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Rill flow velocity affected by the subsurface water flow depth of purple soil in Southwest China

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Journal of Mountain Science 2022年第3期19卷 704-714页

作者： tao ting-ting CHEN Shi-qi CHEN Xiao-yan College of Resources and Environment Southwest UniversityChongqing 400716China

Subsurface water flow above the weakly permeable soil layer commonly occurs on purple soil ***,it remains difficult to quantify the effect of subsurface water flow on the surface flow *** experiments were performed to measure the rill flow velocity on purple soil slopes containing a subsurface water flow layer with the electrolyte tracer method considering 3 subsurface water flow depths(SWFDs:5,10,and 15 cm),3 flow rates(FRs:2,4,and 8 L min^(-1)),and 4 slope gradients(SGs:5°,10°,15°,and 20°).As a result,the pulse boundary model fit the electrolyte transport processes very well under the different *** measured rill flow velocities were 0.202 to 0.610 m s^(-1) under the various *** regression results indicated a positive dependence of the flow velocity on the FR and SG but a negative dependence on the *** SWFD had notable effects on the rill flow *** the SWFD from 15 to 5 cm increased the flow ***,the flow velocities under the 10-and 15-cm SWFDs were 89%and 86%,respectively,of that under the 5-cm *** flow velocity under the 5-,10-and 15-cm SWFDs was decreased to 89%,80%,and 77%,respectively,of that on saturated soil *** results will enhance the understanding of rill flow hydrological processes under SWFD impact.

关键词： Rill erosion Subsurface water flow Electrolyte tracer method Flow velocity Purple soil

A New Flowchart-based Device Monitoring and Management System

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A New Flowchart-based Device Monitoring and Management Syste...

Fructus Zanthoxyli extract improves glycolipid metabolism disorder of type 2 diabetes mellitus via activation of AMPK/PI3K/Akt pathway:Network pharmacology and experimental validation

第25届中国控制与决策会议

作者： Zhu Qun-xiong tao ting-ting Xu Yuan College of Information Science and Technology Beijing University of Chemical Technology

ISBN: (纸本)9781467355339

Due to the isolation between the production flow and device information in current petrochemical enterprises, they can’t fully play their roles respectively. Aiming at this problem, a new flowchart-based device monitoring and management system is proposed by using SVG dynamic technology to better integrate device information into process flow. First, we develop a flowchart-based device monitoring and management system through PHP technology, MySQL database technology and html5 front-end technology. Then we choose front controller pattern and command pattern as the basic design principle. Next, we propose a BNF model to express graph units and design process flow chart by reusing the graph units. After that, we develop a lightweight Ajax engine to interact the process flow chart with the database. Finally, the proposed system is applied to MIBK equipment, which provides an effective management tool for device management of enterprises.

关键词： Equipment Management System Process Flow Chart Scalable Vector Graphics Ajax

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Journal of Integrative Medicine 2022年第6期20卷 543-560页

作者： ting Zhang Qing Zhang Wei Zheng ting tao Ruo-lan Li Li-yu Wang Wei Peng Chun-jie Wu School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137Sichuan ProvinceChina

Objective:This study investigated the potential mechanisms behind the beneficial effects of Fructus Zanthoxyli(FZ)against type 2 diabetes mellitus(T2DM)based on network pharmacology and experimental ***:Ultra-high-performance liquid chromatography coupled with hybrid quadrupole-orbitrap high-resolution mass spectrometry,and gas chromatography-mass spectrometry were used to identify the constituents of ***,the differentially expressed genes linked to the treatment of diabetes with FZ were screened using online databases(including Gene Expression Omnibus database and Swiss Target Prediction online database),and the overlapping genes and their enrichment were analyzed by Kyoto Encyclopedia of Genes and Genomes(KEGG).Finally,the pathway was verified by in vitro experiments,and cell staining with oil red and Nile red showed that the extract of FZ had a therapeutic effect on ***:A total of 43 components were identified from FZ,and 39 differentially expressed overlapping genes were screened as the possible targets of FZ in *** dug component-target network indicated that PPARA,PPARG,PIK3R3,JAK2 and GPR88 might be the core genes targeted by FZ in the treatment of ***,the enrichment analysis of KEGG showed that effects of FZ against T2DM were closely correlated with the adenosine monophosphate-activated protein kinase(AMPK)and phosphatidylinositol-3-kinase(PI3K)/protein kinase B(Akt)signaling *** vitro experiments further confirmed that FZ significantly inhibited palmitic acid-induced lipid formation in Hep G2 ***,FZ treatment was able to promote the AMPK and PI3K/Akt expressions in Hep G2 ***:Network pharmacology combined with experimental validation revealed that FZ extract can improve the glycolipid metabolism disorder of T2DM via activation of the AMPK/PI3K/Akt pathway.

