zhi Teng Jiang Zhang Saikit Lam Ta Zhou Zong-Rui Ma Jia-Bao Sheng Victor cWTam Shara WYLee Hong Ge Jing cai Department of Medical Informatics Nantong UniversityNantong 226001JiangsuChina Department of Health Technology and Informatics the Hong Kong Polytechnic UniversityHong Kong 999077China The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518000GuangdongChina Department of Radiation Oncology the Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhou 450008China

Modern medicine is reliant on various medical imaging technologies for non-invasively observing patients’***,the interpretation of medical images can be highly subjective and dependent on the expertise of ***,some potentially useful quantitative information in medical images,especially that which is not visible to the naked eye,is often ignored during clinical *** contrast,radiomics performs high-throughput feature extraction from medical images,which enables quantitative analysis of medical images and prediction of various clinical *** have reported that radiomics exhibits promising performance in diagnosis and predicting treatment responses and prognosis,demonstrating its potential to be a non-invasive auxiliary tool for personalized ***,radiomics remains in a developmental phase as numerous technical challenges have yet to be solved,especially in feature engineering and statistical *** this review,we introduce the current utility of radiomics by summarizing research on its application in the diagnosis,prognosis,and prediction of treatment responses in patients with *** focus on machine learning approaches,for feature extraction and selection during feature engineering and for imbalanced datasets and multi-modality fusion during statistical ***,we introduce the stability,reproducibility,and interpretability of features,and the generalizability and interpretability of ***,we offer possible solutions to current challenges in radiomics research.

关键词： Artificial intelligence Radiomics Feature extraction Feature selection Modeling Interpretability Multimodalities Head and neck cancer

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