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Potential applications of single-incision laparoscopic totally preperitoneal hernioplasty

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2202-2210页

作者： Xiao-Jun Wang ting Fei Xiong-Hua Xiang Quan Wang en-c.eng Zhou Department of Gastrointestinal Surgery The First Affiliated Hospital of Ningbo UniversityNingbo 315020Zhejiang ProvinceChina Ambulatory Surgery center Xijing HospitalAir Force Military Medical UniversityXi’an 710032Shaanxi ProvinceChina

BAcKGROUND The totally preperitoneal(TPP)approach is a new concept that was recently *** the TPP approach combined with single-incision laparoscopic hernia repair has its own advantages,there is little evidence reflecting the characteristics and feasibility of either *** To analyze the potential applications of single-incision laparoscopic TPP(SILTPP)inguinal hernia hernioplasty for the treatment of inguinal *** A total of 152 SIL-TPP surgeries were performed at the First Affiliated Hospital of Ningbo University from February 2019 to November 2022.A single-port,named Iconport,and standard laparoscopic instruments were used during the *** data,intraoperative parameters and short-term postoperative outcomes were collected and retrospectively *** The demographic data of 152 patients underwent SIL-TPP were shown in Table *** average age was 49.5 years(range from 21 to 81 years).The average body mass index was 27.7 kg/m^(2)(range from 17.7 kg/m^(2) to 35.6 kg/m^(2)).SIL-TPP were conducted successfully in 147 *** patients were converted to the SILtransabdominal preperitoneal laparoscopic herniorrhaphy at the initial stage of the study due to a lack of *** 2 patients with incisional hernias,an auxiliary operation hole was added during the SIL-TPP procedure,as required for *** mean operative time was 64.5 minutes(range:36.0-110.0 minutes)for unilateral direct and femoral hernias and 81.6 minutes for indirect hernias(range:40.0-150.0 minutes).The mean postoperative hospital stay was 3.4 *** SIL-TPP is feasible and has advantages for inguinal hernia ***-TPP has potential benefits for patients with various abdominal wall ***,doctors should be encouraged to actively apply the TPP approach combined with a single incision in their daily work.

关键词： Totally preperitoneal hernioplasty Iconport Single incision laparoscopic Totally extraperitoneal herniorrhaphy Single incision laparoscopic totally preperitoneal hernioplasty

Factors influencing willingness to participate in ophthalmic clinical trials and strategies for effective recruitment

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International Journal of Ophthalmology(english edition) 2024年第1期17卷 157-163页

作者： Jia-en Liang Meng-Yin Liang en-en Zhang Yu-Ying Peng Ling-Ling c.en Jia-Yu Deng ting Lin Jun Fu Jia-Ni Zhang Shao-Li Li Fei Li Hui-Ming Xaio Wen-Min Huang Yu-Hong Liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina

AIM:To explore the factors influencing individuals’willingness to participate in ophthalmic clinical ***:A questionnaire survey was conducted from January to April 2021 among patients and their family members at Zhongshan Ophthalmic center,Sun Yat-sen University,in Guangzhou,*** survey gathered data on respondents’willingness,demographic and socioeconomic profiles,as well as their reasons and concerns regarding engagement in clinical ***:Of the 1078 residents surveyed(mean age 31.2±13.1y;65.8%females)in Guangzhou,749(69.5%)expressed a willingness to participate in future ophthalmic clinical *** characteristics associated with greater willingness included a younger age,lower annual income,higher education,prior participation experience,previous ophthalmic treatment,and a better understanding of clinical *** the exception of age,these characteristics were significantly linked to a higher *** primary barrier to participation,expressed by 64.8%of those willing and 54.4%of those unwilling,was“Uncertain efficacy”.In terms of motivations,the willing group ranked“Better therapeutic benefits”(35.0%),“Professional monitoring”(34.3%),and“Trust in healthcare professionals”(33.1%)as their top three reasons,whereas the unwilling participants indicated“Full comprehension of the protocol”(46.2%)as the key ***:This study reveals a substantial willingness to participate in ophthalmic clinical trials and demonstrates the predictive role of demographic and socioeconomic *** in motivators and concerns between willing and unwilling participants highlight the significance of tailored recruitment ***,the need for and trust in healthcare professionals stand out as powerful motivations,underscoring the importance of enhancing physician-patient relationships,adopting patient-centered communication approaches,and addressing individualized needs to improve accrual rates.