关键词： Fructus Zanthoxyli Zanthoxylum bungeanum Maxim Type 2 diabetes mellitus Network pharmacology Glucose and lipid metabolism Phosphatidylinositol-3-kinase AMPK/PI3K/Akt

Iron-catalyzed decarboxylative and oxidative decarbonylative cross-coupling:a new strategy for the synthesis of monofluoroalkenes

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Organic Chemistry Frontiers 2022年第3期9卷 831-837页

作者： Xiao-Yu Lu Meng-Yuan Ge ting-Hua tao Xiao-Mei Sun Meng-ting Gao Shu-ting Bao Qi-Le Liu Ze-Jie Xia Jing Xia School of Materials and Chemical Engineering ChuZhou UniversityChu Zhou239000China School of Chemistry and Chemical Engineering AnHui UniversityHe Fei230601China

Herein,an iron(II)-catalyzed decarboxylative and oxidative decarbonylative cross-coupling ofα-fluoro cinnamic acids with aliphatic aldehydes is *** methodology provided a novel and practical strategy for the construction of monofluoroalkenes from abundant and readily available aliphatic aldehydes,which are key functional groups in used in synthetic transformations in the pharmaceutical and agrochemical sciences.

关键词： oxidative carbonyl catalyzed

Apatinib for treatment of a pseudomyxoma peritonei patient after surgical treatment and hyperthermic intraperitoneal chemotherapy:A case report

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World Journal of Clinical Cases 2019年第22期7卷 3881-3886页

作者： Rong Huang Xiu-Ling Shi Yun-Fei Wang Fei Yang ting-tao Wang Cun-Xu Peng Department of Clinical Medicine Jining Medical UniversityJining 272000Shandong ProvinceChina Department of Gynecology The Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJining 272000Shandong ProvinceChina

BACKGROUND Pseudomyxoma peritonei(PMP)is a rare benign,but progressive,disease according to myxoma *** resection is the preferred and most effective treatment,but the outcomes are often *** SUMMARY A 63-year-old Chinese woman with PMP received apatinib at a daily dose of 0.5 mg for 15 d per cycle and at a daily dose of 0.4 mg to date for recurrent abdominal distension after surgical treatment and hyperthermic intraperitoneal *** the follow-up period,apatinib was the maintenance treatment with a progression-free period of 10 mo and the toxicity of apatinib was controllable and ***,recurrence occurred 10 mo after *** two operations,the patient gave up treatment at the 18th mo and eventually died of intestinal obstruction and multiple organ *** Apatinib may be an option for recurrent PMP after surgical treatment,but this conclusion remains to be confirmed.

关键词： Pseudomyxoma peritonei Abdominal distention Anti-angiogenic agent Apatini Case report

Recovery of a patient with severe COVID-19 by acupuncture and Chinese herbal medicine adjuvant to standard care

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Journal of Integrative Medicine 2021年第5期19卷 460-466页

作者： Xin Yin Shu-bin Cai Lan-ting tao Lu-ming Chen Zhong-de Zhang Su-hong Xiao Arthur Yin Fan Xu Zou Department of Critical Care Medicine Second Clinical CollegeGuangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of General Medicine No.3 Division Second Clinical CollegeGuangzhou University of Chinese Medicine.Guangzhou 510120Guangdong ProvinceChina Department of Emergency Medicine Second Clinical CollegeGuangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Second Clinical College Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina SH Clinic for Acupuncture&Chinese Medicine Indianapolis.IN 46268USA TCM American Alumni Association(TCMAAA) IndianapolisIN 46268USA American TCM Association(ATCMA) ViennaVA 22182USA McLean Center for Complementary and Alternative Medicine PLCViennaVA 22182USA

There is currently no drug or therapy that can cure the coronavirus disease 2019(COVID-19), which is highly contagious and can be life-threatening in severe cases. Therefore, seeking potential effective therapies is an urgent task. An older female at the Leishenshan Hospital in Wuhan, China, with a severe case of COVID-19 with significant shortness of breath and decrease in peripheral oxygen saturation(SpO_(2)),was treated using manual acupuncture and Chinese herbal medicine granule formula Fuzheng Rescue Lung with Xuebijing Injection in addition to standard care. The patient’s breath rate, SpO_(2), heart rate,ratio of neutrophil/lymphocyte(NLR), ratio of monocyte/lymphocyte(MLR), C-reactive protein(CRP),and chest computed tomography were monitored. Acupuncture significantly improved the patient’s breathing function, increased SpO_(2), and decreased her heart rate. Chinese herbal medicine might make the effect of acupuncture more stable;the use of herbal medicine also seemed to accelerate the absorption of lung infection lesions when its dosage was increased. The combination of acupuncture and herbs decreased NLR from 14.14 to 5.83, MLR from 1.15 to 0.33 and CRP from 15.25 to 6.01 mg/L. These results indicate that acupuncture and Chinese herbal medicine, as adjuvants to standard care, might achieve better results in treating severe cases of COVID-19.