关键词： participation willingness recruitment strategy ophthalmic clinical trial

Risk factors of non-arteritic anterior ischaemic optic neuropathy and central retinal artery occlusion

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International Journal of Ophthalmology(english edition) 2024年第5期17卷 869-876页

作者： chu-Han Ma cong-Yao Wang ting-ting Dai ting-ting c.en Wen-Hui Zhu Department of Ophthalmology the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina

AIM:To investigate the difference in risk factors between non-arteritic anterior ischaemic optic neuropathy(NAION)and central retinal artery occlusion(cRAO)and develop a predictive diagnostic ***:The study included 37 patients with monocular NAION,20 with monocular cRAO,and 24 with ***,age,and systemic diseases were *** routine,lipids,hemorheology,carotid and brachial artery doppler ultrasound,and echocardiography were *** optic disc area,cup area,and cup-to-disc ratio(c/D)of the unaffected eye in the NAION and cRAO group and the right eye in the hypertension group were ***:The carotid artery intimal medial thickness(c-IMT)of the affected side of the cRAO group was thicker(P=0.039)and its flow-mediated dilation(FMD)was lower(P=0.049)than the NAION *** with hypertension patients,NAION patients had higher whole blood reduced viscosity low-shear(WBRV-L)and erythrocyte aggregation index(EAI;P=0.045,0.037),and cRAO patients had higher index of rigidity of erythrocyte(IR)and erythrocyte deformation index(EDI;P=0.004,0.001).The optic cup and the c/D of the NAION group were smaller than the other two groups(Pc prediction model showed high diagnostic specificity(83.7%)and sensitivity(85.6%),which was highly related to hypertension,the c-IMT of the affected side,FMD,platelet(PLT),EAI,and c/***:cRAO patients show thicker c-IMT and worse endothelial function than *** and cRAO may be related to abnormal hemorheology.A small cup and small c/D may be involved in *** diagnostic nomogram can be used to preliminarily identify NAION and cRAO.

关键词： non-arteritic anterior ischaemic optic neuropathy central retinal artery occlusion risk factors diagnostic prediction model nomogram

coordination for a closed-loop Supply chain with Recycling Platform considering Dynamic Setting

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Journal of Systems Sc.ence and Systems engineering 2024年第4期33卷 425-451页

作者： Zehua Xiang ting Ji Lingfeng Dong School of Management Zhejiang UniversityHangzhou310058China School of Business Hangzhou City UniversityHangzhou310015China Alibaba Business college Hangzhou Normal UniversityHangzhou311121China

This paper presents a dynamic closed-loop supply chain(cLSc)model,incorporating a manufacturer,a retailer,and an internet recycling platform(IRP),utilizing differential game theory while considering the forgetting effect of *** model encompasses factors such as the quality level of used products and Big Data marketing(BDM),comparing optimal equilibriums under decentralized and cooperative decision *** effectively coordinate the dynamic cLSc at each time point,we propose a revenue-sharing and cost-sharing(RScS)combined *** addition to ensuring reasonable sharing of revenues and costs,this contract allows the manufacturer to flexibly adjust wholesale prices for final products and transfer prices for used products in order to distribute profits appropriately and achieve Pareto optimality within the cLSc ***,our results indicate that there exists a threshold for Big Data marketing effic.ency;high-effic.ency BDM not only facilitates increased recycling on Internet platforms but also reduces unit recycling costs for ***,when implementing the combined contract,Big Data marketing effic.ency does not impact the transfer price paid by manufacturers to Internet recycling platforms.

关键词： Big Data marketing differential game closed-loop supply chain coordination internet recycling platform

Exhaustive review of acceleration strategies for Monte carlo simulations in photon transit

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Journal of Innovative Optical Health Sc.ences 2024年第5期17卷 5-21页

作者： Louzhe Xu Zijie Zhu ting Li Institute of Biomedical engineering chinese Academy of Medical Sc.ences&Peking Union Medical college Tianjin 300192 P.R.China

Monte carlo simulation techniques have become the quintessence and a pivotal nexus of inquiry in the realm of simulating photon movement within biological *** the stochastic sampling of tissue archetypes delineated by explicit optical characteristics,Monte carlo simulations possess the theoretical capacity to render unparalleled accuracy in the depiction of exceedingly intricate ***,the quintessential challenge associated with Monte carlo simulation methodologies resides in their extended computational duration,which significantly impedes the re¯nement of their ***,this discourse is speci¯cally dedicated to exploring innovations in strategies and technologies aimed at expediting Monte carlo *** delves into the foundational concepts of various acceleration tactics,evaluates these strategies concerning their speed,accuracy,and practicality,and amalgamates a comprehensive overview and critique of acceleration methodologies for Monte carlo ***,the discourse envisages prospective trajectories for the employment of Monte carlo techniques within the domain of tissue optics.

关键词： Medical optics photon transport simulation Monte carlo simulation acceleration

One more step to realistic cO_(2) reduction reactions——geometric structures evolutions at gas-solid interface

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Rare Metals 2024年第2期43卷 849-852页

作者： Ya-Qiang Xie Xin Yu ting Wang college of the environment and Ecology Xiamen UniversityXiamen361102China

A rational design of copper(cu)nanocatalyst is critical to the effic.ent carbon dioxide(cO_(2))conversion toward c1/c2 chemical ***,the lack of actual information on the vicinal cu interfaces hinders the intrinsic activitystructure correlation *** with atomic-scale in situ characterizations(AP-STM and synchrotron-based AP-XPS),Park and co-workers study and identify the adsorbate-driven morphological evolution of cu nanoclusters on the cu(997)surface,providing real-space evidence for the critical role of vicinal structures on cu *** observed surface roughening trends caused by dissociated atomic oxygen and cO adsorbates subsequently affect the result of successive catalytic reactions to produce critical intermediates,such as carbonate and formate,during the cO_(2)reduction reaction.

关键词： reaction critical rational

Atmospheric chemistry of 2-nitrobenzaldehyde:Initiated by photo-excitation,OH-oxidation,and small TiO_(2) clusters adsorption catalysis

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Journal of environmental Sc.ences 2024年第5期139卷 123-137页

作者： Feng-Yang Bai Xiang-Huan Liu ting-ting Meng Zhou Yu Yi-c.en Wang Shuang Ni Zhen Zhao Institute of catalysis for energy and environment College of Chemistry and Chemical EngineeringShenyang Normal UniversityShenyang 110034China

The fate of 2-nitrobenzaldehyde(2-NBA)is of interest in atmospheric chemistry as it is a semi-volatile organic compound with high *** study presents a quantum chemical study of the gas-phase reactions of 2-NBA photo-excitation and OH-oxidation in the absence and presence of small TiO_(2) *** further understand the unknown photolysis mechanism,the photo-reaction pathways of ground singlet state and the lying excited triplet state of 2-NBA were investigated including the initial and subsequent reactions of proton transfer,direct cO,NO_(2),and HcO elimination routes in the presence of O_(2) and ***,the OH-mediated degradation of 2-NBA proceeded via five H-extraction and six OH-addition channels by indirect mechanism,which follows a succession of reaction steps initiated by the formation of weakly stable intermediate *** H-extraction from the-cHO group was the dominant pathway with a negative activation energy of-1.22 kcal/*** calculated rate coeffic.ents at 200–600 K were close to the experimental data in literature within 308-352 K,and the kinetic negative temperature independence was found in both experimental literature and computational ***,2-NBA was favored to be captured onto small TiO_(2) clusters via six adsorption configurations formed via various combination of three types of bonds of Ti…O,Ti…c,and O…H between the molecularly adsorbed 2-NBA and TiO_(2) *** indicted that the chemisorptions of aldehyde oxygen have largest *** results suggested adsorption conformations have a respectable impact on the catalysis *** study is significant for understanding the atmospheric chemistry of 2-nitrobenzaldehyde.