关键词： COVID-19 Severe case Case report Acupuncture Chinese herbal medicine Integrative therapy

Phenformin alone or combined with gefitinib inhibits bladder cancer via AMPK and EGFR pathways

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Cancer Communications 2018年第1期38卷 542-555页

作者： Yanjun Huang Sichun Zhou Caimei He Jun Deng ting tao Qiongli Su Kwame Oteng Darko Mei Peng Xiaoping Yang Key Laboratory of Study and Discovery of Targeted Small Molecules of Hunan Province and Department of Pharmacy in the School of Medicine and Laboratory of Animal Nutrition and Human Health Hunan Normal UniversityChangsha 410013HunanP.R.China Department of Pharmacy Xiangya HospitalCentral South UniversityChangsha 410008HunanP.R.China

Background:In previous studies,we have shown that the combination of metformin and gefitinib inhibits the growth of bladder cancer *** we examined whether the metformin analogue phenformin,either used alone or in combination with gefitinib,could inhibit growth of bladder cancer ***:The growth-inhibitory effects of phenformin and gefitinib were tested in one murine and two human bladder cancer cell lines using MTT and clonogenic *** on cell migration were assessed in a wound healing *** action between the two drugs was assessed using CompuSyn *** potential involvement of AMPK and EGFR pathways in the effects of phenformin and gefitinib was explored using Western ***:In MTT and clonogenic assays,phenformin was>10-fold more potent than metformin in inhibiting bladder cancer cell *** also potently inhibited cell migration in wound healing assays,and promoted *** signaling was activated;EGFR signaling was *** was synergistic with gefitinib,with the combination of drugs showing much stronger anticancer activity and apoptotic activation than phenformin ***:Phenformin shows potential as an effective drug against bladder cancer,either alone or in combination with gefitinib.

关键词： Phenformin Gefitinib Bladder cancer AMPK EGFR

Berberine potentizes apoptosis induced by X-rays irradiation probably through modulation of gap junctions

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Chinese Medical Journal 2011年第8期124卷 1221-1228页

作者： LIU Bing WANG Qin YUAN Dong-dong HONG Xiao-ting tao Liang Department of Pharmacology Zhongshan School of Medicine SunYat-sen University Guangzhou Guangdong 510080 China

Background Clinical combination of some traditional Chinese medical herbs, including berberine, with irradiation is demonstrated to improve efficacy of tumor radiotherapy, yet the mechanisms for such effect remain largely unknown. The present study investigated the effect of berberine on apoptosis induced by X-rays irradiation and the relation between this effect and gap junction intercellular communication （GJIC）.Methods The role of gap junctions in the modulation of X-rays irradiation-induced apoptosis was explored by manipulation of connexin （Cx） expression, and gap junction function, using oleamide, a GJIC inhibitor, and *** In transfected HeLa cells, Cx32 expression increased apoptosis induced by X-rays irradiation, while inhibition of gap junction by oleamide reduced the irradiation responses, indicating the dependence of X-rays irradiation-induced apoptosis on GJIC. Berberine, at the concentrations without cytotoxicity, enhanced apoptosis induced by irradiation only in the presence of functional gap *** These results suggest that berberine potentizes cell apoptosis induced by X-rays irradiation, probably through enhancement of gap junction activity.

关键词： berberine gap junctions X-rays irradiation apoptosis

产业集聚能促进物流业效率提升吗?——来自中国省域面板数据的实证分析

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商业研究 2017年第1期 75-83页

作者：陶婷婷中国人民大学商学院北京100872

基于产业集聚基础理论、外部性理论及产业效率理论,本文分别对物流业产业集聚和产业效率进行定量测度,分集聚类型实证分析专业化集聚及多样化集聚对物流业效率影响的传导路径。研究显示:我国目前物流业集聚的区域差异大,专业化集聚对产... 详细信息

基于产业集聚基础理论、外部性理论及产业效率理论,本文分别对物流业产业集聚和产业效率进行定量测度,分集聚类型实证分析专业化集聚及多样化集聚对物流业效率影响的传导路径。研究显示:我国目前物流业集聚的区域差异大,专业化集聚对产业效率的影响表现为正向的线性关系,多样化集聚则表现为先减后增的U型非线性关系;劳动力、资本等传统投入要素对提高物流业效率的作用已经不大,专业化集聚及多样化集聚对产业效率的影响也因地区差异而有所不同。因此,应从差异性推进物流业产业集聚、综合性利用物流业集聚优势、合理调整物流产业结构等方面战略性提升物流业产业效率。

关键词：专业化集聚多样化集聚物流产业效率数据包络分析 Tobit回归