关键词： 2-nitrobenzaldehyde OH radical oxidation Rate coeffic.ent Photolysis mechanism Adsorption catalysis

Silencing of Jumonji domain-containing 1c inhibits the osteogenic differentiation of bone marrow mesenchymal stem cells via nuclear factor-κB signaling

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World Journal of Stem cells 2024年第2期16卷 151-162页

作者： Jing-Yi Li ting-ting Wang Li Ma Yu Zhang Di Zhu Department of Medical cosmetology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of General Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Plastic Surgery China-Japan Friendship HospitalBeijing 100029China Senior Department of Hematology The Fifth Medical CentreGeneral Hospital of Chinese People’s Liberation ArmyBeijing 100071China Department of Orthopaedic Surgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

BAcKGROUND Osteoporosis is a common metabolic bone disorder induced by an imbalance between osteoclastic activity and osteogenic *** osteoporosis,bone mesenchymal stem cells(BMScs)exhibit an increased ability to differentiate into adipocytes and a decreased ability to differentiate into osteoblasts,resulting in bone *** domain-containing 1c(JMJD1c)has been demonstrated to suppress *** To examine the effect of JMJD1c on the osteogenesis of BMScs and the potential underlying *** BMScs were isolated from mouse bone marrow *** Red O staining,Alizarin red staining,alkaline phosphatase staining and the expression of adipo-genic and osteogenic-associated genes were assessed to determine the differen-tiation of *** marrow-derived macrophages(BMMs)were incubated with receptor activator of nuclear factor-kappaΒligand to induce osteoclast differentiation,and osteoclast differen-tiation was confirmed by tartrate-resistant acid phosphatase *** related genes were measured via reverse transcription coupled to the quantitative polymerase chain reaction and western ***-linked immunosorbent assays were used to measure the levels of inflammatory cytokines,including tumor necrosis factor alpha,interleukin-6 and interleukin-1 *** The osteogenic and adipogenic differentiation potential of BMScs isolated from mouse bone marrow samples was ***1c mRNA and protein expression was upregulated in BMScs after osteoblast induction,while p-nuclear factor-κB(NF-κB)and inflammatory cytokines were not significantly *** of JMJD1c repressed osteogenic differentiation and enhanced NF-κB activation and inflammatory cytokine release in ***,JMJD1c expression decreased during BMM osteoclast *** The JMJD1c/NF-κB signaling pathway is potentially involved in BMSc osteogenic differentiation and may play vital roles in the pathogenesis of osteoporosis.

关键词： Osteoporosis Mesenchymal stem cells Osteogenesis Jumonji domain-containing 1c Nuclear factor-κB

Dietary inflammatory index and its impact on severity and recurrence of Tourette syndrome in children

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World Journal of Psychiatry 2024年第8期14卷 1208-1215页

作者： Xiao-Ping Wu Rong-Rong Fang ting-ting Ji Department of Pediatrics Qingdao Chengyang People’s HospitalQingdao 266109Shandong ProvinceChina

BAcKGROUND Tourette syndrome(TS)is a neurodevelopmental disorder characterized by the presence of motor and vocal tics,typically beginning in *** signifi-cant research efforts,the exact pathophysiology of TS remains incompletely *** studies suggest that inflammation may play a role in the severity and progression of TS,pointing to the potential influence of dietary and lifestyle factors on the ***,research on the specific connection between dietary inflammatory index(DII)and TS is still in its early stages,requir-ing additional clinical and epidemiological studies to validate the strength and specific mechanisms of this *** A total of 207 children diagnosed with TS in the pediatric department of Qingdao c.engyang People’s Hospital from January 2022 to January 2023 were *** were divided into stable and unstable groups based on follow-up *** enrollment,general information of the children[age,gender,body mass index(BMI),guardian’s education level,DII score,medical history,family history,academic stress,electronic device usage,medication,and disease progression]was assessed,and serum inflammatory levels were measured during follow-up *** scores and Yale Global Tic Severity Scale(YGTSS)scores were ***,based on YGTSS scores,the children were classified into mild,moderate,and severe *** DII,interleukin-6(IL-6),c-reactive protein(cRP),and tumor necrosis factor-alpha(TNF-α)levels in each group were *** Follow-up surveys were completed by 207 children and their *** them,117 children were in the stable group,and 90 were in the recurrent *** found no statistically significant differences in age,gender,comorbidities,BMI,and disease duration between the two groups(P>0.05).However,academic stress,electronic device usage,medication,guardian’s education level,and DII scores showed statistically significant differences between the groups(P

关键词： Dietary inflammation index Tourette's syndrome correlation analysis Pro-inflammatory foods Inflammation levels Impact on severity and recurrence